Difference between revisions of "Placenta - Maternal Decidua"

From Embryology
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(Preimplantation factor)
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===Preimplantation factor===
 
===Preimplantation factor===
  
* Preimplantation factor (PIF) is a 15 amino acid peptide secreted by viable embryos.
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* Preimplantation factor (PIF) secreted only by viable embryos.
* regulates immunity, promoting embryo-decidual adhesion, and regulating adaptive apoptotic processes.<ref><pubmed>20452489</pubmed></ref>  
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* a 15 amino acid peptide MVRIKPGSANKPSDD
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* regulates immunity, promoting embryo-decidual adhesion, and regulating adaptive apoptotic processes.<ref><pubmed>20452489</pubmed></ref>
 +
 
 
===Activin A===
 
===Activin A===
  

Revision as of 16:35, 2 August 2011

Introduction

--Mark Hill 22:31, 26 May 2010 (EST) Currently Template page only.

This page gives an overview of aspects of maternal component of placental development, formed initially by the decidualization of the endometrium.

In week 2, the trophoblast shell cells proliferate and form a syncitiotrophoblast and cytotrophoblast layer around the conceptus. Syncitiotrophoblast cells migrate into the uterine wall, forming maternal blood-filled spaces (lacunae).

Decidualization is the process of converting endometrial stromal cells into decimal cells and requires at least 8–10 days of hormone stimulation.

  • initiated during the mid-secretory phase of the menstrual cycle
  • in response to elevated progesterone levels
  • acts mainly through progesterone receptor (PR) PR-A (other isoform is PR-B)


Placentation begins once the conceptus begins to implant in the uterine wall and the placenta will have both a fetal and a maternal component.


Placenta Links: placenta | Lecture - Placenta | Lecture Movie | Practical - Placenta | implantation | placental villi | trophoblast | maternal decidua | uterus | endocrine placenta | placental cord | placental membranes | placenta abnormalities | ectopic pregnancy | Stage 13 | Stage 22 | placenta histology | placenta vascular | blood vessel | cord stem cells | 2013 Meeting Presentation | Placenta Terms | Category:Placenta
Historic Embryology - Placenta 
1883 Embryonic Membranes | 1907 Development Atlas | 1909 | 1910 Textbook | 1917 Textbook | 1921 Textbook | 1921 Foetal Membranes |1921 human | 1921 Pig implantation | 1922 Single placental artery | 1923 Placenta Review | 1939 umbilical cord | 1943 human and monkey | 1944 chorionic villus and decidua parietalis | 1946 placenta ageing | 1960 monkey | 1972 Placental circulation | Historic Disclaimer

Maternal Decidua

The maternal uterine endometrium stromal cells (fibroblast-like) are transformed by steroid hormones (progesterone) and embryonic signals into the decidua.

The entire maternal decidua is divided into three regions: decidua basalis, decidua capsularis and decidua parietalis.

These 3 regions are named by their positional relationship to the conceptus.

Decidualization Factors

Preimplantation factor

  • Preimplantation factor (PIF) secreted only by viable embryos.
  • a 15 amino acid peptide MVRIKPGSANKPSDD
  • regulates immunity, promoting embryo-decidual adhesion, and regulating adaptive apoptotic processes.[1]

Activin A

Member of the a transforming growth factor beta (TGFbeta) superfamily, contributes to human endometrial stromal cells (HESC) decidualization and has been localized to decidual cells in the human endometrium. (possibly also BMP2 and TGFbeta1)[2]


Prokineticin 1

Prokineticin 1 (PROK1) signalling via prokineticin receptor 1 (PROKR1) regulates Dickkopf 1 (DKK1) expression, a negative regulator of canonical Wnt signaling.[3]

References

  1. <pubmed>20452489</pubmed>
  2. <pubmed>18434375</pubmed>
  3. <pubmed>21546446</pubmed>

Reviews

Articles

<pubmed>21144801</pubmed>

Search PubMed

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Cite this page: Hill, M.A. (2019, August 26) Embryology Placenta - Maternal Decidua. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Placenta_-_Maternal_Decidua

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G