Difference between revisions of "Ovary Development"

From Embryology
m
m
Line 150: Line 150:
 
There are several different nomenclatures for the stages of follicle maturation. It probably does not matter which naming system you use, as long as you are consistent and use the same set of terminology for all stages. Early stages of follicle development appear to be gonadotropin (Gn) independent and with development become gonadotropin "sensitive" and then "dependent" . (UK spelling is gonadotrophin).
 
There are several different nomenclatures for the stages of follicle maturation. It probably does not matter which naming system you use, as long as you are consistent and use the same set of terminology for all stages. Early stages of follicle development appear to be gonadotropin (Gn) independent and with development become gonadotropin "sensitive" and then "dependent" . (UK spelling is gonadotrophin).
  
[[File:Ovary-_follicle_stages.jpg|thumb|500px|Follicle development stages and the relationship to gonadotropin (Gn){{#pmid:19589134|PMID19589134}}]]
+
[[File:Ovary-_follicle_stages.jpg|500px]]
[[File:Human_ovary_follicle_development.jpg|thumb|Human ovary follicle development]]
+
 
 +
Follicle development stages and the relationship to gonadotropin (Gn){{#pmid:19589134|PMID19589134}}]]
 +
 
 +
[[File:Human_ovary_follicle_development.jpg|500px]]
 +
 
 +
Human ovary follicle development]]
  
 
{{Follicle class table}}
 
{{Follicle class table}}
Line 159: Line 164:
 
| [[File:Ova44he.jpg|400px]]
 
| [[File:Ova44he.jpg|400px]]
  
Primate primordial follicles {{HE}}
+
Primate primordial follicles {{HE}}. Note the single layer of follicle cells surrounding the oocyte.
 
| [[File:HertigAdams1967 fig04.jpg|400px]]
 
| [[File:HertigAdams1967 fig04.jpg|400px]]
  

Revision as of 19:09, 1 May 2018

Embryology - 20 Sep 2019    Facebook link Pinterest link Twitter link  Expand to Translate  
Google Translate - select your language from the list shown below (this will open a new external page)

العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt    These external translations are automated and may not be accurate. (More? About Translations)

Introduction

Adult human ovary viewed by endoscopy

The female gonad is the ovary and is closely associated with female internal genital (reproductive) tract development. In humans, these laterally paired organs lie within the peritoneal cavity. Genes such as WNT-4 and DAX-1 necessary for initiation of female pathway ovary development, female gonad is not considered a default process.


Initial gonad development in females and males is virtually identical with germ cells migrating into an indifferent gonad. In females with XX, the ovary then begins to develop and the subsequent structure and timecourse of germ cell then differs between males and females. In the ovary oocytes proliferate prior to birth and arrest in meiosis 1.


Links: Menstrual Cycle | X Chromosome | Category:Ovary


Genital Links: genital | Lecture - Medicine | Lecture - Science | Lecture Movie | Medicine - Practical | primordial germ cell | meiosis | Female | X | ovary | corpus luteum | oocyte | uterus | vagina | reproductive cycles | menstrual cycle | Male | Y | SRY | testis | spermatozoa | ductus deferens | penis | prostate | endocrine gonad‎ | Genital Movies | genital abnormalities | Assisted Reproductive Technology | puberty | Category:Genital
Historic Embryology - Genital 
1901 Urinogenital Tract | 1902 The Uro-Genital System | 1904 Ovary and Testis | 1904 Leydig Cells | 1904 Hymen | 1905 Testis vascular | 1909 Prostate | 1912 Prostate | 1912 Urinogenital Organ Development | 1914 External Genitalia | 1914 Female | 1915 Cowper’s and Bartholin’s Glands | 1920 Wolffian tubules | 1921 Urogenital Development | 1921 External Genital | 1927 Female Foetus 15 cm | 1932 Postnatal Ovary | 1935 Prepuce | 1935 Wolffian Duct | 1942 Sex Cords | 1943 Testes Descent | 1953 Germ Cells | Historic Embryology Papers | Historic Disclaimer

Some Recent Findings

Testosterone metabolism
  • Review - Polycystic ovary syndrome[1] "This article aims to provide a balanced review of the latest advances and current limitations in our knowledge about PCOS while also providing a few clear and simple principles, based on current evidence-based clinical guidelines, for the proper diagnosis and long-term clinical management of women with PCOS."
  • Quantitative proteomic profiling human ovary from early to mid-gestation[2] "Here, quantitative mass spectrometry was conducted on ovarian tissue collected at key stages during the first two trimesters of human gestational development, confirming the expression profiling data using immunofluorescence as well as in-vitro modeling with human oogonial stem cells (OSCs) and human embryonic stem cells (ESCs). A total of 3,837 proteins were identified in samples spanning developmental days 47-137. Bioinformatics clustering and Ingenuity Pathway Analysis identified DNA mismatch repair and base excision repair as major pathways upregulated during this time. Additionally, MAEL and TEX11, two key meiosis-related proteins, were identified as highly expressed during the developmental window associated with fetal oogenesis."
  • Review - Role of androgens in the ovary[3] "It has been well established for decades that androgens, namely testosterone (T) plays an important role in female reproductive physiology as the precursor for oestradiol (E2). However, in the last decade a direct role for androgens, acting via the androgen receptor (AR), in female reproductive function has been confirmed. Deciphering the specific roles of androgens in ovarian function has been hindered as complete androgen resistant females cannot be generated by natural breeding. In addition, androgens can be converted into estrogens which has caused confusion when interpreting findings from pharmacological studies, as observed effects could have been mediated via the AR or estrogen receptor. The creation and analysis of genetic mouse models with global and cell-specific disruption of the Ar gene, the sole mediator of pure androgenic action, has now allowed the elucidation of a role for AR-mediated androgen actions in the regulation of normal and pathological ovarian function."
More recent papers  
Mark Hill.jpg
PubMed logo.gif

This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.

  • This search now requires a manual link as the original PubMed extension has been disabled.
  • The displayed list of references do not reflect any editorial selection of material based on content or relevance.
  • References also appear on this list based upon the date of the actual page viewing.


References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

More? References | Discussion Page | Journal Searches | 2019 References

Search term: Ovary Development

<pubmed limit=5>Ovary Development</pubmed>

Older papers  
  • Retransplantation of cryopreserved ovarian tissue: the first live birth in Germany[4] "Cryopreserved ovarian tissue can be retransplanted to restore fertility after radiation or chemotherapy. To date, 15 live births after retransplantation have been reported worldwide. We report the first pregnancy and the first live birth after retransplantation in Germany. This was the first live birth after retransplantation of cryopreserved ovarian tissue in Germany and also the first case with histological confirmation that the oocyte from which the patient conceived could only have come from the retransplanted tissue."
  • Mammalian ovary differentiation - A focus on female meiosis[5] "Over the past 50 years, the ovary development has been subject of fewer studies as compare to the male pathway. Nevertheless due to the advancement of genetics, mouse ES cells and the development of genetic models, studies of ovarian differentiation was boosted. This review emphasizes some of new progresses in the research field of the mammalian ovary differentiation that have occurred in recent years with focuses of the period around prophase I of meiosis and of recent roles of small non-RNAs in the ovarian gene expression."
  • Human RSPO1/R-spondin1 is expressed during early ovary development and augments β-catenin signaling[6] "Human testis development starts from around 42 days post conception with a transient wave of SRY expression followed by up-regulation of testis specific genes and a distinct set of morphological, paracrine and endocrine events. Although anatomical changes in the ovary are less marked, a distinct sub-set of ovary specific genes are also expressed during this time. The furin-domain containing peptide R-spondin1 (RSPO1) has recently emerged as an important regulator of ovary development through up-regulation of the WNT/β-catenin pathway to oppose testis formation. Here, we show that RSPO1 is upregulated in the ovary but not in the testis during critical early stages of gonad development in humans (between 6-9 weeks post conception), whereas the expression of the related genes WNT4 and CTNNB1 (encoding β catenin) is not significantly different between these tissues. Furthermore, reduced R-spondin1 function in the ovotestis of an individual (46,XX) with a RSPO1 mutation leads to reduced β-catenin protein and WNT4 mRNA levels, consistent with down regulation of ovarian pathways"

Human Ovary Timeline

Fetal gonad retinoid receptor expression[7]

Approximate Timeline of human development listed below.

Genital Timeline 24 days - intermediate mesoderm, pronephros primordium

28 days - mesonephros and mesonephric duct

35 days - uteric bud, metanephros, urogenital ridge

42 days - cloacal divison, gonadal primordium (indifferent)

49 days - paramesonephric duct, gonadal differentiation

56 days - paramesonephric duct fusion (female)

100 days - primary follicles (ovary)

Ovarian primordial germ cell Timeline

  • 6-7 weeks (GA 8-9 weeks) - mitotic PGC proliferation only
  • 12-14 weeks (GA 14-16 weeks) - formation of syncitial clusters of oogonia and onset of meiotic germ cell differentiation
  • 15-18 weeks (GA 17–20 weeks) - breakdown of syncitial clusters and assembly of primordial follicles

Movies

Gonad-icon.jpg
 ‎‎Ovary
Page | Play
Urogenital septum 001 icon.jpg
 ‎‎Urogenital Septum
Page | Play
Female external 001 icon.jpg
 ‎‎Female External‎‎
Page | Play
Uterus 001 icon.jpg
 ‎‎Uterus
Page | Play
Mouse Primordial Germ Cell Migration
Primordial germ cell 001 icon.jpg
 ‎‎Germ Cell E9.0
Page | Play
Primordial germ cell 002 icon.jpg
 ‎‎Germ Cell E9.5
Page | Play
Primordial germ cell 003 icon.jpg
 ‎‎Germ Cell E10.5
Page | Play

Oogenesis

Human ovary non-growing follicle model

The 2 human ovaries gradually lose follicles both before and after puberty (the beginning of ovulation); beginning with about several million before birth, maximum number at birth, 300-400,000 by puberty and finally by late 40’s have only a few follicles left. Recent studies suggest that the original calculations of ovary follicle numbers at birth were over-estimates and the actual figure should be about 2.5 million.[8] The number of antral follicles detected within the ovary also decreases with increasing maternal age.

In humans, a primodial follicle take about 150 days to develop into a preantral follicle (primary) and another 120 days to form an antral follicle (secondary). A number of antral follicles will then "compete" for 14-15 days to become the dominant follicle, which will undergo ovulation.

Fetal Ovary

Fetal ovary meiosis 03.jpg

Fetal human ovary meiosis (second trimester)[9] H2AFX and SYCP3 are meiotic markers

Infant Ovary

Histology of the female infant ovary Human infant ovary follicle 01.jpg
Overview Follicle

This image shows a region (see inset) of the infant ovary cortex.

There are a large number of developing oocytes which will eventually form a dense primordial germ layer at the ovary periphery.

Later stages of follicle development are completely absent and will begin to only appear just prior to puberty.

Table showing the Growth of the Ovary  
Vertex-breech
length
Greatest diam.
of head
Right Ovary Left Ovary Comparison between
Breadth Length Breadth Length Length Breadth
R. L. R. L.
50.0 42.6 0.9 1.9 0.9 2.5 .. +
125.0 123.0 1.2 5.9 1.5 4.1 + .. .. +
138.0 115.0 1.6 5.0 2.0 5.0 .. +
156.0 131.0 1.9 7.2 2.0 7.1 + .. .. +
173.0 163.5 3.0 9.0 ... ... .. .. .. ..
190.0 175.0 2.9 7.7 2.1 7.8 .. + + ..
223.0 162.0 2.9 10.5 3.0 9.1 + .. .. +
235.0 190.0 4.2 10.0 3.8 12.0 .. + + ..
260.0 213.0 3.6 11.1 4.0 11.4 .. + .. +
272.0 213.0 3.0 10.0 3.5 9.2 + .. .. +
305.0 238.0 3.0 9.9 3.9 10.9 .. + .. +
347.0 ... 3.5 10.8 4.9 8.5 + .. .. +
355.0 273.0 4.0 14.0 5.2 9.9 + .. .. +
386.0 324.0 5.1 11.5 3.0 9.9 + .. + ..
402.0 301.0 5.05 10.5 3.0 12.0 .. + + ..
3 weeks ... 5.0 17.0 5.0 14.0 + ..
6 weeks ... 7.5 15.0 7.0 14.7 + .. + ..
6 weeks ... 7.0 18.0 8.0 17.0 + .. .. +
10 weeks ... ... 14.0 ... 16.0 + ..
2 months ... 6.0 14.5 4.0 13.0 + .. + ..
3 months ... 6.0 15.5 5.0 14.7 + .. + ..
7 months ... 5.9 15.5 4.5 18.1 .. + + ..
15 months ... 9.0 18.0 9.0 19.5 + ..
I.75 years ... 7.0 20.0 8.5 15.0 + .. .. +
4 years ... 10.0 27.0 12.7 23.2 + .. .. +
5.5 years ... 11.1 29.0 9.1 26.1 + .. + ..
14 years ... 11.9 26.5 12.0 29.5 .. + .. +
The measurements are all given in millimeters, breech length is measured along the nape and the back.
Reference: Felix W. The development of the urinogenital organs. In Keibel F. and Mall FP. Manual of Human Embryology II. (1912) J. B. Lippincott Company, Philadelphia. pp 752-979.
    Links: 1912 Ovary Growth | Table Ovary Growth Table | Collapsible Table | Ovary Development

Postnatal Oogenesis

There is a dogma in mammalian development that new oocyte and follicle production does not occur during postnatal life. There is substantial data that shows human ovarian changes postnatally are loss by apoptosis of prenatal oocytes. A research group (Tilly JL, Johnson J. 2004, 2007) has published experiments using mice, showing potentially other sources/sites (bone marrow) of oocyte (putative germ cell) generation. They recently stated that the argument should be based upon "experimental approaches than simply an absence of evidence, especially from gene expression analyses". Several other research groups (Eggan K etal. 2004 and Veitia etal. 2007) have argued against these findings.

Adult Follicle Structure

Secondary (Antral) Follicle Structure

A follicle usually contains a single oocyte (egg, ovum, female gamete) and a series of supporting cells and a single fluid-filled space in layers surrounding this cell. The 3 layers below are arranged in layers outward from the oocyte.

Granulosa Cells

  • A specific cell type that proliferates in association with the oocyte within the developing follicles of the ovary. These cells form the follicle stratum granulosa and are also given specific names based upon their position within the follicle.
  • With development of the antral follicle, there are two populations of granulosa cells with distinct characteristics and functions: mural granulosa cells and cumulus cells.[10]
    • mural granulosa cells - an endocrine role by producing steroid hormones and various other ligands
    • cumulus cells - play a support role for oocyte development

Alternate Histological Terms

    • The membrana granulosa cells sit on the follicular basal lamina and line the antrum as a stratified epitelium. Following ovulation, these granulosa cells contribute to corpus luteum.
    • The cumulus oophorus is a column of granulosa cells that attaches the oocyte to the follicle wall. At ovulation, this column of cells is broken or separates to release the oocyte from its follicle attachment.
    • The corona radiata are the granulosa cells that directly surround the oocyte, and are released along with it at ovulation. Following ovulation, the corona radiata provide physical protection to the oocyte and are the initial structural barrier that spermatazoa must penetrate during fertilization.


Links: Granulosa cell

Follicular Fluid

  • The antrum is a fluid-filled space in the secondary (antral) follicle
  • At ovulation, fluid is released along with the oocyte
  • Thought to "carry" the oocyte out of the follicle (like a boat on a wave)
  • Aids entry into the uterine tube

Theca Interna

(Greek, thek = box) The ovarian follicle endocrine cells forming the inner layer of the theca folliculi surrounding the developing follicle within the ovary. This vascularized layer of cells respond to leutenizing hormone (LH) synthesizing and secreting androgens (androstendione) transported to glomerulosa cells which process initially into testosterone and then by aromatase into estrogen (estradiol). Theca cells do not begin hormonal functions until puberty.

Theca Externa

(Greek, thek = box) The ovarian follicle stromal cells forming the outer layer of the theca folliculi surrounding the developing follicle within the ovary. Consisting of connective tissue cells, smooth muscle and collagen fibers.

Follicle Classification

There are several different nomenclatures for the stages of follicle maturation. It probably does not matter which naming system you use, as long as you are consistent and use the same set of terminology for all stages. Early stages of follicle development appear to be gonadotropin (Gn) independent and with development become gonadotropin "sensitive" and then "dependent" . (UK spelling is gonadotrophin).

Ovary- follicle stages.jpg

Follicle development stages and the relationship to gonadotropin (Gn)[11]]]

Human ovary follicle development.jpg

Human ovary follicle development]]

Human Ovarian Follicle Classification
Class Alternate nomenclature Type Number of Cells Size (diameter µm) Size ultrasound (mm)
primordial follicle small 1, 2, 3 25 less than 50
primary follicle preantral 4
5
26 - 100
101 - 300
up to 200
secondary follicle antral
small antral
large antral

6
7

3001 - 500
501 - 1000
500
1000 - 6000
less than 18
preovulatory follicle Graafian 8 greater than 1000 greater than 6000 18 – 28
  Links: ovary | oocyte | menstrual cycle

Primordial Follicle

Ova44he.jpg

Primate primordial follicles (Stain - Haematoxylin Eosin). Note the single layer of follicle cells surrounding the oocyte.

HertigAdams1967 fig04.jpg

Electron Micrograph of a human oocyte in a primordial follicle. Most of the organelles are concentrated in one pole of the oocyte.[12]

Primary Follicle

Ovary histology 005.jpg

Histological image of a primary follicle.

Atresia

At any one time the majority of follicles are destined not to complete maturation and at any stage (from type 4-7) degeneration of the follicle can occur. Cells die by apoptosis.

Follicle Growth

Ovary follicle size graph

Graph shows species comparison in follicle size growth (diameter) at different stages of follicle development.[13] (See also Oocyte size graph)

Human Ovarian Follicle Classification  
Class Alternate nomenclature Type Number of Cells Size (diameter µm) Size ultrasound (mm)
primordial follicle small 1, 2, 3 25 less than 50
primary follicle preantral 4
5
26 - 100
101 - 300
up to 200
secondary follicle antral
small antral
large antral

6
7

3001 - 500
501 - 1000
500
1000 - 6000
less than 18
preovulatory follicle Graafian 8 greater than 1000 greater than 6000 18 – 28
  Links: ovary | oocyte | menstrual cycle

Follicle Factors

Ovarian developmental genes[14]

There are both external endocrine factors and internal follicle factors that can influence the development and atresia of ovarian follicles.

External Factors

Leutenizing Hormone (LH)

  • from the anterior pituitary
  • stimulate the theca interna to synthesize and secrete androgens (androstendione) transported to granulosa cells
  • granulosa cells process initially into testosterone and then by aromatase into estrogen (estradiol)

Follicle-stimulating hormone (FSH)

  • from the anterior pituitary
  • initiates follicle growth through the granulosa cells
  • involved in selecting the most advanced (sensitive) follicle to proceed to ovulation

Internal Factors

Oocyte Factors

  • Growth Differentiation Factor-9 (GDF-9) - involved in the differentiation of theca cells during this early stage of follicular development OMIM 601918
  • Bone morphogenetic protein 15 (BMP15)
  • Fibroblast growth factor 8B (FGF8B)

Granulosal Factor(s)

  • stimulates the recruitment of theca cells from cortical stromal cells

Thecal Factor(s)

  • appear to be several inhibitors of apoptotic cell death
  • Epidermal growth factor (EGF)
  • Transforming growth factor alpha (TGF-α)
  • keratinocyte growth factor (KGF)
  • hepatocyte growth factor (HGF)
  • Bone morphogenetic protein 7 (BMP-7) also known as osteogenic protein-1 or OP-1

Ovary Growth

Table below is from historic data (1912) from measurement of human histological materials.[15]

Table showing the Growth of the Ovary
Vertex-breech
length
Greatest diam.
of head
Right Ovary Left Ovary Comparison between
Breadth Length Breadth Length Length Breadth
R. L. R. L.
50.0 42.6 0.9 1.9 0.9 2.5 .. +
125.0 123.0 1.2 5.9 1.5 4.1 + .. .. +
138.0 115.0 1.6 5.0 2.0 5.0 .. +
156.0 131.0 1.9 7.2 2.0 7.1 + .. .. +
173.0 163.5 3.0 9.0 ... ... .. .. .. ..
190.0 175.0 2.9 7.7 2.1 7.8 .. + + ..
223.0 162.0 2.9 10.5 3.0 9.1 + .. .. +
235.0 190.0 4.2 10.0 3.8 12.0 .. + + ..
260.0 213.0 3.6 11.1 4.0 11.4 .. + .. +
272.0 213.0 3.0 10.0 3.5 9.2 + .. .. +
305.0 238.0 3.0 9.9 3.9 10.9 .. + .. +
347.0 ... 3.5 10.8 4.9 8.5 + .. .. +
355.0 273.0 4.0 14.0 5.2 9.9 + .. .. +
386.0 324.0 5.1 11.5 3.0 9.9 + .. + ..
402.0 301.0 5.05 10.5 3.0 12.0 .. + + ..
3 weeks ... 5.0 17.0 5.0 14.0 + ..
6 weeks ... 7.5 15.0 7.0 14.7 + .. + ..
6 weeks ... 7.0 18.0 8.0 17.0 + .. .. +
10 weeks ... ... 14.0 ... 16.0 + ..
2 months ... 6.0 14.5 4.0 13.0 + .. + ..
3 months ... 6.0 15.5 5.0 14.7 + .. + ..
7 months ... 5.9 15.5 4.5 18.1 .. + + ..
15 months ... 9.0 18.0 9.0 19.5 + ..
I.75 years ... 7.0 20.0 8.5 15.0 + .. .. +
4 years ... 10.0 27.0 12.7 23.2 + .. .. +
5.5 years ... 11.1 29.0 9.1 26.1 + .. + ..
14 years ... 11.9 26.5 12.0 29.5 .. + .. +
The measurements are all given in millimeters, breech length is measured along the nape and the back.
    Links: 1912 Ovary Growth | Table Ovary Growth Table | Collapsible Table | Ovary Development
Table showing the Growth of the Ovary  
Vertex-breech
length
Greatest diam.
of head
Right Ovary Left Ovary Comparison between
Breadth Length Breadth Length Length Breadth
R. L. R. L.
50.0 42.6 0.9 1.9 0.9 2.5 .. +
125.0 123.0 1.2 5.9 1.5 4.1 + .. .. +
138.0 115.0 1.6 5.0 2.0 5.0 .. +
156.0 131.0 1.9 7.2 2.0 7.1 + .. .. +
173.0 163.5 3.0 9.0 ... ... .. .. .. ..
190.0 175.0 2.9 7.7 2.1 7.8 .. + + ..
223.0 162.0 2.9 10.5 3.0 9.1 + .. .. +
235.0 190.0 4.2 10.0 3.8 12.0 .. + + ..
260.0 213.0 3.6 11.1 4.0 11.4 .. + .. +
272.0 213.0 3.0 10.0 3.5 9.2 + .. .. +
305.0 238.0 3.0 9.9 3.9 10.9 .. + .. +
347.0 ... 3.5 10.8 4.9 8.5 + .. .. +
355.0 273.0 4.0 14.0 5.2 9.9 + .. .. +
386.0 324.0 5.1 11.5 3.0 9.9 + .. + ..
402.0 301.0 5.05 10.5 3.0 12.0 .. + + ..
3 weeks ... 5.0 17.0 5.0 14.0 + ..
6 weeks ... 7.5 15.0 7.0 14.7 + .. + ..
6 weeks ... 7.0 18.0 8.0 17.0 + .. .. +
10 weeks ... ... 14.0 ... 16.0 + ..
2 months ... 6.0 14.5 4.0 13.0 + .. + ..
3 months ... 6.0 15.5 5.0 14.7 + .. + ..
7 months ... 5.9 15.5 4.5 18.1 .. + + ..
15 months ... 9.0 18.0 9.0 19.5 + ..
I.75 years ... 7.0 20.0 8.5 15.0 + .. .. +
4 years ... 10.0 27.0 12.7 23.2 + .. .. +
5.5 years ... 11.1 29.0 9.1 26.1 + .. + ..
14 years ... 11.9 26.5 12.0 29.5 .. + .. +
The measurements are all given in millimeters, breech length is measured along the nape and the back.
Reference: Felix W. The development of the urinogenital organs. In Keibel F. and Mall FP. Manual of Human Embryology II. (1912) J. B. Lippincott Company, Philadelphia. pp 752-979.
    Links: 1912 Ovary Growth | Table Ovary Growth Table | Collapsible Table | Ovary Development

Postnatal Growth

Human ovary postnatal growth.jpg

Human ovary postnatal volume growth[16]

Corpus Luteum

Human ovary with corpus luteum (white ring).

The corpus luteum (Latin, corpus = body, luteum = yellow) develops from the remains of Graffian follicle after ovulation. Functions as an endocrine organ (produce progesterone and oestrogens) supporting pregnancy and preventing menstruation (loss of the endometrial lining). Formed during the luteal phase (secretory phase) of the menstrual cycle by proliferation of both follicular granulosa cells (granulosa lutein cells) and thecal cells (theca lutein cells), which together interact to produce progesterone and oestrogens.

Peak luteal function during the menstrual cycle, determined by maximum luteal area, progesterone concentration and estradiol concentration, is observed about 6 days following ovulation.[17]

If fertilization and pregnancy does not occur, the corpus luteum degenerates to form the corpus albicans.

History

  • Regnier de Graaf (1641 – 1673) was the first observer in the ovary of a cow as a yellow structure, the yellow colour was caused by accumulation of steroidal hormones.
  • Ludwig Fraenkel (1870 - 1951) first identified the endocrine function of the corpus luteum.[18]

Embryo Virtual Slide

Human Ovary and Corpus Luteum

Human ovary - corpus luteum 01.jpg

 ‎‎Mobile | Desktop | Original

Ovary | Embryo Slides
Corpus Luteum Links: anatomy overview | image - histology overview | image - Layers granulosa and theca | image - Layers detail granulosa and theca | image - low power label | image - high power label | image - low power | image - high power | image - corpus albicans | theca and granulosa lutein cells | Granulosa cell | corpus luteum | granulosa lutein cells | theca lutein cells | corpus albicans | ovary | menstrual cycle
  Historic Papers: 1969 corpus luteum ultrastructure 1 | 1969 corpus luteum ultrastructure 2

Corpus Albicans

Human ovary with corpus albicans (white arrow).

Ovary histology 003.jpg

Corpus albicans histology

(corpora albicantia) (Latin, corpus = body, albicans = whitish) The histological structure formed by luteolysis of the corpus luteum in the ovary. If implantation does not occur and the hormone hCG is not released the corpus luteum degenerates and the structure is white, not yellow, because of the absence of steroid hormone synthesis/accumulation.


Corpus Luteum Links: anatomy overview | image - histology overview | image - Layers granulosa and theca | image - Layers detail granulosa and theca | image - low power label | image - high power label | image - low power | image - high power | image - corpus albicans | theca and granulosa lutein cells | Granulosa cell | corpus luteum | granulosa lutein cells | theca lutein cells | corpus albicans | ovary | menstrual cycle
  Historic Papers: 1969 corpus luteum ultrastructure 1 | 1969 corpus luteum ultrastructure 2

Animal Models

Bovine Ovary

Ovarian development model.jpg



Links: Bovine Development
Ovarian Development Model[19]
  • A - The development of the ovary commences at the mesonephric surface epithelium (yellow cells) in the location of the future gonadal ridge.
  • B - Some mesonephric surface epithelial cells change phenotype into GREL (Gonadal Ridge Epithelial-Like) cells (yellow-blue cells).
  • C - The GREL cells proliferate and the basal lamina underlying the mesonephric surface epithelium breaks down allowing stromal cells (green) to penetrate into the gonadal ridge.
  • D - GREL cells continue to proliferate and PGCs (grey) migrate into the ridge between the GREL cells. Mesonephric stroma including vasculature (red) continues to penetrate and expand in the ovary.
  • E - Oogonia proliferate and stroma penetrates further towards the ovarian surface enclosing oogonia and GREL cells into ovigerous cords. The cords are surrounded by a basal lamina at their interface with stroma, but are open to the ovarian surface. Stromal areas including those between the ovigerous cords contain capillaries.
  • F - A compartmentalization into cortex and medulla becomes obvious. The cortex is characterised by alternating areas of ovigerous cords and stroma, whereas the medulla is formed by stromal cells, vasculature and tubules originating from the mesonephros (rete ovarii). Once stroma penetrates below the cells on the surface it spreads laterally. The GREL cells at the surface are then aligned by a basal lamina at their interface with the stroma and begin to differentiate into typical ovarian surface epithelium (yellow cells). Some germ cells at the surface are also compartmentalized to the surface as stroma expands below it.
  • G - Ovigerous cords are partitioned into smaller cords and eventually into follicles. These contain GREL cells that form granulosa cells (blue cells) and oogonia that form oocytes. The first primordial follicles appear in the inner cortex-medulla region, surrounded by a basal lamina. A now fully intact basal lamina underlies multiple layers of surface epithelial cells.
  • H - At the final stage the surface epithelium becomes mostly single-layered and a tunica albuginea, densely packed with fibres, develops from the stroma below the surface epithelial basal lamina. Some primordial follicles become activated and commence development into primary and preantral follicles.

Histology

Ovary histology: Tunica Albuginea x20 | Tunica albuginea, Germinal epithelium x40 | Primary follicle, primordial follicle, oocyte, x40 | Secondary follicle, cumulus oophorus, zona pelucida, granulosa cells, oocyte x20 | Corpus luteum, theca lutein cells, granulosa lutein cells, Loupe | Corpus luteum, theca lutein cells, granulosa lutein cells, x10 | Corpus luteum, theca lutein cells, granulosa lutein cells, x40 | Corpus albicans, primary follicle, primordial follicle, granulosa cells, oocyte x20 | Menstrual Cycle | Ovary Development

Abnormalities

See also Genital System - Abnormalities

International Classification of Diseases

E28 Ovarian dysfunction

  • Excl.: isolated gonadotropin deficiency (E23.0); postprocedural ovarian failure (E89.4)

E28.0 Estrogen excess

  • Use additional external cause code (Chapter XX), if desired, to identify drug, if drug-induced.

E28.1 Androgen excess

  • Hypersecretion of ovarian androgens
  • Use additional external cause code (Chapter XX), if desired, to identify drug, if drug-induced.

E28.2 Polycystic ovarian syndrome

  • Sclerocystic ovary syndrome
  • Stein-Leventhal syndrome

E28.3 Primary ovarian failure

  • Decreased oestrogen
  • Premature menopause NOS
  • Resistant ovary syndrome
  • Excl.: menopausal and female climacteric states (N95.1); pure gonadal dysgenesis (Q99.1); Turner syndrome (Q96.-)

E28.8 Other ovarian dysfunction

  • Ovarian hyperfunction NOS

E28.9 Ovarian dysfunction, unspecified

Polycystic Ovary Syndrome

Mouse ovary normal and polycystic ovary syndrome model.[20]

International Classification of Diseases - E28.2 Polycystic ovarian syndrome.

Polycystic ovary syndrome (PCOS) or Stein-Leventhal syndrome (1930s researchers) clinical term for a metabolic hormone syndrome leading to anovulation and with many other symptoms (hyperandrogenism, insulin resistance) and is one of the most common forms of female infertility, see reviews.[21][22] Using the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine criteria, about 15% - 20% of women suffer from this disease. Ovarian cysts arise through incomplete follicular development or failure of ovulation (anovulation). A range of drugs has been used to induce ovulation in these women and more recently in vitro maturation (IVM) has also been suggested as a possible future technique. Androgen has been recently identified as a key mediator in the development of polycystic ovary syndrome.[23]


In December 2012, the NIH held a workshop on "Evidence-based Methodology on Polycystic Ovary Syndrome". PCOS is a common disorder affecting 5 million women of reproductive-age in the United States. Symptoms include: irregular or no menstrual periods in women of reproductive age (ovulatory dysfunction), acne, weight gain, excess hair growth on the face and body (hirsutism), thinning scalp hair, ovarian cysts (polycystic ovarian morphology) and mental health problems.

One key workshop finding was that the name "Polycystic Ovary Syndrome" is inappropriate for defining the condition and should be renamed to reflect the complex metabolic, hypothalamic, pituitary, ovarian, and adrenal interactions that characterize the syndrome and their reproductive implications.

  • Androgen Excess + Ovulatory Dysfunction
  • Androgen Excess + Polycystic Ovarian Morphology
  • Ovulatory Dysfunction + Polycystic Ovarian Morphology
  • Androgen Excess + Ovulatory Dysfunction + Polycystic Ovarian Morphology

Recurrent pregnancy loss also occurs in about 50% of total pregnancies with polycystic ovary syndrome.[24]


A recent study in the Han Chinese population[25] identified associations between PCOS and three genetic loci: 2p16.3, 2p21 and 9q33.3.


Links: Menstrual Cycle | Genital Abnormalities | Endocrine Abnormalities | 2012 NIH Workshop on PCOS | 2011 Australia Guideline assessment and management PCOS | OMIM 184700]

Ovarian Cancer

Ovarian cancer is a major cause of death in the postnatal female population. A recent mouse study has identified a population of cancer-prone stem cells located at the hilum region of the ovary that are prone to epithelial ovarian cancer.[26]


Luteoma of Pregnancy

Luteoma of pregnancy is a rare nonneoplastic tumor-like mass of the ovary that emerges during pregnancy and regresses spontaneously after delivery. Luteomas can be hormonally active producing androgens that can result in maternal and fetal hirsutism and virilization.

Image: Dr Ed Uthman (Houston, Texas) - other pathology images


References

  1. Escobar-Morreale HF. (2018). Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol , 14, 270-284. PMID: 29569621 DOI.
  2. Bothun A, Gao Y, Takai Y, Ishihara O, Seki H, Karger B, Tilly J & Woods DC. (2018). Quantitative proteomic profiling of the human ovary from early to mid-gestation reveals protein expression dynamics of oogenesis and folliculogenesis. Stem Cells Dev. , , . PMID: 29631484 DOI.
  3. Walters KA & Handelsman DJ. (2017). Role of androgens in the ovary. Mol. Cell. Endocrinol. , , . PMID: 28687450 DOI.
  4. Müller A, Keller K, Wacker J, Dittrich R, Keck G, Montag M, Van der Ven H, Wachter D, Beckmann MW & Distler W. (2012). Retransplantation of cryopreserved ovarian tissue: the first live birth in Germany. Dtsch Arztebl Int , 109, 8-13. PMID: 22282711 DOI.
  5. Baillet A & Mandon-Pepin B. (2012). Mammalian ovary differentiation - a focus on female meiosis. Mol. Cell. Endocrinol. , 356, 13-23. PMID: 21964319 DOI.
  6. Tomaselli S, Megiorni F, Lin L, Mazzilli MC, Gerrelli D, Majore S, Grammatico P & Achermann JC. (2011). Human RSPO1/R-spondin1 is expressed during early ovary development and augments β-catenin signaling. PLoS ONE , 6, e16366. PMID: 21297984 DOI.
  7. Childs AJ, Cowan G, Kinnell HL, Anderson RA & Saunders PT. (2011). Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad. PLoS ONE , 6, e20249. PMID: 21674038 DOI.
  8. Wallace WH & Kelsey TW. (2010). Human ovarian reserve from conception to the menopause. PLoS ONE , 5, e8772. PMID: 20111701 DOI.
  9. Heeren AM, He N, de Souza AF, Goercharn-Ramlal A, van Iperen L, Roost MS, Gomes Fernandes MM, van der Westerlaken LA & Chuva de Sousa Lopes SM. (2016). On the development of extragonadal and gonadal human germ cells. Biol Open , 5, 185-94. PMID: 26834021 DOI.
  10. Hultén MA, Patel S, Jonasson J & Iwarsson E. (2010). On the origin of the maternal age effect in trisomy 21 Down syndrome: the Oocyte Mosaicism Selection model. Reproduction , 139, 1-9. PMID: 19755486 DOI.
  11. Orisaka M, Tajima K, Tsang BK & Kotsuji F. (2009). Oocyte-granulosa-theca cell interactions during preantral follicular development. J Ovarian Res , 2, 9. PMID: 19589134 DOI.
  12. Hertig AT. and Adams EC. Studies on the human oocyte and its follicle. I. Ultrastructural and histochemical observations on the primordial follicle stage. (1967) J Cell Biol. 34(2):647-75. PMID 4292010
  13. Griffin J, Emery BR, Huang I, Peterson CM & Carrell DT. (2006). Comparative analysis of follicle morphology and oocyte diameter in four mammalian species (mouse, hamster, pig, and human). J. Exp. Clin. Assist. Reprod. , 3, 2. PMID: 16509981 DOI.
  14. Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D & Ottolenghi C. (2009). Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev. Biol. , 9, 36. PMID: 19538736 DOI.
  15. Felix W. The development of the urinogenital organs. In Keibel F. and Mall FP. Manual of Human Embryology II. (1912) J. B. Lippincott Company, Philadelphia. pp 752-979.
  16. Khadilkar VV, Khadilkar AV, Kinare AS, Tapasvi HS, Deshpande SS & Maskati GB. (2006). Ovarian and uterine ultrasonography in healthy girls between birth to 18 years. Indian Pediatr , 43, 625-30. PMID: 16891683
  17. Baerwald AR, Adams GP & Pierson RA. (2005). Form and function of the corpus luteum during the human menstrual cycle. Ultrasound Obstet Gynecol , 25, 498-507. PMID: 15846762 DOI.
  18. Simmer HH. (1971). The first experiments to demonstrate an endocrine function of the corpus luteum. On the occasion of the 100th birthday of Ludwig Fraenkel (1870-1951). Sudhoffs Arch , 55, 392-417. PMID: 4261581
  19. Hummitzsch K, Irving-Rodgers HF, Hatzirodos N, Bonner W, Sabatier L, Reinhardt DP, Sado Y, Ninomiya Y, Wilhelm D & Rodgers RJ. (2013). A new model of development of the mammalian ovary and follicles. PLoS ONE , 8, e55578. PMID: 23409002 DOI.
  20. Yaba A & Demir N. (2012). The mechanism of mTOR (mammalian target of rapamycin) in a mouse model of polycystic ovary syndrome (PCOS). J Ovarian Res , 5, 38. PMID: 23185989 DOI.
  21. Sirmans SM & Pate KA. (2013). Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol , 6, 1-13. PMID: 24379699 DOI.
  22. Azziz R & Adashi EY. (2016). Stein and Leventhal: 80 years on. Am. J. Obstet. Gynecol. , 214, 247.e1-247.e11. PMID: 26704896 DOI.
  23. Caldwell ASL, Edwards MC, Desai R, Jimenez M, Gilchrist RB, Handelsman DJ & Walters KA. (2017). Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome. Proc. Natl. Acad. Sci. U.S.A. , 114, E3334-E3343. PMID: 28320971 DOI.
  24. Chakraborty P, Goswami SK, Rajani S, Sharma S, Kabir SN, Chakravarty B & Jana K. (2013). Recurrent pregnancy loss in polycystic ovary syndrome: role of hyperhomocysteinemia and insulin resistance. PLoS ONE , 8, e64446. PMID: 23700477 DOI.
  25. Chen ZJ, Zhao H, He L, Shi Y, Qin Y, Shi Y, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J & Zhao Y. (2011). Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat. Genet. , 43, 55-9. PMID: 21151128 DOI.
  26. Flesken-Nikitin A, Hwang CI, Cheng CY, Michurina TV, Enikolopov G & Nikitin AY. (2013). Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature , 495, 241-5. PMID: 23467088 DOI.

Reviews

Escobar-Morreale HF. (2018). Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol , 14, 270-284. PMID: 29569621 DOI.

Nef S & Vassalli JD. (2009). Complementary pathways in mammalian female sex determination. J. Biol. , 8, 74. PMID: 19735582 DOI.

Hultén MA, Patel S, Jonasson J & Iwarsson E. (2010). On the origin of the maternal age effect in trisomy 21 Down syndrome: the Oocyte Mosaicism Selection model. Reproduction , 139, 1-9. PMID: 19755486 DOI.

Articles

Duffin K, Bayne RA, Childs AJ, Collins C & Anderson RA. (2009). The forkhead transcription factor FOXL2 is expressed in somatic cells of the human ovary prior to follicle formation. Mol. Hum. Reprod. , 15, 771-7. PMID: 19706741 DOI.

Search Pubmed

Search Pubmed: Ovary Development | Follicle Development | Follicle Atresia

Additional Images

Historic Images

Historic Disclaimer - information about historic embryology pages 
Mark Hill.jpg
Pages where the terms "Historic Textbook" and "Historic Embryology" appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms and interpretations may not reflect our current scientific understanding.     (More? Embryology History | Historic Embryology Papers)

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.


Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Genital Links: genital | Lecture - Medicine | Lecture - Science | Lecture Movie | Medicine - Practical | primordial germ cell | meiosis | Female | X | ovary | corpus luteum | oocyte | uterus | vagina | reproductive cycles | menstrual cycle | Male | Y | SRY | testis | spermatozoa | ductus deferens | penis | prostate | endocrine gonad‎ | Genital Movies | genital abnormalities | Assisted Reproductive Technology | puberty | Category:Genital
Historic Embryology - Genital 
1901 Urinogenital Tract | 1902 The Uro-Genital System | 1904 Ovary and Testis | 1904 Leydig Cells | 1904 Hymen | 1905 Testis vascular | 1909 Prostate | 1912 Prostate | 1912 Urinogenital Organ Development | 1914 External Genitalia | 1914 Female | 1915 Cowper’s and Bartholin’s Glands | 1920 Wolffian tubules | 1921 Urogenital Development | 1921 External Genital | 1927 Female Foetus 15 cm | 1932 Postnatal Ovary | 1935 Prepuce | 1935 Wolffian Duct | 1942 Sex Cords | 1943 Testes Descent | 1953 Germ Cells | Historic Embryology Papers | Historic Disclaimer

| Menstrual Cycle | X Chromosome



Cite this page: Hill, M.A. (2019, September 20) Embryology Ovary Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Ovary_Development

What Links Here?
© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G