Musculoskeletal System - Muscle Development
Introduction
There are 3 different types of muscle: skeletal, cardiac and smooth. This page describes skeletal muscle development, descriptions of cardiac muscle and smooth muscle development can be found in other notes. (More? Cardiac or GIT Development)
Skeletal muscle forms by fusion of mononucleated myoblasts to form mutinucleated myotubes.
Differentiation/determination of mesoderm into muscle cells is thought to involve a family of basic Helix-Loop-Helix transcription factors, the first of which discovered was MyoD1. (see OMIM entry). It needs to form a dimer to be active and is maintained in an inactive state by binding of Id (see OMIM entry).
System Links: Introduction | Cardiovascular | Coelomic Cavity | Endocrine | Gastrointestinal Tract | Genital | Head | Immune | Integumentary | Musculoskeletal | Neural | Neural Crest | Placenta | Renal | Respiratory | Sensory | Birth |
--Mark Hill 09:25, 14 April 2010 (EST) Page Template only - content from original UNSW Embryology site currently being edited and updated.
Myotome
In both development and the adult, the group of skeletal muscles supplied by a specific segmental spinal nerve is referred to as a myotome. The muscle arises from a specific somite and the spinal nerve arises from a specific level of the spinal cord (identified by veretebral column).
In humans this corresponds to the following spinal nerves (from top to bottom) and muscular functions:
- C3,4 and 5 supply the diaphragm for breathing.
- C5 supply shoulder muscles and muscles to bend our elbow.
- C6 for bending the wrist back.
- C7 for straightening the elbow.
- C8 bends the fingers.
- T1 spreads the fingers.
- T1 –T12 supplies the chest wall and abdominal muscles.
- L2 bends the hip.
- L3 straightens the knee.
- L4 pulls the foot up.
- L5 wiggles the toes.
- S1 pulls the foot down.
- S3,4 and 5 supply the bladder, bowel, sex organs, anal and other pelvic muscles.
Additional Images
Terms
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 23) Embryology Musculoskeletal System - Muscle Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_-_Muscle_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G