Musculoskeletal System - Tendon Development: Difference between revisions
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Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Tendon+development ''Tendon development''] | Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Tendon+development ''Tendon development''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=syndetome ''syndetome''] | ||
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* '''Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates'''{{#pmid:20699295|PMID20699295}} "The formation of the musculoskeletal system represents an intricate process of tissue assembly involving heterotypic inductive interactions between tendons, muscles and cartilage. An essential component of all musculoskeletal systems is the anchoring of the force-generating muscles to the solid support of the organism: the skeleton in vertebrates and the exoskeleton in invertebrates. Here, we discuss recent findings that illuminate musculoskeletal assembly in the vertebrate embryo, findings that emphasize the reciprocal interactions between the forming tendons, muscle and cartilage tissues. We also compare these events with those of the corresponding system in the Drosophila embryo, highlighting distinct and common pathways that promote efficient locomotion while preserving the form of the organism." | * '''Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates'''{{#pmid:20699295|PMID20699295}} "The formation of the musculoskeletal system represents an intricate process of tissue assembly involving heterotypic inductive interactions between tendons, muscles and cartilage. An essential component of all musculoskeletal systems is the anchoring of the force-generating muscles to the solid support of the organism: the skeleton in vertebrates and the exoskeleton in invertebrates. Here, we discuss recent findings that illuminate musculoskeletal assembly in the vertebrate embryo, findings that emphasize the reciprocal interactions between the forming tendons, muscle and cartilage tissues. We also compare these events with those of the corresponding system in the Drosophila embryo, highlighting distinct and common pathways that promote efficient locomotion while preserving the form of the organism." | ||
Revision as of 01:18, 8 January 2020
Embryology - 29 Mar 2024 Expand to Translate |
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Introduction
This page describes skeletal tendon development, during formation of the connective tissue connection muscle to bone.
The syndetome is the embryonic structural origin of tendons from the somite and originates from the dorsolateral edge of the sclerotome. Expression of the basic helix-loop-helix (bHLH) transcription factor scleraxis (SCX) in early progenitor cells is thought to be key regulator in the formation of tendon and ligament tissues.[1] Scleraxis may also have additional roles in other tissues such as in early heart valve development.[2]
The origins of some muscles and tendons in the head differ from those found in the remained of the body.
See also notes Connective Tissue Development.
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Tendon development | syndetome |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
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Molecular
Mesoderm Development and Pax[8]
dark green - syndetome originates from the dorsolateral edge of the sclerotome, as Pax1 and Pax9 are downregulated and scleraxis (Scx) upregulation leads to syndegenesis. Pax, paired homeobox; MYOD1, myogenic differentiation antigen 1; MYF5, myogenic factor 5; NKX, NK homeobox; SCX, scleraxis.
Scleraxis
Scleraxis (SCX) is a member of the basic helix-loop-helix (bHLH) transcription factor family. It is expressed in early mesoderm progenitor cells and may regulate the formation of tendon and ligament tissues.[1]
Scleraxis may also have additional roles in other tissues such as in early heart valve development.[2]
- Cytogenetic location: 8q24.3
- Links: NCBI databases - Scleraxis | OMIM 609067
Tenomodulin
Tenomodulin (TNMD, Tnmd) is a marker of tendon differentiation, its expression has been shown to be regulated by the transcription factors Scleraxis and Mohawk.[9] May also affect the tendon stem/progenitor cells.
- Links: NCBI databases - Tenomodulin
Histology
References
- ↑ 1.0 1.1 <pubmed>11585810</pubmed> Cite error: Invalid
<ref>
tag; name 'PMID11585810' defined multiple times with different content - ↑ 2.0 2.1 Barnette DN, VandeKopple M, Wu Y, Willoughby DA & Lincoln J. (2014). RNA-seq analysis to identify novel roles of scleraxis during embryonic mouse heart valve remodeling. PLoS ONE , 9, e101425. PMID: 24983472 DOI.
- ↑ Lim J, Munivez E, Jiang MM, Song IW, Gannon F, Keene DR, Schweitzer R, Lee BH & Joeng KS. (2017). mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development. Sci Rep , 7, 17175. PMID: 29215029 DOI.
- ↑ Russo V, Mauro A, Martelli A, Di Giacinto O, Di Marcantonio L, Nardinocchi D, Berardinelli P & Barboni B. (2015). Cellular and molecular maturation in fetal and adult ovine calcaneal tendons. J. Anat. , 226, 126-42. PMID: 25546075 DOI.
- ↑ Brown JP, Finley VG & Kuo CK. (2014). Embryonic mechanical and soluble cues regulate tendon progenitor cell gene expression as a function of developmental stage and anatomical origin. J Biomech , 47, 214-22. PMID: 24231248 DOI.
- ↑ Schweitzer R, Zelzer E & Volk T. (2010). Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates. Development , 137, 2807-17. PMID: 20699295 DOI.
- ↑ Gilsohn E & Volk T. (2010). Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction. Development , 137, 785-94. PMID: 20110313 DOI.
- ↑ Blake JA & Ziman MR. (2014). Pax genes: regulators of lineage specification and progenitor cell maintenance. Development , 141, 737-51. PMID: 24496612 DOI.
- ↑ Miyabara S, Yuda Y, Kasashima Y, Kuwano A & Arai K. (2014). Regulation of Tenomodulin Expression Via Wnt/β-catenin Signaling in Equine Bone Marrow-derived Mesenchymal Stem Cells. J Equine Sci , 25, 7-13. PMID: 24834008 DOI.
Reviews
Articles
Brent AE, Schweitzer R & Tabin CJ. (2003). A somitic compartment of tendon progenitors. Cell , 113, 235-48. PMID: 12705871
Search PubMed
Search Pubmed: Tendon Development | myotendinous junction development
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Cite this page: Hill, M.A. (2024, March 29) Embryology Musculoskeletal System - Tendon Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_-_Tendon_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G