Sensory - Balance Development
From Embryology
Introduction
Some Recent Findings
- Lmo4 in the vestibular morphogenesis of mouse inner ear[2] "Our results demonstrate that Lmo4 controls the development of the dorsolateral otocyst into semicircular canals and cristae through two distinct mechanisms: regulating the expression of otic specific genes and stimulating the proliferation of the dorsolateral part of the otocyst."
- Saccular function and motor development in children with hearing impairments[3] "The purpose of this study was to evaluate saccular function in children with hearing impairments using the Vestibular Evoked Myogenic Potential (VEMP). The impact of the saccular hypofunction on the timely maturation of normal balance strategies was examined using the Movement Assessment Battery for Children (Movement ABC). ...No VEMP was evoked in two thirds of the hearing impaired (HI) children in response to the bone-conducted stimulus. Children who were reportedly hearing impaired since birth had significantly poorer scores when tested with the Movement ABC."
Inner Ear Labyrinth
- Cochlea - Otic vesicle - Otic placode (ectoderm)
- Semicircular canals - Otic vesicle - Otic placode (ectoderm)
- Saccule and utricle - Otic vesicle - Otic placode (ectoderm)
Cranial Nerve VIII
- Auditory component - Otic vesicle and neural crest (ectoderm)
- Vestibular component - Otic vesicle and neural crest (ectoderm)
- The inner ear is derived from a pair of surface sensory placodes (otic placodes) in the head region.
- These placodes fold inwards forming a depression, then pinch off entirely from the surface forming a fluid-filled sac or vesicle (otic vesicle, otocyst).
- The vesicle sinks into the head mesenchyme some of which closely surrounds the otocyst forming the otic capsule.
- The otocyst finally lies close to the early developing hindbrain (rhombencephalon) and the developing vestibulo-cochlear-facial ganglion complex.
Links: Inner Ear
References
Reviews
Articles
- Development of the mouse cochlea database (MCD). Santi PA, Rapson I, Voie A. Hear Res. 2008 Sep;243(1-2):11-7. Epub 2008 May 25. PMID:18603386 | PMC2628570
- A mathematical model of human semicircular canal geometry: a new basis for interpreting vestibular physiology. Bradshaw AP, Curthoys IS, Todd MJ, Magnussen JS, Taubman DS, Aw ST, Halmagyi GM. J Assoc Res Otolaryngol. 2010 Jun;11(2):145-59. Epub 2009 Dec 1. PMID: 19949828
Search PubMed
May 2010 "Inner Ear Development" All (4027) Review (452) Free Full Text (750)
Search Pubmed: Balance Development | Vestibular Development |Semicircular Canal Development
External Links
- Neuroscience Neuroscience - The Inner Ear
Glossary Links
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Cite this page: Hill, M.A. (2024, April 19) Embryology Sensory - Balance Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Sensory_-_Balance_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G