Mouse Development: Difference between revisions

Revision as of 23:26, 2 September 2009

Introduction

The mouse (taxon-mus) has always been a good embryological model, easy to generate (litters 8-20) and quick (21d) (More? [mouse1.htm Mouse Stages] and [mouse4.htm Mouse Timeline]). Mouse embryology really expanded when molecular biologists used mice for gene knockouts, suddenly you had to understand about development in order to understand the effect of knocking out the gene (More? see [../DNA/DNA6.htm KnockoutList]). There are over 450 different strains of inbred research mice, and this has recently been organized into a chart (More? [#Genealogy Rat Genealogy]). While being an ideal model organism, only a relatively small amount (1.5%) of the total mouse genome sequenced (More? see [#Genome Seq Mouse Genome Sequencing]). Those interested in the mouse reproductive cycle, should also look at the [mouse2.htm Mouse Estrous Cycle]

Carnegie Stages Comparison

Data For Carnegie Stages Comparison Graph (Species/Days)														(All Species Data)
Species	Stage	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23
Human	Days	20	22	24	28	30	33	36	40	42	44	48	52	54	55	58
Mouse	Days	9	9.5	10	10.5	11	11.5	12	12.5	13	13.5	14	14.5	15	15.5	16
Rat	Days	10.5	11	11.5	12	12.5	13	13.5	14	14.5	15	15.5	16	16.5	17	17.5

References

Human - O'Rahilly, Early human development and the chief source of information on staged human embryos. Eur. J. Obstet. Gynec. Reprod. Biol. 9 p273 (1979)

Mouse - Theiler, The house mouse. Springer-Verlag, NY (1972)

Rat - Witschi, Growth. Altman and Dittmer (ed), Fed. Soc. Exp. Biol., Washington (1962)

Reference for Staging the Mouse Embryo

Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Downs KM, Davies T Development 1993 Aug;118(4):1255-66 PubMed Entry | Development Article

"We describe and illustrate a set of morphological landmarks for classifying mouse embryos by gross morphology from before gastrulation to the beginning of organogenesis. These landmarks are visible at the resolution of the dissecting microscope in embryos that are intact except for reflexion of Reichert's membrane. Adoption of these criteria should facilitate interpretation of both the expression patterns of genes and the consequences of experimental manipulation of embryos during early postimplantation development."

The Mouse its Reproduction and Development Rugh, R. Oxford University Press, Oxford (1990)

Demonstration of the E12.5 mouse embryo cardiovascular system. (lateral and dorsal views) placental vessels in the first image (on right of embryo).

Mouse Knockouts

Knowledge about mouse development has rapidly expanded as it has become the model animal system for genetic "knock out " studies. This technology actually requires development of defined breeding programs, pseudo-pregnancy, in vitro fertilization, molecular biology, and good old fashioned histology. Without understanding normal development the molecular biologists don't stand a hope of understanding what their gene knock out has done. There is a database of all existing mouse knockouts and their consequences.

Murine Development Control Genes

Kessel, M. and Gruss, P. Science 249 374-379 (1990)

An early review of the genes, and method of identifying them, involved in early mouse development. In particular discusses Homeobox genes. (homeobox is 183bp encoding a 61 amino acid DNA-binding domain)

Gene families
- Hox
- Pax
- POU

The Genealogy Chart of Inbred Strains

This chart shows the origins and relationships of inbred mouse strains. The chart is available as a PDF document [../pdf/mouse_genealogy.pdf Locally] or from JAX Labs and was originally published by Beck etal., 2000.

Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing MF, Fisher EM. Genealogies of mouse inbred strains. Nat Genet. 2000 Jan;24(1):23-5.

Mouse Genome Sequencing

Mouse Genome (17 August 2001)

Finished Sequence- 47.6 Mb,1.5 % of genome
Draft Sequence- 375 Mb, 11.7 % of genome
See also Breakdown by chromosome

(More? see external Link- Mouse Genome Sequencing)

Mouse Internet Links

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, April 24) Embryology Mouse Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Mouse_Development

What Links Here?

@@ Line 135: / Line 135: @@
 (More? see external Link- [http://www.ncbi.nlm.nih.gov/genome/seq/MmHome.html Mouse Genome Sequencing])
+== Mouse Internet Links ==
+* [http://www.ncbi.nlm.nih.gov/genome/seq/MmHome.html NCBI- Mouse Genome Sequencing]
+* [http://www.ebi.ac.uk/genomes/mot/10090_1000.html EBI- Mouse Genome Sequencing]
+* [http://www.anex.med.tokushima-u.ac.jp/index.html ANEX Rat and Mouse Database - (University of Tokushima)]
+* [http://www.lists.ic.ac.uk/hypermail/transgenic-list/ Archives of Transgenic-List]
+* [http://www.bku.com/ B Universal Ltd.]
+* [http://www.bio.net/hypermail/BIGBLUE/ BIG BLUE (Big Blue Transgenic Mouse Mailing List Archives)]
+* [http://darwin.ceh.uvic.ca/bigblue/bigblue.htm Big Blue lacI Transgenic Mouse Page]
+* [http://www.criver.com/ Charles River Laboratories, Inc.]
+* [http://www.chrysalis-cro.com/transgenic/ Chrysalis DNX Transgenic Services]
+* [http://www.covance.com/ Covance Research Products]
+* [http://embryo.mc.duke.edu/animal/cdAtlas/cdAtlas.html Digital Atlas of Mouse Embryology]
+* [http://www.cns.ohiou.edu/ictto/ebi/transgenic.html Edison Biotechnology Institute (Ohio University)]
+* [http://www.informatics.jax.org/encyclo.html Encyclopedia of the Mouse Genome (Jackson Laboratory)]
+* [http://www.hgmp.mrc.ac.uk/MBx/MBxHomepage.html EUCIB Mouse Backcross Database (MBx)]
+* [http://www.genome.wi.mit.edu/cgi-bin/mouse/index Genetic and Physical Maps of the Mouse Genome (Whitehead Institute/MIT)]
+* [http://cedar.genetics.soton.ac.uk/public_html/ Genetic Location Database (University of Southampton)]
+* [http://www.genomesystems.com/ Genome Systems, Inc.]
+* [http://www.harlan.com/ Harlan Sprague Dawley, Inc.]
+* [http://www.cdc.gov/ncidod/EID/vol1no4/rice2.htm Helicobacter hepaticus, a Recently Recognized Bacterial Pathogen, Associated with Chronic Hepatitis and Hepatocellular Neoplasia in Laboratory Mice (CDC)]
+* [http://www.criver.com/techdocs/helico-1.html Helicobacter Infection in Laboratory Mice: History, Significance, Detection and Management (Charles River)]
+* [http://www.nap.edu/bookstore/isbn/0309037948.html Infectious Diseases of Mice and Rats (NAS-ILAR)]
+* [http://www.nap.edu/bookstore/isbn/0309042836.html Infectious Diseases of Mice and Rats Companion Guide (NAS-ILAR)]
+* [http://www.afip.org/vetpath/POLA/micerat.txt Infectious Diseases of Mice and Rats (AFIP-POLA)]
+* [http://www.bis.med.jhmi.edu/Dan/tbase/docs/knockout.html It's a Knockout]
+* [http://www.jax.org/ Jackson Laboratory]
+* [http://www.informatics.jax.org/doc/lists.html Jackson Laboratory BioInformatics Electronic Bulletin Board System]
+* [gopher://hobbes.jax.org:70/11/ Jackson Laboratory Gopher Server]
+* [http://www.jax.org/resources/documents/imr/ Jackson Laboratory Induced Mutant Resouce]
+* [http://darwin.ceh.uvic.ca/people/koop/KoopGen.html Koop Human and Mouse Genome Project Research (University of Victoria)]
+* [gopher://hobbes.informatics.jax.org:70/00/pub/stocks/lanelist.txt Lane List of Named Mutations and Polymorphic Loci]
+* [http://www.lexgen.com/ Lexicon Genetics, Inc.]
+* [http://www.cdc.gov/ncidod/EID/vol1no4/barton.htm#top Lymphocytic Choriomeningitis Virus: An Unrecognized Teratogenic Pathogen (CDC)]
+* [http://www.m-b.dk/ M & B Breeding and Research Centre Ltd.]
+* [http://condor.mbcr.bcm.tmc.edu/BEP/ERMB/home.html Mammary Transgene Database (Baylor College of Medicine)]
+* [http://www.cshl.org/books/manipulating_mouse_embryo.html Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory)]
+* [http://mcbio.med.buffalo.edu/mapmgr.html Map Manager Software]
+* [http://www.ornl.gov/ORNLReview/rev27-12/text/mnmmain.html Mice and Men: Making the Most of Our Similarities (ORNL)]
+* [http://ourworld.compuserve.com/homepages/TheBroons/ Microinjection Workshop]
+* [http://genex.hgu.mrc.ac.uk/ Mouse Atlas and Gene Expression Database Project]
+* [http://ws4.niai.affrc.go.jp/dbsearch2/mmap/mmap.html Mouse Cytogenetic Map Image]
+* [http://www.informatics.jax.org/ Mouse Genome Informatics (Jackson Laboratory)]
+* [gopher://larry.pathology.washington.edu:70/11/idiograms/Mouse Mouse Idiograms]
+* [http://www.informatics.jax.org/bin/strains/search Mouse Inbred Strains (Jackson Labs)]
+* [http://ws4.niai.affrc.go.jp/dbsearch2/mmap/mlink.html Mouse Linkage Map]
+* [http://www.informatics.jax.org/nomen/ Mouse Nomenclature Rules and Guidelines (Jackson Labs)]
+* [http://www.cco.caltech.edu/~mercer/htmls/rodent_page.html Mouse and Rat Research Home Page]
+* [http://hyperarchive.lcs.mit.edu/HyperArchive/Archive/sci/mouse-up-15-hc.hqx MouseUp HyperCard Transgenic Mouse Database (Macintosh)]
+* [http://www.mgc.har.mrc.ac.uk/ MRC Mouse Genome Centre]
+* [http://www.ncifcrf.gov/VETPATH/emerg.html Murine Helicobacters (NCI)]
+* [http://www.grs.nig.ac.jp/NIG_mouse/mouse.default.html National Institute of Genetics Mouse Genetic Resources (Japan)]
+* [http://www.nih.gov/od/ors/dirs/vrp/nihagr.htm NIH Animal Genetic Resource]
+* [http://www.ncifcrf.gov/VETPATH/nihtg.html NIH Directory of Transgenic Mice]
+* [http://www.ncifcrf.gov/VETPATH/club.html NIH Mouse Club]
+* [http://www.hhmi.org/GeneticTrail/mice/kayo.htm Of Mice and Men (HHMI's Blazing a Genetic Trail)]
+* [http://www.angis.su.oz.au/Databases/BIRX/omia/omia_form.html Online Mendelian Inheritance in Animals (University of Sydney)]
+* [http://www.ncifcrf.gov/VETPATH/GAM.html Pathology of Genetically-altered Mice]
+* [http://mickey.utmem.edu/ Portable Dictionary of the Mouse Genome]
+* [http://www.criver.com/techdocs/past-1.html Review of Pasteurella pneumotropica (Charles River)]
+* [http://www.taconic.com/ Taconic]
+* [http://www.cshl.org/books/targeted_mutagenesis.html Targeted Mutagenesis in Mice: A Video Guide]
+* [http://www.bis.med.jhmi.edu/Dan/tbase/tbase.html TBASE - Transgenic/Targeted Mutation Database]
+* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/cancer.htm The Mouse in Science: Cancer Research]
+* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/mabs.htm The Mouse in Science: Monoclonal Antibodies]
+* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/vaccines.htm The Mouse in Science: Vaccines]
+* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/whymice.htm The Mouse in Science: Why Mice?]
+* [http://www.ucc.uconn.edu/%7Ewwwbiotc/Transg.html Transgenic Animal Facility (University of Connecticut Biotechnology Center)]
+* [http://www.life.uiuc.edu/biotech/transgenic.html Transgenic Animal Facility (University of Illinois Biotechnology Center)]
+* [http://www.uiowa.edu/~vpr/research/units/transgen.htm Transgenic Animal Facility (University of Iowa)]
+* [http://www.ki.se/core/meg.html Transgenic Animal Facility (Karolinska Institute)]
+* [http://ccmb.microbiol.uwa.edu.au/ccmbtrans.html Transgenic Animal Facility (University of Western Australia)]
+* [http://www.biotech.wisc.edu/Service/transan.html Transgenic Animal Facility (University of Wisconsin Biotechnology Center)]
+* [http://www.med.umich.edu/tamc/ Transgenic Animal Model Core (University of Michigan)]
+* [http://www.bcm.tmc.edu/urol/spore/transgen_core.html Transgenic Core (Baylor College of Medicine SPORE)]
+* [http://www.uchsc.edu/sm/animal/tmcl/txhmpg.html Transgenic Facility (University of Colorado Health Science Center)]
+* [http://www.uky.edu/Transgenic/ Transgenic Facility (University of Kentucky)]
+* [http://som1.ab.umd.edu/Microbiology/Transgene.html Transgenic & Knockout Mouse Facility (University of Maryland at Baltimore)]
+* [http://www.lists.ic.ac.uk/hypermail/transgenic-list/ Transgenic-List Archives]
+* [http://www-rics.bwh.harvard.edu/derm/tg_core.html Transgenic Models of Skin Disease Core (Harvard Skin Disease Research Center)]
+* [http://www.mssm.edu/molbio/bcmb/BCMB_Core_Facilities.html Transgenic Mouse Core Facilities (Mount Sinai School of Medicine)]
+* [http://www.med.virginia.edu/~sp3i/tghome.html Transgenic Mouse Core Facility (University of Virginia)]
+* [http://cpmcnet.columbia.edu/research/equip/eq-cctrn.htm Transgenic Mouse Facility (Columbia-Presbyterian Cancer Center)]
+* [http://genetics.mc.duke.edu/transgenX.html Transgenic Mouse Facility (Duke Comprehensive Cancer Center)]
+* [http://www.pharm.sunysb.edu/transgenic/Transgenic.html Transgenic Mouse Facility (SUNY-Stony Brook)]
+* [http://darwin.bio.uci.edu/~tjf/index.html Transgenic Mouse Facility (University of California-Irvine)]
+* [http://www.cosm.sc.edu/ibrt/mouse.html Transgenic Mouse Facility (University of South Carolina)]
+* [http://info.med.yale.edu/ycc/transgenic.html Transgenic Mouse Facility (Yale University Cancer Center)]
+* [http://www-mp.ucdavis.edu/tgmice/firststop.html Transgenic Mouse Program (University of California-Davis)]
+* [http://kccc-www.med.nyu.edu/mouse.htm Transgenic Mouse Research Facility (New York University Kaplan Comprehensive Cancer Center)]
+* [http://www.cshl.org/books/transgenic_techniques.html Transgenic Techniques in Mice: A Video Guide (Cold Spring Harbor Laboratory)]
+* [http://www.transgenics-berlin.com/ Transgenics (Berlin-Buch GmbH)]
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