Organoids

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Introduction

Human Blastocyst (Carnegie Stage 3)

Organoids stem cell derived self-organized three-dimensional in vitro tissue cultures. These cultures have been be manipulated to replicate some of the complexity of an in vivo organ, or to produce only certain types of organ related cells.

Stem Cell Links: Introduction | Timeline | Placental Cord Blood | Adult | Induced | Yamanaka Factors | Somatic Cell Nuclear Transfer | Ethics | Organoids | Category:Stem Cell

Some Recent Findings

  • Generation of human oogonia from induced pluripotent stem cells in vitro[1] "Human pluripotent stem cells (hPSCs) have been induced into primordial germ cell-like cells (hPGCLCs); however, further differentiation to a mature germ cell has not been achieved. Here, we show that hPGCLCs differentiate progressively into oogonia-like cells during a long-term in vitro culture (~four months) in xenogeneic reconstituted ovaries with mouse embryonic ovarian somatic cells. The hPGCLC-derived oogonia display hallmarks of epigenetic reprogramming, i.e., genome-wide DNA demethylation, imprint erasure, and extinguishment of aberrant DNA methylation in hPSCs, and acquire an immediate precursory state for meiotic recombination. Furthermore, the inactive X chromosome shows a progressive demethylation and reactivation, albeit partially. These findings establish the germline competence of hPSCs and provide a critical step toward human in vitro gametogenesis." oocyte


More recent papers  
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Search term: Organoids | Culture Organoid Culture

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References

  1. Yamashiro C, Sasaki K, Yabuta Y, Kojima Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T & Saitou M. (2018). Generation of human oogonia from induced pluripotent stem cells in vitro. Science , , . PMID: 30237246 DOI.

Journals

Reviews

Trounson A & DeWitt ND. (2016). Pluripotent stem cells progressing to the clinic. Nat. Rev. Mol. Cell Biol. , 17, 194-200. PMID: 26908143 DOI.


Articles

Pekkanen-Mattila M, Pelto-Huikko M, Kujala V, Suuronen R, Skottman H, Aalto-Setälä K & Kerkelä E. (2010). Spatial and temporal expression pattern of germ layer markers during human embryonic stem cell differentiation in embryoid bodies. Histochem. Cell Biol. , 133, 595-606. PMID: 20369364 DOI.


Search PubMed

May 2006 "stem cell" 154,176 reference articles of which 16,449 were reviews.

Search PubMed Now: stem cell | embryonic stem cell | adult stem cell |


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Cite this page: Hill, M.A. (2019, November 13) Embryology Organoids. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Organoids

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