https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&feed=atom&action=historyPaper - Some Observations on the Development of the Ventral Pancreas in Man - Revision history2024-03-19T04:47:21ZRevision history for this page on the wikiMediaWiki 1.39.6https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=377512&oldid=prevZ8600021 at 01:41, 29 April 20192019-04-29T01:41:30Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>5mm.embryo. Here the ventral pancreas is seen filing up the angle that the hepatic outgrowth makes with the bowel and partially encircling the latter. It is horseshoe-shaped with a left limb smaller than the more projecting right limb, but commencing somewhat cranial to the latter. The whole bibbed outgrowth already appears as if it were being drawn out dorsalwards and to <del style="font-weight: bold; text-decoration: none;">theright</del>(fig.1). If sections (lOu) of this are examined, one finds that the ventral pancreas extends through seven sections in al. The left "lobe" appears first, two sections cranial to the right one, as a projection from the most caudal part of the opening of the bile duct into the gut (Plate I, fig. 4). If one looks at a section midway through this pancreas, one sees a definitely bilobed mass and in this, I suggest, are two lumina, of which the leftisthe larger and the more obvious (fig. 5). In the next section below this one (fig. 6) these two lumina are apparently fusing into one-a fine septum is seen dividing the common lumen-and the rest of the pancreas caudal to this is solid. Traced cranialwards, in the next section cranial to fig. 5 the right lumen has disappeared, but I can trace the left lumen through this one and the section next above it to open, I think, into the bile duct (fig. 4).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>5mm.embryo. Here the ventral pancreas is seen filing up the angle that the hepatic outgrowth makes with the bowel and partially encircling the latter. It is horseshoe-shaped with a left limb smaller than the more projecting right limb, but commencing somewhat cranial to the latter. The whole bibbed outgrowth already appears as if it were being drawn out dorsalwards and to <ins style="font-weight: bold; text-decoration: none;">the right </ins>(fig.1). If sections (lOu) of this are examined, one finds that the ventral pancreas extends through seven sections in al. The left "lobe" appears first, two sections cranial to the right one, as a projection from the most caudal part of the opening of the bile duct into the gut (Plate I, fig. 4). If one looks at a section midway through this pancreas, one sees a definitely bilobed mass and in this, I suggest, are two lumina, of which the leftisthe larger and the more obvious (fig. 5). In the next section below this one (fig. 6) these two lumina are apparently fusing into one-a fine septum is seen dividing the common lumen-and the rest of the pancreas caudal to this is solid. Traced cranialwards, in the next section cranial to fig. 5 the right lumen has disappeared, but I can trace the left lumen through this one and the section next above it to open, I think, into the bile duct (fig. 4).</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Odgers1930 fig01.jpg|600px]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Odgers1930 fig01.jpg|600px]]</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>These few observations of mine <del style="font-weight: bold; text-decoration: none;">fal</del>, I think, into line pretty well with those of previous observers. In the youngest, 5 mm<del style="font-weight: bold; text-decoration: none;">. </del>embryo, the ventral pancreas appears bibbed with two lumina: in the older, 7<del style="font-weight: bold; text-decoration: none;">-</del>1 mm<del style="font-weight: bold; text-decoration: none;">. </del>stage, there is but a single outgrowth, which appears to correspond to the right horn of the earlier one. This agrees entirely with Thyng's description of a slightly older 7<del style="font-weight: bold; text-decoration: none;">-</del>5 mm<del style="font-weight: bold; text-decoration: none;">. </del>embryo and with Lewis, who found a similar single outgrowth in the seven embryos of the Harvard Collection between 7.5 and 11 mm<del style="font-weight: bold; text-decoration: none;">. </del>in length. It is, however, hardly fair to assume from these later embryos, that the outgrowth was originally unpaired, and it is rather in the interpretation of the earlier stages that differences of opinion arise. As Siwe says, "In mehreren anderen FMillen kann man cine Andeutung zu Paarigkeit sehen- wenn man so will (oder auch nicht, wenn man nichtwill)." Iwould suggest that there are originally two separate outgrowths, right and left, which fuse very early. Of these the right is the more extensive. M. Tribe, in describing the development of the pancreas in marsupials, shows that the right ventral outgrowth contributes four times as much as does the left to the adult gland and remarks "in man the two ventral outgrowths are of such unequal size that one of them has frequently been overlooked altogether." This more extensive right lobed rag sits fellow to the right and dorsally.This appearance has been noted already as beginning in the 5 mm. stage and its persistence leads to the appearance of a single outgrowth, which, by the growth of the bile duct, is entirely divorced from the bowel wall. The lumina I describe in the 5 mm. stage are exactly similar to those figured by Jankelowitz in his 4.9 mm. embryo. While I realise that too much stress should not be laid upon them or upon their apparent fusion, Siwe, I think, rightly says "that one can hardly dismiss the question as Helly does, when he believes that two lumina can occur in any homogeneous anlage. Helly has not shown that the anlage was ever originally solid and further these lumina appear so early that one rather has reason to assume that no compact stage preceded them. The other possibility that a lumen, branched to right and left, could be the primary formation is at least as much justified." The duplication of the ventral duct, which I found in my 11.4 mm. embryo, is most readily explained by a delayed fusion of two separate outgrowths. I would suggest that the more slender and more cranial of the ducts represents the original left ventral proliferation, while the larger and more caudal of the two is formed by the larger right outgrowth.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>These few observations of mine <ins style="font-weight: bold; text-decoration: none;">fall</ins>, I think, into line pretty well with those of previous observers. In the youngest, 5 mm embryo, the ventral pancreas appears bibbed with two lumina: in the older, 7<ins style="font-weight: bold; text-decoration: none;">.</ins>1 mm stage, there is but a single outgrowth, which appears to correspond to the right horn of the earlier one. This agrees entirely with Thyng's description of a slightly older 7<ins style="font-weight: bold; text-decoration: none;">.</ins>5 mm embryo and with Lewis, who found a similar single outgrowth in the seven embryos of the Harvard Collection between 7.5 and 11 mm in length. It is, however, hardly fair to assume from these later embryos, that the outgrowth was originally unpaired, and it is rather in the interpretation of the earlier stages that differences of opinion arise. As Siwe says, "In mehreren anderen FMillen kann man cine Andeutung zu Paarigkeit sehen- wenn man so will (oder auch nicht, wenn man nichtwill)." Iwould suggest that there are originally two separate outgrowths, right and left, which fuse very early. Of these the right is the more extensive. M. Tribe, in describing the development of the pancreas in marsupials, shows that the right ventral outgrowth contributes four times as much as does the left to the adult gland and remarks "in man the two ventral outgrowths are of such unequal size that one of them has frequently been overlooked altogether." This more extensive right lobed rag sits fellow to the right and dorsally. This appearance has been noted already as beginning in the 5 mm. stage and its persistence leads to the appearance of a single outgrowth, which, by the growth of the bile duct, is entirely divorced from the bowel wall. The lumina I describe in the 5 mm. stage are exactly similar to those figured by Jankelowitz in his 4.9 mm. embryo. While I realise that too much stress should not be laid upon them or upon their apparent fusion, Siwe, I think, rightly says "that one can hardly dismiss the question as Helly does, when he believes that two lumina can occur in any homogeneous anlage. Helly has not shown that the anlage was ever originally solid and further these lumina appear so early that one rather has reason to assume that no compact stage preceded them. The other possibility that a lumen, branched to right and left, could be the primary formation is at least as much justified." The duplication of the ventral duct, which I found in my 11.4 mm. embryo, is most readily explained by a delayed fusion of two separate outgrowths. I would suggest that the more slender and more cranial of the ducts represents the original left ventral proliferation, while the larger and more caudal of the two is formed by the larger right outgrowth.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Odgers1930 fig03.jpg|600px]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Odgers1930 fig03.jpg|600px]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Fig. 3.''' Drawing of a model of the duodenum and ventral pancreas, viewed from the right side, in an 11.4 mm<del style="font-weight: bold; text-decoration: none;">. </del>embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; W and W1 mark the two ventral pancreatic ducts.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Fig. 3.''' Drawing of a model of the duodenum and ventral pancreas, viewed from the right side, in an 11.4 mm embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; W and W1 mark the two ventral pancreatic ducts.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Again, fusion of the two ventral elements seems a more probable ex- planation of the appearances noted than to assume that the left outgrowth atrophies. Debeyre in 1909 found the two ventral anlages in a 4<del style="font-weight: bold; text-decoration: none;">*</del>5mm<del style="font-weight: bold; text-decoration: none;">. </del>embryo, but, as he could of course only find a single outgrowth in the 12 mm<del style="font-weight: bold; text-decoration: none;">. </del>stage,assumed that the left proliferation early disappears. I have already pointed out that in Helly's <del style="font-weight: bold; text-decoration: none;">11mm. </del>embryo the apparent degeneration of one of the ventral masses, abnormally unfused at this age and entirely separated from each other by the bile duct, cannot be admitted as good evidence of the normal atrophy of one outgrowth.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Again, fusion of the two ventral elements seems a more probable ex- planation of the appearances noted than to assume that the left outgrowth atrophies. Debeyre in 1909 found the two ventral anlages in a 4<ins style="font-weight: bold; text-decoration: none;">.</ins>5mm embryo, but, as he could of course only find a single outgrowth in the 12 mm stage, assumed that the left proliferation early disappears. I have already pointed out that in Helly's <ins style="font-weight: bold; text-decoration: none;">11 mm </ins>embryo the apparent degeneration of one of the ventral masses, abnormally unfused at this age and entirely separated from each other by the bile duct, cannot be admitted as good evidence of the normal atrophy of one outgrowth.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Further, a paired origin for the ventral pancreas in Man should be expected from the way in which this is developed in other animals. <del style="font-weight: bold; text-decoration: none;">Inalvertebrates </del>except Cyclostomes, it arises from the fusion of bilateral anlages (Siwe). Again, certain anomalous conditions in the adult are most easily explained in this way. Duplication of Wirsung's duct, which has been observed <del style="font-weight: bold; text-decoration: none;">oc- casionally</del>, would be the result of delayed fusion of the two separate outgrowths (Hasse), while the occurrence of an annular pancreas can be best ascribed to abnormally directed growth of the left ventral lobe,"when the left lobe tends to encircle the intestine instead of extending into the ventral mesentery " (Lewis).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Further, a paired origin for the ventral pancreas in Man should be expected from the way in which this is developed in other animals. <ins style="font-weight: bold; text-decoration: none;">In all vertebrates </ins>except Cyclostomes, it arises from the fusion of bilateral anlages (Siwe). Again, certain anomalous conditions in the adult are most easily explained in this way. Duplication of Wirsung's duct, which has been observed <ins style="font-weight: bold; text-decoration: none;">occasionally</ins>, would be the result of delayed fusion of the two separate outgrowths (Hasse), while the occurrence of an annular pancreas can be best ascribed to abnormally directed growth of the left ventral lobe,"when the left lobe tends to encircle the intestine instead of extending into the ventral mesentery " (Lewis).</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Two other points arise out of an examination of the older 14 mm<del style="font-weight: bold; text-decoration: none;">. </del>and 23 mm<del style="font-weight: bold; text-decoration: none;">. </del>embryos. The time of fusion between the dorsal and the ventral pancreas must be variable. Keibel and Elze in the Normentafeln described them as uniting between the 12 and the 14 mm<del style="font-weight: bold; text-decoration: none;">. </del>stage. Inmy 14mm. embryo, while there is considerable interlocking, it is quite easy to pick out the two portions infact,they are more distinct than in the earlier,11-4mm.,one. Siwe mentions that fusion had not commenced in one embryo of 17 mm. Certainlyinmy 23 mm. specimen it was guesswork attempting to separate dorsal from ventral pancreas, which had completely joined together.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Two other points arise out of an examination of the older 14 mm and 23 mm embryos. The time of fusion between the dorsal and the ventral pancreas must be variable. Keibel and Elze in the Normentafeln described them as uniting between the 12 and the 14 mm stage. Inmy 14mm. embryo, while there is considerable interlocking, it is quite easy to pick out the two portions infact,they are more distinct than in the earlier,11-4mm.,one. Siwe mentions that fusion had not commenced in one embryo of 17 mm. Certainlyinmy 23 mm. specimen it was guesswork attempting to separate dorsal from ventral pancreas, which had completely joined together.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Lastly, an examination ofthe reconstructions from the 11<del style="font-weight: bold; text-decoration: none;">-</del>4 and the 14 mm<del style="font-weight: bold; text-decoration: none;">. </del>embryos suggests that the ventral pancreas must form much less of the fully developed gland than is often stated. I think it cannot be responsible really for more than the middle lateral part of its head, immediately about the terminal portion of Wirsung's duct.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Lastly, an examination ofthe reconstructions from the 11<ins style="font-weight: bold; text-decoration: none;">.</ins>4 and the 14 mm embryos suggests that the ventral pancreas must form much less of the fully developed gland than is often stated. I think it cannot be responsible really for more than the middle lateral part of its head, immediately about the terminal portion of Wirsung's duct.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Summary and Conclusions==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Summary and Conclusions==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Reconstruction models <del style="font-weight: bold; text-decoration: none;">ofthe </del>pancreas were made from human embryos 5, 7<del style="font-weight: bold; text-decoration: none;">-</del>1, 11<del style="font-weight: bold; text-decoration: none;">-</del>4, 14 and 23 mm<del style="font-weight: bold; text-decoration: none;">. </del>in length. In the 5mm<del style="font-weight: bold; text-decoration: none;">. </del>embryo the ventral pancreas appears as a bibbed mass, in which two apparent lumina can be distinguished: this is replaced in the 7<del style="font-weight: bold; text-decoration: none;">-</del>1mm<del style="font-weight: bold; text-decoration: none;">. </del>stage by a single outgrowth.These observations rather tend to support the view that the ventral pancreas in man is developed by two separate proliferations from the hepatic diverticulum, both of which, fusing early, may share in the formation of the adult gland. This view finds confirmation in the11-4mm.embryo examined. Here there is a duplication of the ventral duct, apparently due to delayed fusion of the two ventral anlages.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Reconstruction models <ins style="font-weight: bold; text-decoration: none;">of the </ins>pancreas were made from human embryos 5, 7<ins style="font-weight: bold; text-decoration: none;">.</ins>1, 11<ins style="font-weight: bold; text-decoration: none;">.</ins>4, 14 and 23 mm in length. In the 5mm embryo the ventral pancreas appears as a bibbed mass, in which two apparent lumina can be distinguished: this is replaced in the 7<ins style="font-weight: bold; text-decoration: none;">.</ins>1mm stage by a single outgrowth.These observations rather tend to support the view that the ventral pancreas in man is developed by two separate proliferations from the hepatic diverticulum, both of which, fusing early, may share in the formation of the adult gland. This view finds confirmation in the11-4mm.embryo examined. Here there is a duplication of the ventral duct, apparently due to delayed fusion of the two ventral anlages.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Arthur Thomson 1911.jpg|thumb|150px|Prof. Arthur Thomson]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>I should like to express my thanks to Prof. Arthur Thomson for much helpful advice and to Mr W. Chesterman for a great deal of assistance in preparing the reconstructions and for producing these microphotographs.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>I should like to express my thanks to Prof. Arthur Thomson for much helpful advice and to Mr W. Chesterman for a great deal of assistance in preparing the reconstructions and for producing these microphotographs.</div></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=369676&oldid=prevZ8600021 at 04:41, 31 January 20192019-01-31T04:41:31Z<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:41, 31 January 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>See the reference and links below for the current notes pages.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>See the reference and links below for the current notes pages.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><br></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><br></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>:'''<del style="font-weight: bold; text-decoration: none;">Pancreas Links</del>:''' [[Endocrine - Pancreas Development]] | [[Gastrointestinal Tract - Pancreas Development]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>:'''<ins style="font-weight: bold; text-decoration: none;">ModernNotes</ins>:''' [[Endocrine - Pancreas Development]] | [[Gastrointestinal Tract - Pancreas Development]]</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Endocrine Links}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Endocrine Links}}</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">SINCE </del>1888, when Phisalix first demonstrated that the human pancreas arises by a ventral outgrowth in addition to the dorsal diverticulum already described by His, two details with regard to its origin have been matters of doubt and disagreement and still remain so. These may be briefly put in the form of two questions:</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Since </ins>1888, when Phisalix first demonstrated that the human pancreas arises by a ventral outgrowth in addition to the dorsal diverticulum already described by His, two details with regard to its origin have been matters of doubt and disagreement and still remain so. These may be briefly put in the form of two questions:</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># Is the ventral pancreatic outgrowth in man single or paired?</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># Is the ventral pancreatic outgrowth in man single or paired?</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># If it is the latter, do both portions of it share in the formation of the adult gland?</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># If it is the latter, do both portions of it share in the formation of the adult gland?</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>The accounts given in different standard text-books suggest varying answers to these questions. Keith and Arey in their text-books and Lewis, who wrote the account ofthe development ofthe pancreas in Keibel and Mall, describe a single ventral formation, while in Buchanan's and Cunningham's manuals, "the ventral diverticulum is at first double, right and left out- growths arising from the liver bud; the left formation quickly disappears." A similar view is taken by McMurrich, who writes" of the ventral outgrowths, that upon the left side may be wanting, or, if formed, early disappears. Broman describes a single ventral anlage, "which is derived from paired thickenings of the wall of the foregut."</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>The accounts given in different standard text-books suggest varying answers to these questions. Keith and Arey in their text-books and Lewis, who wrote the account ofthe development ofthe pancreas in Keibel and Mall, describe a single ventral formation, while in Buchanan's and Cunningham's manuals, "the ventral diverticulum is at first double, right and left out- growths arising from the liver bud; the left formation quickly disappears." A similar view is taken by McMurrich, who writes" of the ventral outgrowths, that upon the left side may be wanting, or, if formed, early disappears. Broman describes a single ventral anlage, "which is derived from paired thickenings of the wall of the foregut."</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Ilelly </del>and Kollman both published cases of paired ventral pancreases which have not fused. It is worthwhile quoting IHelly's description in some detail because, as far as I know, it is on this evidence, and this alone, that the statement so commonly made, that the left outgrowth atrophies, is founded. He studied an embryo, 11 mm. in length, which he said corresponded in the development of its organs to the 7-5mm. embryo of His. The ventral pancreas arose in this case from the bile duct 20p above its opening into the duodenum in the form of right and left anlages, of which the right was the more considerable. He could not see any actual coalescence between the two, which were always separated by the choledochus: this independence was distinctly shown in his reconstruction. Microscopically he found a great difference between the two. While the right one appeared to be actively growing,with a distinct lumen and recognisable alveoli, the left one gave him the impression of degeneration with smaller and less distinct cells: in this part no lumen could be distinguished. He concluded that the significance of this observation was that it filed the gap between the view that there were two ventral outgrowths in man and the idea that there was only one. It is to be expected, he says, that in embryos older than four weeks the left anlage has already disappeared.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Helly </ins>and Kollman both published cases of paired ventral pancreases which have not fused. It is worthwhile quoting IHelly's description in some detail because, as far as I know, it is on this evidence, and this alone, that the statement so commonly made, that the left outgrowth atrophies, is founded. He studied an embryo, 11 mm. in length, which he said corresponded in the development of its organs to the 7-5mm. embryo of His. The ventral pancreas arose in this case from the bile duct 20p above its opening into the duodenum in the form of right and left anlages, of which the right was the more considerable. He could not see any actual coalescence between the two, which were always separated by the choledochus: this independence was distinctly shown in his reconstruction. Microscopically he found a great difference between the two. While the right one appeared to be actively growing,with a distinct lumen and recognisable alveoli, the left one gave him the impression of degeneration with smaller and less distinct cells: in this part no lumen could be distinguished. He concluded that the significance of this observation was that it filed the gap between the view that there were two ventral outgrowths in man and the idea that there was only one. It is to be expected, he says, that in embryos older than four weeks the left anlage has already disappeared.</div></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=276128&oldid=prevZ8600021 at 06:41, 27 February 20172017-02-27T06:41:10Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Ref-Odgers1930}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Ref-Odgers1930}}</div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|-</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| [[File:Mark_Hill.jpg|90px|left]] This historic 1930 paper by Odgers describes embryonic development of the ventral pancreas. This is the smaller of the 2 developmental lobes and is rotated dorsally to fuse with the larger lope.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[<del style="font-weight: bold; text-decoration: none;">Historic </del>Embryology <del style="font-weight: bold; text-decoration: none;">Papers</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[<ins style="font-weight: bold; text-decoration: none;">Book - Manual of Human </ins>Embryology <ins style="font-weight: bold; text-decoration: none;">17-8|1912 Pancreas Development</ins>]] <ins style="font-weight: bold; text-decoration: none;">| [[Paper - Some Observations on the Development of the Ventral Pancreas in Man|1930 Ventral Pancreas]]</ins></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><br></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">See the reference and links below for the current notes pages.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><br></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">:'''Pancreas Links:''' [[Endocrine - Pancreas Development]] | [[Gastrointestinal Tract - Pancreas Development]]</ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Historic Disclaimer}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Historic Disclaimer}}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Some Observations on the Development of the Ventral Pancreas in Man==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Some Observations on the Development of the Ventral Pancreas in Man==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">:'''Pancreas Links:''' [[Endocrine - Pancreas Development]] | [[Gastrointestinal Tract - Pancreas Development]] | [[Book - Manual of Human Embryology 17-8|1912 Pancreas Development]] | [[Paper - Some Observations on the Development of the Ventral Pancreas in Man|1930 Ventral Pancreas]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=225304&oldid=prevZ8600021 at 08:23, 22 April 20162016-04-22T08:23:28Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Some Observations on the Development of the Ventral Pancreas in Man==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Some Observations on the Development of the Ventral Pancreas in Man==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:'''Pancreas Links:''' [[Endocrine - Pancreas Development]] | [[Gastrointestinal Tract - Pancreas Development]] | [[Book - Manual of Human Embryology 17-8|1912 Pancreas Development]] | [[Paper - Some Observations on the Development of the Ventral Pancreas in Man|1930 Ventral Pancreas]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:'''Pancreas Links:''' [[Endocrine - Pancreas Development]] | [[Gastrointestinal Tract - Pancreas Development]] | [[Book - Manual of Human Embryology 17-8|1912 Pancreas Development]] | [[Paper - Some Observations on the Development of the Ventral Pancreas in Man|1930 Ventral Pancreas]]</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Ref-Odgers1930}}</ins></div></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=185001&oldid=prevZ8600021 at 03:14, 5 July 20152015-07-05T03:14:07Z<p></p>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=184275&oldid=prevZ8600021 at 13:09, 29 June 20152015-06-29T13:09:29Z<p></p>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=184133&oldid=prevZ8600021: /* Description of Plate I */2015-06-29T04:27:18Z<p><span dir="auto"><span class="autocomment">Description of Plate I</span></span></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ZIMMERMANN, K. W. (1898). Arch. f. Micr. Anat. Bd. LII.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ZIMMERMANN, K. W. (1898). Arch. f. Micr. Anat. Bd. LII.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>==Description of Plate <del style="font-weight: bold; text-decoration: none;">I</del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>==Description of Plate <ins style="font-weight: bold; text-decoration: none;">1</ins>==</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Odgers1930 plate01.jpg|600px]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Fig.4. Section through the caudal end of the hepatic outgrowth. G. gut; B.D. bile-duct; V.P.L. left ventral pancreas, showing at a an apparent lumen opening into the junction of the bile-duct with the duodenum. (x200.)</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>Fig.4.<ins style="font-weight: bold; text-decoration: none;">''' </ins>Section through the caudal end of the hepatic outgrowth. G. gut; B.D. bile-duct; V.P.L. left ventral pancreas, showing at a an apparent lumen opening into the junction of the bile-duct with the duodenum. (x200.)</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Fig.5. Section midway through the ventral pancreas. G. gut; V.P.L. and V.P.D. mark the bilobed ventral pancreas, in which at a and bare two separate lumina. (x200.)</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>Fig.5.<ins style="font-weight: bold; text-decoration: none;">''' </ins>Section midway through the ventral pancreas. G. gut; V.P.L. and V.P.D. mark the bilobed ventral pancreas, in which at a and bare two separate lumina. (x200.)</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Fig. 6. Section immediately caudal to fig. 5. a. gut; V.P.L. and V.P.D. mark the ventral pancreas, in which atc there is a single lumen divided by a fine septum. (x200.)</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>Fig. 6.<ins style="font-weight: bold; text-decoration: none;">''' </ins>Section immediately caudal to fig. 5. a. gut; V.P.L. and V.P.D. mark the ventral pancreas, in which atc there is a single lumen divided by a fine septum. (x200.)</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=184127&oldid=prevZ8600021 at 04:22, 29 June 20152015-06-29T04:22:23Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>These few observations of mine fal, I think, into line pretty well with those of previous observers. In the youngest, 5 mm. embryo, the ventral pancreas appears bibbed with two lumina: in the older, 7-1 mm. stage, there is but a single outgrowth, which appears to correspond to the right horn of the earlier one. This agrees entirely with Thyng's description of a slightly older 7-5 mm. embryo and with Lewis, who found a similar single outgrowth in the seven embryos of the Harvard Collection between 7.5 and 11 mm. in length. It is, however, hardly fair to assume from these later embryos, that the outgrowth was originally unpaired, and it is rather in the interpretation of the earlier stages that differences of opinion arise. As Siwe says, "In mehreren anderen FMillen kann man cine Andeutung zu Paarigkeit sehen- wenn man so will (oder auch nicht, wenn man nichtwill)." Iwould suggest that there are originally two separate outgrowths, right and left, which fuse very early. Of these the right is the more extensive. M. Tribe, in describing the development of the pancreas in marsupials, shows that the right ventral outgrowth contributes four times as much as does the left to the adult gland and remarks "in man the two ventral outgrowths are of such unequal size that one of them has frequently been overlooked altogether." This more extensive right lobed rag sits fellow to the right and dorsally.This appearance has been noted already as beginning in the 5 mm. stage and its persistence leads to the appearance of a single outgrowth, which, by the growth of the bile duct, is entirely divorced from the bowel wall. The lumina I describe in the 5 mm. stage are exactly similar to those figured by Jankelowitz in his 4.9 mm. embryo. While I realise that too much stress should not be laid upon them or upon their apparent fusion, Siwe, I think, rightly says "that one can hardly dismiss the question as Helly does, when he believes that two lumina can occur in any homogeneous anlage. Helly has not shown that the anlage was ever originally solid and further these lumina appear so early that one rather has reason to assume that no compact stage preceded them. The other possibility that a lumen, branched to right and left, could be the primary formation is at least as much justified." The duplication of the ventral duct, which I found in my 11.4 mm. embryo, is most readily explained by a delayed fusion of two separate outgrowths. I would suggest that the more slender and more cranial of the ducts represents the original left ventral proliferation, while the larger and more caudal of the two is formed by the larger right outgrowth.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>These few observations of mine fal, I think, into line pretty well with those of previous observers. In the youngest, 5 mm. embryo, the ventral pancreas appears bibbed with two lumina: in the older, 7-1 mm. stage, there is but a single outgrowth, which appears to correspond to the right horn of the earlier one. This agrees entirely with Thyng's description of a slightly older 7-5 mm. embryo and with Lewis, who found a similar single outgrowth in the seven embryos of the Harvard Collection between 7.5 and 11 mm. in length. It is, however, hardly fair to assume from these later embryos, that the outgrowth was originally unpaired, and it is rather in the interpretation of the earlier stages that differences of opinion arise. As Siwe says, "In mehreren anderen FMillen kann man cine Andeutung zu Paarigkeit sehen- wenn man so will (oder auch nicht, wenn man nichtwill)." Iwould suggest that there are originally two separate outgrowths, right and left, which fuse very early. Of these the right is the more extensive. M. Tribe, in describing the development of the pancreas in marsupials, shows that the right ventral outgrowth contributes four times as much as does the left to the adult gland and remarks "in man the two ventral outgrowths are of such unequal size that one of them has frequently been overlooked altogether." This more extensive right lobed rag sits fellow to the right and dorsally.This appearance has been noted already as beginning in the 5 mm. stage and its persistence leads to the appearance of a single outgrowth, which, by the growth of the bile duct, is entirely divorced from the bowel wall. The lumina I describe in the 5 mm. stage are exactly similar to those figured by Jankelowitz in his 4.9 mm. embryo. While I realise that too much stress should not be laid upon them or upon their apparent fusion, Siwe, I think, rightly says "that one can hardly dismiss the question as Helly does, when he believes that two lumina can occur in any homogeneous anlage. Helly has not shown that the anlage was ever originally solid and further these lumina appear so early that one rather has reason to assume that no compact stage preceded them. The other possibility that a lumen, branched to right and left, could be the primary formation is at least as much justified." The duplication of the ventral duct, which I found in my 11.4 mm. embryo, is most readily explained by a delayed fusion of two separate outgrowths. I would suggest that the more slender and more cranial of the ducts represents the original left ventral proliferation, while the larger and more caudal of the two is formed by the larger right outgrowth.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Fig. 3.''' Drawing of a model of the duodenum and ventral pancreas, viewed from the right side, in an 11<ins style="font-weight: bold; text-decoration: none;">.4 mm</ins>. embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; W and W1 mark the two ventral pancreatic ducts.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Fig. 3.''' Drawing of a model of the duodenum and ventral pancreas, viewed from the right side, in an 11<del style="font-weight: bold; text-decoration: none;">'4mm</del>. embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; W and W1 mark the two ventral pancreatic ducts.</div></td><td colspan="2" class="diff-side-added"></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=184117&oldid=prevZ8600021 at 04:16, 29 June 20152015-06-29T04:16:50Z<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:16, 29 June 2015</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>11.4 mm.embryo. Fig.3 shows a drawing of the ventral pancreas from a photograph of a reconstruction at this stage. In it one can see two ventral pancreatic ducts, one cranial to, and much smaller than the other: these run parallel to each other and both open, one immediately above its felow, into the common bileduct. I attempted to trace up these ducts to discover if they drain two distinct lobes of the ventral pancreas, but they both appear to issue from a fused mass of gland.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>11.4 mm.embryo. Fig.3 shows a drawing of the ventral pancreas from a photograph of a reconstruction at this stage. In it one can see two ventral pancreatic ducts, one cranial to, and much smaller than the other: these run parallel to each other and both open, one immediately above its felow, into the common bileduct. I attempted to trace up these ducts to discover if they drain two distinct lobes of the ventral pancreas, but they both appear to issue from a fused mass of gland.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Odgers1930 fig02.jpg|600px]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Fig. 2. Drawing of a model of the duodenum and pancreas, viewed from below, in a 7-1 mm. embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; D.P. dorsal pancreas.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>Fig. 2.<ins style="font-weight: bold; text-decoration: none;">''' </ins>Drawing of a model of the duodenum and pancreas, viewed from below, in a 7-1 mm. embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; D.P. dorsal pancreas.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Fig. 3. Drawing of a model of the duodenum and ventral pancreas, viewed from the right side, in an 11'4mm. embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; W and W1 mark the two ventral pancreatic ducts.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>Fig. 3.<ins style="font-weight: bold; text-decoration: none;">''' </ins>Drawing of a model of the duodenum and ventral pancreas, viewed from the right side, in an 11'4mm. embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; W and W1 mark the two ventral pancreatic ducts.</div></td></tr>
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</table>Z8600021https://embryology.med.unsw.edu.au/embryology/index.php?title=Paper_-_Some_Observations_on_the_Development_of_the_Ventral_Pancreas_in_Man&diff=184105&oldid=prevZ8600021 at 04:08, 29 June 20152015-06-29T04:08:23Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>5mm.embryo. Here the ventral pancreas is seen filing up the angle that the hepatic outgrowth makes with the bowel and partially encircling the latter. It is horseshoe-shaped with a left limb smaller than the more projecting right limb, but commencing somewhat cranial to the latter. The whole bibbed outgrowth already appears as if it were being drawn out dorsalwards and to theright(fig.1). If sections (lOu) of this are examined, one finds that the ventral pancreas extends through seven sections in al. The left "lobe" appears first, two sections cranial to the right one, as a projection from the most caudal part of the opening of the bile duct into the gut (Plate I, fig. 4). If one looks at a section midway through this pancreas, one sees a definitely bilobed mass and in this, I suggest, are two lumina, of which the leftisthe larger and the more obvious (fig. 5). In the next section below this one (fig. 6) these two lumina are apparently fusing into one-a fine septum is seen dividing the common lumen-and the rest of the pancreas caudal to this is solid. Traced cranialwards, in the next section cranial to fig. 5 the right lumen has disappeared, but I can trace the left lumen through this one and the section next above it to open, I think, into the bile duct (fig. 4).</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>5mm.embryo. Here the ventral pancreas is seen filing up the angle that the hepatic outgrowth makes with the bowel and partially encircling the latter. It is horseshoe-shaped with a left limb smaller than the more projecting right limb, but commencing somewhat cranial to the latter. The whole bibbed outgrowth already appears as if it were being drawn out dorsalwards and to theright(fig.1). If sections (lOu) of this are examined, one finds that the ventral pancreas extends through seven sections in al. The left "lobe" appears first, two sections cranial to the right one, as a projection from the most caudal part of the opening of the bile duct into the gut (Plate I, fig. 4). If one looks at a section midway through this pancreas, one sees a definitely bilobed mass and in this, I suggest, are two lumina, of which the leftisthe larger and the more obvious (fig. 5). In the next section below this one (fig. 6) these two lumina are apparently fusing into one-a fine septum is seen dividing the common lumen-and the rest of the pancreas caudal to this is solid. Traced cranialwards, in the next section cranial to fig. 5 the right lumen has disappeared, but I can trace the left lumen through this one and the section next above it to open, I think, into the bile duct (fig. 4).</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Odgers1930 fig01.jpg|600px]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Fig. 1.''' Drawing of a model of the duodenum and pancreas, viewed from below, in a 5 mm. embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; D.P. dorsal pancreas.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Fig. 1.''' Drawing of a model of the duodenum and pancreas, viewed from below, in a 5 mm. embryo. D. duodenum; B.D. bile-duct; V.P. ventral pancreas; D.P. dorsal pancreas.</div></td></tr>
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</table>Z8600021