Stem Cells - Adult

From Embryology

Introduction

The term "stem cell" is now used widely to cover many different cells derived from both embryo and adult tissues.

A useful guide (online PDF document) to stem cells was produced in a report by the National Institute of Health (NIH, USA, May 2000) [../pdf/fullrptstem.pdf Stem Cells: A Primer] (note large size - 4.84 Mb) and more recently NIH has established a Stem Cell information page.

Stem Cell Links: Introduction | Timeline | Placental Cord Blood | Adult | Induced pluripotent stem cell | Yamanaka Factors | Somatic Cell Nuclear Transfer | Ethics | Organoids | Adult Human Cell Types | Category:Stem Cell

Some Recent Findings

Nature advance online publication 23 July 2009 | doi:10.1038/nature08267; Received 9 January 2009; Accepted 3 July 2009; Published online 23 July 2009 Xiao-yang Zhao iPS cells produce viable mice through tetraploid complementationnear-final version

"Here we report the generation of several iPS cell lines that are capable of generating viable, live-born progeny by tetraploid complementation. These iPS cells maintain a pluripotent potential that is very close to ES cells generated from in vivo or nuclear transfer embryos. We demonstrate the practicality of using iPS cells as useful tools for the characterization of cellular reprogramming and developmental potency, and confirm that iPS cells can attain true pluripotency that is similar to that of ES cells."

  • Generation of pluripotent stem cells from adult human testis.[1]
  • Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin.[2]
  • Pluripotent neural crest stem cells in the adult hair follicle.[3]

Induced Pluripotent Stem Cell

(iPS cell) A reprogrammed adult stem cell to form an embryonic stem cell, from which tissues or whole animals can develop. Can be generated by the expression of just four specific transcription factors.

Links: Nature Jul09 | ABC - Mice pups bred from adult stem cells

Bone Marrow Stem Cell

Bone marrow stromal stem cells

Hair Follicle Stem Cell

M. Sieber-Blum, M. Grim, Y.F. Hu, V. Szeder Pluripotent neural crest stem cells in the adult hair follicle. Dev Dyn. 2004 Oct;231(2):258-69.

Dental Pulp Stem Cell (DPSC)

Dental pulp stem/stromal cell (DPSC) are similar to bone marrow derived mesenchymal stem/stromal cells (hBMSCs) in the expression pattern of cell surface markers and their pluripotent differentiation capability.

Huang AH, Snyder BR, Cheng PH, Chan AW.Putative dental pulp-derived stem/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of mice.Stem Cells. 2008 Oct;26(10):2654-63. Epub 2008 Aug 7.PMID: 18687995

Munoz JR, Stoutenger BR, Robinson AP, Spees JL, Prockop DJ.Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice.Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18171-6. Epub 2005 Dec 5. Erratum in: Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):2000-2.PMID: 16330757

Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, DenBesten P, Robey PG, Shi S.Stem cell properties of human dental pulp stem cells.J Dent Res. 2002 Aug;81(8):531-5.PMID: 12147742

Spermatogonial Stem Cell

 

References

  1. <pubmed>18849962</pubmed>
  2. <pubmed>17158956</pubmed>
  3. <pubmed>15366003</pubmed>

Reviews

<pubmed>17157222</pubmed> <pubmed>17123233</pubmed> <pubmed>17076989</pubmed>


Articles

<pubmed>17282993</pubmed> <pubmed>17234930</pubmed>

Search PubMed

Search PubMed: Feb 2007 "adult stem cells" 811 reference articles of which 367 were reviews.

Search PubMed Now: adult stem cells | induced pluripotent stem cell |

Glossary Links

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Cite this page: Hill, M.A. (2024, March 28) Embryology Stem Cells - Adult. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Stem_Cells_-_Adult

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G