Neural Crest - Cardiac: Difference between revisions

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Introduction

Cardiac Neural Crest Migration

Draft Page (notice removed when completed).

Cardiac neural crest has an important contribution to the developing heart outflow tract.^[1] It has been shown to not contribute to any of the heart conduction system.^[2]

These projects are the sole work of undergraduate science students and may contain errors in fact or descriptions.

Historic Embryology - Neural Crest
1879 Olfactory Organ \| 1905 Cranial and Spinal Nerves \| 1908 10 mm Peripheral \| 1910 Mammal Sympathetic \| 1920 Human Sympathetic \| 1928 Cranial ganglia \| 1939 10 Somite Embryo \| 1942 Origin \| 1957 Adrenal

Cardiovascular System Development

Some Recent Findings

Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion^[3] "Proper development of the great vessels of the heart and septation of the cardiac outflow tract requires cardiac neural crest cells. These cells give rise to the parasympathetic cardiac ganglia, the smooth muscle layer of the great vessels, some cardiomyocytes, and the conotruncal cushions and aorticopulmonary septum of the outflow tract. Ablation of cardiac neural crest cells results in defective patterning of each of these structures. Previous studies have shown that targeted deletion of the forkhead transcription factor C2 (Foxc2), results in cardiac phenotypes similar to that derived from cardiac neural crest cell ablation. We report that Foxc2-/- embryos on the 129s6/SvEv inbred genetic background display persistent truncus arteriosus and hypoplastic ventricles before embryonic lethality. Foxc2 loss-of-function resulted in perturbed cardiac neural crest cell migration and their reduced contribution to the outflow tract as evidenced by lineage tracing analyses together with perturbed expression of the neural crest cell markers Sox10 and Crabp1. Foxc2 loss-of-function also resulted in alterations in PlexinD1, Twist1, PECAM1, and Hand1/2 expression in association with vascular and ventricular defects." heart | Foxc2

FGF8 signaling is chemotactic for cardiac neural crest cells^[4] "neural crest cells migrate into the pharyngeal arches where they support development of the pharyngeal arch arteries. The pharyngeal endoderm and ectoderm both express high levels of FGF8. We hypothesized that FGF8 is chemotactic for cardiac crest cells. To begin testing this hypothesis, cardiac crest was explanted for migration assays under various conditions. Cardiac neural crest cells migrated more in response to FGF8."

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Cardiac Neural Crest <pubmed limit=5>Cardiac Crest</pubmed>

Older papers
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table. See also the Discussion Page for other references listed by year and References on this current page.

Cardiac Neural Crest

<pubmed limit=5>Cardiac Neural Crest</pubmed>

References

↑ Creazzo TL, Godt RE, Leatherbury L, Conway SJ & Kirby ML. (1998). Role of cardiac neural crest cells in cardiovascular development. Annu. Rev. Physiol. , 60, 267-86. PMID: 9558464 DOI.
↑ Boullin J & Morgan JM. (2005). The development of cardiac rhythm. Heart , 91, 874-5. PMID: 15958352 DOI.
↑ Inman KE, Caiaffa CD, Melton KR, Sandell LL, Achilleos A, Kume T & Trainor PA. (2018). Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion. Dev. Dyn. , 247, 1286-1296. PMID: 30376688 DOI.
↑ Rosa AL, Alvarez ME, Lawson D & Maccioni HJ. (1990). A polypeptide of 59 kDa is associated with bundles of cytoplasmic filaments in Neurospora crassa. Biochem. J. , 268, 649-55. PMID: 2141976

Reviews

Plein A, Fantin A & Ruhrberg C. (2015). Neural crest cells in cardiovascular development. Curr. Top. Dev. Biol. , 111, 183-200. PMID: 25662261 DOI.

Keyte AL, Alonzo-Johnsen M & Hutson MR. (2014). Evolutionary and developmental origins of the cardiac neural crest: building a divided outflow tract. Birth Defects Res. C Embryo Today , 102, 309-23. PMID: 25227322 DOI.

Creazzo TL, Godt RE, Leatherbury L, Conway SJ & Kirby ML. (1998). Role of cardiac neural crest cells in cardiovascular development. Annu. Rev. Physiol. , 60, 267-86. PMID: 9558464 DOI.

Articles

Glossary Links

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Cite this page: Hill, M.A. (2024, April 16) Embryology Neural Crest - Cardiac. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Cardiac

What Links Here?

[PMID9558464-1] Creazzo TL, Godt RE, Leatherbury L, Conway SJ & Kirby ML. (1998). Role of cardiac neural crest cells in cardiovascular development. Annu. Rev. Physiol. , 60, 267-86. PMID: 9558464 DOI.

[PMID15958352-2] Boullin J & Morgan JM. (2005). The development of cardiac rhythm. Heart , 91, 874-5. PMID: 15958352 DOI.

[PMID30376688-3] Inman KE, Caiaffa CD, Melton KR, Sandell LL, Achilleos A, Kume T & Trainor PA. (2018). Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion. Dev. Dyn. , 247, 1286-1296. PMID: 30376688 DOI.

[PMID2141976-4] Rosa AL, Alvarez ME, Lawson D & Maccioni HJ. (1990). A polypeptide of 59 kDa is associated with bundles of cytoplasmic filaments in Neurospora crassa. Biochem. J. , 268, 649-55. PMID: 2141976

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
+{{Header}}
 ==Introduction==
+[[File:Cardiac Neural Crest Migration.jpg|thumb|alt=Cardiac Neural Crest Migration|Cardiac Neural Crest Migration]]
+Draft Page (notice removed when completed).
+Cardiac neural crest has an important contribution to the developing heart outflow tract.{{#pmid:9558464|PMID9558464}} It has been shown to not contribute to any of the heart conduction system.{{#pmid:15958352|PMID15958352}}
+{{Neural Crest Links}}
+[[Cardiovascular System Development]]
+==Some Recent Findings==
+{|
+|-bgcolor="F5FAFF"
+|
+* '''Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion'''{{#pmid:30376688|PMID30376688}} "Proper development of the great vessels of the heart and septation of the cardiac outflow tract requires cardiac neural crest cells. These cells give rise to the parasympathetic cardiac ganglia, the smooth muscle layer of the great vessels, some cardiomyocytes, and the conotruncal cushions and aorticopulmonary septum of the outflow tract. Ablation of cardiac neural crest cells results in defective patterning of each of these structures. Previous studies have shown that targeted deletion of the forkhead transcription factor C2 ([https://www.omim.org/entry/602402 Foxc2]), results in cardiac phenotypes similar to that derived from cardiac neural crest cell ablation. We report that Foxc2-/- embryos on the 129s6/SvEv inbred genetic background display persistent truncus arteriosus and hypoplastic ventricles before embryonic lethality. Foxc2 loss-of-function resulted in perturbed cardiac neural crest cell migration and their reduced contribution to the outflow tract as evidenced by lineage tracing analyses together with perturbed expression of the neural crest cell markers Sox10 and Crabp1. Foxc2 loss-of-function also resulted in alterations in PlexinD1, Twist1, PECAM1, and Hand1/2 expression in association with vascular and ventricular defects." {{heart}} | [https://www.omim.org/entry/602402 Foxc2]
+* '''{{FGF}}8 signaling is chemotactic for cardiac neural crest cells'''{{#pmid:2141976|PMID2141976}} "neural crest cells migrate into the pharyngeal arches where they support development of the pharyngeal arch arteries. The pharyngeal endoderm and ectoderm both express high levels of FGF8.  We hypothesized that FGF8 is chemotactic for cardiac crest cells. To begin testing this hypothesis, cardiac crest was explanted for migration assays under various conditions. Cardiac neural crest cells migrated more in response to FGF8."
+|}
+{| class="wikitable mw-collapsible mw-collapsed"
+! More recent papers &nbsp;
+|-
+| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}}
-Draft Page (notice removed when completed).
+Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Cardiac+Neural+Crest ''Cardiac Neural Crest'']
+<pubmed limit=5>Cardiac Crest</pubmed>
+|}
+{| class="wikitable mw-collapsible mw-collapsed"
+! Older papers &nbsp;
+|-
+| {{Older papers}}
+|}
-{{Neural Crest Links}}| [[Cardiovascular System Development]]
+===Cardiac Neural Crest===
+<pubmed limit=5>Cardiac Neural Crest</pubmed>
-==2011==
-===FGF8 signaling is chemotactic for cardiac neural crest cells===
+==References==
-Dev Biol. 2011 Jun 1;354(1):18-30. doi: 10.1016/j.ydbio.2011.03.010. Epub 2011 Mar 17.
-Sato A, Scholl AM, Kuhn EN, Stadt HA, Decker JR, Pegram K, Hutson MR, Kirby ML.
+<references/>
-Source
-Department of Pediatrics (Neonatology), Duke University, Durham, NC 27710, USA.
-Erratum in
-Dev Biol. 2012 Oct 1;370(1):164. Kuhn, E B [corrected to Kuhn, E N].
-Abstract
-Cardiac neural crest cells migrate into the pharyngeal arches where they support development of the pharyngeal arch arteries. The pharyngeal endoderm and ectoderm both express high levels of FGF8. We hypothesized that FGF8 is chemotactic for cardiac crest cells. To begin testing this hypothesis, cardiac crest was explanted for migration assays under various conditions. Cardiac neural crest cells migrated more in response to FGF8. Single cell tracing indicated that this was not due to proliferation and subsequent transwell assays showed that the cells migrate toward an FGF8 source. The migratory response was mediated by FGF receptors (FGFR) 1 and 3 and MAPK/ERK intracellular signaling. To test whether FGF8 is chemokinetic and/or chemotactic in vivo, dominant negative FGFR1 was electroporated into the premigratory cardiac neural crest. Cells expressing the dominant negative receptor migrated slower than normal cardiac neural crest cells and were prone to remain in the vicinity of the neural tube and die. Treating with the FGFR1 inhibitor, SU5402 or an FGFR3 function-blocking antibody also slowed neural crest migration. FGF8 over-signaling enhanced neural crest migration. Neural crest cells migrated to an FGF8-soaked bead placed dorsal to the pharynx. Finally, an FGF8 producing plasmid was electroporated into an ectopic site in the ventral pharyngeal endoderm. The FGF8 producing cells attracted a thick layer of mesenchymal cells. DiI labeling of the neural crest as well as quail-to-chick neural crest chimeras showed that neural crest cells migrated to and around the ectopic site of FGF8 expression. These results showing that FGF8 is chemotactic and chemokinetic for cardiac neural crest adds another dimension to understanding the relationship of FGF8 and cardiac neural crest in cardiovascular defects.
-Copyright © 2011 Elsevier Inc. All rights reserved.
-PMID 2141976
+===Reviews===
-==2010==
+{{#pmid:25662261}}
-===Factors controlling cardiac neural crest cell migration===
-Cell Adh Migr. 2010 Oct-Dec;4(4):609-21.
+{{#pmid:25227322}}
-Kirby ML, Hutson MR.
+{{#pmid:9558464}}
-Source
-Department of Pediatrics, Duke University, Durham, NC, USA. mlkirby@duke.edu
-Abstract
-Cardiac neural crest cells originate as part of the postotic caudal rhombencephalic neural crest stream. Ectomesenchymal cells in this stream migrate to the circumpharyngeal ridge and then into the caudal pharyngeal arches where they condense to form first a sheath and then the smooth muscle tunics of the persisting pharyngeal arch arteries. A subset of the cells continue migrating into the cardiac outflow tract where they will condense to form the aorticopulmonary septum. Cell signaling, extracellular matrix and cell-cell contacts are all critical for the initial migration, pauses, continued migration, and condensation of these cells. This review elucidates what is currently known about these factors.
-PMID 20890117
+===Articles===
-==10 Most Recent==
-{{10 Most Recent}}
-===Cardiac Neural Crest===
-<pubmed limit=5>Cardiac Neural Crest</pubmed>
-{{Template:Glossary}}
+{{Glossary}}
-{{Template:Footer}}
+{{Footer}}
-[[Category:Heart]] [[Category:Neural Crest]]
+[[Category:Heart]] [[Category:Neural Crest]] [[Category:Cardiovascular]]