Talk:2011 Group Project 6

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Group 6: User:z3290841 | User:z3291317 | User:z3291324 | User:z3291423


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2011 Projects: Turner Syndrome | DiGeorge Syndrome | Klinefelter's Syndrome | Huntington's Disease | Fragile X Syndrome | Tetralogy of Fallot | Angelman Syndrome | Friedreich's Ataxia | Williams-Beuren Syndrome | Duchenne Muscular Dystrolphy | Cleft Palate and Lip

Peer Review

Group 6 Peer Review

  • Good introduction, although an image straight up would be nice!
  • History is presented well, although a table format at the end that summarises everything you have said would be nice. Also, does the history stop around the 1950's? It seems like there has been nothing done on it until 1970/1980? Hence, the table format would be nice if it appears that I've missed information.
  • Epidemiology section is really quite short. Is there nothing more that can be said on it? Does it have preference to specific race?
  • Signs and symptoms - from the way that the page is formatted it appears that you've gone down onto the level 4 headings with 4 ='s paraphrasing each heading. Try to use 3 or so just to make sur e the headings are larger and each subsection can be identified.
  • The genetics/aetiology section should be explained better; whilst this is aimed at academics, it is almost impossible to understand the information pertaining to the genetics section.
  • The pathophysiology and abnormalities section is well explained, and the diagram is excellent to show exactly where the problem lies. A well done section, and a well-selected image for the blood flow patterns.
  • Diagnostic tests: Still need to insert those images on the right hand side column! Also, ensure that the referencing is done in the correct format - this section still needs work.
  • Treatment/Management section is done well, with a good balance between text and table.
  • Current and Future research: Perhaps more dates? The formatting here also needs to be fixed up, and try to have dates on the papers that you are quoting from (although I understand it's difficult without the references in place)
  • The glossary section needs more terms added to it! Especially from the genetics/aetiology section which is already terribly difficult to understand.
  • Referencing section is quite short - but understandably the whole project feels like the referencing just needs to be finished.
  • Overall a nice-looking project with a lot of promise. The spacing and format of the project makes it easy to read - perhaps more images and the use of some tables might also assist in the presentation of this project.

--Leonard Tiong 10:49, 28 September 2011 (EST)

Group 6

  • My first impression is that this project is lacking images. There is way too much text in comparison to images.
  • An image would nicely complement the introduction
  • I feel that history would work better in a timeline
  • Epidemiology needs a table/graph
  • Good links in signs/symptoms although another image would be nice
  • Genetics needs to be explained a little better
  • Student drawn images were great- obviously a lot of effort has been put into these
  • Diagnostic test table needs an image and needs to be referenced properly
  • Again, an image is needed for prognosis
  • Glossary needs to be extended
  • Overall a good project but you need to fix a few things

Group 6

  • Introduction: the contend is ok, but the structure could be clearer
  • History: too text heavy, a timeline would be nice
  • Epidemiology: more content would be good
  • Symptoms: the picture could be more general
  • Genetics/ Aetiology: the structure could be better, maybe use some more subheadings, and put the gene profile in tables
  • Pathophysiology: you need references
  • Diagnostic tests: why does it say “insert images”, that should be fixed
  • Treatment/ management: looks like there are some references missing? Deleate “Want to learn about more surgery and treatment methods?”, the contend is good, types of shunt would look better as a table
  • Prognosis: references missing? good use of subheadings,
  • Glossary: incomplete

--Z3387190 21:52, 27 September 2011 (EST)

Group 6 peer assessment

  • Introduction is clear though lack images where a image of example of a blue baby would suffice
  • History begins clearly though becomes about surgical history instead of the disease, where time line is not even present of how understanding of this disease improved.
  • Epidemiology should be expanded either the genetics of the disease, in general have more information of the causes, incidence and distribution of the disease.
  • Signs and symptoms poorly structured and requires more images also doesn’t have an introduction to the signs and symptoms. Although the extra links to comparison of the heart is useful and nicely used.
  • Pathophysiology should add supplementary information to back up all the information.
  • Diagnosis please add the images, while there is the content though no image following also first box has “insert text” very confusing.
  • Treatment/management indicate the separation of surgery and other treatment types in the introduction which is lacking otherwise all is A ok
  • Glossary needs to be referenced to other sections of the web page also expanded as most language used is unknown without a dictionary.
  • Referencing needs to be fixed as links is not proper referencing also the repeats need to be removed

z3332250 23:53, 26 September 2011 (EST)

Comments on Group Project 6


  • The flow between sections and sub-sections is good with appropriate placements of headings and sub-headings.
  • Some of the references have good use of multiple referencing so as to avoid duplication.
  • The external links under signs and symptoms is very apt and will interest readers.


  • Almost half of the references are not properly formatted.
  • Some of the words that should be in the glossary are not under that section e.g. Velocardiofacial, Conotruncal, Hypothyroidism, nengoitrous, embryotoxon.
  • Punctuation in some sections can be better.

Specific corrections:

  • ”muattional” under 22q11.21 sub-heading is spelt incorrectly.
  • ”cyamnosis” under signs and symptoms is spelt incorrectly.
  • ”enlargenemt" under clubbing is spelt incorrectly.
  • Insert a timeline under history to provide a summary.
  • It might be better to have genetics section before signs and symptoms.
  • Under Treatment/Management, it will be good to put “medical therapy”, “palliative procedures” and “surgery” as sub-headings.

--Z3389806 08:03, 26 September 2011 (EST)

Group 6 Critique

  1. • Introduction is ok, however it needs to be structured a lot better than what it is
  2. • History is interesting
  3. • Epidemiology needs a lot more detail. A few lines is not good enough
  4. • Signs and Symptoms is ok
  5. • Genetics needs to be explained a lot more clearly than what it is
  6. • Abnormalities is ok
  7. • Diagnostic tests table is impressive
  8. • Treatment/management section is very good
  9. • Prognosis and future directions section is great
  10. • Glossary is incomplete. Check the first term and fix this

--Robert Klein 19:05, 24 September 2011 (EST)

Tetralogy of Fallot

  • An image in the 'Introduction' to introduce the topic would not go astray
  • "...Infants turning blue when crying..." middle of sentence, no capital is required. What is tet spells?
  • History might work better as a timeline, otherwise at least bold the dates so I know whats going on
  • Surgical history has been covered through most of 'Contemporary History', there's not a whole lot of point having two subheadings here
  • The 'Epidemiology' is a bit sparce? Are there no other stats to add to this section?
  • There is a lot of good in information in 'Genetics', but I think you need something to break it up, you've got the images of the chromosomes (which are very good), but can you find other images? Maybe put some of the information into a table?
  • The 'Abnormalities' section looks really good. The information is clear, succinct, with good illustrative images
  • Though in number 4 under 'abnormalities' can you give a quick definition on what hypertrophy actually is?
  • Diagnosis is poor, it isn't referenced and clearly isn't finished ("insert text here"). This does not flow on from the rest of the page at all. It looks a bit dry with no colour or images
  • There are minimal references in 'Treatment', surely you didn't all that information out of only a few papers?
  • I like the table in 'Treatment'
  • Can you make the subheadings in 'Treatment' as actually subheadings as opposed to just bold?
  • It's coming along, but you need more images! It starts off well, but there aren't many toward the end.
  • Make sure you finish the project off!

Group 6-

  • No way near enough images. As I scrolled through there was HEAPS of text and only a few images, all of which are on the right hand side. It would be better if they were scattered around
  • An image in the introduction would be helpful
  • What are ‘tet spells’? mentioned in the introduction (described later but when seen in the introduction it looks like a typo)
  • History would work better as a list of dates rather than paragraphs. I do like the section at the top with the quote though
  • Epidemiology needs an image- perhaps a table or a graph.
  • Signs and symptoms could do with another image to visualise the clinical manifestations
  • I really liked the audio clips but the first one didn’t work on my computer? I couldn’t hear anything. Not sure if it was just me
  • I think you can come up with a better way of formatting the genetics section. Maybe a table? The information is good it just looks a bit funny
  • The pathogenesis doesn’t actually say HOW is happens in infants. Is this a condition formed during embryonic development or after?
  • The diagnosis section is far from complete. This needs to be corrected
  • Diagnosis section is also not referenced properly
  • Why is there a reference at the bottom of the diagnosis section?
  • As funny as this was: ‘Want to learn about more surgery and treatment methods? Check here!’…. maybe not appropriate sorry. It should be a little more formal. If you want the reader’s attention- try colour.
  • Prognosis- image needed please. Maybe a graph?
  • The glossary also needs to be extended
  • The references need to be tidied up- there are also not many?
  • You need to reference your images properly. ‘normal fetal blood flow and tetralogy of fallot’ is an example. You have but the copyright but not the reference. The web address is not a reference
  • You are clearly on your way with the project but more work is required. You need to FINISH the content and format it a little better with more images.

Group 6 Assessment'

  • First, I’d like to note good job on using a reference more than once in the correct way instead of referencing the same thing multiple times. At least this is done in the first few sections. First time I’ve seen this done correctly!
  • The introduction, however, has no references whatsoever. Where did this information come from?
  • It might also be good to add a simple picture in the introduction section so it looks more appealing.
  • Good information included in the history section. It might look better if this were laid out in a bullet format though.
  • The epidemiology section looks rather bland. Not only is there not a picture, but there also isn’t very much information included. Think about what else you could include here or what you could go into depth about.
  • The signs and symptoms section has good information, but it might be a good idea to represent this information in a better format, possibly in a chart, with pictures of each symptom included in the chart.
  • Finger-clubbing.jpg also needs a detailed description still.
  • Good organization and format under the Genetics section.
  • Under the pathyphysiology and Abnormalities section there are no references made. Where did this information come from? Diagnostic Tests and Treatment also needs more referencing.
  • Pictures still haven’t been inserted into the Diagnostic Tests chart.
  • More referencing is needed for the Prognosis section. Also, does the glossary terms need to be referenced?
  • It would be a good idea also to have the glossary terms linked with the words in the wiki page, so that the reader can easily get access to the word in the glossary. References 7-14 are the same reference. Fix these so they are under one single reference number.
  • For the references given throughout the wiki, there isn’t any consistency in how the [#] is given. The [#] is sometimes right after the sentence, sometimes a space is given between the sentence and citation number, and the end of the sentence (period or comma) is sometimes before or after the reference #...
  • Overall, there is a substantial amount of information given within this page, which is good. I like the basic format of everything and most of the pictures which are included. Just work on weaving everything together better and referencing things correctly. Good job!

--Z3391078 15:32, 27 September 2011 (EST)

Group 6

  • Nice overall structure and good use of headings and subheading. It gives the page a nice flow.
  • INtroduction is nice and straight to the point and gives the reader a good overview of your topic.
  • I like the historical section with interesting subheadings used, maybe you could add a timeline just to simplify the info.
  • Signs and symptoms nicely arranged. could you add some more pictures here?
  • Pathophysiology and Abnormalities section need to have the references accompanying the information. Just so the read can identify where all the info is from.
  • The diagnostic tests table would be nice with some colour and when the images are it will look complete. It's a little text heavy for a table maybe try bullet points. also the referencing system has changed in this table? and a little unsure of the reference at the bottom of the section?
  • Treatment/Management section is nicely arranged.. could you add another picture here just to compensate for the amount of text. the table really brightens up the page!
  • Future directions section is nicely summarised and I like the tone of voice used here. just make sure the referencing is correct as it is a little confusing and interrupts the flow of the section.
  • Maybe the use of similar tables and colour scheme will increase the continuity of the page.
  • Make sure your references are not doubled in the list.
  • Ensure all of your pictures are correctly referenced.
  • Make sure all acronyms and scientific wording is in the glossary.

  • Intro: What's a tet spell?
  • History: Very good in general. Not sure it makes sense to split it into 2 parts, with surgical being separate? I think it would work just as well combining the two.
  • Edidemiology: Looks fine
  • Signs and Symptoms: Otherwise good, but considering you have a whole subsection entitled clubbing, I'd suggest explaining what it is right there, and not just in the glossary.
  • Genetics/Aetiology: Love the detail and depth, though the more technical terms should be explained in the glossary. Tiny comment: "there is only a single copy of the gene in one allele" - I know what you're trying to say, only one allele is functioning, but saying it like this kinda means, this allele only has one copy of the gene, whereas usually there are multiple copies of a gene in one allele, which is, as far as I know, not the case (that would just be contradictory, as an allele is a copy/varient of a gene).
  • Pathophysiology and Abnormalities: Very good, nice use of figures.
  • Diagnostic Tests: Not sure I like the table. It is just a hell of a lot of text... in a table. It doesn't really help give an overview, maybe just have subheadings, with (once you have an image) a picture on the side? Also, referencing needs fixing.
  • Treatment/Management: Very good, nice amount of detail. Again not sure a table is required. Also, the colour is a bit in your face, but that might just be me. I like the links at the end.
  • Prognosis: Content seems fine. A bit odd there's only one reference?
  • Future directions: Otherwise seems fine, though referencing needs fixing.
  • Glossary: A bit poor. More technical terms need to be explained.
  • General: The last few sections lack some figures, it is just a lot of text. The content in general (as in of the whole project) was really good, so well done!

Peer Assessment: Group Project 6

  • The introduction and the section on pathophysiology and abnormalities have no references. This needs to be rectified.
  • The introduction and some of the history section have short paragraphs that are only one sentence long and would be improved, both for formatting and information purposes, by incorporating them into the rest of the information.
  • Inserting a small timeline in the history section would make the sequence of events more accessible to the reader.
  • Some sentences are too long such as, 'Children with TOF don’t grow at the rate of normal children as whilst breastfeeding in infancy, the babies would get tired quicker and during the growth of the infant, normal functionability of the heart and oxygen saturated blood is needed for proper growth'. This sentence could be broken up and also improved by a greater explanation of why the process of growth is abnormal in TOF.
  • Maybe explain more about what 'clubbing' is.
  • In the diagnostic tests section the images need to be inserted and needs to be properly referenced. The information is good but as noted one section is totally void of text.
  • The section on prognoses needs proper referencing.
  • The section on future directions is well written, however the referencing needs to be adapted to the wiki format.
  • Under the information in some of the images you have uploaded such as in the portait of A. Fallot, you still need to add {{Template:2011 Student Image}}.
  • The project is informative, however formatting and referencing are issues that need to be addressed.

--z3217345 22:23, 27 September 2011 (EST)



--z3291423 11:57, 22 September 2011 (EST)

Hey Jaz, thanks for letting me english can fail me at it up... regards--Z3291317 18:49, 18 September 2011 (EST)

Hey guys! i just realised that the caption of helen taussig and ballot say portraight....not PORTRAIT!?!! i tried to change it but it don't really know how..anyone have any ideas to this?! :S thanks --z3291423 00:06, 17 September 2011 (EST)

Table Test! --z3291423 22:16, 16 September 2011 (EST)

Type of Shunt Description Reasons for it not being used Image
Pott’s Shunt This shunt is a connection that is established between the lower part of the Aorta (on the left side of chest) to the left branch of the Pulmonary artery. The shunt has a tendency to increase the pulmonary blood flow and it is also very hard to close when complete repair is undertaken Insert image
Waterston Shunt This shunt was placed between the back of the Aorta, to the right branch of the pulmonary. This shunt’s use is more suited to those with pulmonary artery stenosis and also the procedure is quite difficult to perform. Insert Image
Glenn Shunt The Super Vena Cava is anastomosed via a shunt to the right pulmonary artery. This procedure is very complicated and difficult to perform, also complete repair becomes a laborious task. Insert image

Table test (fingers crossed!) --Jacqueline Ellero 10:49, 15 September 2011 (EST)

TOF diagnostic techniques

This table describes different diagnostic tests for TOF
Diagnostic technique How the procedure works Presentation in TOF patient Image
Physical examination TOF is often diagnosed during fetal life by echocardiography (Apitz, Webb, & Redington, 2009). If TOF is not detected during fetal life, certain signs and symptoms at birth may alert the need for further investigation. These signs and symptoms include mild to moderate cyanosis, which worsens when the baby cries, difficulty feeding and difficulty gaining weight. However, TOF often goes undiagnosed until adult life. Most adult patients will appear normal, however, some may present with cyanosis and clubbing of the fingers. The jugular venous pressure is usually normally (raised jugular venous pressure often indicates right ventricular failure). If the aorta is pushed to the right (so it is continuous with both the left and right ventricle), a lift below the right sternoclavicular joint may be noted. (Somerville, 1993) Insert text here Insert physical examination image
Heart murmurs Heart murmurs are sounds caused by the turbulent flow of blood. They are heard using a stethoscope. They are often the result of problems including valvular stenosis (narrowing of valves), valvular regurgitation (leakage of valves due to incomplete closure) or defects in the heart wall allowing blood to flow in unusual directions. Examination of the heart of a patient with TOF may reveal a loud second heart sound (produced by the closure of the pulmonary valve). A harsh systolic ejection murmur may be heard and a palpable thrill may be felt along the left sternal border. These sounds occur because the pulmonary outflow tract is obstructed. Although this murmur is often present, sometimes it may be short or difficult to hear and is often missed on physical examination. A pansystolic (occurring throughout the whole of systole) murmur may also be heard. This type of murmur occurs due to the ventricular septal defect between the left and right ventricles. The increased pressure in the left ventricle forces blood back into the right ventricle, causing a murmur, which lasts the whole of systole (contraction phase). Insert heart murmur image
Electrocardiogram Once TOF is suspected, electrocardiogram and chest radiographs are performed. Electrocardiography is used to assess the electrical activity of the heart. The electrical activity is detected by electrodes, which are placed on the skin of the patient and recorded by an external device. The electrocardiogram is extremely important in detecting a right bundle branch block (a block in the electrical conducting system of the heart), which is common in patients with TOF. An electrocardiogram will also reveal a heart that is deviated slightly to the right and an enlarged right ventricle due to the ventricular hypertrophy.(Somerville, 1993) Insert electrocardiogram image here
Chest radiograph A chest radiograph (or chest x-ray) uses ionising radiation to develop an image of the patient’s chest. It is used to diagnoses many conditions including the thorax and structures within the thoracic cavity including the heart, lungs and major blood vessels entering and leaving the heart. Chest radiographs are often used to screen for certain diseases but further tests are required for a definitive diagnosis. In a patient with TOF, a chest radiograph will demonstrate a prominent right ventricular shadow, giving the heart a boot-like appearance, which is typical of patients with TOF. The right ventricular hypertrophy causes the apex of the right ventricle to rise on top of the relatively unfilled left ventricle, giving the heart its boot-shaped appearance on examination. (Bailliard & Anderson, 2009) The radiograph will also show a right-sided aorta in approximately one-quarter of patients. (Somerville, 1993) Insert CXR image here
Echocardiogram An echocardiogram (also called a cardiac ultrasound) is performed to confirm the above findings. Echocardiography uses ultrasound to produce two-dimensional (and now also three-dimensional) images of the heart. It assesses cardiac tissue, valve function, the velocity of blood flow and any abnormal communications within the heart. The echocardiogram identifies important abnormalities of the heart including obstruction of the pulmonary outflow tract, the size of the pulmonary arteries, the degree of aortic override and the size of the defect in the interventricular septum. (Bailliard & Anderson, 2009) Insert echo image here
Magnetic resonance imaging Magnetic resonance imaging (MRI) is evolving as the most important technique for evaluating the size and functioning of the right ventricle. An MRI machine uses a magnetic field to produce a detailed image of the scanned area of the body. It is especially useful in viewing soft tissues as it provides greater contrast than techniques such as x-ray. MRI’s are important in assessing pulmonary valve competence and the severity of regurgitation (the amount of blood that flows back into the right ventricle due to the incomplete closure of the pulmonary valves) in patients with TOF. It can measure the volume and mass of the right and left ventricles and can assess the degree of pulmonary outflow tract obstruction. Finally, MRIs are important in measuring the degree of ventricular septal defect. (Somerville, 1993) Insert MRI image here

Hey peeps just put a intro just as a draft...tell me what you guys think of it. Edit it as you may wish.... And Jaq, if you describe briefly how each test works it would be good, regards --Z3291317 23:16, 14 September 2011 (EST)

hey jaz, ive fixed up the diagnosis, but feel free to add anything! or let me know if you think i should add anything. --z3291324 10:06, 14 September 2011 (EST) should i describe each diagnostic test!!??--z3291324 10:07, 14 September 2011 (EST)

Hey Guys! just added a very few changes, links etc to treatment. I've begun to add make a bit of notes on diagnosis that could just add a bit of detail to the diagnosis section. just wondered if any of you guys know what particular section of the ECG indicates...Left Ventricular Hypertrophy etc maybe ill call up a cardiologist :P nonetheless ill add references and some things to diagnosis tmrw night. regards, --z3291423 00:15, 14 September 2011 (EST)

Hey jaq. no particular order, the referencing system in the wiki automatically arranges it according to the order it is found in the text. In text referencing is NEEDED, lol. Type in the text title into Pubmed and when the article is found, the pmid code will be found at the bottom of the abstract for that article. if you cant figure out how to reference, put in the pubmed ids as intext citations then ill fix it for you...Make pathophys a bit more simpler, but do not compromise the anatomical words, i.e. write the anatomical word, then write in brackets what it means, eg. ...anterolaterally (at the top away from the midline) is just an example (a crap one to lol). Also did you find any new info for diagnostic tests? and Rom, why did you remove info from the 22q section???? regards --Z3291317 22:02, 13 September 2011 (EST)

hey guys, quick question about the referencing. are they in any particular order? or should i just add mine to the end of the list? and do we need to do in-text referencing?? and how do you find the pmid code? also, any suggestions on how i should improve pathophys? ie make it more anatomical based or reword it so its simpler? thanks --z3291324 21:30, 13 September 2011 (EST)

Hey Rom, looking good thus far. if you need help with referencing even after trying so much i can help you during the 1 hour we have afta the lecture tomorrow to go through and help you fix em up... its a bit tricky but can get a handle of it... --Z3291317 20:37, 12 September 2011 (EST)

Hey guys sorry for the delay, but I'm slowly uploading all my stuff up. I'm just a bit confused about how I do the reference tag thing, as you can see there is a massive red thing on our reference list. I tried copying how you guys did it but I failed at it. I'll be posting some more in the next couple of hours, I just need to get a hang of this coding thing gah! --z3290841 19:36, 12 September 2011 (EST)

hey rommel, we really need to see your part of the project and get your suggestions on parts we have done because its due on thursday --z3291324 19:16, 12 September 2011 (EST)

Hey Peeps, Just reconstucted the referencing so they are done exactly as it should be... Also just uploaded a pic of Mr fallot Himself without any copyright restrictions ( aha ow ye ow ye, took me long before i found it lol). I left the intext references jac and jaz put in their sections for future reference. Thats about it for now... Jaz i hope u liked the pics i showed you, and i hope rom is going well in his section... See yous soon... Regards --Z3291317 17:36, 11 September 2011 (EST)

update: uploaded the drawn images, took ages but its finally done :) and I've just finished the future directions :) so it should be fine to edit and look over in the next couple of days! regards --z3291423 13:16, 11 September 2011 (EST)

looking good jaz. thanks for the articles fru. ive had a quick look at them but will need to fix it up after work this arvo! --z3291324 11:59, 11 September 2011 (EST)

Hey Jac, ive got 2 articles that i will send to your email, both talk about Cardiac Magnetic Resonance, one some detail about electrocardiography. Also, Jaz i have an article that has a section based on 'Future Innovations' for TOF, have a read and i reckon it will help out with the future directions part... i will send these articles to your emails so look at them when yous can... and rom, you breathing my friend?... regards --Z3291317 01:29, 11 September 2011 (EST)

hey guys, just reworded diagnosis so it makes sense. can anyone suggest any good articles to read for diagnosis? im having trouble accessing a lot of articles (they keep asking for passwords) and a lot of the articles dont discuss diagnosis in much detail at all. help is much appreciated!! thanks :) --z3291324 21:12, 10 September 2011 (EST)

hey rom, this might be helpful for genetics. not sure what youve got already though --z3291324 20:50, 10 September 2011 (EST)

also what should i do about the symptoms-pathophys overlap. should i alter the pathophys so its more anatomical like in the below article??--z3291324 20:10, 10 September 2011 (EST)

On to it now fru. thanks for the article. should i reword pathophys too so its easier to read/understand?--z3291324 20:08, 10 September 2011 (EST)

Hey Fru: in regards to the below comments, im working on future directions now :) also i read through the history section and it seems a lot more better :) just one mistake is the "durng such operations there need". Ill have my edited prognosis and futures up by tonight! :) ohh and the heart! regards --z3291423 11:03, 10 September 2011 (EST)

Hey Jac i was reading the article: Review - Tetralogy of Fallot by Frederique Bailliard and Robert H Anderson ( im sure you have this one) and theres a section absed on " Anatomical variants of Tetralogy of Fallot, and associated anomalies". i believe if you could also include this section into the Pathophysiology section it would be great! Furthermore would you please do the things Mark said in regards to your sections it would be good, especially the diagnostic tests part :). Also to everyone we need to get Future Directions and especially Genetics up ASAP! thus respective people have them completed asap. --Z3291317 22:49, 9 September 2011 (EST)

Hey jaz, the prognosis sounds pretty good. maybe expand/explain how the hypoxic spells, brain abscesses etc cause death. i think in general we could expand upon most sections. off to work now guys but ill fix up my couple of sections tonight/tomorrow morn! --z3291324 08:30, 9 September 2011 (EST)

Thanks Fru! I will definitely crack onto those suggestions, I'm going to first email the owner of the children's hospital video on youtube to get permission for using the video, and then ill put it up in my section. ALSO, I've nearly done the picture! I've got an outline and as your reading this, i should have it coloured, labelled and ready for upload! :D

have a great weekend guys!

Reagards --z3291423 23:29, 8 September 2011 (EST)

Hey jaz just read your prognosis section. You made it well, however,i picked up 2 things you could do and it woould be good if you do them: 1. The causes of death after no surgery has done; if you can explain how these 'causes of death' occur due to TOF, it will portray the role TOF has in these problems. 2. You should talk about any complications that could arise in both patients that dont have corrected TOF and the ones who do have the surgery (i.e. any conditions that could develop after having the surgery or not, not just the death of the patient if they dont correct their heart). Other than that great work! :) --Z3291317 23:17, 8 September 2011 (EST)

Ye Jaz, thanks for the pic. Aswell ive attached a reviewed file of the treatment section on an email i sent to you. Maybe the youtube cideo based on the TOF fix up can now be put under this section as an embedded video... --Z3291317 22:19, 8 September 2011 (EST)

hey jaz, the treatment section is much better, much easier to read. thanks for the heart pic! im pretty sure my section is he one that is too "verbose" so anyone feel free to fix it up--z3291324 19:47, 8 September 2011 (EST)

Hey Guys! sorry prognosis took me a bit longer to do, but It will be up by tonight :) and ill upload the heart pic as well :) which took forever to make! regards --z3291423 16:05, 8 September 2011 (EST)

hey guys just put up some diagnosis, let me know if you want me to add anything to it. furkan, glossary looks good! rommel, how are you going with the genetics do you need any help? and jaz are you able to post up the prognosis? once they are all up we should go through and edit them all together and fix up the wording. --z3291324 15:50, 8 September 2011 (EST)

Hey going to start constucting the glossary wordbank as i read the entire document. Please add words yous think i missed out on... Also i found a pic of Mr Fallot but i think theres copyright rights on it. i think i gotta clear it somehow...--Z3291317 19:19, 7 September 2011 (EST)

hey jaz, i think the treamtment section is alright. maybe reword the first bit into sentences (i think it was the bit on how severe the cyanosis is) so its a bit clearer. but otherwise good :) what do you think about pathophys?--z3291324 12:40, 7 September 2011 (EST)

hey guys, i cant tell if this pic has copyright or not. can someone please have a look for me? thanks!--z3291324 09:49, 6 September 2011 (EST) --> REPLY: I looked at the pic and looks great. however, i couldnt see if it was copyright or not. HOWEVER, it is found on a public government website, and from what i remember Mark said we can use these materials. To make sure just please check it with him aswell. Also, im going to format your pathophysioligy section now so it looks prettier :)--Z3291317 19:19, 7 September 2011 (EST)

Hey guys, i Just finished the Treatment part, I've got palliative in this heading to still complete but Its very brief so i thought id get cracking on getting that drawing done and also the prognosis will be up by tomorrow! also check this out! --z3291423 23:57, 5 September 2011 (EST) -->REPLY: Cool animation. Would we use an external link to this animation due to copyright restrictions?--Z3291317 19:19, 7 September 2011 (EST)

Hey Peepz

I just finished the sections of History, Signs and symptoms and Epidemiology

just please check these sections, especially the epidemiology one, do yous want it more detailed or is it enough?

z3291324 your section seems alright so far, show us your edited version so we can fully critic it then.

p.s. the post below my one i dont really understand itl who is speking to who and what are yous refering to? lol

Regards --Z3291317 23:44, 4 September 2011 (EST)

j: the article on future treatment directions sounds good. i might add some of the info in to the pathophysiology section because it links in well with the pulmonary stenosis and right ventricular hypertrophy. --z3291324 13:47, 2 September 2011 (EST) I think this article makes some good points which could be added into the treatment section (eg discuss treatment/surgery after birth and also follow up treatments in adulthood- pulmonary valve replacement etc due to valvular incompetence and regurgitation because of the growing heart)


hey guys. ive written some basic notes (UNEDITED) for pathophysiology. Just want to get an idea of how much detail i should go into before i start adding links to journal articles etc. can someone please have a quick look through and give me an idea of how much more detail is needed. thanks :)

The four features of tetralogy of fallot are pulmonary stenosis, overriding aorta, ventricular spetal defect and right ventricular hypertrophy. These features result from the anterosuperior displacement of the infundibular septum. The severity of symtpoms is determined by the extent of right ventricular outflow obstruction.

Pulmonary stenosis (Symptoms include cyanosis, right ventricular hypertrophy, hepatomegaly and peripheral oedema (of the legs). More mild symptoms include sudden fainting and dizziness from exercise. )

Valvular or infundibular stenosis (narrowing of the outflow tract of the right ventricle). Obstructs the outflow of blood from the right ventricle reducing pulmonary flow. If the pulmonary stenosis is mild, a left to right shunt (with no cyanosis) will form, due to the higher pressure in the left ventricle. However, significant pulmonary stenosis can raise right ventricular pressure above the left ventricular pressure and cause a right to left shunt (cyanosis etc). The pathophysiology of pulmonary stenosis usually worsens with age because the pulmonary orifice stays the same size despite an increase in the size of the heart.

Overriding aorta The aortic valve has a biventricular connection. Instead of being positioned over the left ventricle, the aortic valve is located above the interventricular spetal defect allowing blood from both the right and left ventricles to pass through the aortic valve. The degree to which the overriding aorta is continuous with the right ventricle determines the severity of symptoms. Because the right ventricle receieves deoxygenated blood from the systemic circulation, the percent oxygenation of bloood entering the aorta and hence back into the systemic circulation is decreased.

Ventricular septal defect The interventricular septum dividing the left and right ventricles is incomplete at its superior, membranous end. During ventricular contraction, blood from the left ventricle passes into the right ventricle and then re-enters the pulmonary circulation. Leakage of blood from the left to right ventricle raises the right ventricular volume and pressure resulting in pulmonary hypertension. (Shortness of breath, dizziness and fainting) If the right ventricular pressure exceeds that of the left, the left to right shunt is reversed and the patient will experience cyanosis and deoxygenated blood is by-passing the lungs and entring the systemic circulation. (also breathlessness, poor feeding and failure to thrive in infancy.)

Rigth ventricular hypertrophy Compensatory response to pulmonary stenosis be contined.

--z3291324 13:38, 2 September 2011 (EST)

link to pathology textbook

hey guys, this is the link to tetralogy of fallot in robbins pathology --z3291324 13:05, 2 September 2011 (EST)

More genetics and Surgery

Hey Peeps, i forund another article in regards to Genetics as it does an genotype-phenotype anaylis os TOF Patients. Have a read and see if it can help in the assignment subsection. if you cant get the full article tell me and ill give you the pdf of it.

Article: PMID: 19948535

And Regards to surgery and its prognosis post-operation i found these articles that may be helpful for 3291423. Again if yous cant find the pdf tell me and i'll send yous the pdf articles of these.

Articles: PMID: 20091166 ; PMID: 21769263 ; PMID: 21566339 (hey 3291423 this is the article i showed you in the lab and you wanted it from me)

Anyways peeps i hope all the assignments are coming along well

Regards --Z3291317 19:03, 1 September 2011 (EST)

REPLY: Thanks z3291317, I had a look through the files and am using them now for summarising :) also, can you send through the picture of what you want the abnormal TOF heart to look like and ill get cracking on it to produce/draw it :)

regards --z3291423 22:15, 1 September 2011 (EST)


Hey guys, found some articles relating to genetics and the deletion of the 22q11 gene. take a look :) --z3291423 21:09, 27 August 2011 (EST)

AS Bassett, EWC Chow and J Husted et al., Clinical features of 78 adults with 22q11 deletion syndrome, Am J Med Genet 138 (2005), pp. 307–313.

Treatment and future directions info/readings

Hey guys, found this really amazing article about treatments and their repercussions --z3291423 21:09, 27 August 2011 (EST)

Online lab 4 info

I my friends , colleagues and countrymen am going to be undertaking the research of the subsection Genetics/Aetiology in the topics that have been discussed. --z3290841 10:18, 25 August 2011 (EST)

Im going to be researching Treatment/Management, Prognosis & Future directions. - z3291423

regards, --z3291423 23:30, 24 August 2011 (EST)

Thanks for typing them up. I'm going to research Pathophysiology and abnormalities and diagnostic tests. --z3291324 15:40, 24 August 2011 (EST)

Hey Group 6

From the Meeting on Tuesday after the Embryo lecture, we had concluded that we are going to divide the group project of TOF into the following sub-sections (if i am not mistaken):

  • Introduction
  • History
  • Epidemiology
  • Signs and Symptoms
  • Genetics/Aetiology
  • Pathopgysiology and Abnormalities
  • Diagnostic Tests
  • Treatment/Management
  • Prognosis
  • Future Directions
  • Glossary
  • References

From these subsections, I (z3291317) will research the History, Epidemiology and Signs & Symptoms subsections of the group Project.

Just wanted to put forward my part for the group project :)

Regards --Z3291317 15:01, 24 August 2011 (EST)


Hey Group 6

When i was looking around for info in regards to TOF, i found some videos on youtube made by an american hospital which we could use on our page in the "more info" section. Check them out and tell me what yous think...

- -

So what you guys think? --Z3291317 22:54, 21 August 2011 (EST)

COMMENT: great stuff! that really is a great tool, maybe we can incorporate that in as a link, or something to really explain it! without all the mumbo jumbo :) --z3291423 22:22, 22 August 2011 (EST)


Found really good article detailing some clinical aspects its called: The clinical anatomy of tetralogy of Fallot, - Tetraology of ballot by christian apitz, just google scholar it via unsw or use the link I've given you :) --z3291423 19:10, 20 August 2011 (EST)


Hey guys, this is an image of tetralogy of fallot with pulmonary atresia

Tetralogy of Fallot with pulmonary atresia.jpg --z3291324 22:07, 17 August 2011 (EST)

Hey guys, just found this still frame showing large ventricular septal defect, aortic override, and right ventricular hypertrophy which are all very common to patients with ToF Some common effects for patients with Tetralogy of Fallot.jpg --z3291423 21:43, 17 August 2011 (EST)

Hey guys this is my image of our disease, it is just outlining some of the basic changes that happens to the heart, mainly the right ventricle.

Right ventricle of heart with Tetralogy of Fallot.jpg

--z3290841 13:42, 17 August 2011 (EST)

Hey Group 6, its z3291317

I just wanted to make it clear that we add all new entries into our discussion page at the top of the page and not at the bottom of it. Thats how we are told to edit this discussion page.

Anyways this is my Image for Lab 3 Question 2:

Normal fetal blood flow and Tetralogy of Fallot.jpg

I hope it would be beneficial for our page...

--Z3291317 12:05, 17 August 2011 (EST)

--Z3291317 17:00, 7 August 2011 (EST) Hey Group 6

i just done some research on a possible group project subject. It is quite detailed and interesting (to me) disease to write on.What do you guys think? Here is the review and research article for it:

The Disease:Tetralogy of Fallot

Review Article:

Orphanet J Rare Dis. 2009 Jan 13;4:2.

Tetralogy of Fallot.

Bailliard F, Anderson RH.

North Carolina Children's Heart Center, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Link: [1]

Description: This paper gives an overview about the disease, how it happens, and clinical manifestations.

Research Article:

J Med Genet. 2010 May;47(5):321-31. Epub 2009 Nov 30.

Comprehensive genotype-phenotype analysis in 230 patients with tetralogy of Fallot.

Rauch R, Hofbeck M, Zweier C, Koch A, Zink S, Trautmann U, Hoyer J, Kaulitz R, Singer H, Rauch A.

Institute of Medical Genetics, Schorenstrasse 16, CH-8603 Zurich-Schwerzenbach, Switzerland.

Link: [2]

Description: A study was done to see the prevalent phenotype for Tetralogy of fallot, and it was found that the 22q11.2 deletion was the most common type in Tetralogy of Fallot.


  1. <pubmed>19144126</pubmed>
  2. <pubmed>19948535</pubmed>

--Z3291317 17:00, 7 August 2011 (EST)

--z3290841 09:36, 8 August 2011 (EST)

Hey Guys,

I did research on Cystic fibrosis and these are the 2 articles that I found that explains a lot about the disease, and the genetic research on it.

Review Article:

Cystic Fibrosis: Seminar

Description: This is basically outlining the pathophysiology of the disease, disease manifestation,current treatments diagnostic tool.

Ratjen F & Doring G.(2003).Cystic Fibrosis: Seminar.The Lancet, 361, 681-9. Retrieved from

Research Article:

Gene expression profile study in CFTR mutated bronchial cell lines

Description: This article provides information about the severity of gene expression in relation of the extent or type of mutation.

Gambardella S, Biancolella M, D'Apice M, Amati F, Sangiuolo F, Farcomenti A, Chillemi G, Bueno S, Desideri A & Novelli G.(2006).Gene expression profile study in CFTR mutated bronchial cell lines.Clinical and Experimental Medicine , 6, 157-65. Retrieved from

--z3290841 09:36, 8 August 2011 (EST)

--z3291324 20:48, 10 August 2011 (EST)

Hey guys, I like the disease that Furkan found (tetralogy of fallot)! What does everyone think?

These are the two articles I found. The review article gives a pretty good description of the disease, symptoms, treatment and complications etc. The research article looks at some of the genetic causes.

Goldmuntz, E., Geiger, E., & Benson, D. W. (2001). NKX2.5 mutations in patients with tetralogy of fallot. Circulation, 104(21), 2565-2568.

Apitz, C., Webb, G. D., & Redington, A. N. (2009). Tetralogy of Fallot. Lancet, 374(9699), 1462-1471.

Hey kiddes just done some research! check it out, its about Hypoplastic left heart syndrome

Review article:

2001 May-Jun;21(3):705-17. Hypoplastic left heart syndrome. Bardo DM, Frankel DG, Applegate KE, Murphy DJ, Saneto RP.

Link: [1]


2011 Aug 1;108(3):421-7. Epub 2011 May 31. Prenatal diagnosis of hypoplastic left heart syndrome in current era. Kipps AK, Feuille C, Azakie A, Hoffman JI, Tabbutt S, Brook MM, Moon-Grady AJ. Link: [2]


1. Bardo DM, Frankel DG, Applegate KE, Murphy DJ, Saneto RP ""Hypoplastic left heart syndrome.""Radiographics. 2001 May-Jun;21(3):705-17 [1]

2. Kipps AK, Feuille C, Azakie A, Hoffman JI, Tabbutt S, Brook MM, Moon-Grady AJ ""Prenatal diagnosis of hypoplastic left heart syndrome in current era."" Am J Cardiol. 2011 Aug 1;108(3):421-7. Epub 2011 May 31 [2]

Peer Assessments

  • I would suggest placing the history section into a timeline or table format just so that significant dates are more clear and emphasised.
  • The gene profile section was great. It was in detail, it was coherent and the inclusion of gene images enhanced my understanding of this particular section.
  • Maybe for the “how the procedure works” section of the diagnostics table could have been summarised into a flow diagram or through images, rather than having a chunk of text. This could make it more straight forward to the reader.
  • Your website was generally well-written and to the point. You varied your formatting regularly which made your page entertaining.
  • My last suggestion would to only use the image of the shunt once and finding a different image as the repetitiveness of this is slightly disengaging

--z3332629 15:26, 22 September 2011 (EST)

  1. <pubmed>11353117</pubmed>
  2. <pubmed>21624547</pubmed>