Nephron Development Movie
From Embryology
Embryology - 25 Apr 2024 Expand to Translate |
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<mediaplayer width='400' height='280' image="http://embryology.med.unsw.edu.au/embryology/images/5/59/Renal_001_icon.jpg">File:Nephron_development.mp4</mediaplayer> | Early Renal Development
This animation shows the process of early renal (kidney) development. Legend
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Nephron Development
- disorganised mesenchymal cells become a highly organised epithelial tubule
- Condensation - groups of about 100 cells condense tightly together to form a distinct mass
- Epithelialisation - condensed cells lose their mesenchymal character and gain epithelial
- At end of this period formed a small epithelial cyst complete with a basement membrane, cell-cell junctions and a defined cellular apico-basal polarity.
Early morphogenesis
- cyst invaginates twice to form a comma
- then a S-shaped body one invagination site later becomes the glomerular cleft
- At about this time blood vessel progenitors invade cleft to begin construction of vascular component of glomerulus
- Tubule maturation specialised transporting segments of nephron differentiate complex of convoluted tubules is created