https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&feed=atom&action=historyPaper - The development of the islands of Langerhans in the human embryo - Revision history2024-03-28T21:56:07ZRevision history for this page on the wikiMediaWiki 1.39.6https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=415856&oldid=prevZ8600021: Redirected page to Paper - The development of the islands of Langerhans in the human embryo (1903)2020-07-26T00:26:03Z<p>Redirected page to <a href="/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo_(1903)" title="Paper - The development of the islands of Langerhans in the human embryo (1903)">Paper - The development of the islands of Langerhans in the human embryo (1903)</a></p>
<a href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=415856&oldid=387706">Show changes</a>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387706&oldid=prevZ8600021: /* Embryology of the Islands */2019-08-05T00:19:36Z<p><span dir="auto"><span class="autocomment">Embryology of the Islands</span></span></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>In the next preparation (No. 3), from an embryo 54 mm. in length, the early development of the islands can be easily seen. The freshness and excellent preservation of this specimen adapted it for a most careful and accurate study of the relations and differentiation of the cells. The glands are still represented by branching processes of cells, lying in an abundant stroma, but here and there a few processes which have become tubular are seen. The cells are closely crowded together, especially at the periphery or growing portion of the process. They have rather deeply staining, round or oval vesicular nuclei, and a very small amount of slightly granular protoplasm. The protoplasm is readily demonstrable in those cells forming tubular processes ; the nuclei are seen at the periphery, while the clear protoplasm at the attachment of the cells to the basement membranes forms a ring about the lumen. Here and there, and generally at the periphery, in either the solid or tubular processes, is occasionally seen a much larger cell with deeply staining chromatin and <del style="font-weight: bold; text-decoration: none;">eithcr </del>with clear or eosinophilic protoplasm <del style="font-weight: bold; text-decoration: none;">hese </del>cells <del style="font-weight: bold; text-decoration: none;">Corlluh 1910</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>In the next preparation (No. 3), from an embryo 54 mm. in length, the early development of the islands can be easily seen. The freshness and excellent preservation of this specimen adapted it for a most careful and accurate study of the relations and differentiation of the cells. The glands are still represented by branching processes of cells, lying in an abundant stroma, but here and there a few processes which have become tubular are seen. The cells are closely crowded together, especially at the periphery or growing portion of the process. They have rather deeply staining, round or oval vesicular nuclei, and a very small amount of slightly granular protoplasm. The protoplasm is readily demonstrable in those cells forming tubular processes ; the nuclei are seen at the periphery, while the clear protoplasm at the attachment of the cells to the basement membranes forms a ring about the lumen. Here and there, and generally at the periphery, in either the solid or tubular processes, is occasionally seen a much larger cell with deeply staining chromatin and <ins style="font-weight: bold; text-decoration: none;">either </ins>with clear or eosinophilic protoplasm<ins style="font-weight: bold; text-decoration: none;">, but I have not been able to convince myself that they represent the primary differentiation leading to the formation of the islands. They always occur singly and the arrangement of the chromatin is suggestive of karyolcinesis. Entirely distinct from them are the small groups of </ins>cells <ins style="font-weight: bold; text-decoration: none;">lying at the side of a glandular process, but in direct continuity with it (Fig. 1). Each group is composed of ten to fifteen cells which have a round, lightly staining nucleus, and a comparatively large amount of finely granular protoplasm staining deeply with eosin. The cells are closely applied one to the other and form round or oval masses which can readily be distinguished from the aeinar process from which they arise. Sometimes they lie in a semilunar projection of the gland without distinct connections; but in following the group through a series of sections, the continuity with the gland can generally be demonstrated. The masses are generally distinctly separated from the surrounding connective tissue by a narrow space, which gives the effect of a capsule. This differentiation of cells represents, I believe, the earliest stage of the development of the islands, and is identical with that described by Laguesse in the sheep, and later by Renaut in the human embryo</ins>.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Pearce1903 fig01.jpg|Alt=Human embryo 54 mm pancreas|500px]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Pearce1903 fig01.jpg|Alt=Human embryo 54 mm pancreas|500px]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Fig. 1.''' Pancreas of an embryo 54 mm in length. Early stage of the differentiation of an island of pond to those described by Langerhans. A round mass composed of cells rich In protoplasm is seen continuous with the <del style="font-weight: bold; text-decoration: none;">guesse and Renaut, but I have </del>periphery of the gland.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Fig. 1.''' Pancreas of an embryo 54 mm in length. Early stage of the differentiation of an island of pond to those described by Langerhans. A round mass composed of cells rich In protoplasm is seen continuous with the periphery of the gland.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">not been able to convince myself that they represent the primary differentiation leading to the formation of the islands. They always occur singly and the arrangement of the chromatin is suggestive of karyolcinesis. Entirely distinct from them are the small groups of cells lying at the side of a glandular process, but in direct continuity with it (Fig. 1). Each group is composed of ten to fifteen cells which have a round, lightly staining nucleus, and a comparatively large amount of finely granular protoplasm staining deeply with eosin. The cells are closely applied one to the other and form round or oval masses which can readily be distinguished from the aeinar process from which they arise. Sometimes they lie in a semilunar projection of the gland without distinct connections; but in following the group through a series of sections, the continuity with the gland can generally be demonstrated. The masses are generally distinctly separated from the surrounding connective tissue by a narrow space, which gives the effect of a capsule. This differentiation of cells represents, I believe, the earliest stage of the development of the islands, and is identical with that described by Laguesse in the sheep, and later by Renaut in the human embryo.</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In another preparation (No. 4) of about the same age, although the preservation is also perfect, this differentiation is not so distinct. The study of this preparation added little to the above description.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In another preparation (No. 4) of about the same age, although the preservation is also perfect, this differentiation is not so distinct. The study of this preparation added little to the above description.</div></td></tr>
</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387162&oldid=prevZ8600021 at 01:26, 3 August 20192019-08-03T01:26:43Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>! Online Editor &nbsp;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>! Online Editor &nbsp;</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>| [[file:Mark_Hill.jpg|90px|left]] This historic 1903 paper by Pearce is a very early description of the development of the islands of Langerhans, the endocrine portion of the pancreas. The study include embryos from the [[Carnegie Collection]].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| [[file:Mark_Hill.jpg|90px|left]] This historic 1903 paper by Pearce is a very early description of the development of the islands of Langerhans, the endocrine portion of the pancreas. The study include embryos <ins style="font-weight: bold; text-decoration: none;">and fetuses </ins>from the [[Carnegie Collection]].</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><br><br></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><br><br></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[https://archive.org/details/americanjournalo02wist/page/n6 Internet Archive - 1903 THE AMERICAN JOURNAL OF ANATOMY Vol 2]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[https://archive.org/details/americanjournalo02wist/page/n6 Internet Archive - 1903 THE AMERICAN JOURNAL OF ANATOMY Vol 2]</div></td></tr>
</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387160&oldid=prevZ8600021: /* Introduction */2019-08-03T01:23:14Z<p><span dir="auto"><span class="autocomment">Introduction</span></span></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>The work falls into two categories: (1) the study of the embryonic normal pancreas, and (2) the study of the pancreas in congenital {{syphilis}}. Of the second portion of the study, only those parts which confirm or aid in explaining the normal development will be presented at this time.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>The work falls into two categories: (1) the study of the embryonic normal <ins style="font-weight: bold; text-decoration: none;">{{</ins>pancreas<ins style="font-weight: bold; text-decoration: none;">}}</ins>, and (2) the study of the pancreas in congenital {{syphilis}}. Of the second portion of the study, only those parts which confirm or aid in explaining the normal development will be presented at this time.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>For the materials for this study, I am indebted to Professor Marchand, of Leipzig, to Professor Mall, of Baltimore, and Dr. Longcope, of Philadelphia, to whom I wish to express my sincere thanks.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>For the materials for this study, I am indebted to Professor Marchand, of Leipzig, to <ins style="font-weight: bold; text-decoration: none;">[[Embryology History - Franklin Mall|</ins>Professor Mall<ins style="font-weight: bold; text-decoration: none;">]]</ins>, of Baltimore, and Dr. Longcope, of Philadelphia, to whom I wish to express my sincere thanks.</div></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387152&oldid=prevZ8600021: /* References */2019-08-03T01:16:53Z<p><span dir="auto"><span class="autocomment">References</span></span></p>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387150&oldid=prevZ8600021: /* Embryology of the Islands */2019-08-03T01:16:26Z<p><span dir="auto"><span class="autocomment">Embryology of the Islands</span></span></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>My study of the development of the islands has been carried out on the pancreases of twenty-one human embryos. Some of the material was poorly preserved and unsatisfactory for detailed study, but fortunatelythe better preserved material supplied the most important phases of the diiferentiation of the islands. The process of development which I have observed would seem to be so satisfactory that I have not deemed it necessary to wait for more material before the publication of my results. The study was carried out on serial sections, the greater part of the material having been imbedded ir paraffin, but some were imbedded in celloidin. The sections were stained either with haematoxylin and eosin or with safranin and picric acid. The following list indicates the source of the material, and the length and probable age of the embryo. The length given is that from breech to vertex. The method of computing age is that recommended by Mall (12). Series from a catalogued collection are indicated by a number in Roman characters placed after the name of the possessor.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>My study of the development of the islands has been carried out on the pancreases of twenty-one human embryos. Some of the material was poorly preserved and unsatisfactory for detailed study, but fortunatelythe better preserved material supplied the most important phases of the diiferentiation of the islands. The process of development which I have observed would seem to be so satisfactory that I have not deemed it necessary to wait for more material before the publication of my results. The study was carried out on serial sections, the greater part of the material having been imbedded ir paraffin, but some were imbedded in celloidin. The sections were stained either with haematoxylin and eosin or with safranin and picric acid. The following list indicates the source of the material, and the length and probable age of the embryo. The length given is that from breech to vertex. The method of computing age is that recommended by Mall (12). Series from a catalogued collection are indicated by a number in Roman characters placed after the name of the possessor.</div></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387148&oldid=prevZ8600021 at 01:16, 3 August 20192019-08-03T01:16:05Z<p></p>
<a href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387148&oldid=387094">Show changes</a>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387094&oldid=prevZ8600021 at 00:36, 3 August 20192019-08-03T00:36:34Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">1. Prof. Mall (No. </del>{{<del style="font-weight: bold; text-decoration: none;">CE22</del>}}<del style="font-weight: bold; text-decoration: none;">), Baltimore, length 20 mm., probable age 47 days. </del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>{{<ins style="font-weight: bold; text-decoration: none;">Pearce1903 table1</ins>}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">2. u L: (No_ XLV)’ H H 23 H 4: u 53 cc </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">3. Dr. Longcope, Philadelphia, “ 54 “ H H 73 H </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">4. H as cm as 60 u at H 73 cc </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">5. Prof. Mall (No. {{CE44}}), Baltimore, “ 70 H H H 84 H </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">6. H H (No. {{CE23}}), Baltimore, “ 70 H “ H 84 H </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">7_ u as (No_ {{CE34}} ), u H 80 H u u 89 u </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">8. H Marchand, Leipzig, “ 90 H “ H 94 “ </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">9. H Mall, Baltimore, “ 94 H H H 97 H </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">10. H Marchand, Leipzig, no measurement, supposed 3 months. </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">11. Dr. Longcope, Philadelphia, length 115 mm., probable H 115 days. </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">12. Prof. Mall, Baltimore, H 116 “ H 116 “ </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">13. Dr. Longcope, Philadelphia, H 127 H “ H 127 H </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">14. Prof. Ma1l (No. {{CE48}}), Baltimore, H 130 H “ H 130 H </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">15. Dr. Longcope, Philadelphia, H 145 H H “ 145 H </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">17_ u u st H 160 u H H 160 u </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">18. Prof. Mall, Baltimore, H 170 H H “ 170 “ </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">19. Dr. Longcope, Philadelphia, H 200 H H H 200 H </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">20. Prof. Mall, Baltimore, H 205 “ H H 205 H </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387080&oldid=prevZ8600021: /* Embryology of the Islands */2019-08-02T05:31:20Z<p><span dir="auto"><span class="autocomment">Embryology of the Islands</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:31, 2 August 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Pearce1903 fig01.jpg|Alt=Human embryo 54 mm pancreas|500px]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Pearce1903 fig01.jpg|Alt=Human embryo 54 mm pancreas|500px]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Fig. 1. Pancreas of an embryo 54 mm<del style="font-weight: bold; text-decoration: none;">. </del>in length. Early stage of the differentiation of an island of pond to those described by Langerhans. A round mass composed of cells rich In protoplasm is seen continuous with the guesse and Renaut, but I have periphery of the gland.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>Fig. 1.<ins style="font-weight: bold; text-decoration: none;">''' </ins>Pancreas of an embryo 54 mm in length. Early stage of the differentiation of an island of pond to those described by Langerhans. A round mass composed of cells rich In protoplasm is seen continuous with the guesse and Renaut, but I have periphery of the gland.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Preparation No. 10 is a perfectly preserved pancreas from a foetus believed to be of the third month; it presents many points of interest. Numerous primitive islands are scattered through the tail and body, while for the first time, a few are seen in the head. These last, however, represent the very early stages of development. Although most of the islands are in intimate connection with the acinus, an arrangement is frequently seen which indicates the manner in which the island eventually becomes separated from the acinus. As illustrated in Fig. 2, an island may be almost entirely separated from the acinus; the only evidence of continuity being a solid stalk-like process of cells. In the acinar portion of this process, a gradual transition of the cells from the type of the gland to that of the island may be traced. Most of the cells in the process are identical almost with those in the island. Followed through a series of sections, such an island has no connection with the acinus other than this __ solid process. The connecting process I is in some instances short and broad, in ‘ others long and narrow; occasionally it A may be constricted by the surrounding ‘ tissue as though about to be completely fj separated. Indeed, in this series com- pletely separated islands are seen in the splenic portion for the first time.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Preparation No. 10 is a perfectly preserved pancreas from a foetus believed to be of the third month; it presents many points of interest. Numerous primitive islands are scattered through the tail and body, while for the first time, a few are seen in the head. These last, however, represent the very early stages of development. Although most of the islands are in intimate connection with the acinus, an arrangement is frequently seen which indicates the manner in which the island eventually becomes separated from the acinus. As illustrated in Fig. 2, an island may be almost entirely separated from the acinus; the only evidence of continuity being a solid stalk-like process of cells. In the acinar portion of this process, a gradual transition of the cells from the type of the gland to that of the island may be traced. Most of the cells in the process are identical almost with those in the island. Followed through a series of sections, such an island has no connection with the acinus other than this __ solid process. The connecting process I is in some instances short and broad, in ‘ others long and narrow; occasionally it A may be constricted by the surrounding ‘ tissue as though about to be completely fj separated. Indeed, in this series com- pletely separated islands are seen in the splenic portion for the first time.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>A careful study of this stage of the development has convinced me that the ‘ separation of the island is brought about by an encroachment of the connected with the gland acinus by 9. tion of the connecting cells and their 9°11“ P1‘°°°33 0‘ 00113final disappearance between the island and acinus. The island then lies free to one side of the primitive acinus in a mass of connective tissue; a condition just the reverse of that in the adult pancreas. Later, in the fifth and sixth month, when the rapid development of the acinus occurs, the glandular elements surround and enclose the island, and it then occupies the center of the lobule. The isolated appearance of the islands at this period of separation recalls and seems to support v. Hansemann’s view that the islands develop from the cells of the connective tissue. Without the knowledge of the earlier stages of proliferation and temporary connection with the acinus which I have described, their isolated position would indeed be inexplicable. From v. Hansemann’s description, I cannot discover that he studied embryos of a period corresponding to that represented by No. 3 of my series. The advanced vascularization at this stage affords evidence of the manner in which the vessels enter the island. Unlike the glomerulus of the kidney, to which the island is somewhat analogous owing to its very rich capillary network, we have not one, but several afferent as well as efferent vessels. In those islands still connected with the acinus, a vessel does not accompany the connecting process of cells. By following an island through a series of sections, from four to seven branches, Without definite arrangement however, may be seen entering from the periphery. The vessels at the periphery anastomose freely and form a network much richer than that about a glandular structure of equal size. At this period the cells between the capillary network of the island assume a definite <del style="font-weight: bold; text-decoration: none;">ar~ rangement </del>in columns or rows.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>A careful study of this stage of the development has convinced me that the ‘ separation of the island is brought about by an encroachment of the connected with the gland acinus by 9. tion of the connecting cells and their 9°11“ P1‘°°°33 0‘ 00113final disappearance between the island and acinus. The island then lies free to one side of the primitive acinus in a mass of connective tissue; a condition just the reverse of that in the adult pancreas. Later, in the fifth and sixth month, when the rapid development of the acinus occurs, the glandular elements surround and enclose the island, and it then occupies the center of the lobule. The isolated appearance of the islands at this period of separation recalls and seems to support v. Hansemann’s view that the islands develop from the cells of the connective tissue. Without the knowledge of the earlier stages of proliferation and temporary connection with the acinus which I have described, their isolated position would indeed be inexplicable. From v. Hansemann’s description, I cannot discover that he studied embryos of a period corresponding to that represented by No. 3 of my series. The advanced vascularization at this stage affords evidence of the manner in which the vessels enter the island. Unlike the glomerulus of the kidney, to which the island is somewhat analogous owing to its very rich capillary network, we have not one, but several afferent as well as efferent vessels. In those islands still connected with the acinus, a vessel does not accompany the connecting process of cells. By following an island through a series of sections, from four to seven branches, Without definite arrangement however, may be seen entering from the periphery. The vessels at the periphery anastomose freely and form a network much richer than that about a glandular structure of equal size. At this period the cells between the capillary network of the island assume a definite <ins style="font-weight: bold; text-decoration: none;">arrangement </ins>in columns or rows.</div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Pearce1903 fig02.jpg|Alt=Human embryo 54 mm pancreas|500px]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Fig. 2<del style="font-weight: bold; text-decoration: none;">- 1 </del>an embryo of about the third month. A fairly well connective tissue, causing an attenua- <del style="font-weight: bold; text-decoration: none;">d°"°1°P°‘3 “land °fL“"8°1"h*m3i3 896"</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>Fig. 2<ins style="font-weight: bold; text-decoration: none;">.''' Pancreas of </ins>an embryo of about the third month. A fairly well <ins style="font-weight: bold; text-decoration: none;">developed island of Langerhans is seen connected with the acinus buy a solid process of cells.</ins></div></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_The_development_of_the_islands_of_Langerhans_in_the_human_embryo&diff=387062&oldid=prevZ8600021 at 05:22, 2 August 20192019-08-02T05:22:53Z<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:22, 2 August 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>In the next preparation (No. 3), from an embryo 54 mm. in length, the early development of the islands can be easily seen. The freshness and excellent preservation of this specimen adapted it for a most careful and accurate study of the relations and differentiation of the cells. The glands are still represented by branching processes of cells, lying in an abundant stroma, but here and there a few processes which have become tubular are seen. The cells are closely crowded together, especially at the periphery or growing portion of the process. They have rather deeply staining, round or oval vesicular nuclei, and a very small amount of slightly granular protoplasm. The protoplasm is readily demonstrable in those cells forming tubular processes ; the nuclei are seen at the periphery, while the clear protoplasm at the attachment of the cells to the basement membranes forms a ring about the lumen. Here and there, and generally at the periphery, in either the solid or tubular processes, is occasionally seen a much larger cell with deeply staining chromatin and eithcr with clear or eosinophilic protoplasm hese cells Corlluh 1910<del style="font-weight: bold; text-decoration: none;">.1. Pancreasof an embryo 54 mm. in length</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>In the next preparation (No. 3), from an embryo 54 mm. in length, the early development of the islands can be easily seen. The freshness and excellent preservation of this specimen adapted it for a most careful and accurate study of the relations and differentiation of the cells. The glands are still represented by branching processes of cells, lying in an abundant stroma, but here and there a few processes which have become tubular are seen. The cells are closely crowded together, especially at the periphery or growing portion of the process. They have rather deeply staining, round or oval vesicular nuclei, and a very small amount of slightly granular protoplasm. The protoplasm is readily demonstrable in those cells forming tubular processes ; the nuclei are seen at the periphery, while the clear protoplasm at the attachment of the cells to the basement membranes forms a ring about the lumen. Here and there, and generally at the periphery, in either the solid or tubular processes, is occasionally seen a much larger cell with deeply staining chromatin and eithcr with clear or eosinophilic protoplasm hese cells Corlluh 1910.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Pearce1903 fig01.jpg|Alt=Human embryo 54 mm pancreas|500px]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">E </del>1 stage of the differentiation of an island of pond to those <del style="font-weight: bold; text-decoration: none;">descnbed b-‘ Ld L;:EyE'l‘l.l8.l18</del>. A round mass composed of cells rich In protoplasm is seen continuous with the guesse and Renaut, but I have periphery of the gland.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Fig. </ins>1<ins style="font-weight: bold; text-decoration: none;">. Pancreas of an embryo 54 mm. in length. Early </ins>stage of the differentiation of an island of pond to those <ins style="font-weight: bold; text-decoration: none;">described by Langerhans</ins>. A round mass composed of cells rich In protoplasm is seen continuous with the guesse and Renaut, but I have periphery of the gland.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
</table>Z8600021