Sheep Development

From Embryology
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Introduction

Sheep with lamb with second (twin) lamb being born.

Domestic sheep (Ovis aries)

  • term gestational days = 145 days

Some Recent Findings

  • Development of morulae from the oocytes of cultured sheep preantral follicles[1] "Sheep preantral follicles (PFs) measuring 250-400 microm in diameter were cultured for six days in serum-free media supplemented differently with growth factors and hormones. ...In combination with T4 and FSH, IGF-I+GH supported the best development of the PFs. Culture of PFs in micro drops or agar gel supported similarly high development. In vitro fertilization of the oocytes from the cultured sheep PFs resulted in the embryos developing to the morula stage for the first time."
  • Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model[2]

Development Overview

  • day 4 - embryo enters the uterus at the morula stage of development
  • day 6 - develops into a blastocyst
  • day 8 - blastocyst hatches from zona pellucida
  • day 11-16 - elongates to a filamentous form
  • day 14 - 16 - binucleate cells begin to differentiate in the trophoblast
  • day 16 - adplantation

See also Implantation mechanisms: insights from the sheep[3]

Dolly

Dolly the sheep (5 July 1996 – 14 February 2003)

A female domestic sheep remarkable in being the first mammal to be cloned from an adult somatic cell, using the process of nuclear transfer.[4]

Cloned by Ian Wilmut, Keith Campbell and colleagues at the Roslin Institute near Edinburgh in Scotland, born on 5 July 1996 and she lived until the age of six (5 July 1996 – 14 February 2003). The cell used as the donor for the cloning of Dolly was taken from a mammary gland, and the production of a healthy clone therefore proved that a cell taken from a specific part of the body could recreate a whole individual. As Dolly was cloned from part of a mammary gland, she was named after the famously curvaceous country western singer Dolly Parton.


Links: Roslin Institute, Edinburgh | Science Museum - Dolly the sheep, 1996-2003

References

  1. <pubmed>20615540</pubmed>
  2. <pubmed>20610723</pubmed>
  3. <pubmed>15579583</pubmed>
  4. <pubmed>9039911</pubmed>


Reviews

<pubmed>19726075</pubmed> <pubmed>16008756</pubmed>

Articles

<pubmed>19909921</pubmed> <pubmed>15047940</pubmed>| Reproduction

Search PubMed

Search Pubmed: sheep development | ovine development | ovine embryo development

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Cite this page: Hill, M.A. (2024, March 28) Embryology Sheep Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Sheep_Development

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G