Neural System - Molecular

Embryology - 23 Apr 2024        Expand to Translate
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Introduction

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Some Recent Findings

More recent papers

This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Notch <pubmed limit=5>Notch</pubmed>

Notch

Developmental Signals - Notch

Spinal Cord

Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes. Caudal to rostral decreasing FGF gradient, leads to Delta-1 expression decrease in cells that leave the stem zone (light blue) and move into the PNTZ where they intermingle with cells that do not express Delta-1. Generates differences in DELTA/NOTCH signalling between adjacent cells that may initiate lateral inhibition. Upregulation of Delta-1 in single NP cells which signal (blue arrows) and activate NOTCH signalling in adjacent cells, which as a consequence express Hes5 and are maintained in a proliferating state. Delta-1 expressing NP cell divides into two cells that express Tis21. Double Delta-1/Tis21 labelled NP down regulate the expression of Delta-1 as they reach the NZ and begin to divide in a neurogenic manner. One of the daughter cells upregulates Delta-1 expression and differentiates as a neuron while the other one, which receives NOTCH signalling (blue arrows), remains as neurogenic NP. Hensen node (HN), neural tube (NT), neurogenic zone (NZ), proliferation to neurogenesis transition zone (PNTZ), presomitic territory (PS), somite (S).

Hypothalamus

Hypothalamus Development Gene Interaction Model

Links: Hypothalamus Development

References

Reviews

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Search Bookshelf Notch

Search Pubmed Now: Notch Signaling

External Links

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• OMIM - NOTCH 1

Glossary Links

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Cite this page: Hill, M.A. (2024, April 23) Embryology Neural System - Molecular. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_System_-_Molecular

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G