Organoids

Embryology - 25 Apr 2024 Expand to Translate
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Introduction

Human Blastocyst (Carnegie Stage 3)

Organoids stem cell derived self-organized three-dimensional in vitro tissue cultures. These cultures have been be manipulated to replicate some of the complexity of an in vivo organ, or to produce only certain types of organ related cells.

Some Recent Findings

Generation of human oogonia from induced pluripotent stem cells in vitro^[1] "Human pluripotent stem cells (hPSCs) have been induced into primordial germ cell-like cells (hPGCLCs); however, further differentiation to a mature germ cell has not been achieved. Here, we show that hPGCLCs differentiate progressively into oogonia-like cells during a long-term in vitro culture (~four months) in xenogeneic reconstituted ovaries with mouse embryonic ovarian somatic cells. The hPGCLC-derived oogonia display hallmarks of epigenetic reprogramming, i.e., genome-wide DNA demethylation, imprint erasure, and extinguishment of aberrant DNA methylation in hPSCs, and acquire an immediate precursory state for meiotic recombination. Furthermore, the inactive X chromosome shows a progressive demethylation and reactivation, albeit partially. These findings establish the germline competence of hPSCs and provide a critical step toward human in vitro gametogenesis." oocyte

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Organoids \| Culture Organoid Culture

Older papers

References

↑ Yamashiro C, Sasaki K, Yabuta Y, Kojima Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T & Saitou M. (2018). Generation of human oogonia from induced pluripotent stem cells in vitro. Science , , . PMID: 30237246 DOI.

Journals

Reviews

Trounson A & DeWitt ND. (2016). Pluripotent stem cells progressing to the clinic. Nat. Rev. Mol. Cell Biol. , 17, 194-200. PMID: 26908143 DOI.

Articles

Pekkanen-Mattila M, Pelto-Huikko M, Kujala V, Suuronen R, Skottman H, Aalto-Setälä K & Kerkelä E. (2010). Spatial and temporal expression pattern of germ layer markers during human embryonic stem cell differentiation in embryoid bodies. Histochem. Cell Biol. , 133, 595-606. PMID: 20369364 DOI.

Search PubMed

May 2006 "stem cell" 154,176 reference articles of which 16,449 were reviews.

Search PubMed Now: stem cell | embryonic stem cell | adult stem cell |

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

NIH (USA) Human Embryonic Stem Cell Registry | [feed://hescregapp.od.nih.gov/hesc.xml RSS]
StemBook - Table of Contents
International Society for Stem Cell Research (ISSCR) is an independent, nonprofit organization formed in 2002 to foster the exchange of information on stem cell research.
University of Michigan Stem Cells Explained
Transcript of discussion on ABC Radio (Dr. J Kahn , Dr. JWagner) on Genetic Technology And Ethics
A brief article on Cord Blood stem cells and their therapeutic potential from the BBC.
Monash University (Australia) Monash Immunology and Stem Cell Laboratories (MISCL)
Europe - ESTOOLS DATA@HAND "resource contains human gene expression array data from 97 GEO and ArrayExpress sample sets, which involve altogether 1674 Affymetrix, Illumina and Agilent arrays. The source of the biological samples is mainly pluripotent stem cells, their differentiated progeny, and their parent cells. All data has been preprocessed so as to enable computational analysis with analysis workflows and tools provided."

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, April 25) Embryology Organoids. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Organoids

What Links Here?

[PMID30237246-1] Yamashiro C, Sasaki K, Yabuta Y, Kojima Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T & Saitou M. (2018). Generation of human oogonia from induced pluripotent stem cells in vitro. Science , , . PMID: 30237246 DOI.

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