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Nishimura H. Takano K. Tanimura T, and Yasuda M. Normal and abnormal development of human embryos: First report of the analysis of 1,213 intact embryos. (1968) Teratology, 1: 281-290. PubMed 5759548

Online Editor Note
This historic 1968 paper by Nishimura and colleagues describes human embryos from the Kyoto Collection. Nishimura H. Tanimura T. Semba R. Uwabe C. Normal development of early human embryos: Observation of 90 specimens at Carnegie stages 7 to 13. (1974)Teratology 10(1): 1-5. PubMed 4853372 Modern Notes: Kyoto Collection

Historic Disclaimer - information about historic embryology pages
Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History \| Historic Embryology Papers)

Normal and Abnormal Development of Human Embryos: First Report of the Analysis of 1,213 Intact Embryos

Hideo Nishimura (1912–1995)

Abstract

This survey of the development of a large number of virtually unselected human embryos from healthy women allowed us to establish more reliable standards of normal development with respect to crown-rump length, body weight, and external form than those usually cited. Remarkable variation was noted with regard to the relation between clinical age and these attributes and thus it is concluded that crown-rump length and body weight are more reliable indicators of the general state of development than clinically established age.

Dead embryos occurred with a significantly greater frequency in women with a history of genital bleeding during pregnancy than in those without. Externally malformed embryos were found with increasing frequency with advancing developmental stage, with the maximum figure of 3.92% at horizons 19–23. Malformations observed included external defects such as exencephaly, cyclopia, myeloschisis, cleft lip, and several limb malformations. It is of considerable interest that the incidence of most of these defects was far higher than that observed in newborn infants.

Literature Cited

Aoki, H. 1962 On notiﬁed induced abortions in Japan. Annual Reports of the Institute of Population Problems, Ministry of Health and Welfare, Japan, 7: 45—52. (In Japanese.)

Arey, L. B. 1965 Developmental Anatomy. Saunders, Philadelphia.

Hellmann, K. 1966 Immunosuppression by thalidomide: Implications for teratology. Lancet, 1: 1136-1137.

Iffy, L., T. H. Shepard, A. Jakobovits, R. J. Lemire, and P. Kerner 1967 The rate of growth in young embryos of Streeter’s horizons XIII to XXIII. Acta Anat., 66: 178-186.

Jirasek, J. E., J. Uher, and M. Uhrova 1966 Water and nitrogen content of the body of young human embryos. Am. J. Obstet. Gynec., 96: 861-871.

Mitani, S. 1954 Malformations of the newborn infants. J. Jap. Obstet. Gynec. Soc., 1: 301-315. Nakamura, K., O. Saito, and T. Cho 1955 Measurements of early Japanese embryos. F.irst Report: Body length and body Weight.

Bull. Kobe Med. Coll., 6: 113-117. (In Japanese.) Neel, J. M. 1958 A study of major congenital defects in Japanese infants. Am. J. Hum. Genet., 10: 398-445.

Nishimura, H., K. Takano, T. Tanimura, M. Yasuda, and T. Uchida 1966 High incidence of several malformations in the early human embryos as compared with infants. Biol. Neonat., 10: 93-107.

Patten, B. M. 1953 Human McGraw-Hill, New York.

Pearson, A. A., H. Nishimura, T. Tanimura, and R. W. Sauter 1968 Observations on the development of the external form of the Japanese embryo. Anat. Rec., 160: (Abstract) 489-490.

Section of Statistics in The Secretariat of Ministry of Health and Welfare, Japan. 1963 Statistics on Eugenie Protection in Japan, 1963. Ministry of Health and Welfare, Japan, Tokyo. (In Japanese.)

Shimamura, A. 1957 Age determination and physical measurements of Japanese embryo. Jap. J. Leg. Med., 11: 795-811. (In Japanese.)

Stevenson, A. C., H. A. Johnston, M. I. P. Stewart, and D. G. Golding 1966 Congenital malformations. Bull. Wld. Hlth. 0rg., 34, Suppl.: 1-127.

Streeter, G. L. 1942 Developmental horizons in human embryos. Description of age group XI, 13 to 20 somites, and age group XII, 21 to 29 somites. Carnegie Contr. Embryol., 30: 213-245.

1945 Developmental horizons in human embryos. Description of age group XIII, embryos about 4 or 5 millimeters long and age group XIV, period of indentation of the lens vesicle. Carnegie Contr. Embryol., 31: 29-63.

1948 Developmental horizons in human embryos. Description of age groups XV, XVI, XVII and XVIII, being the third issue of a sur vey of the Carnegie collection. Carnegie Contr. Embryol., 32: 133-203.

1951 Developmental horizons in human embryos. Description of age groups XIX, XX, XXI, XXII and XXIII, being the ﬁfth issue of a survey of the Carnegie collection. Carnegie Contr. Ernbryol, 34: 165-196.

Takakusu, A., and T. Ban 1963 On the age of Japanese embryos. Med. J. Osaka Univ., 13.285-291.

Witschi E. Development of Vertebrates. (1956) Saunders, Philadelphia.

Cite this page: Hill, M.A. (2024, April 19) Embryology Paper - Normal and abnormal development of human embryos. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Paper_-_Normal_and_abnormal_development_of_human_embryos

What Links Here?

@@ Line 25: / Line 25: @@
 Dead embryos occurred with a significantly greater frequency in women with a history of genital bleeding during pregnancy than in those without. Externally malformed embryos were found with increasing frequency with advancing developmental stage, with the maximum figure of 3.92% at horizons 19–23. Malformations observed included external defects such as exencephaly, cyclopia, myeloschisis, cleft lip, and several limb malformations. It is of considerable interest that the incidence of most of these defects was far higher than that observed in newborn infants.
+==Literature Cited==
+Aoki, H. 1962 On notiﬁed induced abortions in Japan. Annual Reports of the Institute of Population Problems, Ministry of Health and Welfare, Japan, 7: 45—52. (In Japanese.)
+Arey, L. B. 1965 Developmental Anatomy. Saunders, Philadelphia.
+Hellmann, K. 1966 Immunosuppression by thalidomide: Implications for teratology. Lancet, 1: 1136-1137.
+Iffy, L., T. H. Shepard, A. Jakobovits, R. J. Lemire, and P. Kerner 1967 The rate of growth in young embryos of Streeter’s horizons XIII to XXIII. Acta Anat., 66: 178-186.
+Jirasek, J. E., J. Uher, and M. Uhrova 1966 Water and nitrogen content of the body of young human embryos. Am. J. Obstet. Gynec., 96: 861-871.
+Mitani, S. 1954 Malformations of the newborn infants. J. Jap. Obstet. Gynec. Soc., 1: 301-315. Nakamura, K., O. Saito, and T. Cho 1955 Measurements of early Japanese embryos. F.irst Report: Body length and body Weight.
+Bull. Kobe Med. Coll., 6: 113-117. (In Japanese.) Neel, J. M. 1958 A study of major congenital defects in Japanese infants. Am. J. Hum. Genet., 10: 398-445.
+Nishimura, H., K. Takano, T. Tanimura, M. Yasuda, and T. Uchida 1966 High incidence of several malformations in the early human embryos as compared with infants. Biol. Neonat., 10: 93-107.
+Patten, B. M. 1953 Human McGraw-Hill, New York.
+Pearson, A. A., H. Nishimura, T. Tanimura, and R. W. Sauter 1968 Observations on the development of the external form of the Japanese embryo. Anat. Rec., 160: (Abstract) 489-490.
+Section of Statistics in The Secretariat of Ministry of Health and Welfare, Japan. 1963 Statistics on Eugenie Protection in Japan, 1963. Ministry of Health and Welfare, Japan, Tokyo. (In Japanese.)
+Shimamura, A. 1957 Age determination and physical measurements of Japanese embryo. Jap. J. Leg. Med., 11: 795-811. (In Japanese.)
+Stevenson, A. C., H. A. Johnston, M. I. P. Stewart, and D. G. Golding 1966 Congenital malformations. Bull. Wld. Hlth. 0rg., 34, Suppl.: 1-127.
+Streeter, G. L. 1942 Developmental horizons in human embryos. Description of age group XI, 13 to 20 somites, and age group XII, 21 to 29 somites. Carnegie Contr. Embryol., 30: 213-245.
+Developmental horizons in human embryos. Description of age group XIII, embryos about 4 or 5 millimeters long and age group XIV, period of indentation of the lens vesicle. Carnegie Contr. Embryol., 31: 29-63.
+Developmental horizons in human embryos. Description of age groups XV, XVI, XVII and XVIII, being the third issue of a sur vey of the Carnegie collection. Carnegie Contr. Embryol., 32: 133-203.
+Developmental horizons in human embryos. Description of age groups XIX, XX, XXI, XXII and XXIII, being the ﬁfth issue of a survey of the Carnegie collection. Carnegie Contr. Ernbryol, 34: 165-196.
+Takakusu, A., and T. Ban 1963 On the age of Japanese embryos. Med. J. Osaka Univ., 13.285-291.
+{{Ref-Witschi1956}}

Paper - Normal and abnormal development of human embryos: Difference between revisions

Revision as of 10:49, 4 November 2017

Normal and Abnormal Development of Human Embryos: First Report of the Analysis of 1,213 Intact Embryos

Abstract

Literature Cited