Embryology - 19 Apr 2024 Expand to Translate
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Brewer JI. A human embryo in the bilaminar blastodisc stage (The Edwards-Jones-Brewer ovum). (1938) Contrib. Embryol., Carnegie Inst. Wash. Publ. 496, 27: 85-93.

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This historic 1938 paper by Brewer describes early human development before gastrulation. An embryo age of 15 days could make this specimen Carnegie stage 6 in Week 2. This embryo was initially given the serial number (H1496) and later incorporated into the Carnegie Collection as embryo no. 8819.

Also described in: Brewer JI. A normal human ovum in a stage preceding the primitive streak (The Edwards-Jones-Brewer ovum). (1937) Amer. J Anat., 61: 429-481.

Brewer JI. and Fitzgerald JE. Six normal and complete presomite human ova. (1937) Amer. J. Obstet. Gynecol, 34: 210-224.

Modern Notes:

Historic Papers: 1909 | 1925 | 1937

Carnegie Collection - Stage 6
Serial No.	Grade	Fixative	Embedding Medium	Thinness (µm)	Stain	Year	Notes
6026	Poor	?	?	6?	(Stain - Haematoxylin Eosin)	1929	Lockyer embryo. Abnormal. Ramsey (1937)
6734	Poor	Zenker—acetic	P	10	(Stain - Haematoxylin Eosin)	1934	Yale embryo. Ramsey (1938)
6900	Poor	Formol	P	15	(Stain - Haematoxylin Eosin)	1940	Linzenmeier (1914)
7634	Poor	Formol	P	10	(Stain - Haematoxylin Eosin) etc.	1940	Torpin embryo. Kraﬂca (1941)
7762	Good	Zenker—formol	P	8	?	1940	Wilson (1945)
7800	Exc.	?	C—P	8	(Stain - Haematoxylin Eosin)	1940	Abnormal
7801	Exc.	Bouin	C—P	8	(Stain - Haematoxylin Eosin)	1940	Heuser et al. (1945)
7850	Exc.	Alc. & Bouin	C—P	6	(Stain - Haematoxylin Eosin)	1940	Abnormal
8290	Exc.	Bouin	C—P	8	H. phlox.	1944
8360	Exc.	Alc. & Bouin	C—P	6	(Stain - Haematoxylin Eosin), phlox.	1944
8362	Poor	p	C—P	6	(Stain - Haematoxylin Eosin), phlox	1944
8672	Exc.	Ale. & Bouin	C—P	6	(Stain - Haematoxylin Eosin)	1949
8819	Exc.	Formol—chrom. subl.	C—P	8	(Stain - Haematoxylin Eosin)	1951	Edwards-Jones-Brewer (H1496). Brewer (1937, 38)^[1]^[2]
8905	Poor	Ale.	p	6	(Stain - Haematoxylin Eosin), phlox.	1951	Abnormal
8910	Good	Formol	C—P	8	(Stain - Haematoxylin Eosin), phlox.	1951
9222	Good	Bouin	C—P	6 & 10	Azan	1954	Abnormal. Possibly stage 7
9250	Exc.	Bouin	p	8	(Stain - Haematoxylin Eosin)	1954
9595	Poor	p	p	8	(Stain - Haematoxylin Eosin)	1958
10003	Good	Bouin	p	5	Various	1963
Abbreviations Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections. Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P). Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution) ? - unknown or not determined.
References ↑ Brewer JI. A normal human ovum in a stage preceding the primitive streak (The Edwards-Jones-Brewer ovum). (1937) Amer. J Anat., 61: 429-481. ↑ Brewer JI. A human embryo in the bilaminar blastodisc stage (The Edwards-Jones-Brewer ovum). (1938) Contrib. Embryol., Carnegie Inst. Wash. Publ. 496, 27: 85-93.

Note that original paper has been altered in layout and figures interred into the original text. See the links below for the current notes pages.

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Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History \| Historic Embryology Papers)

Brewer JI. A normal human ovum in a stage preceding the primitive streak (The Edwards-Jones-Brewer ovum). (1937) Amer. J Anat., 61: 429-481.

A human embryo in the bilaminar blastodisc stage (The Edwards-Jones-Brewer ovum)

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Cite this page: Hill, M.A. (2024, April 19) Embryology Paper - A human embryo in the bilaminar blastodisc stage. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Paper_-_A_human_embryo_in_the_bilaminar_blastodisc_stage

What Links Here?

[Brewer1937-1] Brewer JI. A normal human ovum in a stage preceding the primitive streak (The Edwards-Jones-Brewer ovum). (1937) Amer. J Anat., 61: 429-481.

[Brewer1938-2] Brewer JI. A human embryo in the bilaminar blastodisc stage (The Edwards-Jones-Brewer ovum). (1938) Contrib. Embryol., Carnegie Inst. Wash. Publ. 496, 27: 85-93.

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