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Stem cell presentation
Hi, I have listed some papers which I am interested in doing because it is highly relevant to my own project. But I am more than happy if you post other papers and topics which interest you and we can work on them together and get ready earlier.
Here is a good source for overview and status of 3 Person IVF. http://www.geneticsandsociety.org/article.php?id=6527
- discovered in muscle by Kölliker in 1857
- mitochondria are the "powerhouses" of the cell and the location where respiration occurs at the cellular level.
- mitochondria contain their own DNA (mitochondrial DNA or mtDNA) that has been originally inherited only from the oocyte (maternal inheritance).
- The spermatozoa (paternal) mitochondria- energy for fertilization motility but are generally destroyed during the first mitotic cell divisions.
- This pattern of inheritance has important implications for a variety of mitochondrial associated diseases, usually occurring in tissues requiring lots of energy (muscle, brain).
Eukaryotic mitochondrial genomes
- double stranded circular DNA (mitoDNA. mtDNA)
- 1981 complete human sequence (16,569 nucleotides)
- 37 genes
- encodes 13 polypeptides involved in oxidative phosphorylation
- remaining genes transfer RNA (tRNA) and ribosomal RNA (rRNA)
- multiple copies within the matrix
- maternally inherited
- remainder encoded by nuclear DNA
- proteins made in cytosol and imported into mitochondria
link to Embryology website Mitochondria
--Z3251292 (talk) 17:29, 21 August 2015 (AEST) hi all,sorry that I still could not make my way to uni today due to illness. I will definitely be back next week. I have added few sub-headings to the points you guys setup, feel free to change them. BTW, would you like to pick one of the 5 topics for now? and start working on it? or there was some good arrangement already? please let me know.
--Z3292373 (talk) 20:51, 24 August 2015 (AEST) Hey, ummm sorry i lead us astray putting up those headings female fertility had been taken so we have to pick another. I put up the list of ones left. My choice would be three parent ivf. So ill do a bit of research and on that now (add some headings)just 'cuase i got some free time, but by all means if you guys would like to do something else that interests you I'm more then happy to change.
Note to self doing history benifits.
This wiki page does well in covering a lot of areas relating to the topic, however the website does not outline the information found/used quite clear enough or to the right extent. The page would benefit largely in focusing much more attention to the mechanics of the process itself and how it physically works. There is lots of information regarding other various aspects relating to the topic, however the fundamentals of the topic are not clearly discussed on the page, and it is not clear what goes on in the process.
The page should also fix up some grammatical and syntax errors. Read through the page carefully and ensure all paragraphs make sense ensuring that the quality of the information portrayed is fully appreciated. To also make the page clearer, some thought should be given to rethinking the order of the subheadings. Having a natural cohesion throughout the page as a whole is important – some subheadings do not fit into place correctly and could be moved around a little bit. Also having linking sentences within paragraphs – involving each subheading with others and the topic as a whole – will make the page much more cohesive.
The page used a good amount of supporting pubmed articles, hwoever more images/media files could be used to break up the concentrated use of text. The video used is relevant and informative – however there is no copyright information.--Z5015534 (talk) 22:44, 10 October 2015 (AEDT)
Hi guys! I'll start of by saying that the images and video you have included are excellent and are relevant to your topic of discussion. Also, you have a large number of reliable references which is good to see. However you have yet to include a hand drawn image, which is required for the wiki page. I feel like you could probably eliminate the typed out 'timeline of mitochondrial donation' and instead use this as an opportunity to use a hand drawn image of the timeline. Furthermore, the timeline under 'cystoplasmic transfer' feels a bit awkward and unnecessary. You could probably include this timeline alongside the 'timeline of mitochondrial donation'.
Under the 'Technical Progression' section it would be best to incorporate human embryo, mouse and human models under a sub-sub heading, as at the moment it feels a bit jumbled.
I would also recommend moving the 'Benefits' heading towards the end of the page. It feels odd reading about the benefits of three person embryos before I gain a proper understanding of how they work. Also it might be worth talking about the disadvantages (if there are any) to three person embryos to balance out the 'benefits' section. As has been previously stated, make sure you sort out the copyright information for your video as it would be a shame to lose marks if it was missing. Also, don't forget to add the 'student template' to the 'Swapping mitochondrial DNA mammalian oocytes' image as it is currently absent.
The entire project is presented simplistically and all the content is relevant and easy to understand. Majority of the flaws I found were based around poor grammar and syntax which could be fixed up with some editing. Below is a more detailed breakdown of some of the things you could fix.
Firstly, I liked that the introduction was brief and concise and gives the reader a basic understanding of the topic of three person embryo. The video was also informative and provided some background information around the topic. I was informed that mitochondrial DNA was the major factor concerning this topic however there was a lack of information about its importance to the body so a short summary could be included along with some examples of diseases it could cause.
Also, the use of a timeline to present the history is a great idea and I think it could be improved and would look more aesthetically pleasing if it were to be placed into a table. I also think the 1990s, 2000s and 2010s label could be removed to make it look less clustered since they aren’t particularly necessary.
Some information under the heading ‘Technical Progression’ has yet to be filled in but from what is there I’d like to suggest exchanging the bullet points for numbering instead for the information under ‘Pronuclear transfer’ and ‘Polar body transfer’ since they sounded like sequence steps as opposed to separate points.
Finally, I found the layout of the table under the heading ‘Legal status’ to be very well put together. There are however some countries placed under the incorrect continents and I found that the order was easily changed and mixed up. I also noticed that several of the countries were linked to the same sources which made the information very unspecific. Instead of just links I think a few sentences explaining the legislation would be more informative.
I liked how you guys started the introduction and provides partially a brief overview of what your project is about. But I believe it is not enough to allow the audience an insight to your project page. This is something that needs to be worked on and maybe add some images also. However, the choice of short video used in the introduction is great. This is definitely a benefit for your page as it will reinforce the information you have been trying to get across. Like I mentioned, one thing you could work on is adding images and explaining the content in more depth. There is great amount of reference at the end of the page in the reference list which is fantastic!, however there is no in- text referencing in each section such as introduction or in some of the parts of the “Technical Progression” like “Cytoplasmic transfer” or “Spindle-chromosome transfer”. Having in-text referencing will allow the audience to know exactly where the information was read from and for the interest of the audience can read that specific paper in detail.
I also noticed that there are no information for “Benefits” and “Legal Status” or there is limited information for such headings like “Ethics”. I’m assuming you didn’t get the chance to upload information there or you haven’t had the time. This is something you need to work on so that the audience has some note of what this page is about. Also you need to change the format of the page for example it is to move the 'Benefits' heading towards the end of the page after the audience gained a good level of understanding of the project. You included some great images but be careful with copyright as I didn’t see it. But also consider some more images, tables, diagrams as well as hand drawn images in some sections, to make it more inviting and not overwhelming with just content. I do appreciate that the section of “Technical Progression” is subdivided into “Human Model”, timeline” and etc. But maybe consider adding in the current research, historic research, limitations and disadvantages to ensure that you can get all the marks possible by addressing all the key concepts. The timeline is a great idea that outlines the significant progresses and in turn helps put major events into perspective, making it more effective for students to study and understand.
Well done on making the “Glossary” at the end. This is exactly what I would have expected to see and I used it while I was reading through your page. Also it is great to see the table in the “Prohibited” section but I would suggest you to write some sentences explaining the legislation rather than just pasting the links.
Overall, this project page has room for improvement by giving certain sections of the page the attention they deserve. Images are imperative in allowing a balance between text and the image itself. Diagrams, tables and animations can sometimes be refreshing, and less overwhelming to see them among paragraphs of content. Try and work on time management, or set a group deadline that everyone has to meet so that all the information can be well up before the due date so your group can have time to edit and add images and play around with the page comfortably. Goodluck!
It would be nice if the history section could start earlier in time e.g. who came up with the idea of 3 person embryos. It kind of feels as though 3 person embryos popped out of nowhere. This is just a small nuance but the first sentence in “Hereditary mitochondrial Disease” doesn't really make sense. It sounds incomplete. I think you have too many timelines going on in your page and it makes it a bit confusing. There is one under “History” and another timeline in “technical progression”. I understand they may be timelines for different things, but it’s all too much history. Maybe the “technical progression” timeline could be simplified into a paragraph?
Some sections have too many subsections e.g. “technical progression”, and this makes the section messy and hard to read. It is however good for the table of contents though as it makes it easier to specify what you want to read on the page so my suggestion would be to keep some subheading but cut down a bit. You guys are listing papers to read too often. People want to have the information summarized for them on a wiki page, not have to outsource all the information themselves. It’s too time consuming and if they wanted to read a bunch of articles, they would go on PubMed themselves. However, I do like that some articles have been listed but maybe cut it down to one or two great ones instead of 4-5 etc.
I really like the table under the subheading “prohibited”, however, it would be nice to have a little summary next to the links about what each countries stance is, because again it’s too time consuming to have to read all those links. I also think some sections need a lot more work e.g. “ethics” and “benefits” and some more words could be added to the glossary. For example, a definition of what the word gamete mean would be good as, whilst we may know what it means, other people who view your page may not.
I really likes the images you used in “technical” progression. They were easy to understand and simplified the text a lot. It would be good however to add a few more images, perhaps to “history”. Some hand-drawn ones would be good. You've got a good amount of references in there, just maybe add a few more. This indicates that you have done significant research and they appear to be correctly cited. The key points of your topic are clearly described and I feel as though your intro., whilst short, really opens up the topic well. Your page relates well to the learning aims of embryology.
To conclude, I think you've got a great framework and some really good information in there. Just makes sure your page doesn't look too busy and is easy to read. A little bit more work needs to be done in some of the sections and a bit more technical touch ups and you should be good!
Your group’s topic looks very interesting! You have addressed the key points of your topic, and the placement of the video gives the reader a great overview of your project.
COMMENDATIONS: • Information has been organised well most of the time. Good use of bullet points and subheadings.
• The table under “Prohibitions” is a great way of summarising information, and it was easy to read.
• I like the addition of a glossary, however, more terms could be added here as a lot of jargon has been used in your text.
• Cytoplasmic transfer images were great as they aided the text well. These images could be re-sized as some of the text is blurry.
RECOMMENDATIONS: • Be mindful of spelling and capitalisation, e.g. “Hereditary Mitochondrial Disease” rather than “Hereditory mitochndrial Disease.”
• In terms of formatting, more spacing between major headings will make reading the page easier and will allow your information to flow.
• I recommend adopting a set formatting scheme for each section: i.e. make sure that the subheadings are all the same size, that they are in bold/italic (if that is what you intended).
• Some references and PMIDs are placed throughout the page. These should all be under your References heading at the end of the page.
• Information is missing under certain headings, e.g. “Mitochondria Linked Infertility.” I’m assuming that information from the two links provided will be summarised for the final submission.
• Hand drawn image is absent – maybe you could hand draw one of your timelines? (Seeing that both of them currently take the same format/structure).
Great job so far!