Respiratory System - Postnatal: Difference between revisions

From Embryology
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[[File:Neonatal rib orientation.jpg|thumb|Rib orientation]]
[[File:Neonatal rib orientation.jpg|thumb|Rib orientation]]


===Alveolar Stage===
==Alveolar Stage==
[[File:Alveolar-sac-01.jpg|thumb|Alveolar sac structure]]
* The postnatal lung, with '''alveoli''' forming.
* The postnatal lung, with '''alveoli''' forming.
* Expansion of gas exchange alveoli, vascular beds (capillaries), lymphatics and innervation.
* Expansion of gas exchange alveoli, vascular beds (capillaries), lymphatics and innervation.
* Very premature infants will still be at the earlier Saccular stage.
===Preterm Saccular Stage===
* '''week 24 to near term.'''
* most peripheral airways form widened "airspaces", termed '''saccules'''.
* saccules widen and lengthen the airspace (by the addition of new generations).
* future gas exchange region expands significantly.
* Fibroblastic cells also undergo differentiation, they produce extracellular matrix, collagen, and elastin.
** May have a role in epithelial differentiation and control of '''surfactant secretion'''.
* Alveolar Cells Type II (Type II pneumocytes)
** begin to secrete '''surfactant''', levels of secretion gradually increase to term.
** allows alveoli to remain inflated
* Vascular tree - also grows in length and diameter during this time.


:'''Links:''' [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920089/figure/f2-ehp.0901856/ Principal stages of lung development in humans]
:'''Links:''' [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920089/figure/f2-ehp.0901856/ Principal stages of lung development in humans]


===Alveoli===
==Alveoli Number==
* At birth about 15% of adult alveoli number have formed
* At birth about 15% of adult alveoli number have formed
** 20 - 50 million to in the adult about 300 million.
** 20 - 50 million to in the adult about 300 million.
* remaining subdivisions develop in the first few postnatal years  
* remaining subdivisions develop in the first few postnatal years  
* [[Talk:SH_Lecture_-_Respiratory_System_Development#Respiratory_Alveoli|Alveoli Number]]
[[File:Postnatal alveoli number.jpg|thumb|300px|Postnatal alveoli number]]
{|
|-bgcolor="CEDFF2"
| '''Age''' (months)
| '''Alveoli''' (million)
| '''Respiratory Airways''' (million)
| '''Generations of Airways'''
|-
|Birth
| 24
| 1.5
|
|- bgcolor="F5FAFF"
| 3
| 86
| 1.8
|
|-
| 3
| 77
| 2.5
| 21
|- bgcolor="F5FAFF"
| 3
| 73
| 2.0
|
|-
| 7
| 112
| 3.7
|
|- bgcolor="F5FAFF"
| 13
| 129
| 4.5
| 22
|-
| 16
| 127
| 4.7
|
|- bgcolor="F5FAFF"
| 22
| 160
| 7.1
|
|-
| 48
| 257
| 7.9
|
|- bgcolor="F5FAFF"
| 98
| 280
| 14.0
| 23
|-
| Adult
| 296
| 14.0
| 23
|}
 
Dunnill MS. '''Postnatal growth of the lung.''' Thorax 1962;17:329–333. [http://ajrccm.atsjournals.org/cgi/ijlink?linkType=PDF&journalCode=thoraxjnl&resid=17/4/329 PDF]
 
<pubmed>139844</pubmed>| [http://www.annualreviews.org/doi/pdf/10.1146/annurev.ph.39.030177.001345 PDF]
 
<pubmed>1094872</pubmed>


==Respiratory Rate==
==Respiratory Rate==

Revision as of 12:30, 1 March 2012

Introduction

This site mainly focuses on prenatal development, but the respiratory system is one of those that continues to grow and change postnatally. This page includes some topics related to this postnatal development.

Respiratory Links: respiratory | Science Lecture | Lecture Movie | Med Lecture | Stage 13 | Stage 22 | upper respiratory tract | diaphragm | Histology | Postnatal | respiratory abnormalities | Respiratory Quiz | Respiratory terms | Category:Respiratory
Historic Embryology - Respiratory 
1902 The Nasal Cavities and Olfactory Structures | 1906 Lung | 1912 Upper Respiratory Tract | 1912 Respiratory | 1913 Prenatal and Neonatal Lung | 1914 Phrenic Nerve | 1918 Respiratory images | 1921 Respiratory | 1922 Chick Pulmonary Vessels | 1934 Right Fetal Lung | 1936 Early Human Lung | 1937 Terminal Air Passages | 1938 Human Histology

Some Recent Findings

References | Recent References


Postnatal alveoli number
Rib orientation

Alveolar Stage

Alveolar sac structure
  • The postnatal lung, with alveoli forming.
  • Expansion of gas exchange alveoli, vascular beds (capillaries), lymphatics and innervation.
  • Very premature infants will still be at the earlier Saccular stage.

Preterm Saccular Stage

  • week 24 to near term.
  • most peripheral airways form widened "airspaces", termed saccules.
  • saccules widen and lengthen the airspace (by the addition of new generations).
  • future gas exchange region expands significantly.
  • Fibroblastic cells also undergo differentiation, they produce extracellular matrix, collagen, and elastin.
    • May have a role in epithelial differentiation and control of surfactant secretion.
  • Alveolar Cells Type II (Type II pneumocytes)
    • begin to secrete surfactant, levels of secretion gradually increase to term.
    • allows alveoli to remain inflated
  • Vascular tree - also grows in length and diameter during this time.
Links: Principal stages of lung development in humans

Alveoli Number

  • At birth about 15% of adult alveoli number have formed
    • 20 - 50 million to in the adult about 300 million.
  • remaining subdivisions develop in the first few postnatal years
Postnatal alveoli number
Age (months) Alveoli (million) Respiratory Airways (million) Generations of Airways
Birth 24 1.5
3 86 1.8
3 77 2.5 21
3 73 2.0
7 112 3.7
13 129 4.5 22
16 127 4.7
22 160 7.1
48 257 7.9
98 280 14.0 23
Adult 296 14.0 23

Dunnill MS. Postnatal growth of the lung. Thorax 1962;17:329–333. PDF

<pubmed>139844</pubmed>| PDF

<pubmed>1094872</pubmed>

Respiratory Rate

  • neonatal rate is higher (30-60 breaths/minute) than adult (12-20 breaths/minute).
    • tachypnea - (Greek, rapid breathing) an increased respiratory rate of greater than 60 breaths/minute in a quiet resting baby
Age Rate (breaths/minute)
Infant (birth - 1 year) 30 - 60
Toddler (1 - 3 years) 24 - 40
Preschool (3 - 6 years) 22 - 34
School age (6 - 12 years) 18 - 30
Adolescent (12 - 18 years) 12 - 16

Rib Orientation

Infant Rib

  • lies virtually horizontal
  • allowing diaphragmatic breathing only.

Adult Rib

  • lies oblique (both anterior and lateral views)
  • allows for both pump-handle and bucket handle types of inspiration.

References


Reviews

<pubmed></pubmed> <pubmed>1</pubmed> <pubmed></pubmed>

Articles

<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed>

Search PubMed

Search Pubmed: PostnatalTract Development |

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Cite this page: Hill, M.A. (2024, March 28) Embryology Respiratory System - Postnatal. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Respiratory_System_-_Postnatal

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G