Talk:2011 Group Project 2

From Embryology

Group 2: User:z3279511 | User:z3288196 | User:z3288729 | User:z3288827


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2011 Projects: Turner Syndrome | DiGeorge Syndrome | Klinefelter's Syndrome | Huntington's Disease | Fragile X Syndrome | Tetralogy of Fallot | Angelman Syndrome | Friedreich's Ataxia | Williams-Beuren Syndrome | Duchenne Muscular Dystrolphy | Cleft Palate and Lip


Hey sorry I missed the lab class today, im having some family troubles but will be back in sydney on the weekend. If somebody could let me know what happened etc I would really appreciate it. Are we still doing Duchennes or did another group choose it too?

Hello, I hope that you family gets better soon. So, we had to flip a coin with another group about Duchennes and unfortunately lost. We decided that we'll all think about what else we would find interesting until Sunday and post our suggestions here so that we can make a decision about it on Sunday or early this week. If I understand right, it would be the best if we find a disorder that is really caused during embryonic development. Hence Duchennes and Thalassamia for example are not the best ones any way. Have a good week end guys. --Anna Marx 18:51, 11 August 2011 (EST)

Thanks Anna, I will have a look at some now and see what I can find :) --Sarah Jenkins 15:20, 12 August 2011 (EST)

New Ideas

  • Conjoined twins. It results from abnormalities in the original process of cell division.

  • Spina Bifida is due to incomplete closing of the neural tube

  • Cri Du chat syndrome

  • Ectodermal dysplasia

Another Idea

Hi! I think there are so many interesting congenital diseases/abnormalities which we could choose. I have had a look around and I think that DiGeorge Syndrome would be a good topic! First, it is due to some abnormalities in the chromosome 22, hence there is a genetic component. Second, it occurs in 1 of 4000 people and there are lots of variations from person to person, hence there will be a lot of research and a lot of information that we can use. Third, a defect in the migration of neural crest cells is included, which means it happens during embryonic development. So, may be you can have a look into it and let me know what you think. Have a good week end, Anna --Anna Marx 15:03, 13 August 2011 (EST)

I had a quick look and this looks like a good one. I'm happy to do DiGeorge if everyone else is?? --Sarah Jenkins 10:40, 14 August 2011 (EST)

Ok, sounds good! What about the rest of the group? Do you guys like DiGeorge too? I am open for any other suggestion, however I would suggest, that we make our decision soon, so that we can start our research about it. So I'll open a little "Agree with you signature" box and wait what happens :) --Anna Marx 17:41, 14 August 2011 (EST)

DiGeorge Syndrome

If you like to make DiGeorge Syndrome to our team project, sign below.

--Anna Marx 17:43, 14 August 2011 (EST) --Sarah Jenkins 19:09, 15 August 2011 (EST)

Project Plan

I think it is important to keep moving on with the project. We need to quickly agree on things and get the job done. From previous experience, getting the work done early is a benefit to everyone involved. The project needs to be broken down into subheadings. I have listed some below which need to be covered without doubt, and I am open to other ideas as well. If everyone could pick 2 that they are happy to take on it means that everyone will have a round about even job. I spoke to Anna Earlier and she said she was willing to do the drawings. Is that still ok? If so I think its fair that you only have to do one subheading of theory work.

  • Introduction (Sarah)
  • Historical background of the disease and its research (Sarah)
  • Epidemiology (Leonard)
  • Etiology
  • Pathogenesis (Leonard)
  • Clinical manifestations (and explanations of these) (Anna)
  • Treatment options if available (Anna)
  • Diagnosis of the disease, pre and post natally (Sarah)
  • Further research possibilities
  • Image (Anna)

I would prefer it if i could do the introduction, historical background and diagnosis. I am willing to do 3 because the introduction is a pretty easy one. If anyone has a problem with this let me know. I also think first in best dressed to picking topics. I only think its fair and if not, we can sort it out later. --Sarah Jenkins 19:09, 15 August 2011 (EST)

Hi, thank you for the layout. I think it is a good start! I an still happy to do the drawings. So let me know if you have specific wishes or if you have suggestions of what we/I need to draw. I can also do Clinical manifestations and treatment options, which would make it three as well. However I thought pathogenesis will be a big one because that would include all the genetics. May be it will be enough if one person on it's own. Otherwise etiology would go well with it, leaving epidemiology and further research for the last one;) Further research might be big too... However, I am open to adjust. --Anna Marx 21:03, 15 August 2011 (EST)

Hey guys, sorry I haven't been in touch, just been busy with some orchestra stuff outside of uni. The stuff so far sounds great, I'll get to work tomorrow getting some papers together and seeing what I can find out about the condition. I wouldn't mind doing the epidemiology and pathogenesis sections - Anna, I think he said we only had to submit one self-drawn picture but I wouldn't mind doing some either, since I draw everything for anatomy :D either way, let me know what you think! So far things sound really great, thanks for getting so much done and once again my apologies for not having chucked in my two cents earlier! --Leonard Tiong 23:02, 15 August 2011 (EST)

Awesome, now that we are on the way there it should be easier to focus our reading. We also need to do a glossary, and i think its easier if we do it as we go. so when we come across words that need a definition (to non science people) just chuck it in the glossary. even if we define it later, having it there is easier than having to go through and pick them out later. :) thanks for being so enthusiastic. :) --Sarah Jenkins 07:13, 16 August 2011 (EST)

Review Article

Hey guys, just found a review article that I thought was rather interesting, it's an animal model for Duchenne's muscular dystrophy[1]. I also found a primary journal article that discusses drug delivery for the condition [2]. I will print these articles for myself tonight and give them a quick read tomorrow and then paste a quick summary of the articles here just for you guys to consider :)

Review Mammalian models of Duchenne Muscular Dystrophy: pathological characteristics and therapeutic applications.

Primary Detection of duchenne/becker muscular dystrophy carriers in a group of Iranian families by linkage analysis.

--Sarah Jenkins 10:00, 6 August 2011 (EST)

Primary Diagnosis and management of Duchenne muscular dystrophy in a developing country over a 10-year period.

Review Advances in Duchenne muscular dystrophy gene therapy.

--Anna Marx 12:52, 8 August 2011 (EST)

More Articles

Hello! Those articles above look great. From the little research I have done it looks like there is plenty of research to choose from, so that makes our job a little easier I hope. The primary journal article I found talks about the expression of the DMD Gene Products in Embryonic Stem Cells, so hoping that this will allow us to elaborate a bit on the genetic aspects of the development and potential early identification, as symptoms do not usually appear in humans until a few years of age [3]. Also the review article I found refers to two other types of muscular dystrophies as well as DMD (SCARMD, CMD), highlighting many key developments in research. Seem to be very informative, also refers a bit to the importance of animal models in these developments [4].

--Z3288196 12:19, 11 August 2011 (EST)

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