Rat Development

From Embryology
Rat.jpg

Introduction

Rats (taxon- rattus) are readily available as inbred, outbred and mutant strains. They have been generally beaten as a model by their mice brethren, as the molecular tools that became available (stem cells, knockout genes, etc).


Rat embryos do have the advantage of being much larger than mouse embryos and easy to breed. Another advantage of rats is in vision development studies, as that retinal development continues postnatally (most vertebrate neurological systems are difficult to access during periods of development). Rat development is also generally 1 day behind that of mouse. (The table below gives details relating to the staging of rat development). Below this are a list of internet resources relating to the rat.

rat | original Rat page

Some Recent Findings

  • Comparison of staging systems for the gastrulation and early neurulation period in rodents[1]"Because there is no standard developmental staging system for the early postimplantation period of rodent embryos, investigators must now choose between a variety of systems that differ significantly. We have reviewed many of these staging systems and have summarized the ambiguities within them and the inconsistencies among them. In order to compare systems, we first obtained a consensus of the order of developmental events from the literature, and then attempted to fit existing systems into this order taking into account inconsistencies in terminology and blurred borderlines between stages."

Species Stages Comparison

The table below gives an approximate comparison of human, mouse and rat embryos based upon Carnegie staging.

Species Stage
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human [2] Days 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse [3] Days 9 9.5 10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16
Rat [4] Days 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5
Links: Carnegie Stage Comparison

Adrenal and Gonad Development

Adrenal and gonad steroidogenic factor 1 expression.jpg

Adrenal and gonad steroidogenic factor 1 expression[5]

References

  1. <pubmed>1440421</pubmed>
  2. <pubmed>400868</pubmed>
  3. The House Mouse: Atlas of Mouse Development by Theiler Springer-Verlag, NY (1972, 1989). | online book
  4. Witschi, E. (1962) Development: Rat. In: Growth Including Reproduction and Morphological Development. Altman, P. L. , and D. S. Dittmer, ed. Fed. Am. Soc. Exp. Biol., Washington DC, pp. 304-314.
  5. <pubmed>14594453</pubmed>| Nucl Recept.

Search Pubmed: Rat Development

Additional Images

Historic Images


Links: Bailey, F.R. and Miller, A.M. (1921)

External Links

  • Rat Genome Database RGD <pubmed>17151068</pubmed>
Animal Development: axolotl | bat | cat | chicken | cow | dog | dolphin | echidna | fly | frog | goat | grasshopper | guinea pig | hamster | horse | kangaroo | koala | lizard | medaka | mouse | opossum | pig | platypus | rabbit | rat | salamander | sea squirt | sea urchin | sheep | worm | zebrafish | life cycles | development timetable | development models | K12
Historic Embryology  
1897 Pig | 1900 Chicken | 1901 Lungfish | 1904 Sand Lizard | 1905 Rabbit | 1906 Deer | 1907 Tarsiers | 1908 Human | 1909 Northern Lapwing | 1909 South American and African Lungfish | 1910 Salamander | 1951 Frog | Embryology History | Historic Disclaimer

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, March 28) Embryology Rat Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Rat_Development

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G