Musculoskeletal System - Tendon Development: Difference between revisions
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* Embryonic mechanical and soluble cues regulate tendon progenitor cell gene expression as a function of developmental stage and anatomical origin.<ref><pubmed>20699295</pubmed></ref> "Stem cell-based engineering strategies for tendons have yet to yield a normal functional tissue, due in part to a need for tenogenic factors. Additionally, the ability to evaluate differentiation has been challenged by a lack of markers for differentiation.... Based on scleraxis expression, TGFβ2 was tenogenic for TPCs at all stages, while loading was for late-stage cells only, and FGF4 had no effect despite regulation of other genes. When factors were combined, TGFβ2 continued to be tenogenic, while FGF4 appeared anti-tenogenic. Various treatments elicited distinct responses by axial vs. limb TPCs of specific stages. These results identified tenogenic factors, suggest tendon engineering strategies should be customized for tissues by anatomical origin, and provide stage-specific gene expression profiles of limb and axial TPCs as benchmarks with which to monitor tenogenic differentiation of stem cells." | |||
* '''Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates'''<ref><pubmed>20699295</pubmed></ref> "The formation of the musculoskeletal system represents an intricate process of tissue assembly involving heterotypic inductive interactions between tendons, muscles and cartilage. An essential component of all musculoskeletal systems is the anchoring of the force-generating muscles to the solid support of the organism: the skeleton in vertebrates and the exoskeleton in invertebrates. Here, we discuss recent findings that illuminate musculoskeletal assembly in the vertebrate embryo, findings that emphasize the reciprocal interactions between the forming tendons, muscle and cartilage tissues. We also compare these events with those of the corresponding system in the Drosophila embryo, highlighting distinct and common pathways that promote efficient locomotion while preserving the form of the organism." | * '''Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates'''<ref><pubmed>20699295</pubmed></ref> "The formation of the musculoskeletal system represents an intricate process of tissue assembly involving heterotypic inductive interactions between tendons, muscles and cartilage. An essential component of all musculoskeletal systems is the anchoring of the force-generating muscles to the solid support of the organism: the skeleton in vertebrates and the exoskeleton in invertebrates. Here, we discuss recent findings that illuminate musculoskeletal assembly in the vertebrate embryo, findings that emphasize the reciprocal interactions between the forming tendons, muscle and cartilage tissues. We also compare these events with those of the corresponding system in the Drosophila embryo, highlighting distinct and common pathways that promote efficient locomotion while preserving the form of the organism." | ||
* '''Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction''' <ref><pubmed>20110313</pubmed></ref> | * '''Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction''' <ref><pubmed>20110313</pubmed></ref> |
Revision as of 23:07, 9 March 2014
Embryology - 25 Apr 2024 Expand to Translate |
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Introduction
This page describes skeletal tendon development, during formation of the connective tissue connection muscle to bone.
The origins of some muscles and tendons in the head differ from those found in the remained of the body.
See also notes Connective Tissue Development.
Some Recent Findings
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<pubmed>12705871</pubmed>
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Cite this page: Hill, M.A. (2024, April 25) Embryology Musculoskeletal System - Tendon Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_-_Tendon_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G