Somatic Cell Nuclear Transfer: Difference between revisions

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===Animal Timeline===
==SCNT Animal Timeline==


* '''1996''' - Sheep<ref><pubmed>8598906</pubmed></ref>
* '''1996''' - Sheep<ref><pubmed>8598906</pubmed></ref>
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* '''1999''' - Goat<ref><pubmed>10331804</pubmed></ref>
* '''1999''' - Goat<ref><pubmed>10331804</pubmed></ref>
* '''2000''' - Pig<ref><pubmed>10993078</pubmed></ref>
* '''2000''' - Pig<ref><pubmed>10993078</pubmed></ref>


==References==
==References==

Revision as of 13:19, 22 August 2012

Introduction

Page Under Development

Dolly the Sheep
Mice cloned from adult keratinocytes[1]

In 1996 Dolly the sheep was the first animal to be produced by somatic cell nuclear transfer (SCNT) using an adult-derived somatic cell as nuclear donor. A somatic cell refers to the fact that a cell that is not a germ cell (spermatozoa, oocyte) is used to generate a zygote from which the embryo develops. This topic is closely related to Stem Cells.

A range of different cell types has now been successfully applied to a range of species (cattle, mice, goats, pigs, cats, rabbits, horses, rats, dogs and ferrets. (see review[2])

SCNT Links: Introduction | Stem Cells - SCNT | Epigenetics | Stem Cells | ART | Fertilization | Week 1 | Category:Zygote

Some Recent Findings

  • Number of blastomeres and distribution of microvilli in cloned mouse embryos during compaction[3] "We concluded that: (i) the cleavage of blastomeres in cloned embryos was slow at least before compaction; (ii) the distribution of microvilli in cloned, normal, parthenogenetic, and tetraploid embryos was coherent before and after compaction; and (iii) the initiation of compaction in somatic cell nuclear transfer (SCNT) embryos was delayed compared with that of intracytoplasmic sperm injection (ICSI) embryos."


SCNT Animal Timeline

References

  1. ↑ <pubmed>17299040</pubmed>| PMC1815251
  2. ↑ <pubmed>22681293</pubmed>
  3. ↑ <pubmed>20735894</pubmed>
  4. ↑ <pubmed>8598906</pubmed>
  5. ↑ <pubmed>9596577</pubmed>
  6. ↑ <pubmed>9690471</pubmed>
  7. ↑ <pubmed>10331804</pubmed>
  8. ↑ <pubmed>10993078</pubmed>

Journals

  • Zygote An international journal dedicated to the rapid publication of original research in early embryology, Zygote covers interdisciplinary studies in animals and humans, from gametogenesis through fertilization to gastrulation.

Reviews

<pubmed>22536140</pubmed> <pubmed>22000472</pubmed> <pubmed>21982229</pubmed> <pubmed>21555407</pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed>

Articles

Search Pubmed

June 2010 "zygote" All (6213) Review (651) Free Full Text (1543)

Search Pubmed: somatic cell nuclear transfer


Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, April 19) Embryology Somatic Cell Nuclear Transfer. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Somatic_Cell_Nuclear_Transfer

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
Retrieved from ‘https://embryology.med.unsw.edu.au/embryology/index.php?title=Somatic_Cell_Nuclear_Transfer&oldid=99755’
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