Neural - Tectum Development: Difference between revisions
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* '''Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development'''<ref name "PMID22390724"><pubmed>22390724</pubmed>| [http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref> "During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7." | |||
Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development<ref name "PMID22390724"><pubmed>22390724</pubmed>| [http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref> "During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7." | |||
* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref> | * '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref> | ||
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[[Talk:Neural - Tectum Development|Recent References]] | [[#References|References]] | [[Talk:Neural - Tectum Development|Recent References]] | [[#References|References]] | ||
==Developmental Signaling Model== | |||
[[File:Tectum signaling model 01.jpg]] | |||
Model of interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. <ref name "PMID22390724"><pubmed>22390724</pubmed>| [http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref> | |||
== Development Overview == | == Development Overview == |
Revision as of 07:52, 11 June 2012
Introduction
Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.
The early central nervous system begins as a simple neural plate that folds to form a groove then tube, open initially at each end. Failure of these opening to close contributes a major class of neural abnormalities (neural tube defects).
Within the neural tube stem cells generate the 2 major classes of cells that make the majority of the nervous system : neurons and glia. Both these classes of cells differentiate into many different types generated with highly specialized functions and shapes. This section covers the establishment of neural populations, the inductive influences of surrounding tissues and the sequential generation of neurons establishing the layered structure seen in the brain and spinal cord.
- Neural development beginnings quite early, therefore also look at notes covering Week 3- neural tube and Week 4-early nervous system.
- Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in other notes sections.
Some Recent Findings
|
Recent References | References
Developmental Signaling Model
Model of interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. [3]
Development Overview
Neuralation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.
- Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest
Neural Tube | Primary Vesicles | Secondary Vesicles | Adult Structures |
---|---|---|---|
week 3 | week 4 | week 5 | adult |
prosencephalon (forebrain) | telencephalon | Rhinencephalon, Amygdala, hippocampus, cerebrum (cortex), hypothalamus, pituitary | Basal Ganglia, lateral ventricles | |
diencephalon | epithalamus, thalamus, Subthalamus, pineal, posterior commissure, pretectum, third ventricle | ||
mesencephalon (midbrain) | mesencephalon | tectum, Cerebral peduncle, cerebral aqueduct, pons | |
rhombencephalon (hindbrain) | metencephalon | cerebellum | |
myelencephalon | medulla oblongata, isthmus | ||
spinal cord, pyramidal decussation, central canal |
Early Brain Vesicles
Primary Vesicles
Secondary Vesicles
References
- ↑ <pubmed>22390724</pubmed>| BMC Dev Biol.
- ↑ <pubmed>20558153</pubmed>
- ↑ <pubmed>22390724</pubmed>| BMC Dev Biol.
Reviews
<pubmed>19206138</pubmed>
Articles
<pubmed>18230116</pubmed>
Search PubMed
Search Pubmed: Tectum Embryology | Tectum Development
Glossary Links
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Cite this page: Hill, M.A. (2024, April 19) Embryology Neural - Tectum Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Tectum_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G