Quicktime Movie - Blastocyst Development

Embryology - 19 Apr 2024 Expand to Translate
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Human Blastocyst (day 3 to 6)

Movie shows in vitro development of a human morula stage to blastocyst stage. The movie covers the period of the first week (day 3 and day 6) post-fertilization and finishes with the blastocyst "hatching out" of the protective zone pellucida, ready to begin implantation in the second week.

00:00 day 3 - Initially a solid mass of cells morula stage (labelled H) enclosed by the zona pellucida.

00:18 day 4 - blastocoel formation, now blastocyst stage.

00:22 - inner cell mass (embryoblast)

00:29 - maximal expansion of blastocyst in ZP

00:31 - contraction

00:32 - re-expansion

00:37 day 5 - contraction

00:38 - re-expansion

00:39 - contraction (collapse)

00:40 - re-expansion (blastocoel enlargement)

00:41 - commence blastocyst hatching (1 o'clock position)

00:44 day 6 - complete hatching, blastocyst expansion (inner cell mass 2 o'clock position)

00:47 - trophoblast layer thickens

00:53 - movie finishes

Human blastocyst development (in vitro) from day 1 to day 6.

Day 1 - zygote, the first diploid cell.
Day 2 - 2 then 4 blasomeres, the first cells formed by mitotic cell division.
Day 3 - morula.
Day 4 - compacting morula.
Day 5 - blastocyst.
Day 6 - hatching blastocyst from zona pellucida shell, after this event the blastocyst can now attach and implant into the uterine wall.

Links: Zygote | Morula | Blastocyst | Zona pellucida | Implantation

Reference

<pubmed>20890283</pubmed>| Nat Biotechnol.

Copyright

Reprinted by permission from Macmillan Publishers Ltd: Nat Biotechnol. (Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Wong CC, Loewke KE, Bossert NL, Behr B, De Jonge CJ, Baer TM, Pera RA. Nat Biotechnol. 2010 Oct 3. [Epub ahead of print] PMID 20890283), copyright (2010)

Licensee: Mark A Hill License Date: Oct 06, 2010 License Number: 2523401420894 Publication: Nature Biotechnology Title: Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage Type Of Use: Web Site