Difference between revisions of "Talk:2011 Group Project 11"

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Please include your reviews below this section, and nowhere else in this discussion. This is to facilitate easy reference later. Thank you.   
Please include your reviews below this section, and nowhere else in this discussion. This is to facilitate easy reference later. Thank you.   
'''Group 11'''
'''*The key points relating to the topic that your group allocated are clearly described.'''
Key points are there, but content is lacking especially in the introduction.
'''*The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.'''
Timeline should be included under 'history'
Glossary is limited. in Genetic Configuration, the part about 4 sections, number 1 and 2 are together - are they meant to be presented like this? it looks out of place when 3 and 4 have their own paragraph each. It would be nice to have a subheading for pathology of cleft lip and cleft palate to separate the two for easy location.
'''*Content is correctly cited and referenced.'''
References are duplicated. no references in treatment or Problems associated with Cleft Palate. fix up reference for File:Variations of Cleft Lip or Palate.jpg, File:Bilateral Cleft Lip Variations.jpg and File:Furlow Z-plasty technique.jpg.
'''*The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.'''
File:NeuromericOrganization.jpg and File:Veau-Wardill-Kilner technique of palate repair in a unilateral cleft lip and palate.jpg needs a description.
'''*Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.'''
Current and future research is very limited, does not show any research that extends beyond formal teaching.
'''*Relates the topic and content of the Wiki entry to learning aims of embryology.'''
Link to embryology present in identifying risks in cleft plate and lip development. Developmental staging also covers it.
'''*Develops and edits the wiki entries in accordance with the above guidelines.'''
Some evidence of developing wiki page with guidelines. will help if changes are made.
--Amanda Tan 21:29, 28 September 2011 (EST)
'''Group 11: Peer Assessment'''
'''Group 11: Peer Assessment'''

Revision as of 21:29, 28 September 2011

Group 11: User:z3308965 | User:z3292953 | User:z3308968 | User:z3272325 | User:z3284061


--Mark Hill 07:35, 30 September 2011 (EST) Currently all students originally assigned to each group are listed as equal authors/contributors to their project. If you have not contributed the content you had originally agreed to, nor participated in the group work process, then you should contact the course coordinator immediately and either discuss your contribution or request removal from the group author list. Remember that all student online contributions are recorded by date, time and the actual contributed content. A similar email reminder will be sent to all current students.

Please note the Universities Policy regarding Plagiarism

In particular this example:

"Claiming credit for a proportion of work contributed to a group assessment item that is greater than that actually contributed;"

Academic Misconduct carries penalties. If a student is found guilty of academic misconduct, the penalties include warnings, remedial educative action, being failed in an assignment or excluded from the University for two years.

2011 Projects: Turner Syndrome | DiGeorge Syndrome | Klinefelter's Syndrome | Huntington's Disease | Fragile X Syndrome | Tetralogy of Fallot | Angelman Syndrome | Friedreich's Ataxia | Williams-Beuren Syndrome | Duchenne Muscular Dystrolphy | Cleft Palate and Lip

Peer review of Group Project 11

Please include your reviews below this section, and nowhere else in this discussion. This is to facilitate easy reference later. Thank you.

Group 11

*The key points relating to the topic that your group allocated are clearly described. Key points are there, but content is lacking especially in the introduction.

*The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area. Timeline should be included under 'history' Glossary is limited. in Genetic Configuration, the part about 4 sections, number 1 and 2 are together - are they meant to be presented like this? it looks out of place when 3 and 4 have their own paragraph each. It would be nice to have a subheading for pathology of cleft lip and cleft palate to separate the two for easy location.

*Content is correctly cited and referenced. References are duplicated. no references in treatment or Problems associated with Cleft Palate. fix up reference for File:Variations of Cleft Lip or Palate.jpg, File:Bilateral Cleft Lip Variations.jpg and File:Furlow Z-plasty technique.jpg.

*The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations. File:NeuromericOrganization.jpg and File:Veau-Wardill-Kilner technique of palate repair in a unilateral cleft lip and palate.jpg needs a description.

*Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities. Current and future research is very limited, does not show any research that extends beyond formal teaching.

*Relates the topic and content of the Wiki entry to learning aims of embryology. Link to embryology present in identifying risks in cleft plate and lip development. Developmental staging also covers it.

*Develops and edits the wiki entries in accordance with the above guidelines. Some evidence of developing wiki page with guidelines. will help if changes are made.

--Amanda Tan 21:29, 28 September 2011 (EST)

Group 11: Peer Assessment

  • You have picked an interesting topic, surely you can write a more engaging introduction
  • Some of you headings and subheadings need rearrangement
  • The history section is good but takes a bid too much space. May be you can compress it a bid, make it a little shorter?
  • Some of you information is double
  • The neuroembryology and functional anatomy of craniofacial cleft is interesting and well written
  • Good diagnostic section. An image would be nice
  • Some more references in the treatment and associated problems section are needed
  • You could put some more words into the glossary
  • You have some "double referencing"
  • Overall, you have an interesting page. Good work. You just need a little more formatting, referencing and fixing here and there.--z3279511 17:16, 28 September 2011 (EST)

Group 11

  • Introduction: needs more contend
  • History: the contend is ok, references are missing, include the timeline
  • Diagnosis: well done
  • Syndromes and anomalies: the contend looks fine, some parts are missing, the conditions would look better in a table
  • Development:?
  • Aetiology: looks fine, but are there references missing?
  • What staging are you talking about?
  • Types: well done
  • Pathophysiology: unfinished, otherwise good, maybe add some subheadings for more structure
  • Configuration: references missing, what is the third paragraph womb or external environment?
  • Neuroembryology: well done, nice image
  • Treatment: references missing, maybe add a detailed outline of the most frequent techniques
  • Problems: references missing
  • Research: add more contend
  • Glossary: incomplete
  • Rearrange the order of headings
  • Some images lack a copyright notice
  • Textbooks ?

--Z3387190 14:34, 28 September 2011 (EST)

Group 11

  • Introduction is way too short and should include an image
  • History would work better just in a timeline
  • I think you should rearrange your headings from here on to make your project flow in a logical way
  • Current/future research should be extended and explained
  • Glossary needs to be extended
  • I also can’t seem to find your student drawing
  • Some sections repeat some information- go through this

Comments on Group Project 11


  • Good use of tables especially under Diagnosis.
  • Some of the images are quite good especially on the correcting process (surgery) for cleft palate.


  • Placement of headings is not quite appropriate. It gives the page a disjointed feel to it.
  • There is a lack of use of subheadings.
  • The introduction did not give an overview of the condition.

Specific corrections:

  • Timeline should be a subheading under History section
  • Introduction should answer these questions: What is it characterised by? How does it appear on individuals with this condition? What causes it? etc. It will be good to include a picture/ cartoon of an individual with cleft palate and lip.
  • Duplication of references should be avoided.
  • Some of the references are not formatted correctly.
  • For current and future research, it will be good to give a brief synopsis (2-3 sentences) of each point so that readers can get the gist of the direction of cleft palate and lip research that it is heading towards.
  • For genetic configuration, it might be better to use subheadings to point out the 4 different types of environmental factors.
  • Do include a student-drawn image.
  • Some words that should be included in the glossary are Malocclusion, nodules etc.
  • It would be better to make use of tables under treatment.

--Z3389806 11:50, 27 September 2011 (EST)

Group 11 Peer Assessment

  • Introduction needs to be expanded a bit seems like the description of the incidence
  • History needs together with the timeline which would benefit the section, where the timeline is done properly with the image of the founder though time line better together then separated
  • Diagnosis is well done though images would benefit this section
  • Syndromes and anomalies should be expanded a bit though good linkage of the images to the rare cases *Development should be changed to aetiology instead
  • Pathophysiology needs more images though nice use of tables
  • Genetic configuration needs references to back up the evidence otherwise is just statements
  • Neurology greatly structured and well presented and has image to liven the section
  • Treatment generally well structured though ex[and more on the surgical aspect as well problems associated with cleft palate
  • Current and future research needs more information as well separation between the current and the future research.
  • Glossary needs to be expanded further and linked either to section or bolded throughout the web page.
  • References need a little tweaking with the removal of the repeats, also no other information in the sub heading textbooks

z3332250 00:01, 27 September 2011 (EST)

Group 11 Critique

  1. • Introduction is far too short and more work needs to be done
  2. • History is also very short and more information needs to be added
  3. • The timeline is quite good
  4. • Diagnosis is alright
  5. • Syndromes and anomalies associated with cleft is detailed. Good job!
  6. • Development is good. Maybe use more images
  7. • The other sections are good, up until current research. More work needs to be done here as there is not enough information
  8. • Glossary is too short
  9. • Is the gallery really needed if you have images illustrating your text?

--Robert Klein 16:38, 26 September 2011 (EST)

Cleft Palate and Lip

  • Your introduction needs to be seriously expanded. What exactly is it? Defining features? Anything?
  • 'History' could be expanded on a bit, but the timeline looks good. Try to take the spaces out between each date of the timeline, at the moment it's a bit unneccesarily long
  • 'Diagnosis' would fit better towards the end of the page closer to treatment. It is a bit hard to understand before we've even had a proper description of the disorder and clinical symptoms
  • Though the information in 'Diagnosis' is quite good, the table is also quite interesting
  • 'Syndromes and Anomalies Associated with Cleft', title should fixed up 'Associated Syndromes and Anomalies' sound better. It also needs to be finised!
  • There's not even a single reference in 'Atiology'
  • 'Developmental Staging' are you refering to Carnegie stages? If so, say so.
  • Reference!! And finish 'Pathophysiology'. You won't get the marks for just saying 'it will be done soon', think of the rest of your group
  • There is not a single reference in 'Genetic Configuruation', so where then did you get your information? This section also needs images, and a bit of formating. There isn't much consistency in the use of captial letters for 'Cleft Lip'. Either use it or don't, "seems to be related to the cause of Cleft palate and cleft lip incidence" and throughout the page aswell
  • For 'Treatment' and 'Complications' a table would be good. It is not very visually appealing as a long list. That way you can incorporate some more information as well.
  • 'Problems Associated with Cleft Palate' would be better positioned higher up in the page. How do you know what your treating if you don't even know the associated problems. Reference!
  • 'Current and Future Research' really needs to be expanded. There is no where near enough information here
  • The page is coming along, but it really needs to be finished, there are far too many gaps, and no where near enough references. Try reading multiple papers before adding information.

Group 11

  • Interesting topic with good use of pictures, you guys have a great topic with a lot of interesting areas to discuss.
  • The headings could be reorganised for example diagnosis could come after explaining in detail what cleft lips are and how they are formed embryonically.
  • The introduction should introduce the main topics that you will be discussing but only briefly like what cleft palate is.. the information in the intro would fit nicely in epidemiology. (maybe you could add this section in).
  • History section is very interesting I liked the extra research.
  • The time line takes up a lot of room maybe condense it into a table format.
  • Development?? is this a section??
  • maybe put the type of cleft lip/palate into a table with a pictures corresponding to the specific type.
  • Make sure all acronyms are in the glossary.
  • It would be nice if the colours of the tables were continuous throughout the page.
  • Neuroembryology and functional anatomy of craniofacial clefts section is very well written and enjoyable to read.
  • Treatment & Problems associated with Cleft Palate sections have no referencing. It would strengthen and give your page some authority if you cited where your information was from.
  • A little summary for your future and current research would make this section a bit more interesting rather then just using dot points.
  • Make sure your references aren't doubled.
  • Ensure your pictures are referenced correctly.
  • Furlow Z-plasty technique picture is positioned so that it interrupts the flow of reading maybe rethink the position of this picture.
  • Variations of Cleft Lip or Palate picture is great and I think it could be more of a "key " picture on your page maybe centralise it?.
  • No student drawing.
  • Gallery seems a little irrelevant.
  • More needs to be added into glossary eg. Otitis media

Group 11

  • The introduction is no where near long enough and needs an image
  • History needs to be expanded and dates made more obvious to the reader
  • Timeline- should be combined with history. So that my previous point is not needed
  • The order of your subheadings is a little confusing
  • Some sections double up the information
  • Current research needs to be completed, as do other sections
  • The glossary needs to be expanded
  • The project has started to take form but there is work to go to complete the information and format it into a more easily accessible piece of work.

  • Introduction: Too short. Also, how come there are no references? How about starting with a brief anatomical description?
  • History: No reference for the first paragraph? I like the idea of mentioning Plato, but could you then also expand a little bit more on his thoughts? Also, what was the explanation offered by Philippe Frederick Blandin?
  • Timeline: Looks good to me, though some terms should be explained in the glossary.
  • Diagnosis: I'm not sure I'd make this follow on immediately from the Timeline. I would put this section between Types of Cleft Palate/Lip & Pathophysiology, maybe? While you do talk about the technical difficulties just before the Cleft Soft Palate Detection part, but considering you start a new subsection, it's confusing to keep talking as if it was the same paragraph. Maybe say "the technical difficulties mentionned above" instead? An explanation in the glossary of what a cleft soft palate actually is, is definately needed! The Cleft Hard Palate section is very well done.
  • Syndromes and Anomalies associated with cleft: Looks fine.
  • Development: Under construction? or is there meant to be no text, and you're simply splitting this section into the two subsections? If yes, you might want to make that clearer.
  • Aetiology: This part is slightly technical and could do with some more detailed explanations. It doesn't feel like a coherent section.
  • Developmental Staging: Well explained.
  • Types of Cleft Palate/Lip: Looks fine. Though the "algorhythm for repair..." figure seems to be in a slightly random place..? How does it relate to this section (or the next)?
  • Pathophysiology: The cranio-facial development pathway is a very complex process. Since the several points of development at which “Clefting” might occur is based on the condition and the wide range of its phonotypical expression. Make this one sentence? You start talking about neural crest cells quite out of the blue. Has there been any mention of them before? It's quite confusing to have them added into the story without having previously told why. The first two paragraphs under the table lack references? This part repeats what has been partly said before, but adds more physiological detail to it. I'd find it more logical to combine the different aspects to give one, more complete picture.
  • Genetic configuration: Very poor language/sentence structure. Where are the references? Putting womb and external environment together does make sense, but you might want to explain in a sentence why.
  • Neuroembryology and functional anatomy of craniofacial clefts: Excellent explanation, though some terms should be explained in the glossary. Why are some words in bold? Again, this sort of repeats previous information, again with more detail from a different point of view, apparently unrelated to what's been told before, as this section doesn't follow the previous sections?
  • Treatment: Can you explain the different techniques a little bit more, instead of just having bullet points? The figures are really nice, but don't illustrate all of the techniques mentioned.
  • Problems associated with Cleft Palate: Mere list with bullet points isn't enough, more explanations needed.
  • Current and Future Research: Very poor. There must be more than 3 articles?
  • Glossary: Poor. Many more terms need explanations.
  • References: Need fixing. The same article appears lots of times in the list. Watch out with your german references... the fact that you misspell the german makes me wonder whether you could have actually read the papers? In case you're citing a reference cited within the reference you've read, there usually is a special way of doing it.
  • General: Your sections are really random and don't follow logically from one another. There is a lot of repetition of similar content in multiple different places, which is confusing. It is hard to keep an overview. Nevertheless, some of the sections are well done.

Group 11 Assessment

  • The introduction and history sections are not very long… Maybe try adding more information and some pictures.
  • The timeline should be a subheading under the history portion. Also, rather than doing a bulleted list, how about trying to format the information into a chart? This would be more aesthetically appealing.
  • For the diagnosis section, the charts look great. Referencing is completed well also. Only thing I’d suggest is to possibly add a picture.
  • For the references given throughout the wiki, there isn’t any consistency in how the [#] is given. The [#] is sometimes right after the sentence, sometimes a space is given between the sentence and citation number, and the end of the sentence (period or comma) is sometimes before or after the reference #...
  • There are several sentences throughout the wiki page which are missing punctuation at the ends of the sentences.
  • The first portion of Aetiology doesn’t have any referencing…
  • “Normal Palate Shelf…” jpg needs a sentence below it briefly describing it still.
  • The Genetic Configuration section has absolutely no referencing. Neither does the Treatment section or Problems section. Where did all this information come from?
  • Treatment and Problems would also flow better if they were placed into a chart format. Pictures could also be added.
  • The Glossary seems a bit short. Are you sure there are no other words that would be helpful if they were defined? It would also flow better if it were bullet listed.
  • Some of the references are repetitive. Make sure to fix this so they all link to a single reference instead of numerous ones of the same resource.
  • A lot of the information is repetitive as well, and things should be formatted to flow better. Also work on the referencing issues and making the overall page more aesthetically appealing.

--Z3391078 17:26, 27 September 2011 (EST)

Peer Assessment: Group Project 11

  • The introduction could definitely be expanded upon. Maybe include a short description of what cleft palate is.
  • The timeline is great - clear and informative.
  • The treatment, problems with cleft palate and genetic configuration sections are good. It might be good to move the picture in the treatment section to the right so it doesn't disturb the flow of the text. Also these sections need to have referencing added, for reliability purposes and such as if the reader wanted to know more about the findings that 'a number of drugs might be participating in creating this birth defect'.
  • Syndromes and Anomalies associated with cleft section is great and as noted there needs to be some additional text added.
  • The current and future research section could be expanded. Maybe find relevant articles, summarise their findings and see what direction is necessary to head in.
  • In the glossary writing "C" above the group of C words and so on and so forth for the rest of it, would make it easier for the reader to quickly find the desired word.
  • Under the information on all the images you have uploaded, you need to add {{Template:2011 Student Image}}.
  • Some of the references are duplicated. They can instead be linked together using the 'multiple instances on a page' editing guidelines: http://embryology.med.unsw.edu.au/embryology/index.php?title=References#Multiple_Instances_on_Page.
  • Overall the project has a large amount of information and is put together reasonably well.

--z3217345 11:09, 28 September 2011 (EST)


hey guys- keep abreast of the reviews coming in. some of them have valid points. it would be prudent to keep working on our relevant sections (without uploading it and altering the content of the wiki of course). hope you're all having a good weekend. i should be uploading the timeline later today. --Rahul Mohan 17:55, 25 September 2011 (EST)

uploaded another heading 'associated anomalies' --Tahmina Lata 10:58, 22 September 2011 (EST)

Type Comment Picture!
Unilateral Cleft Lip This type of cleft refers to cleft of the lip that have only occurred on one side of the lip.
Unilateral Cleft Palate This type of cleft refers to a cleft of the soft palate that occurs on one side of the palate. The cleft starts medially and extends laterally.
Unilateral cleft lip with a cleft hard palate This refers to a cleft that has extended through the lip and into the hard palate. This cleft is on only one side of the lip and palate.
Unilateral cleft lip with cleft hard and soft palate This type of cleft refers to a cleft that extends through the lip, hard palate and into the soft palate. It also occurs on only one side.
Bilateral cleft palate This refers to a cleft of the soft palate which occurs on both sides of the palate and appears as a opening medially.
Bilateral cleft lip This refers to a cleft of the lip that has occurred on both sides of the lip. There are many variations of this.
Bilateral cleft lip with cleft hard palate This refers to a cleft of the lip and hard palate that occurs on both sides.
Bilateral cleft lip with cleft hard and soft palate This refers to a cleft that has occurred on both sides of the lip and extended into both the hard and soft palates resulting in an medial opening of the soft palate.

hey guys heres the table so far. I'm having a bit of trouble uploading the photos and finding sources for the info in the middle but I'm working on it --Elizabeth Wren 10:36, 22 September 2011 (EST)

Hey guys, just letting you know whats on the page under aetiology and treatment has not been finalised. I will need to upload images and tables. --Fleur McGregor 09:55, 22 September 2011 (EST)

Team, Found some amazing radiology images but they are under copyright. Would like to brainstorm with you all to se how we can request access. http://radiology.rsna.org/content/217/1/236.long --Tahmina Lata 00:15, 22 September 2011 (EST)

Hey Rahul, I am still working on the resolution of the image, I am considering rediesigining the orginial design and increasing the font size. Will update on it soon. I also have uploaded another brief subsection 'Problems associated with Cleft Palate'-hope it is useful. --Tahmina Lata 23:56, 21 September 2011 (EST)

Hey Guys,

I have just uploaded the Draft section Genetic Configuration... It is under review since I'm doing this with Rahul. the final version will be integrated later on. --z3284061 21:37, 21 September 2011 (EST)

Hey Rahul,

I think we should go with the Articles we have, because this is our project, yes we can have a look at the other textbooks. But in the end, remember, this is designed by us as a group! and the mdconsult website does not work! --z3284061 20:53, 21 September 2011 (EST)

Hey Meedo, pursuant to our conversation- here are the 2 links that seem to conflict.

and I've spotted an error in reference 40 and 41. The chapter referred to is chapter 9, not 10. The necessary changes have been made. Timeline should be up soon.

--Rahul Mohan 17:53, 21 September 2011 (EST)

Hey Rahul, I got that info from the text book but I'd probably go by what Dr Hill has. Beth --z3292953 12:20, 21 September 2011 (EST)

guys- i have a problem. in development so far- i'm trying to work on the time line for cleft lip/palate development. it so turns out that there's conflicting information everywhere. on one hand- we have (google turned this up for me) <http://embryology.med.unsw.edu.au/Notes/face2.htm> which is by Dr Hill- in which its stated that "Cleft lip and palate develop between the 4th and 8th week of gestation". On the other hand- we have what's already written up for the section under dev- which has it stated that cleft lip happens from/between carnegie stage 16 and 18- and cleft palate erin week 6 to 10 (which equates roughly to carnegie stage 15 onwards. if we follow what Dr HIll's said- that would amount to stages 10-around 21. so which do we follow?

--Rahul Mohan 23:45, 20 September 2011 (EST)

Hey Tahmina- the resolution could be slightly better. have you tried saving the document as a pdf file? with maximum resolution or something? I'm not entirely certain- but i'm fairly sure it can be done. mm. on another note, guys- here're a few resources that you could check out for your relevant sections if you haven't already:

http://www.organizedwisdom.com/Cleft_Palate (scroll down to the journals section) http://www.jci.org/articles/view/22154/version/1 (particularly helpful for genetic---Meedo) http://dev.biologists.org/content/103/Supplement/41.full.pdf (helpful for development- what i'm working on right now. the last bit on genes might be useful to meedo as well.)

--Rahul Mohan 23:00, 20 September 2011 (EST)

Figure Shows How the CNS is divided to supply different structures

Guys I am parking this image here for the time being as the resolution has not come out that well and I would like some feedback from you to see if we should add this to the page.

--Tahmina Lata 20:33, 20 September 2011 (EST)

Ravichandra KS, Vijayaprasad KE, Vasa AA, Suzan S.

J Indian Soc Pedod Prev Dent. 2010 Oct-Dec;28(4):311-4.

PMID: 21273723 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/15479962 --Fleur McGregor 12:15, 15 September 2011 (EST)

Permission to post figure: https://s100.copyright.com/CustomerAdmin/PLF.jsp?lID=2011090_1316046741757 picture: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086810/bin/nihms284150f2.jpg

I have also included a hand drawn hierarchical table as I could not format such table in wiki. hope it is not looking too poorly done. --Tahmina Lata 23:30, 14 September 2011 (EST)

Hi Everyone,

I have tried to stretch as much as possible and uploaded my final versions of my headings. --Tahmina Lata 23:28, 14 September 2011 (EST)

Hello People,

I have uploaded my section which is just a DRAFT. References are not all completed, and my photos are to be uploaded soon with drawings. --Maqdad Al Saif 20:35, 14 September 2011 (EST)


As we have 5 people in our group we must have more content than other groups so I am adding a third heading 'Neuroembryology and functional anatomy of craniofacial cleft.' We really need to work hard on this as the page so far is not looking the best. I hope that someone will come up with an impressive table.

--Tahmina Lata 23:03, 8 September 2011 (EST)

Hi Guys,

I will be writing about 'Diagnosis of prenatal cleft lip and palate' for my second heading. --Tahmina Lata 22:44, 6 September 2011 (EST)

Here are some more useful links with photos in them.






--Tahmina Lata 22:46, 6 September 2011 (EST)

Hello Everyone,

I have uploaded the timeline here and under the heading- 'History' I am just going to include some interesting historical facts but after researching the other heading- 'Developmental Process' it seems to coincide with developmental staging and so it might not be a good idea to have that as a broad heading. Please let me know if you have any ideas on another heading or I will come up with a different heading and research that. Let me know what you think--Tahmina Lata 22:55, 5 September 2011 EST)

Hey Guys,

Great Work finding the articles :) I noticed in the second article of Tahmina, you can use the pictures to make the content more interesting. The same goes for Fleur, the last 2 articles have great information and pictures.

let's try updating the page before the end of the weekend

Cheers Guys... --Maqdad Al Saif 16:57, 5 September 2011 (EST)

Here are the articles I am studying at this stage:



--Tahmina Lata 21:18, 4 September 2011 (EST)

hey guys,

I've found some pictures which we can either use in the gallery or on the front page.

about my work, it will be all updated during the break but I will share with you what I'm doing. Meedo

--z3284061 11:29, 1 September 2011 (EST)

I also found these useful




--Fleur McGregor 10:41, 1 September 2011 (EST)

Hey guys here some references I found that were kinda useful

Plast Reconstr Surg. 2011 Feb;127(2):812-21.The spectrum of median craniofacial dysplasia.Allam KA, Wan DC, Kawamoto HK, Bradley JP, Sedano HO, Saied S. PMID: 21285785

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Aug;112(2):249-57. Epub 2011 Jun 12.Comparison between multislice and cone-beam computerized tomography in the volumetric assessment of cleft palate.Albuquerque MA, Gaia BF, Cavalcanti MG. PMID: 21664153

Nat Rev Genet. 2011 Mar;12(3):167-78.Cleft lip and palate: understanding genetic and environmental influences.Dixon MJ, Marazita ML, Beaty TH, Murray JC. PMID:21331089

I also found the Larsons textbook had some stuff on cleft palate and lip.

Beth --z3292953 10:20, 1 September 2011 (EST)

Hey fellas, I reckon we could have inserted a brief discussion of the etymology of the word in the introduction. I don't reckon its big enough to warrant a heading of its own. Thus, I've gone ahead and taken the liberty to remove that heading from the page. Also included an "aetiology" section under development of disease- since its looking at causation of disease. Changed current research into Current and Future Research- to increase the scope of that heading.

--Rahul Mohan 12:48, 25 August 2011 (EST)

I am doing history and developmental process.

--Tahmina Lata 10:06, 25 August 2011 (EST)

Hey Guys,

There has been some changes in our page in terms of Subheading order.

Hey Rahul, I'd be happy to share the Genetic Configuration with you... and your comments have been taken into consideration.

--z3284061 11:43, 25 August 2011 (EST)

Thankyou z3284061 for the heads up on what to do.

I've put myself down as finding current research and associated figures. However- pertaining to the latter- this would involve finding figures and diagrams relevant to our research I suppose? I'm definitely not good at art- and as for the diagrams and pics- that would be dependent more on the content we come up with. Also, as a sub-section- isn't it weird to lump all animations and figures under one subsection- isolating it away from the rest of the topic? Thus being the case, I propose that we individually keep a look out for relevant animations under our own sub-heading and I would help out anyone doing a large topic. z3284061 has indicated that that genetic configuration is a large sub heading- so I'll be happy to help with that.

See you in a couple of hours, fellas.

--z3272325 04:18, 25 August 2011 (EST)

Hey Guys,

I think after we discussed last time, I'll be doing Pathophysiology and Genetic Configuration.Hmm, I just think it will be kinda big especially for Genetic Configuration :) if you guys find anything related to it, pleaase don't hesitate to post it in the discussion.

The only one who might not have been allocated to do something specific is z3272325- I think you are meant to do The Animations and figures + Current Associated research :)

Let's Start updating the page whenever we have information :)

Cheers --z3284061 23:11, 24 August 2011 (EST)

For the groupo project I will be researching Developmental Staging and Abnormaility Classification.

--z3292953 11:21, 24 August 2011 (EST)

I am researching the following sub headings: surgical timeline and etimiology. If you all post what you are researching we can forward any information we find regarding your sub heading. --Fleur McGregor 12:16, 23 August 2011 (EST)

Here's the image I've found. --Maqdad Al Saif 13:10, 18 August 2011 (EST)

Cleft lip.jpg

completely forgot I was meant to add a picture here as well. My apologies. And the group discussion's picking up- shall be more productive henceforth. here's a pic for cleft palate.

In vitro fetal palate explant culture[1]


  1. <pubmed>PMC2841638</pubmed>

Wow!! That is sad Meedo! I didnt know you were in hospital! Yes I think the condition is cleft lip and palate however I am working on the classifications of cleft lip as they can be disjoint at many different sites of the lip. --Tahmina Lata 10:11, 18 August 2011 (EST)

Fantasitc Work Tahmina!!!! I can See a flow coming up!!! and z3292953 - Great Photos!!!! Please save the references somewhere Safe :D

As for me, I haven't been able to attend classes since Thursday. I was at the hospital, extremely dysfunctional.

Anyways, I can say that we should finilize the topic to This one... I prefer not to change because it's week 5 now. It will be wise if we dig deeper in the topic and we shall get better information. I will start my search from tomorrow and sorry for the delay. I HAVE ONLY ONE QUESTION IS CLEFT PALATE and LIP KNOWN as the WHOLE condition??? --z3284061 23:46, 17 August 2011 (EST)


The earliest known history of cleft lip is based on a combination of religion, superstition, invention and charlatanism. While Greeks were indifferent of their existence, Spartans and Romans would kill the children with this condition as they were considered to harbour evil spirits.

Between (1295- 1351) the first to note the congenital origin of the cleft was made by Jean Yperman. He also classified the various forms of the condition and laid down the principles for their treatment.

Between (1537-1619) Fabricius ab Aquapendente first suggested the embryological basis of cleft lip.

This is how I started the history, please comment if you think anything needs changing. I will continue the list on and the references at the end.

--Tahmina Lata 20:00, 16 August 2011 (EST)

File-Cleft palate in newborn mice.jpg [1]

--z3292953 12:08, 16 August 2011 (EST)

Hi Guys, I have started working on pathophysiology & history and modified some of the headings to include ones that were more relevant for Cleft palate and Lip.

--Tahmina Lata 21:51, 15 August 2011 (EST)

Mice mutants exhibit cleft palate and umbilical hernia[2]

Mice mutants exhibit cleft palate and umbilical hernia

--Tahmina Lata 19:16, 15 August 2011 (EST)

So after careful consideration we have come to realise that Cleft Palate/Lip will be a more relevant topic to create a page about. Some of you guys left last week when we registered this topic with Dr Hill. Please post here if you are still unsure of the topic. At this stage we are all reseraching different things on the topic so we can discuss about it this week.

--Tahmina Lata 16:44, 15 August 2011 (EST)

There appears to be no group discussion here on possible project topics?? --Mark Hill 23:55, 7 August 2011 (EST)

We have decided to research each subheading listed on the Group Project page and then share all the information found next week. We will then be able to determine a clearer structure to the page based on what literature is available.

--Tahmina Lata 12:34, 11 August 2011 (EST)

Review Article "Cystic fibrosis: pathogenesis and future treatment strategies"-This review summarizes our current understanding of the pathophysiology and treatment of cystic fibrosis lung disease[3]

Research Article "Nasal endoscopic evaluation of children and adolescents with cystic fibrosis"-The questionnaire, clinical examination and especially nasal endoscopy performed as part of this research lead to a detailed assessment of the nasal characteristics of children and adolescents with cystic fibrosis. [4]

--Tahmina Lata 23:13, 10 August 2011 (EST)

Hi Guys,

I've modified the page with the required subheadings, we can change them later but it's important to get our heads around the foundations.

If have have anything to add, please do so. if you have any questions, post it here and we will try and help. --z3284061 22:52, 10 August 2011 (EST)

Novel concepts in evaluating antimicrobial therapy for bacterial lung infections in patients with cystic fibrosis.Rogers GB, Hoffman LR, Döring G. J Cyst Fibros.2011 Jul 18. [Epub ahead of print]

Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis.McNally P, Coughlan C, Bergsson G, Doyle M, Taggart C, Adorini L, Uskokovic MR, El-Nazir B, Murphy P, Greally P, Greene CM, McElvaney NG.J Cyst Fibros. 2011 Jul 22.

--z3292953 15:59, 9 August 2011 (EST)

Hey Guys:

How are we going in the research process? Well, In case anyone wants to change the topic Tomorrow will be the last day we get to change! That’s if everyone agrees to do so.

For the time being, we are working on Cystic Fibrosis. I’ve found some interesting articles regarding the treatment. The first one is a research while the other 2 are both Reviews.

I’ve Moved the articles of z3292953 to the discussion Page :)

Looking forward to create a great wiki page. --z3284061 22:34, 10 August 2011 (EST)

1. Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation

Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation

2. Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis


Chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients is caused by biofilm-growing mucoid strains. Biofilms can be prevented by early aggressive antibiotic prophylaxis or therapy, and they can be treated by chronic suppressive therapy. New results from one small trial suggest that addition of oral ciprofloxacin to inhaled tobramycin may reduce lung inflammation. Clinical trials with new formulations of old antibiotics for inhalation therapy (aztreonam lysine) against chronic P. aeruginosa infection improved patient-reported outcome, lung function, time to acute exacerbations and sputum density of P. aeruginosa. Other drugs such as quinolones are currently under investigation for inhalation therapy. A trial of the use of anti-Pseudomonas antibiotics for long-term prophylaxis showed no effect in patients who were not already infected. Use of azithromycin to treat CF patients without P. aeruginosa infection did not improve lung function. Here I review the recent advances in the treatment of P. aeruginosa lung infections with a focus on inhalation treatments targeted at prophylaxis and chronic suppressive therapy. [5]

3. Changes in strategies for optimal antibacterial therapy in cystic fibrosis.


Aggressive antibiotic therapy of bacterial airway infection is one of the main reasons for the dramatic increase in life expectancy over the last few decades. Staphylococcus aureus and Haemophilus influenzae are the predominant pathogens in younger patients, but the choice of antibiotic therapy against these pathogens remains highly controversial. There is general agreement that patients with pulmonary exacerbations should be treated and many cystic fibrosis (CF) centres will also try to eradicate bacteria in the absence of symptoms. Prophylactic antibiotic therapy, with anti-staphylococcal medications started at the time of diagnosis, is advocated by some groups but its positive effect remains unproven. In fact, recent studies have suggested that continuous prophylactic treatment with anti-staphylococcal antibiotics may increase the risk of early colonisation with Pseudomonas aeruginosa. P. aeruginosa is the main pathogen in older children with CF. While chronic airway infection with mucoid P. aeruginosa is considered irreversible, both the combination of oral ciprofloxacin with inhaled colistin and inhaled tobramycin alone has been used successfully in the early phase of colonisation. In patients chronically infected with P. aeruginosa, standard treatment of pulmonary exacerbations consists of intravenous combination therapy for 2-3 weeks. Controversy exists whether this treatment should be performed routinely every 3 months or only in the presence of a pulmonary exacerbation. Inhaled antibiotics such as tobramycin have been shown to improve lung function and reduce sputum density of P. aeruginosa, but both the optimal dose and the duration of therapy are unclear at the present time [6]

Review: Inhaled bronchodilators for cystic fibrosis. Halfhide C, Evans HJ, Couriel J. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003428. DOI: 10.1002/14651858.CD003428.pub2 from http://www2.cochrane.org/reviews/en/ab003428.html

Research Article: Identification of airborne dissemination of epidemic multiresistant strains of Pseudomonas aeruginosa at a CF centre during a cross infection outbreak. Jones AM, Govan JR, Doherty CJ, Dodd ME. Isalska BJ, Stanbridge TN, Webb AK. Thorax 58(6), 525-527. from http://www.ncbi.nlm.nih.gov/pubmed/12775867 --Rahul Mohan 10:58, 11 August 2011 (EST)


  1. <pubmed>2924885</pubmed>
  2. <pubmed>PMC2841638</pubmed>
  3. <pubmed>19393104</pubmed>
  4. <pubmed>20209279</pubmed>
  5. <pubmed>21463524</pubmed>
  6. <pubmed>11165111</pubmed>

Peer Assessments

  • I would suggest expanding on the current and future research section, maybe add in links to current research institutes or research papers.
  • Perhaps add an image in for problems associated with cleft palate, just to add some dynamics and colour to the page.
  • Perhaps tabulate the treatment section just so that the information is clearer
  • Placing words in bold, although it was just a little touch, helped to highlight the main points you were trying to get across which was good.
  • Good incorporation of tables and different formatting styles
  • Your introduction was clear, simple and straight to the point.
  • You’re referencing needs to be tidied up; there are multiple entries from the same source that tends to clutter your reference section.
  • Your timeline was extremely spaced out, I would suggest deleting the space between your dot points just so that it reads easier.

--z3332629 15:31, 22 September 2011 (EST)