Sensory - Hearing and Balance Development: Difference between revisions

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==Embryonic Origin Overview==
==Embryonic Origin Overview==
[[File:Adult hearing embryonic origins.jpg|thumb|Adult hearing embryonic origins]]
[[File:Adult hearing embryonic origins.jpg|thumb|300px|Adult hearing embryonic origins]]
===External Ear===
===External Ear===



Revision as of 02:20, 15 August 2012

Hearing cartoon.jpg

Introduction

Newborn hearing test

We use the sense of balance and hearing to position ourselves in space, sense our surrounding environment, and to communicate. Portions of the ear appear very early in development as specialized region (otic placode) on the embryo surface that sinks into the mesenchyme to form a vesicle (otic vesicle = otocyst) that form the inner ear.

This region connects centrally to the nervous system and peripherally through specialized bones to the external ear (auricle). This organisation develops different sources forming the 3 ear parts: inner ear (otic placode, otocyst), middle ear (1st pharyngeal pouch and 1st and 2nd arch mesenchyme), and outer ear (1st pharyngeal cleft and 6 surface hillocks).

This complex origin, organisation, and timecourse means that abnormal development of any one system can impact upon the development of hearing.

In Australia, there is now an early postnatal screening of neonatal hearing as part of a NSW State Wide Infant Screening Hearing (SWISH) Program using Automated Auditory Brainstem Response (AABR).

Use the hearing links below to see more detailed information about development of the three hearing divisions and abnormalities.


Hearing Links: Introduction | inner ear | middle ear | outer ear | balance | placode | hearing neural | Science Lecture | Lecture Movie | Medicine Lecture | Stage 22 | hearing abnormalities | hearing test | sensory | Student project

  Categories: Hearing | Outer Ear | Middle Ear | Inner Ear | Balance

Historic Embryology - Hearing 
Historic Embryology: 1880 Platypus cochlea | 1892 Vertebrate Ear | 1902 Development of Hearing | 1906 Membranous Labyrinth | 1910 Auditory Nerve | 1913 Tectorial Membrane | 1918 Human Embryo Otic Capsule | 1918 Cochlea | 1918 Grays Anatomy | 1922 Human Auricle | 1922 Otic Primordia | 1931 Internal Ear Scalae | 1932 Otic Capsule 1 | 1933 Otic Capsule 2 | 1936 Otic Capsule 3 | 1933 Endolymphatic Sac | 1934 Otic Vesicle | 1934 Membranous Labyrinth | 1934 External Ear | 1938 Stapes - 7 to 21 weeks | 1938 Stapes - Term to Adult | 1940 Stapes | 1942 Stapes - Embryo 6.7 to 50 mm | 1943 Stapes - Fetus 75 to 150 mm | 1946 Aquaductus cochleae and periotic (perilymphatic) duct | 1946 aquaeductus cochleae | 1948 Fissula ante fenestram | 1948 Stapes - Fetus 160 mm to term | 1959 Auditory Ossicles | 1963 Human Otocyst | Historic Disclaimer


Senses Links: Introduction | placode | Hearing and Balance hearing | balance | vision | smell | taste | touch | Stage 22 | Category:Sensory

Some Recent Findings

  • Postnatal development primary auditory cortex[1] "The organization of the primary auditory cortex (A1) in particular is governed by acoustic experience during the critical period, an epoch near the beginning of postnatal development throughout which cortical synapses and networks are especially plastic. This neonatal sensitivity to the pattern of sensory inputs is believed to be essential for constructing stable and adequately adapted representations of the auditory world and for the acquisition of language skills by children."
  • Review - The etiology of otosclerosis[2] "Otosclerosis is a common form of hearing loss characterized by abnormal bone remodeling in the otic capsule. It is a complex genetic disease, caused by a combination of genetic and environmental factors. During the past decade, several attempts have been made to identify factors for otosclerosis."

Textbooks

  • Larsen's Human Embryology (4th ed.) Schoenwolf, Larsen, Bleyl, Brauer and Francis-West Chapter 17 Development of the Ears and Eyes
  • The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Chapter 19: p491-511
  • Essentials of Human Embryology Larsen Chapter 12: p252-272
  • Before We Are Born (5th ed.) Moore and Persaud Chapter 20: p460-479
  • UNSW Embryology - original Hearing page
  • Journal of Cell Biology The Cell Biology of the Senses - The cell biology of hearing July 12, 2010 .

Development Timing

Comparison of size at stage 14 to 23
  • Week 3 - otic placode, otic vesicle
  • Week 5 - cochlear part of otic vesicle elongates (humans 2.5 turns)
  • Week 9 - Mesenchyme surrounding membranous labryinth (otic capsule) chondrifies
  • Week 12 - 16 - Capsule adjacent to membranous labryinth undegoes vacuolization to form a cavity (perilymphatic space) around membranous labrynth and fills with perilymph
  • 2nd Trimester - (week 16 - 24) Centres of ossification appear in remaining cartilage of otic capsule form petrous portion of temporal bone. Continues to ossify to form mastoid process of temporal bone.
  • 3rd Trimester - Vibration acoustically of maternal abdominal wall induces startle response in fetus.

Embryonic Origin Overview

Adult hearing embryonic origins

External Ear

  • Auricle - Pharyngeal Arches 1 and 2 (ectoderm, mesoderm)
  • External Auditory Meatus - Pharyngeal Arch 1 groove or cleft (ectoderm)
  • Tympanic Membrane - Pharyngeal Arch 1 membrane (ectoderm, mesoderm, endoderm)

Middle Ear

  • Middle Ear Ossicles
    • Malleus and incus - Pharyngeal Arch 1 cartilage Neural crest (ectoderm)
    • Stapes - Pharyngeal Arch 2 cartilage Neural crest (ectoderm)
  • Middle Ear Muscles
    • Tensor tympani - Pharyngeal Arch 1 (mesoderm)
    • Stapedius - Pharyngeal Arch 2 (mesoderm)
  • Middle ear cavity - Pharyngeal Arch 1 pouch (endoderm)

Inner Ear

  • Inner Ear Labyrinth
    • Cochlea - Otic vesicle - Otic placode (ectoderm)
    • Semicircular canals - Otic vesicle - Otic placode (ectoderm)
    • Saccule and utricle - Otic vesicle - Otic placode (ectoderm)
  • Cranial Nerve VIII
    • Auditory component - Otic vesicle and neural crest (ectoderm)
    • Vestibular component - Otic vesicle and neural crest (ectoderm)

Inner Ear

Stage 13 otocyst
Stage 22 ear
  • The inner ear is derived from a pair of surface sensory placodes (otic placodes) in the head region.
  • These placodes fold inwards forming a depression, then pinch off entirely from the surface forming a fluid-filled sac or vesicle (otic vesicle, otocyst).
  • The vesicle sinks into the head mesenchyme some of which closely surrounds the otocyst forming the otic capsule.
  • The otocyst finally lies close to the early developing hindbrain (rhombencephalon) and the developing vestibulo-cochlear-facial ganglion complex.

Links: Inner Ear

Middle Ear

  • The middle ear ossicles (bones) are derived from 1st and 2nd arch mesenchyme.
  • The space in which these bones sit is derived from the 1st pharyngeal pouch.

Links: Middle Ear

Outer Ear

External ear stages 14-23 and adult (not to scale)
  • The external ear is derived from 6 surface hillocks, 3 on each of pharyngeal arch 1 and 2.
  • The external auditory meatus is derived from the 1st pharyngeal cleft.
  • The newborn external ear structure and position is an easily accessible diagnostic tool for potential abnormalities or further clinical screening.

Links: Outer Ear

Postnatal Changes

Eustacian tube angle changes

There are a number of postnatal changes associated with growth of the head that affect the newborn to adult auditory tube and its functions. The auditory tube (Eustachian, otopharyngeal or pharyngotympanic) space connects the middle ear cavity to nasopharynx portion of pharynx.

Auditory Tube Functions

  • Ventilation - pressure equalization in the middle ear
  • Clearance - allow fluid drainage from the middle ear, tube is normally closed and opened by muscles

Auditory Tube Postnatal

  • Birth - (neonatal to early childhood) the tube is initially short (17-18 mm), narrower and runs almost horizontal. The tube is opened by a single muscle, tensor palati muscle.
  • Adult - the tube is longer (twice as long), wider and runs at approximately 45 degrees to the horizontal. Tube is opened by two separate muscles, tensor palati and levator palati.

Abnormalities

Microtia
Preauricular sinus

There are many different abnormalities of hearing development that can result in hearing loss and can broadly be divided into either conductive or sensorineural loss. These abnormalities can have genetic, environmental or unknown origins. In addition, abnormalities of the external ear (position and structure) is used as a clinical diagnostic tool for developmental abnormalities in other systems.

  • Inner ear - common cavity, severe cochlear hypoplasia
  • Middle ear - rare and can be part of first arch syndrome, Malleus, Incus and Stapes Fixation
    • Cholesteatoma- Epithelium trapped within skull base in development, erosion of bones: temporal bone, middle ear, mastoid
  • Outer ear - Several genetic effects and syndromes, Environmental Effects
    • Microtia - abnormally small external ear
    • Preauricular sinus - occurs in 0.25% births, bilateral (hereditary) 25-50%, unilateral (mainly the left), duct runs inward can extend into the parotid gland, Postnatally sites for infection

Links: Hearing Abnormalities

Congenital Deafness

Sensorineural - cochlear or central auditory pathway Conductive - disease of outer and middle ear

Sensorineural

  • Hereditary
  • recessive- severe
  • dominant- mild
    • can be associated with abnormal pigmentation (hair and irises)
  • Acquired
    • rubella (German measles), maternal infection during 2nd month of pregnancy, vaccination of young girls
    • cytomegalovirus [3]
    • streptomycin
    • antibiotic
    • thalidomide

Conductive

  • disease of outer and middle ear
  • can be produced by otitis media with effusion, that is widespread in young children.
  • temporary blockage of outer or middle ear

Fetal Alcohol Syndrome

Fetal Alcohol Syndrome Face
  • Postion- Lower or uneven height, "railroad track” appearance, curve at top part of outer ear is under-developed, folded over parallel to curve beneath


Newborn Hearing Screening

Newborn hearing test

In Australia, there is now an early postnatal screening of neonatal hearing as part of a NSW State Wide Infant Screening Hearing (SWISH) Program using Automated Auditory Brainstem Response (AABR).

  • Very low birthweight infants and universal newborn hearing screening in a developing country[4]

Links: NSW Statewide Infant Screening - Hearing (SWISH) Program

Bionic Ear

The "Cochlear Implant" was pioneered in development by Professor Graeme Clark (1960s, Australia).[5] It consists of an array of electrodes implanted within cochlea, that directly electrically stimulate the auditory nerve fibres.

  • Young children with cochlear implants compared with children with normal hearing.[6]

References

  1. <pubmed>20559387</pubmed>
  2. <pubmed>20513039</pubmed>
  3. <pubmed>20500943</pubmed>
  4. <pubmed>20450464</pubmed>
  5. <pubmed>18816421</pubmed>JRRD
  6. <pubmed>20452685</pubmed>

Online Textbooks

Reviews

<pubmed>20624897</pubmed>| JCB

The International Journal of Developmental Biology Vol. 51 Nos. 6/7 (2007) Ear Development

Search

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Additional Images


See also Category:Hearing

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Terms

altricial animal - Term used to describe an animal born in a helpless state, with incomplete development of sensory systems at birth. For example rats and mice are born with incomplete development of visual and auditory systems. (More? Animal Development)

ampulla - Term used to describe an anatomical dilation of a tube or canal lumen. Anatomical description of the opening end of the uterine tube lying above the ovary and the enlarged initial segmeny of the semicircular canals of the inner ear vestibular system. (More? Inner Ear)

aneurism - (Greek, aneurysma = a widening, aneurysm) A term used to describe an abnormal widening of a vessel or anatomical tubal structure.

aquaeductus vestibuli - see vestibular aqueduct (More? Inner Ear)

auditory neuropathy - (AN) abnormality of transmission of sound information to the brain.

auditory tube - (eustachian tube) between the middle ear and oral cavity, has a bony (tympanic 1/3) and cartilaginous (pharyngeal 2/3) portion. The main role is equalization of pressure and fluid drainage in the middle ear. (More? Middle Ear)

auricular hillock - see hillock (More? Middle Ear)

atresia - narrowing, usually of an anatomical tube or cavity.

autophagocytosis - (Greek, auto = self, phagy = eating, also called autophagy) a cell death mechanism that uses the cell's own lysosomes to self digest.

border cells - columnar cells within the organ of Corti on the medial portion of the basilar membrane. (More? Inner Ear)

canalis reuniens - (ductus reuniens, canaliculus reuniens, canalis reuniens, Hensen's canal, Hensen's duct, uniting canal, canalis reuniens of Hensen) short narrow canal connecting the cochlea duct to the saccule. (Victor Hensen, 1835-1924) (More? Inner Ear)

cerumen - (ear wax) produced by glands in the skin of the outer portion of the ear canal. (More? [[Hearing - Outer Ear Development|Outer Ear])

chondrified - the developmental differentiation of cartilage from mesenchye, an embryonic connective tissue.

cristae ampullaris - located in the ampulla of the membranous semicircular canals a region with both supporting and hair cells. The hair cell cilia are embedded in the gelatinous cupula. (More? Inner Ear)

claudius cells - (cells of Claudius) columnar cells with microvilli overlying the basilar membrane and extend from Hensen's cells to the spiral prominence. Barrier cells that lie external to the organ of corti in endolymph. (More? Inner Ear)

cochlear sac - embryonic structure, which will form the coiled cochlear duct and contribute to the saccule. (More? Inner Ear)

cochlear aqueduct - a bony channel containing the fibrous periotic duct. It connects the basal turn of the cochlea perilymphatic space with the subarachnoid space of the posterior cranial cavity. (More? Inner Ear)

cochlin - major constituent of the inner ear extracellular matrix. (More? Inner Ear)

collagen type II - major constituent of the inner ear extracellular matrix. (More? Inner Ear)

conductive loss - term used to describe one of the two major classes of hearing loss involving external and middle ear abnormalities (other form is Sensorineural loss).

connexins - channel proteins of the gap junctions that allow rapid communication between adjacent cells. The two connexins Cx26 and Cx30 are the major proteins of cochlear gap junctions.

connexin 26 - A strikingly high proportion (50%) of congenital bilateral nonsyndromic sensorineural deafness cases have been linked to mutations in the GJB2 coding for the connexin26

cupular deposits - basophilic material on the cupulae of the semicircular ducts, an postnatal ageing phenomenon seen in some vestibular labyrinth. (More? Inner Ear)

clinical weeks - taken from last menstrual period (LMP) and therefore approximately two weeks before fertilization occurs.

Deiters' cells - (outer phalangeal cells)

discoidin domain receptor 1 - (DDR1) a tyrosine kinase receptor activated by native collagen, expressed in the basement membrane and with fibrillar collagens. Found in basal cells of the stria vascularis, type III fibrocytes, and cells lining the basilar membrane of the organ of Corti. {Meyer zum Gottesberge, 2008 #1877}

ductus utriculosaccularis - (More? Inner Ear)

endochondral ossification - the process of bone formation from a pre-existing cartilage template. (More? Middle Ear)

endoderm - One of the initial 3 germ cell layers (ectoderm, mesoderm and endoderm) formed by the process of gastrulation. The endoderm forms as a cuboidal epithelium and contributes not only to the trilaminar embryo, but also lines the yolk sac. It will form the entire epithelial lining of the gastrointestinal tract (GIT), contribute to the accessory organs of GIT and also forms the epithelial lining of the respiratory tract.

endolymphatic fluid - (endolymph, Scarpa's fluid) fluid that fills all the membranous labyrinth of the inner ear, except for the cochlea scala tympani and scala vestibuli which are filled with perilymph.

endolymphatic sac - inner ear structure that has anatomically both an intraosseous and extraosseous component. Th e sac has functions regulating endolymph that are both secretory and absorptive. Also the site of endolymphatic sac tumors either sporadical occurring or associated with the autosomal-dominant von Hippel-Lindau (VHL) disease, due to a germ line mutation. (More? Inner Ear)

embryological weeks - taken from the time of fertilization which typically occurs around the middle (day 14), or just after, of the typical 28 day menstrual cycle. (More? Embryonic Development)

Emx2 - homeobox gene affecting middle ear and inner ear development.

eustachian tube - (auditory tube) A cavity linking the pharynx to the middle ear, which develops from the first pharyngeal pouch. Named after Bartolomeo Eustachi (1500 - 1574) an Italian anatomist. (More? Middle Ear)

external auditory meatus - (ear canal) develops from the first pharyngeal cleft. (More? Outer Ear)

ear wax - see cerumen. (More? Outer Ear)

espins - calcium-resistant actin-bundling proteins enriched in hair cell stereocilia and sensory cell microvilli and spiral ganglion neurons (SGNs)

eustachian tube - (auditory tube) between the middle ear and oral cavity, equalization of pressure in the middle ear. (More? Middle Ear)

external auditory meatus - (More? Outer Ear)

fenestra ovalis - (oval window) separates the tympanic cavity from the vestibule of the osseous labyrinth. (More? Inner Ear)

fenestra rotunda - (round window) separates the tympanic cavity from the scala tympani of the cochlea. (More? Inner Ear)

fetus - (foetus) term used to describe human development after the 8th week (10th clinical week, LPM) and covers the developmental periods of second and third trimester.

fibroblast growth factor 1 - (Fgf-1) a growth factor released from cochlea sensory epithelium which stimulates spiral ganglion neurite branching.

fibroblast growth factor 8 - (Fgf-8) a growth factor released by inner hair cells which regulates pillar cell number, position and rate of development.

fibroblast growth factor receptor 3 - (Fgfr-3) a tyrosine kinase receptor with a role in the commitment, differentiation and position of pillar cells in the organ of corti

fundamental frequency - (natural frequency) the lowest frequency in a harmonic series, for the female voice this is about 225 Hz.

helicotrema - term used to describe the cochlear apex. (More? Inner Ear)

Hes - (hairy and enhancer of split) family of factors, which has been shown to be a general negative regulator of neurogenesis (Zheng, 2000).

hillock - a small hill, used to describe the six surface elevations on pharyngeal arch one and two. (More? Outer Ear)

Incus - (anvil) auditory ossicle (More? Middle Ear)

inner phalangeal cells - in the cochlea a single row of cells, that along with and three rows of outer phalangeal cells (Deiter's cells), are the hair cell supporting cells. (More? Inner Ear)

inner pillar cells - organ of Corti cells arranged in rows and form a boundary between the single row of inner hair cells and three rows of outer hair cells. These cells have surface-associated microtubule bundles. (More? Inner Ear)

inner sulcus - area of the cochlear duct. (More? Inner Ear)

interdental region -

internal auditory meatus - (internal acoustic meatus, IAM) Anatomical canal in which CN VII and CN VIII ganglia reside and pass through to the brainstem. This bony canal lies between the posterior surface of the petrous pyramid and the bony labyrinth within the dense petrous bone. Also associated clinically with the site where acoustic neuromas may occur. (More? Inner Ear)

Kolliker's organ - (Kollicker's organ, greater epithelial ridge) Developing cochlear structure consisting of columnar-shaped supporting cells filling the inner sulcus and lying directly under the tectorial membrane. This transient organ regresses and generates the space of the inner sulcus. Rudolph Albert von Kolliker (1817-1905)?? (More? Inner Ear)

lateral semicircular duct - Limbus -

LMP - acronym for last menstrual period, used to clinically measure gestation.

malleus - (hammer) auditory ossicle (More? Middle Ear)

mastoid process - of temporal bone (More? Middle Ear)

Math1 - homolog of the Drosophila proneural gene atonal, necessary and sufficient for the production of hair cells in the mouse inner ear. Negatively regulated by Hes1 and Hes5

meatal plug - temporary blockage of the external auditory meatus which forms at the end of the embryonic period and remains present until the seventh month.

meatus - anatomical opening, cavity or space (external acoustic meatus, internal auditory meatus)

Meckel's cartilage - first pharyngeal ach cartilage, located within the mandibular prominence. This cartilage first appears at stage 16, stage 20 the beginning of membranous ossification. Named after Johann Friedrich Meckel, (1781 - 1833) a German anatomist. (http://www.whonamedit.com/doctor.cfm/1840.html) (More? Middle Ear)

membranous labyrinth - (More? Inner Ear)

mucopolysaccharidosis - (MPS IIIB, Sanfilippo Syndrome type B) abnormality caused by a deficiency in the lysosomal enzyme N-acetyl-glucosaminidase (Naglu). Children with MPS IIIB develop abnormal hearing, and mental functioning culminating in early death.

netrin-1 - secreted growth factor, expressed in the organ of Corti and spiral ganglion cells, role in process outgrowth. (More? Inner Ear)

neural tube -

olivocochlear - brainstem cholinergic and GABAergic efferent system that innervates sensory cells and sensory neurons of the inner ear.

organ of Corti - (More? Inner Ear)

organ of Corti protein II - (OCP-II) cytosolic protein or transcription factor? (More? Inner Ear)

otolithic membrane - extracellular matrix that cover the sensory epithelia of the inner ear. (More? Inner Ear)

ossicle - (small bone) the individual bone of the three middle ear bones (auditory ossicles), which reduce vibrational amplitude but increase force to drive fluid-filled inner ear. (More? Middle Ear)

ossify - (More? Middle Ear)

otic capsule -

otic cup -

otic placode - (More? Inner Ear | Placodes)

otic vesicle - (More? Inner Ear)

otoconin - inner ear biominerals required for vestibular apparatus function. (More? Inner Ear)

otogelin - (Otog) an inner ear specific glycoprotein expressed in cochlea cells at different developmental times. (More? Inner Ear)

otolithic membrane - a membrane within the utricle and saccule containing embedded hair cell cilia and small crystalline bodies of calcium carbonate (otoliths). Functions to detect head motion.

otoliths - small crystalline bodies of calcium carbonate found within the otolitic membrane of the utricle and saccule. (More? Inner Ear)

ototoxic - compound or drug causing temporary or permanent hearing loss.

outer hair cells - (OHCs) three rows of hair cells that function to increase basilar membrane motion through a local mechanical feedback process within the cochlea, the "cochlear amplifier".

outer pillar cells - arranged in rows and form a boundary between the single row of inner hair cells and three rows of outer hair cells. (More? Inner Ear)

paratubal musculature - muscles lying beside the auditory (Eustachian) tube. The tensor veli, palatini (TVP) and tensor tympani muscles. (More? Middle Ear)

perilymph - perilymphatic space - Periotic Capsule - petrous portion - of temporal bone

pejvakin gene - in humans, two missense mutations in this gene cause nonsyndromic recessive deafness (DFNB59) by affecting the function of auditory neurons.

pharyngeal arch - (More? Outer Ear) pharyngeal pouch pharyngeal membrane Pharynx

pillar cells - (PC) form an inner and outer row of support cells that form a boundary between inner and outer hair cells. (More? Inner Ear)

Placode

preyer reflex - ear flick in mouse in response to sound.

presbyacusis

prestin - a motor protein structurally similar to the anion transporter family expressed in cochlear outer hair cells. (More? Inner Ear)

preauricular tag - skin tags located in front of the external ear opening, are common in neonates and in most cases are normal, though in some cases are indicative of other associated abnormalities.

primordium-

protocadherin 15 - (Pcdh15) required for initial formation of stereocilia bundles and changes in the actin meshwork within hair cells. The Ames waltzer (av) mouse mutant has both auditory and vestibular abnormalities from a mutation in this gene.

Reichert's cartilage - pharyngeal ach 2 cartilage, named after Karl Bogislaus Reichert (1811 - 1883) a German anatomist.

Reissner's membrane - (vestibular membrane, vestibular wall) is a membrane located inside the cochlea separating the scala media from scala vestibuli. Named after Ernst Reissner (1824-1878) a German anatomist. It primarily functions as a diffusion barrier, allowing nutrients to travel from the perilymph to the endolymph of the membranous labyrinth.

rhombomere -

Saccular macula -

Saccule - (Latin, sacculus = a small pouch)

sacculocollic reflex -

scala tympani - one of the three Cochlea cavities, it is filled with perilymph.

Scarpa's ganglion - (vestibular ganglion) primary afferent vestibular neuron ganglion of the vestibular nerve. Located within the internal auditory meatus. (More? Inner Ear)

semicircular canals - series of fluid-filled loops of the inner ear required for balance and sensing acceleration. (More? Inner Ear)

sensorineural - term used to describe one of the two major classes of hearing loss involving the central pathway from the cochlear (other form is conductive loss).

space of Nuel - within the cochlea, an organ of Corti space between the outer pillar cells and the phalangeal and hair cells. Named after Jean-Pierre Nuel (1847-1920) a Belgian ophthalmologist. (More? Inner Ear)

spiral ganglion neurons - (SGN) innervate the inner (Type I) and outer (Type II) hair cells of the cochlea. (More? Inner Ear)

stapedius muscle - (innervated by CN VII tympanic branch) one of the two muscles in the middle ear, contraction of this muscle pulls the stapes and dampens auditory ossicle movement. (More? Middle Ear)

stapes - (stirrup) a middle ear auditory ossicle (bone) (More? Middle Ear)

stapes footplate - (More? Middle Ear)

startle response -

stereocilia -finger-like projections from the apical surface of sensory hair cells forming the hair bundle in the cochlea. Formed by tightly cross-linked parallel actin filaments in a paracrystalline array with cell surface specializations (tip links, horizontal top connectors, and tectorial membrane attachment crowns).

stratified squamous epithelia - classification of epithelium which transiently forms a plug in external ear canal to the outer eardrum.

stria vascularis - forms the outer wall of the cochlear duct of the mammalian cochlea is composed primarily of three types of cells. Marginal cells line the lumen of the cochlear duct and are of epithelial origin. Basal cells also form a continuous layer and they may be mesodermal or derived from the neural crest. Intermediate cells are melanocyte-like cells, presumably derived from the neural crest, and are scattered between the marginal and basal cell layers. The stria forms endolymph and also contains a rich supply of blood vessels. (More? Inner Ear)

sulcus -

synostotically - anatomically normally separate skeletal bones fused together. (More? Middle Ear)

tectorial membrane - extracellular matrix that cover the sensory epithelial hair cells of the organ of corti within the cochlea. (More? Inner Ear)

alpha-tectorin and beta- (TECTA, TECTB) major non-collagenous protein component of the tectorial membrane forming a striated-sheet matrix. Synthesized as glycosylphosphatidylinositol-linked, membrane bound precursors.

temporal bone - (More? Middle Ear)

tensor tympani - (innervated by CN V mandibular nerve) one of the two muscles in the middle ear, contraction of this muscle pulls the malleus and tenses the tympanic membrane, dampening auditory ossicle movement. The muscle arises from auditory tube (cartilaginous portion) and is inserted into the malleus (manubrium near the root).

teratogens - trilaminar embryo -

tonotopy - term describing the mapping along the tectorial membrane within the cochlea of the different sound frequencies. (More? Inner Ear)

tympanic cavity -

tympanic membrane -Utricle -Vacuolization - Vesicle - vestibular apparatus - vestibular evoked myogenic potential (VEMP) test

vestibular ganglion - (Scarpa's ganglion) primary afferent vestibular neuron ganglion of the vestibular nerve. Located within the internal auditory meatus. (More? Inner Ear)

vestibular membrane - (Reissner's) extends from the spiral lamina to the outer wall and divides the cochlea into an upper scala vestibuli, a lower scala tympani. (More? Inner Ear)

Vestibulocochlear Nerve - Cranial Nerve VIII

Whirlin - A PDZ scaffold protein expressed in hair cells at the stereocilia tips, essential for the stereocilia elongation process. The DFNB31 gene mutations cause hearing loss in human and mouse. This protein can interact with membrane-associated guanylate kinase (MAGUK) protein, erythrocyte protein p55 (p55). (More? Inner Ear)

Wnt7a - signaling through the Wnt pathway regulates the development of hair cell unidirectional stereociliary bundle orientation. (More? Inner Ear)



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Cite this page: Hill, M.A. (2024, March 28) Embryology Sensory - Hearing and Balance Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Sensory_-_Hearing_and_Balance_Development

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G