Nephron Development Movie

Embryology - 24 Apr 2024 Expand to Translate
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<mediaplayer width='400' height='280' image="http://embryology.med.unsw.edu.au/embryology/images/5/59/Renal_001_icon.jpg">File:Nephron_development.mp4</mediaplayer>

Early Renal Development

This animation shows the process of early renal (kidney) development.

Legend

Uteric Bud - developing ureter, pelvis, calyces, collecting ducts
Metanephric Blastema (intermediate mesoderm) - developing glomeruli, capsule, nephron tubules

Links: MP4 version | Quicktime version | Urogenital Sinus Movie | Renal System Development

disorganised mesenchymal cells become a highly organised epithelial tubule
Condensation - groups of about 100 cells condense tightly together to form a distinct mass
Epithelialisation - condensed cells lose their mesenchymal character and gain epithelial
At end of this period formed a small epithelial cyst complete with a basement membrane, cell-cell junctions and a defined cellular apico-basal polarity.

cyst invaginates twice to form a comma
then a S-shaped body one invagination site later becomes the glomerular cleft
At about this time blood vessel progenitors invade cleft to begin construction of vascular component of glomerulus
Tubule maturation specialised transporting segments of nephron differentiate complex of convoluted tubules is created