Stem Cells - Adult

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Introduction

The term "stem cell" is now used widely to cover many different cells derived from both embryo and adult tissues.

A useful guide (online PDF document) to stem cells was produced in a report by the National Institute of Health (NIH, USA, May 2000) [../pdf/fullrptstem.pdf Stem Cells: A Primer] (note large size - 4.84 Mb) and more recently NIH has established a Stem Cell information page.

Some Recent Findings

Nature advance online publication 23 July 2009 | doi:10.1038/nature08267; Received 9 January 2009; Accepted 3 July 2009; Published online 23 July 2009 Xiao-yang Zhao iPS cells produce viable mice through tetraploid complementationnear-final version

"Here we report the generation of several iPS cell lines that are capable of generating viable, live-born progeny by tetraploid complementation. These iPS cells maintain a pluripotent potential that is very close to ES cells generated from in vivo or nuclear transfer embryos. We demonstrate the practicality of using iPS cells as useful tools for the characterization of cellular reprogramming and developmental potency, and confirm that iPS cells can attain true pluripotency that is similar to that of ES cells."

Conrad S, Renninger M, Hennenlotter J, Wiesner T, Just L, Bonin M, Aicher W, Bühring HJ, Mattheus U, Mack A, Wagner HJ, Minger S, Matzkies M, Reppel M, Hescheler J, Sievert KD, Stenzl A, Skutella T. Generation of pluripotent stem cells from adult human testis. Nature. 2008 Oct 8.

Wong CE, Paratore C, Dours-Zimmermann MT, Rochat A, Pietri T, Suter U, Zimmermann DR, Dufour S, Thiery JP, Meijer D, Beermann F, Barrandon Y, Sommer L. Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J Cell Biol. 2006 Dec 11

M. Sieber-Blum, M. Grim, Y.F. Hu, V. Szeder Pluripotent neural crest stem cells in the adult hair follicle. Dev Dyn. 2004 Oct;231(2):258-69.

Induced Pluripotent Stem Cell

(iPS cell) A reprogrammed adult stem cell to form an embryonic stem cell, from which tissues or whole animals can develop. Can be generated by the expression of just four specific transcription factors.

Links: Nature Jul09 | ABC - Mice pups bred from adult stem cells

Bone Marrow Stem Cell

Bone marrow stromal stem cells

Hair Follicle Stem Cell

M. Sieber-Blum, M. Grim, Y.F. Hu, V. Szeder Pluripotent neural crest stem cells in the adult hair follicle. Dev Dyn. 2004 Oct;231(2):258-69.

Dental Pulp Stem Cell (DPSC)

Dental pulp stem/stromal cell (DPSC) are similar to bone marrow derived mesenchymal stem/stromal cells (hBMSCs) in the expression pattern of cell surface markers and their pluripotent differentiation capability.

Huang AH, Snyder BR, Cheng PH, Chan AW.Putative dental pulp-derived stem/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of mice.Stem Cells. 2008 Oct;26(10):2654-63. Epub 2008 Aug 7.PMID: 18687995

Munoz JR, Stoutenger BR, Robinson AP, Spees JL, Prockop DJ.Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice.Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18171-6. Epub 2005 Dec 5. Erratum in: Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):2000-2.PMID: 16330757

Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, DenBesten P, Robey PG, Shi S.Stem cell properties of human dental pulp stem cells.J Dent Res. 2002 Aug;81(8):531-5.PMID: 12147742

Spermatogonial Stem Cell

 

References

Links: [#Reviews Reviews] | [#Articles Articles] | [#OnlineTextbooks Online Textbooks] | [#SearchTextbooks Search Textbooks] | [#SearchPubMed Search PubMed] | [#Glossary Glossary]

PubMed

Reviews

Moraleda JM, Blanquer M, Bleda P, Iniesta P, Ruiz F, Bonilla S, Cabanes C, Tabares L, Martinez S. Adult stem cell therapy: dream or reality? Transpl Immunol. 2006 Dec;17(1):74-7.

Serafini M, Verfaillie CM. Pluripotency in adult stem cells: state of the art. Semin Reprod Med. 2006 Nov;24(5):379-88.

Pessina A, Gribaldo L. The key role of adult stem cells: therapeutic perspectives. Curr Med Res Opin. 2006 Nov;22(11):2287-300.

Articles

Ross JJ, Verfaillie CM. Evaluation of neural plasticity in adult stem cells. Philos Trans R Soc Lond B Biol Sci. 2007 Feb 5;

Prentice DA, Tarne G. Treating diseases with adult stem cells. Science. 2007 Jan 19;315(5810):328.

Search PubMed: Feb 2007 "adult stem cells" 811 reference articles of which 367 were reviews.

Search PubMed Now: adult stem cells | induced pluripotent stem cell |