Embryology - 18 Apr 2024 Expand to Translate
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O'Rahilly R. and Müller F. Significant features in the early prenatal development of the human brain. (2008) Ann. Anat. 190(2);105-18 (Review) PMID 18356030.

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This 2008 review paper by O'Rahilly and Müller uses the Carnegie Collection embryos to describe the development of the central nervous system.

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Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History \| Historic Embryology Papers)

Significant Features in the Early Prenatal Development of the Human Brain

O'Rahilly R. and Müller F.

Abstract

A review of the early prenatal development of the human brain has been prepared following a long-standing investigation of 192 embryos. The precise sequence of developmental events has been traced with the aid of accurate morphological staging. The three major divisions of the brain appear in the walls of the completely open neural groove at 3(1/2) postfertilizational weeks (stage 9). They do not develop as "cerebral vesicles" in a closed neural tube. The 16 neuromeres and the various subdivisions of the neural crest are highlighted. It is stressed that only two neuropores are normally found in the human. The telencephalon can be distinguished as early as 4 weeks (stage 10) and the five chief subdivisions of the brain are recognizable at 5 weeks (stage 15). The development of the medial (diencephalic) and lateral (telencephalic) ventricular eminences (so-called Ganglienhügel) is elaborated, and their role in the formation of the basal nuclei is clarified. The cortical plate and subplate have been identified as early as 7 weeks (stage 21). Finally, it is pointed out that the timing of the origin of many congenital anomalies of the nervous system shows the special importance of the embryonic period, i.e., the first 8 postfertilizational weeks.

This is a review paper.

Cite this page: Hill, M.A. (2024, April 18) Embryology Paper - Significant features in the early prenatal development of the human brain. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Paper_-_Significant_features_in_the_early_prenatal_development_of_the_human_brain

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