Neural System - Molecular: Difference between revisions
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''Draft Page - notice removed when complete.'' | ''Draft Page - notice removed when complete.'' | ||
[[File:Brain stem subdivisions 01.jpg|alt=Brain stem subdivisions|600px]] | |||
New Brain Stem Subdivisions{{#pmid:30809133|PMID30809133}} | |||
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{{Factor Links}} | {{Factor Links}} | ||
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{{Mechanism Links}} | {{Mechanism Links}} | ||
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{{Molecular System Links}} | |||
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{{Neural Links}} | |||
==Some Recent Findings== | ==Some Recent Findings== | ||
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* '''Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates'''{{#pmid:32375049|PMID32375049}} "Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here, we use RNA sequencing, cell imaging, and lineage tracing of mouse and human in vitro NSCs and monkey brain sections to model the generation of cortical neuronal fates. We show that conserved signaling mechanisms regulate the acute transition from proliferative NSCs to committed glutamatergic excitatory neurons. As human telencephalic NSCs develop from pluripotency in vitro, they transition through organizer states that spatially pattern the cortex before generating glutamatergic precursor fates. NSCs derived from multiple human pluripotent lines vary in these early patterning states, leading differentially to dorsal or ventral telencephalic fates. This work furthers systematic analyses of the earliest patterning events that generate the major neuronal trajectories of the human {{telencephalon}}." | |||
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Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Notch ''Notch''] | Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Notch ''Notch''] | ||
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===Spinal Cord=== | ===Spinal Cord=== | ||
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| Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes. | | Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.{{#pmid:18000541|PMID18000541}} | ||
* Caudal to rostral decreasing FGF gradient, leads to Delta-1 expression decrease in cells that leave the stem zone (light blue) and move into the PNTZ where they intermingle with cells that do not express Delta-1. | * Caudal to rostral decreasing FGF gradient, leads to Delta-1 expression decrease in cells that leave the stem zone (light blue) and move into the PNTZ where they intermingle with cells that do not express Delta-1. | ||
* Generates differences in DELTA/NOTCH signalling between adjacent cells that may initiate lateral inhibition. | * Generates differences in DELTA/NOTCH signalling between adjacent cells that may initiate lateral inhibition. | ||
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[[File:Hypothalamus gene interaction model.jpg|600px]] | [[File:Hypothalamus gene interaction model.jpg|600px]] | ||
Hypothalamus Development Gene Interaction Model | Hypothalamus Development Gene Interaction Model{{#pmid:24360028|PMID24360028}} | ||
:'''Links:''' [[Endocrine_-_Hypothalamus_Development|Hypothalamus Development]] | :'''Links:''' [[Endocrine_-_Hypothalamus_Development|Hypothalamus Development]] | ||
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===Reviews=== | ===Reviews=== | ||
===Search Pubmed=== | ===Search Pubmed=== |
Latest revision as of 10:11, 13 May 2020
Embryology - 19 Apr 2024 Expand to Translate |
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Introduction
Draft Page - notice removed when complete.
New Brain Stem Subdivisions[1]
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
- Molecular System Links: Heart | Neural | Renal | Respiratory | Mechanisms | Factors | Molecular
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Notch |
Notch
Spinal Cord
Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.[3]
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Hypothalamus
Hypothalamus Development Gene Interaction Model[4]
- Links: Hypothalamus Development
References
- ↑ Watson C, Bartholomaeus C & Puelles L. (2019). Time for Radical Changes in Brain Stem Nomenclature-Applying the Lessons From Developmental Gene Patterns. Front Neuroanat , 13, 10. PMID: 30809133 DOI.
- ↑ Micali N, Kim SK, Diaz-Bustamante M, Stein-O'Brien G, Seo S, Shin JH, Rash BG, Ma S, Wang Y, Olivares NA, Arellano JI, Maynard KR, Fertig EJ, Cross AJ, Bürli RW, Brandon NJ, Weinberger DR, Chenoweth JG, Hoeppner DJ, Sestan N, Rakic P, Colantuoni C & McKay RD. (2020). Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates. Cell Rep , 31, 107599. PMID: 32375049 DOI.
- ↑ Hämmerle B & Tejedor FJ. (2007). A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. PLoS ONE , 2, e1169. PMID: 18000541 DOI.
- ↑ Ratié L, Ware M, Barloy-Hubler F, Romé H, Gicquel I, Dubourg C, David V & Dupé V. (2013). Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. Neural Dev , 8, 25. PMID: 24360028 DOI.
Reviews
Search Pubmed
Search Bookshelf Notch
Search Pubmed Now: Notch Signaling
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- OMIM - NOTCH 1
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Cite this page: Hill, M.A. (2024, April 19) Embryology Neural System - Molecular. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_System_-_Molecular
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G