Somatic Cell Nuclear Transfer: Difference between revisions

Revision as of 13:20, 22 August 2012

Introduction

Page Under Development

Dolly the Sheep

Mice cloned from adult keratinocytes^[1]

In 1996 Dolly the sheep was the first animal to be produced by somatic cell nuclear transfer (SCNT) using an adult-derived somatic cell as nuclear donor. A somatic cell refers to the fact that a cell that is not a germ cell (spermatozoa, oocyte) is used to generate a zygote from which the embryo develops. This topic is closely related to Stem Cells.

A range of different cell types has now been successfully applied to a range of species (cattle, mice, goats, pigs, cats, rabbits, horses, rats, dogs and ferrets. (see review^[2])

Some Recent Findings

Number of blastomeres and distribution of microvilli in cloned mouse embryos during compaction^[3] "We concluded that: (i) the cleavage of blastomeres in cloned embryos was slow at least before compaction; (ii) the distribution of microvilli in cloned, normal, parthenogenetic, and tetraploid embryos was coherent before and after compaction; and (iii) the initiation of compaction in somatic cell nuclear transfer (SCNT) embryos was delayed compared with that of intracytoplasmic sperm injection (ICSI) embryos."

SCNT Animal Timeline

1996 - Sheep^[4]
1998 - Cattle^[5], Mouse^[6]
1999 - Goat^[7]
2000 - Pig^[8]

References

↑ <pubmed>17299040</pubmed>| PMC1815251
↑ <pubmed>22681293</pubmed>
↑ <pubmed>20735894</pubmed>
↑ <pubmed>8598906</pubmed>
↑ <pubmed>9596577</pubmed>
↑ <pubmed>9690471</pubmed>
↑ <pubmed>10331804</pubmed>
↑ <pubmed>10993078</pubmed>

Journals

Zygote An international journal dedicated to the rapid publication of original research in early embryology, Zygote covers interdisciplinary studies in animals and humans, from gametogenesis through fertilization to gastrulation.

Reviews

Articles

Search Pubmed

June 2010 "zygote" All (6213) Review (651) Free Full Text (1543)

Search Pubmed: somatic cell nuclear transfer

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, April 19) Embryology Somatic Cell Nuclear Transfer. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Somatic_Cell_Nuclear_Transfer

What Links Here?

[1] <pubmed>17299040</pubmed>| PMC1815251

[2] <pubmed>22681293</pubmed>

[3] <pubmed>20735894</pubmed>

[4] <pubmed>8598906</pubmed>

[5] <pubmed>9596577</pubmed>

[6] <pubmed>9690471</pubmed>

[7] <pubmed>10331804</pubmed>

[8] <pubmed>10993078</pubmed>

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 A range of different cell types has now been successfully applied to a range of species (cattle, mice, goats, pigs, cats, rabbits, horses, rats, dogs and ferrets. (see review<ref><pubmed>22681293</pubmed></ref>)
-:[[Somatic Cell Nuclear Transfer|'''SCNT Links''']]: [[Somatic Cell Nuclear Transfer|Introduction]] | [[Stem_Cells_-_Adult#Somatic_Cell_Nuclear_Transfer|Stem Cells - SCNT]] | [[Molecular_Development_-_Epigenetics|Epigenetics]] | [[Stem Cells]] | [[Assisted Reproductive Technology|ART]] | [[Fertilization]] | [[Week 1]] | [[:Category:Zygote|Category:Zygote]]
+:[[Somatic Cell Nuclear Transfer|'''SCNT Links''']]: [[Somatic Cell Nuclear Transfer|Introduction]] | [[Stem_Cells_-_Induced|Stem Cells - Induced]] | [[Stem_Cells_-_Adult#Somatic_Cell_Nuclear_Transfer|Stem Cells - SCNT]] | [[Molecular_Development_-_Epigenetics|Epigenetics]] | [[Stem Cells]] | [[Assisted Reproductive Technology|ART]] | [[Fertilization]] | [[Week 1]] | [[:Category:Zygote|Category:Zygote]]
 == Some Recent Findings ==