Neural - Cranial Nerve Development: Difference between revisions
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! More recent papers | ! More recent papers | ||
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== Neural Development Overview == | == Neural Development Overview == | ||
Neuralation begins at the trilaminar embryo with formation of the notochord | Neuralation begins at the trilaminar embryo with formation of the {{notochord}} within the {{mesoderm}} that underlies the {{ectoderm}} and do not physically contribute to the nervous system, but is involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system. | ||
:'''Early developmental sequence:''' Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest | :'''Early developmental sequence:''' Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest | ||
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| Primary Terminal Nuclei of the Afferent (sensory) Cranial Nerves | | Primary Terminal Nuclei of the Afferent (sensory) Cranial Nerves | ||
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==CN I Olfactory== | ==CN I Olfactory== | ||
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Olfactory Nerve - Human fetus ([[Week 10]]) | Olfactory Nerve - Human fetus ([[Week 10]]) | ||
| | | | ||
* sensory - olfactory receptor neuron axons | * '''sensory''' - olfactory receptor neuron axons | ||
* olfactory epithelium to cribriform plate of the ethmoid bone then to the olfactory bulb | * olfactory epithelium to cribriform plate of the ethmoid bone then to the olfactory bulb | ||
:'''Links:''' {{smell}} | |||
|} | |} | ||
==CN II Optic== | ==CN II Optic== | ||
{| | {| | ||
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Optic Nerve - Human embryo (week 8, [[Carnegie stage 22]]) | Optic Nerve - Human embryo (week 8, [[Carnegie stage 22]]) | ||
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* sensory - retinal ganglion neuron axons | * '''sensory''' - retinal ganglion neuron axons | ||
* development - CNS out-pouching of the diencephalon (optic stalks) | * development - CNS out-pouching of the diencephalon (optic stalks) | ||
* optic nerve fibres covered with myelin produced by oligodendrocytes | * optic nerve fibres covered with myelin produced by oligodendrocytes | ||
* ensheathed in all three meningeal layers (dura, arachnoid, and pia mater) | * ensheathed in all three meningeal layers (dura, arachnoid, and pia mater) | ||
:'''Links:''' {{vision}} | |||
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==CN III Oculomotor== | ==CN III Oculomotor== | ||
motor - innervates muscles that enable most eye movement | '''motor''' - innervates muscles that enable most eye movement | ||
development - oculomotor nerve is derived from the basal plate of the embryonic midbrain | development - oculomotor nerve is derived from the basal plate of the embryonic midbrain | ||
:'''Links:''' {{vision}} | |||
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==CN IV Trochlear== | ==CN IV Trochlear== | ||
motor - innervates the superior oblique muscle that enables eye movement | '''motor''' - innervates the superior oblique muscle that enables eye movement | ||
{| | {| | ||
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:'''Links:''' {{vision}} | |||
==CN V Trigeminal== | ==CN V Trigeminal== | ||
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mixed motor/sensory | mixed motor/sensory | ||
* sensory - provide tactile, proprioceptive, and nociceptive afference to the face and mouth. | * '''sensory''' - provide tactile, proprioceptive, and nociceptive afference to the face and mouth. | ||
* motor - innervate the skin of the face via ophthalmic (V1), maxillary (V2) and mandibular (V3) divisions. Special visceral efferent (SVE) axons innervate the muscles of mastication via the mandibular (V3) division. | * '''motor''' - innervate the skin of the face via ophthalmic (V1), maxillary (V2) and mandibular (V3) divisions. Special visceral efferent (SVE) axons innervate the muscles of mastication via the mandibular (V3) division. | ||
In the embryo, the trigeminal ganglia is first visible in week 4 [[Carnegie stage 10|stage 10]], initially developing from neural crest cells before neural fold fusion, and after fusion receive contributions from the neural tube roof plate.{{#pmid:17848161|PMID17848161}} | In the embryo, the trigeminal ganglia is first visible in week 4 [[Carnegie stage 10|stage 10]], initially developing from neural crest cells before neural fold fusion, and after fusion receive contributions from the neural tube roof plate.{{#pmid:17848161|PMID17848161}} | ||
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==CN VI Abducent== | ==CN VI Abducent== | ||
motor - innervates the lateral rectus muscle that enables eye movement | '''motor''' - innervates the lateral rectus muscle that enables eye movement | ||
development - from the basal plate of the embryonic pons | development - from the basal plate of the embryonic pons | ||
:'''Links:''' {{vision}} | |||
==CN VII Facial== | ==CN VII Facial== | ||
(N. Facialis; Seventh Nerve; CN VII) | (N. Facialis; Seventh Nerve; CN VII) | ||
{| | {| | ||
| | |Mixed motor/sensory | ||
* '''motor''' - innervates the muscles of facial expression | |||
* | * '''sensory''' - taste from the anterior two-thirds of the tongue and oral cavity | ||
* | |||
Development - second pharyngeal arch | |||
* motor derived from the basal plate of the embryonic pons | |||
* sensory derived from cranial neural crest | |||
:'''Links:''' {{vision}} | {{taste}} | |||
| rowspan=2|[[File:Gray0788.jpg|400px]] | | rowspan=2|[[File:Gray0788.jpg|400px]] | ||
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Facial nerve development - right facial nerve and its nucleus of origin (A. 10 mm embryo, C. neonate).<ref>{{Ref-Streeter1908cranial n}}</ref> | Facial nerve development - right facial nerve and its nucleus of origin (A. 10 mm embryo, C. neonate).<ref>{{Ref-Streeter1908cranial n}}</ref> | ||
==CN VIII Vestibulocochlear== | ==CN VIII Vestibulocochlear== | ||
Cranial nerve eight (CN VIII) In the embryo, cells derive from the otic placode forming the otic vesicle (otocyst). Ganglion previously thought to also involve otic neural crest (rhombomere 4){{#pmid:17848161|PMID17848161}}, but recent studies suggest an entirely placodal origin. In the adult, as in its name it consists of 2 parts vestibular (balance and position in space) and cochlear (hearing, spiral). | Cranial nerve eight (CN VIII) In the embryo, cells derive from the otic placode forming the otic vesicle (otocyst). Ganglion previously thought to also involve otic neural crest (rhombomere 4){{#pmid:17848161|PMID17848161}}, but recent studies suggest an entirely placodal origin. In the adult, as in its name it consists of 2 parts vestibular (balance and position in space) and cochlear (hearing, spiral). | ||
:'''Links:''' {{hearing}} | {{balance}} | |||
<br> | |||
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[[File:Baroreceptor reflex cartoon.jpg|thumb|Baroreceptor reflex CN IX, X{{#pmid:20184720|PMID20184720}}]] | [[File:Baroreceptor reflex cartoon.jpg|thumb|Baroreceptor reflex CN IX, X{{#pmid:20184720|PMID20184720}}]] | ||
==CN IX Glossopharyngeal== | ==CN IX Glossopharyngeal== | ||
Mixed motor/sensory and lies anterior to the medulla oblongata | |||
* '''Branchial motor''' (special visceral efferent) – supplies the stylopharyngeus muscle. | |||
lies anterior to the medulla oblongata | * '''Visceral motor''' (general visceral efferent) – provides parasympathetic innervation of the parotid gland via the otic ganglion. | ||
* '''Visceral sensory''' (general visceral afferent) – carries visceral sensory information from the carotid sinus and carotid body. | |||
Branchial motor (special visceral efferent) – supplies the stylopharyngeus muscle. | |||
Visceral motor (general visceral efferent) – provides parasympathetic innervation of the parotid gland via the otic ganglion. | |||
Visceral sensory (general visceral afferent) – carries visceral sensory information from the carotid sinus and carotid body. | |||
General sensory (general somatic afferent) – provides general sensory information from inner surface of the tympanic membrane, upper pharynx (GVA), and the posterior one-third of the tongue. | General sensory (general somatic afferent) – provides general sensory information from inner surface of the tympanic membrane, upper pharynx (GVA), and the posterior one-third of the tongue. | ||
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(pneumogastric nerve) responsible for heart rate, gastrointestinal peristalsis, sweating, and muscle movements in the mouth, including speech (via the recurrent laryngeal nerve) | (pneumogastric nerve) responsible for heart rate, gastrointestinal peristalsis, sweating, and muscle movements in the mouth, including speech (via the recurrent laryngeal nerve) | ||
Development | |||
* motor derived from the basal plate of the medulla oblongata | * motor derived from the basal plate of the medulla oblongata | ||
* sensory derived from cranial neural crest | * sensory derived from cranial {{neural crest}} | ||
==CN XI Accessory== | ==CN XI Accessory== | ||
motor - innervates the sternocleidomastoid and trapezius muscles | '''motor''' - innervates the sternocleidomastoid and trapezius muscles | ||
* sternomastoid - muscle superficial layer side of the neck, rotation of the head | * sternomastoid - muscle superficial layer side of the neck, rotation of the head | ||
* trapezius - superficial muscles from occipital bone to the lower thoracic vertebrae and laterally to the spine of the scapula, move the scapulae and support the arm | * trapezius - superficial muscles from occipital bone to the lower thoracic vertebrae and laterally to the spine of the scapula, move the scapulae and support the arm | ||
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:'''Links:''' | :'''Links:''' {{tongue}} | [[Paper - The development of the hypoglossal ganglia of pig embryos|1910 Pig hypoglossal ganglia development]] | ||
==Neonatal - Clinical== | ==Neonatal - Clinical== |
Revision as of 14:00, 6 May 2018
Embryology - 20 Apr 2024 ![]() ![]() ![]() |
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Introduction
![](/embryology/images/thumb/9/96/Human_Stage14_neural02.jpg/300px-Human_Stage14_neural02.jpg)
The cranial nerves (ganglia) are represented by a roman numeral (I - XII) and many have additional historic names. They are paired, and can be mixed (motor/sensory), and the brain equivalent of the spinal cord spinal nerves.
In embryonic development, the trigeminal ganglia (CN V, historically the semilunar ganglion, Gasser's ganglion or Gasserian ganglion) is the first to become apparent and is the largest of the cranial nerves. Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system. Differences between birds and mammals:
Neural development beginnings quite early, therefore also look at notes covering Week 3- neural tube and Week 4-early nervous system. Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in other notes sections. |
Cranial Nerves | |
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CN I | Olfactory |
CN II | Optic |
CN III | Oculomotor |
CN IV | Trochlear |
CN V | Trigeminal |
CN VI | Abducent |
CN VII | Facial |
CN VIII | Acoustic |
CN IX | Glossopharyngeal |
CN X | Vagus |
CN XI | Accessory |
CN XII | Hypoglossal |
Cranial Nerves | ||||
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Nerve Number | Name | Type | Origin | Function |
CN I | Olfactory | sensory | telencephalon | smell placode |
CN II | Optic | sensory | retinal ganglial cells | vision |
CN III | Oculomotor | motor | anterior midbrain | extraocular muscles eye movements and pupil dilation (motor) |
CN IV | Trochlear | motor | dorsal midbrain | extraocular muscles (superior oblique muscle) |
CN V | Trigeminal | motor/sensory | pons | touch, mastication |
CN VI | Abducent | motor | extraocular muscles | control eye movements (lateral rectus muscle) |
CN VII | Facial | motor/sensory | pons | facial expression, taste (tongue anterior and central regions) regulate salivary production. |
CN VIII | Acoustic | sensory | vestibular and cochlear nuclei | hearing, placode |
CN IX | Glossopharyngeal | motor/sensory | medulla | swallowing and speech, taste (tongue posterior region) |
CN X | Vagus | motor/sensory | medulla | larynx and pharynx muscles (speech and swallowing), regulates heartbeat, sweating, and peristalsis |
CN XI | Accessory | motor | motor neurons | sternocleidomastoid and trapezius muscles |
CN XII | Hypoglossal | motor | motor neurons | tongue muscles (speech, eating and other oral functions) |
Cranial Nerve Links: Neural | Neural Crest | CN I | CN II | CN III| CN IV | CN V | CN VI | CN VII | CN VIII | CN IX | CN X | CN XI | CN XII | placodes | Category:Cranial Nerve |
Some Recent Findings
![](/embryology/images/thumb/f/f1/Mouse_cranial_nerve_model_SHH.jpg/300px-Mouse_cranial_nerve_model_SHH.jpg)
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Cranial Nerve Development <pubmed limit=5>Cranial Nerve Development</pubmed> |
Neural Development Overview
Neuralation begins at the trilaminar embryo with formation of the notochord within the mesoderm that underlies the ectoderm and do not physically contribute to the nervous system, but is involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.
- Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest
Neural Tube | Primary Vesicles | Secondary Vesicles | Adult Structures |
---|---|---|---|
week 3 | week 4 | week 5 | adult |
prosencephalon (forebrain) | telencephalon | Rhinencephalon, Amygdala, hippocampus, cerebrum (cortex), hypothalamus, pituitary | Basal Ganglia, lateral ventricles | |
diencephalon | epithalamus, thalamus, Subthalamus, pineal, posterior commissure, pretectum, third ventricle | ||
mesencephalon (midbrain) | mesencephalon | tectum, Cerebral peduncle, cerebral aqueduct, pons | |
rhombencephalon (hindbrain) | metencephalon | cerebellum | |
myelencephalon | medulla oblongata, isthmus | ||
spinal cord, pyramidal decussation, central canal |
Embryonic Development
Cranial Nerve Development | |
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stage 14 | stage 16 |
Size Growth
Embryonic Central Nervous System | |||
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Stage 13 | Stage 14 | Stage 16 | Stage 21 |
![]() scale bar = 1 mm |
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Week 4 | Week 5 | Week 6 | Week 8 |
- Human CNS Images: Carnegie stage 13 | Carnegie stage 13 label | Carnegie stage 14 | Carnegie stage 14 label | Carnegie stage 16 | Carnegie stage 16 label | CN V | Carnegie stage 21 lateral | Carnegie stage 21 median | Fetus CRL 240mm | Neural System Development | Cranial Nerves
Motor and Sensory
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Cranial motor nerves brainstem nuclei of origin | Primary Terminal Nuclei of the Afferent (sensory) Cranial Nerves |
CN I Olfactory
![]() Olfactory Nerve - Human fetus (Week 10) |
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CN II Optic
![]() Optic Nerve - Human embryo (week 8, Carnegie stage 22) |
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CN III Oculomotor
motor - innervates muscles that enable most eye movement
development - oculomotor nerve is derived from the basal plate of the embryonic midbrain
- Links: vision
Historic Embryology |
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Mann IC. The developing third nerve nucleus in human embryos (1927) J Anat. 61(4): 424-438. PubMed 17104156 |
CN IV Trochlear
motor - innervates the superior oblique muscle that enables eye movement
Cranial Nerve | Rhombomere |
---|---|
trochlear | 1 |
trigeminal | 2–3 |
abducens | 5–6 |
facial | 4–5 |
- Links: vision
CN V Trigeminal
(semilunar ganglion, Gasser's ganglion or Gasserian ganglion)
three major branches - ophthalmic nerve (V1), maxillary nerve (V2), mandibular nerve (V3)
mixed motor/sensory
- sensory - provide tactile, proprioceptive, and nociceptive afference to the face and mouth.
- motor - innervate the skin of the face via ophthalmic (V1), maxillary (V2) and mandibular (V3) divisions. Special visceral efferent (SVE) axons innervate the muscles of mastication via the mandibular (V3) division.
In the embryo, the trigeminal ganglia is first visible in week 4 stage 10, initially developing from neural crest cells before neural fold fusion, and after fusion receive contributions from the neural tube roof plate.[3]
In the adult, cavum trigeminale (Meckel's cave) is an arachnoidal pouch containing cerebrospinal fluid. Though the dura and arachnoid layers end at the trigeminal ganglion and do not extend to cover the three branches of the trigeminal nerve.[4]
Gasser's ganglion or Gasserian ganglion
This historic terminology was given by Antonius Hirsh who described the ganglion in 1765 and then named the ganglion in the honour of his teacher, Johann Lorenz Gasser (1723-1765) an Austrian anatomist.
CN VI Abducent
motor - innervates the lateral rectus muscle that enables eye movement
development - from the basal plate of the embryonic pons
- Links: vision
CN VII Facial
(N. Facialis; Seventh Nerve; CN VII)
Mixed motor/sensory
Development - second pharyngeal arch
|
![]() Gray Fig. 788. Plan of the Facial and Intermediate Nerves and their Communication with Other Nerves |
The facial nerve (Figs. 788, 790) consists of a motor and a sensory part, the latter being frequently described under the name of the nervus intermedius (pars intermedii of Wrisberg) (Fig. 788). The two parts emerge at the lower border of the pons in the recess between the olive and the inferior peduncle, the motor part being the more medial, immediately to the lateral side of the sensory part is the acoustic nerve. |
Facial nerve development - right facial nerve and its nucleus of origin (A. 10 mm embryo, C. neonate).[5]
CN VIII Vestibulocochlear
Cranial nerve eight (CN VIII) In the embryo, cells derive from the otic placode forming the otic vesicle (otocyst). Ganglion previously thought to also involve otic neural crest (rhombomere 4)[3], but recent studies suggest an entirely placodal origin. In the adult, as in its name it consists of 2 parts vestibular (balance and position in space) and cochlear (hearing, spiral).
|
![]() Embryo (week 5, Stage 13) showing inner ear and CNVIII. |
![]() Embryo (week 8, Stage 2) showing otocyst and CNVIII. |
![](/embryology/images/thumb/f/f9/Baroreceptor_reflex_cartoon.jpg/300px-Baroreceptor_reflex_cartoon.jpg)
CN IX Glossopharyngeal
Mixed motor/sensory and lies anterior to the medulla oblongata
- Branchial motor (special visceral efferent) – supplies the stylopharyngeus muscle.
- Visceral motor (general visceral efferent) – provides parasympathetic innervation of the parotid gland via the otic ganglion.
- Visceral sensory (general visceral afferent) – carries visceral sensory information from the carotid sinus and carotid body.
General sensory (general somatic afferent) – provides general sensory information from inner surface of the tympanic membrane, upper pharynx (GVA), and the posterior one-third of the tongue.
Visceral afferent (special visceral afferent) – provides taste sensation from the posterior one-third of the tongue, including circumvallate papillae.
CN X Vagus
(pneumogastric nerve) responsible for heart rate, gastrointestinal peristalsis, sweating, and muscle movements in the mouth, including speech (via the recurrent laryngeal nerve)
Development
- motor derived from the basal plate of the medulla oblongata
- sensory derived from cranial neural crest
CN XI Accessory
motor - innervates the sternocleidomastoid and trapezius muscles
- sternomastoid - muscle superficial layer side of the neck, rotation of the head
- trapezius - superficial muscles from occipital bone to the lower thoracic vertebrae and laterally to the spine of the scapula, move the scapulae and support the arm
CN XII Hypoglossal
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Neonatal - Clinical
Examination of the baby’s cranial nerve function is often accomplished by observing spontaneous activity.
Newborn - Cranial Nerves | |||||||
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Normal | Abnormal |
Cranial Nerve Development: 3 months | 12 months | 18 months
- Links: Neural Exam Movies | Neonatal Development
Additional Images
Mouse E10.5 Nav2 expression[6]
Historic Images
Historic Disclaimer - information about historic embryology pages |
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Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History | Historic Embryology Papers) |
Thyng FW. The anatomy of a 17.8 mm human embryo. (1914) Amer. J Anat. 17: 31-112. Harvard Collection
References
- ↑ 1.0 1.1 Kurosaka H, Trainor PA, Leroux-Berger M & Iulianella A. (2015). Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling. PLoS ONE , 10, e0120821. PMID: 25799573 DOI.
- ↑ Sajgo S, Ali S, Popescu O & Badea TC. (2016). Dynamic expression of transcription factor Brn3b during mouse cranial nerve development. J. Comp. Neurol. , 524, 1033-61. PMID: 26356988 DOI.
- ↑ 3.0 3.1 O'Rahilly R & Müller F. (2007). The development of the neural crest in the human. J. Anat. , 211, 335-51. PMID: 17848161 DOI.
- ↑ Kehrli P, Maillot C & Wolff MJ. (1997). Anatomy and embryology of the trigeminal nerve and its branches in the parasellar area. Neurol. Res. , 19, 57-65. PMID: 9090638
- ↑ Streeter GL. The nuclei of origin of the cranial nerves in the 10 mm human embryo. (1908) Amer. J Anat. 2:111 - 115.
- ↑ 6.0 6.1 McNeill EM, Roos KP, Moechars D & Clagett-Dame M. (2010). Nav2 is necessary for cranial nerve development and blood pressure regulation. Neural Dev , 5, 6. PMID: 20184720 DOI.
Reviews
Greene ND & Copp AJ. (2009). Development of the vertebrate central nervous system: formation of the neural tube. Prenat. Diagn. , 29, 303-11. PMID: 19206138 DOI.
Barlow LA. (2002). Cranial nerve development: placodal neurons ride the crest. Curr. Biol. , 12, R171-3. PMID: 11882306
Articles
Saitsu H & Shiota K. (2008). Involvement of the axially condensed tail bud mesenchyme in normal and abnormal human posterior neural tube development. Congenit Anom (Kyoto) , 48, 1-6. PMID: 18230116 DOI.
Search PubMed
Search Pubmed: Tectum Embryology | Tectum Development
Glossary Links
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Cite this page: Hill, M.A. (2024, April 20) Embryology Neural - Cranial Nerve Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Cranial_Nerve_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G