Mouse Development: Difference between revisions

From Embryology
Line 260: Line 260:
{{External Links}}
{{External Links}}


* Mouse Gene Expression
===Mouse Embryology===
** [http://www.emouseatlas.org/emage/ EMAGE] is a database of in situ gene expression data in the mouse embryo and an accompanying suite of tools to search and analyse the data. (All site content, except where otherwise noted, is licensed under a [http://creativecommons.org/licenses/by/3.0/ Creative Commons Attribution License].)
* [http://www.cshl.org/books/manipulating_mouse_embryo.html Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory)]
** [http://www.eurexpress.org Eurexpress transcriptome atlas] a High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo.
* [http://embryo.mc.duke.edu/animal/cdAtlas/cdAtlas.html Digital Atlas of Mouse Embryology]
** [http://genepaint.org/Frameset.html GenePaint.org] is a digital atlas of gene expression patterns in the mouse.  
 
===Mouse Gene Expression===
* [http://www.emouseatlas.org/emage/ EMAGE] is a database of in situ gene expression data in the mouse embryo and an accompanying suite of tools to search and analyse the data. (All site content, except where otherwise noted, is licensed under a [http://creativecommons.org/licenses/by/3.0/ Creative Commons Attribution License].)
* [http://www.eurexpress.org Eurexpress transcriptome atlas] a High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo.
* [http://genepaint.org/Frameset.html GenePaint.org] is a digital atlas of gene expression patterns in the mouse.
 
===Mouse Genome===
* [http://www.ncbi.nlm.nih.gov/genome/seq/MmHome.html NCBI- Mouse Genome Sequencing]  
* [http://www.ncbi.nlm.nih.gov/genome/seq/MmHome.html NCBI- Mouse Genome Sequencing]  
* [http://www.informatics.jax.org/ Mouse Genome Informatics]
* [http://www.informatics.jax.org/ Mouse Genome Informatics]
* [http://www.ebi.ac.uk/genomes/mot/10090_1000.html EBI- Mouse Genome Sequencing]  
* [http://www.ebi.ac.uk/genomes/mot/10090_1000.html EBI- Mouse Genome Sequencing]  
* [http://www.anex.med.tokushima-u.ac.jp/index.html ANEX Rat and Mouse Database - (University of Tokushima)]  
* [http://www.anex.med.tokushima-u.ac.jp/index.html ANEX Rat and Mouse Database - (University of Tokushima)]  
* [http://www.genome.wi.mit.edu/cgi-bin/mouse/index Genetic and Physical Maps of the Mouse Genome (Whitehead Institute/MIT)]
* [http://cedar.genetics.soton.ac.uk/public_html/ Genetic Location Database (University of Southampton)]
* [http://darwin.ceh.uvic.ca/people/koop/KoopGen.html Koop Human and Mouse Genome Project Research (University of Victoria)]
* [http://www.genomesystems.com/ Genome Systems, Inc.]
===Mouse Jackson Laboratory===
* [http://www.jax.org/ Jackson Laboratory]
* [http://www.jax.org/resources/documents/imr/ Jackson Laboratory Induced Mutant Resource]
* [http://www.informatics.jax.org/doc/lists.html Jackson Laboratory BioInformatics Electronic Bulletin Board System]
===Mouse Diseases===
* [http://www.cdc.gov/ncidod/EID/vol1no4/rice2.htm Helicobacter hepaticus, a Recently Recognized Bacterial Pathogen, Associated with Chronic Hepatitis and Hepatocellular Neoplasia in Laboratory Mice (CDC)]
* [http://www.criver.com/techdocs/helico-1.html Helicobacter Infection in Laboratory Mice: History, Significance, Detection and Management (Charles River)]
* [http://www.nap.edu/bookstore/isbn/0309037948.html Infectious Diseases of Mice and Rats (NAS-ILAR)]
* [http://www.nap.edu/bookstore/isbn/0309042836.html Infectious Diseases of Mice and Rats Companion Guide (NAS-ILAR)]
* [http://www.afip.org/vetpath/POLA/micerat.txt Infectious Diseases of Mice and Rats (AFIP-POLA)]
* [http://www.ncifcrf.gov/VETPATH/emerg.html Murine Helicobacters (NCI)]
===Mouse Transgenics===
* [http://www.lists.ic.ac.uk/hypermail/transgenic-list/ Archives of Transgenic-List]  
* [http://www.lists.ic.ac.uk/hypermail/transgenic-list/ Archives of Transgenic-List]  
* [http://condor.mbcr.bcm.tmc.edu/BEP/ERMB/home.html Mammary Transgene Database (Baylor College of Medicine)]
* [http://www.cshl.org/books/targeted_mutagenesis.html Targeted Mutagenesis in Mice: A Video Guide]
* [http://www.bis.med.jhmi.edu/Dan/tbase/tbase.html TBASE - Transgenic/Targeted Mutation Database]
* [http://www.bku.com/ B Universal Ltd.]  
* [http://www.bku.com/ B Universal Ltd.]  
* [http://www.bio.net/hypermail/BIGBLUE/ BIG BLUE (Big Blue Transgenic Mouse Mailing List Archives)]  
* [http://www.bio.net/hypermail/BIGBLUE/ BIG BLUE (Big Blue Transgenic Mouse Mailing List Archives)]  
Line 274: Line 303:
* [http://www.criver.com/ Charles River Laboratories, Inc.]  
* [http://www.criver.com/ Charles River Laboratories, Inc.]  
* [http://www.chrysalis-cro.com/transgenic/ Chrysalis DNX Transgenic Services]  
* [http://www.chrysalis-cro.com/transgenic/ Chrysalis DNX Transgenic Services]  
* [http://www.covance.com/ Covance Research Products]  
* [http://www.ucc.uconn.edu/%7Ewwwbiotc/Transg.html Transgenic Animal Facility (University of Connecticut Biotechnology Center)]
* [http://embryo.mc.duke.edu/animal/cdAtlas/cdAtlas.html Digital Atlas of Mouse Embryology]  
* [http://www.life.uiuc.edu/biotech/transgenic.html Transgenic Animal Facility (University of Illinois Biotechnology Center)]
* [http://www.uiowa.edu/~vpr/research/units/transgen.htm Transgenic Animal Facility (University of Iowa)]
* [http://www.ki.se/core/meg.html Transgenic Animal Facility (Karolinska Institute)]
* [http://ccmb.microbiol.uwa.edu.au/ccmbtrans.html Transgenic Animal Facility (University of Western Australia)]
* [http://www.biotech.wisc.edu/Service/transan.html Transgenic Animal Facility (University of Wisconsin Biotechnology Center)]
* [http://www.med.umich.edu/tamc/ Transgenic Animal Model Core (University of Michigan)]
* [http://www.bcm.tmc.edu/urol/spore/transgen_core.html Transgenic Core (Baylor College of Medicine SPORE)]
* [http://www.uchsc.edu/sm/animal/tmcl/txhmpg.html Transgenic Facility (University of Colorado Health Science Center)]
* [http://www.uky.edu/Transgenic/ Transgenic Facility (University of Kentucky)]
* [http://som1.ab.umd.edu/Microbiology/Transgene.html Transgenic & Knockout Mouse Facility (University of Maryland at Baltimore)]
* [http://www.lists.ic.ac.uk/hypermail/transgenic-list/ Transgenic-List Archives]
* [http://www-rics.bwh.harvard.edu/derm/tg_core.html Transgenic Models of Skin Disease Core (Harvard Skin Disease Research Center)]
* [http://www.mssm.edu/molbio/bcmb/BCMB_Core_Facilities.html Transgenic Mouse Core Facilities (Mount Sinai School of Medicine)]
* [http://www.med.virginia.edu/~sp3i/tghome.html Transgenic Mouse Core Facility (University of Virginia)]
* [http://cpmcnet.columbia.edu/research/equip/eq-cctrn.htm Transgenic Mouse Facility (Columbia-Presbyterian Cancer Center)]  
* [http://genetics.mc.duke.edu/transgenX.html Transgenic Mouse Facility (Duke Comprehensive Cancer Center)]
* [http://www.pharm.sunysb.edu/transgenic/Transgenic.html Transgenic Mouse Facility (SUNY-Stony Brook)]
* [http://darwin.bio.uci.edu/~tjf/index.html Transgenic Mouse Facility (University of California-Irvine)]
* [http://www.cosm.sc.edu/ibrt/mouse.html Transgenic Mouse Facility (University of South Carolina)]
* [http://info.med.yale.edu/ycc/transgenic.html Transgenic Mouse Facility (Yale University Cancer Center)]
* [http://www-mp.ucdavis.edu/tgmice/firststop.html Transgenic Mouse Program (University of California-Davis)]
* [http://kccc-www.med.nyu.edu/mouse.htm Transgenic Mouse Research Facility (New York University Kaplan Comprehensive Cancer Center)]
* [http://www.transgenics-berlin.com/ Transgenics (Berlin-Buch GmbH)]
 
===Mouse Unsorted Links===
* [http://www.covance.com/ Covance Research Products]
* [http://www.cns.ohiou.edu/ictto/ebi/transgenic.html Edison Biotechnology Institute (Ohio University)]  
* [http://www.cns.ohiou.edu/ictto/ebi/transgenic.html Edison Biotechnology Institute (Ohio University)]  
* [http://www.informatics.jax.org/encyclo.html Encyclopedia of the Mouse Genome (Jackson Laboratory)]  
* [http://www.informatics.jax.org/encyclo.html Encyclopedia of the Mouse Genome (Jackson Laboratory)]  
* [http://www.hgmp.mrc.ac.uk/MBx/MBxHomepage.html EUCIB Mouse Backcross Database (MBx)]  
* [http://www.hgmp.mrc.ac.uk/MBx/MBxHomepage.html EUCIB Mouse Backcross Database (MBx)]
* [http://www.genome.wi.mit.edu/cgi-bin/mouse/index Genetic and Physical Maps of the Mouse Genome (Whitehead Institute/MIT)]
* [http://cedar.genetics.soton.ac.uk/public_html/ Genetic Location Database (University of Southampton)]
* [http://www.genomesystems.com/ Genome Systems, Inc.]
* [http://www.harlan.com/ Harlan Sprague Dawley, Inc.]  
* [http://www.harlan.com/ Harlan Sprague Dawley, Inc.]  
* [http://www.cdc.gov/ncidod/EID/vol1no4/rice2.htm Helicobacter hepaticus, a Recently Recognized Bacterial Pathogen, Associated with Chronic Hepatitis and Hepatocellular Neoplasia in Laboratory Mice (CDC)]
* [http://www.criver.com/techdocs/helico-1.html Helicobacter Infection in Laboratory Mice: History, Significance, Detection and Management (Charles River)]
* [http://www.nap.edu/bookstore/isbn/0309037948.html Infectious Diseases of Mice and Rats (NAS-ILAR)]
* [http://www.nap.edu/bookstore/isbn/0309042836.html Infectious Diseases of Mice and Rats Companion Guide (NAS-ILAR)]
* [http://www.afip.org/vetpath/POLA/micerat.txt Infectious Diseases of Mice and Rats (AFIP-POLA)]
* [http://www.bis.med.jhmi.edu/Dan/tbase/docs/knockout.html It's a Knockout]  
* [http://www.bis.med.jhmi.edu/Dan/tbase/docs/knockout.html It's a Knockout]  
* [http://www.jax.org/ Jackson Laboratory]
* [http://www.informatics.jax.org/doc/lists.html Jackson Laboratory BioInformatics Electronic Bulletin Board System]
* [gopher://hobbes.jax.org:70/11/ Jackson Laboratory Gopher Server]  
* [gopher://hobbes.jax.org:70/11/ Jackson Laboratory Gopher Server]  
* [http://www.jax.org/resources/documents/imr/ Jackson Laboratory Induced Mutant Resouce]
* [http://darwin.ceh.uvic.ca/people/koop/KoopGen.html Koop Human and Mouse Genome Project Research (University of Victoria)]
* [gopher://hobbes.informatics.jax.org:70/00/pub/stocks/lanelist.txt Lane List of Named Mutations and Polymorphic Loci]  
* [gopher://hobbes.informatics.jax.org:70/00/pub/stocks/lanelist.txt Lane List of Named Mutations and Polymorphic Loci]  
* [http://www.lexgen.com/ Lexicon Genetics, Inc.]  
* [http://www.lexgen.com/ Lexicon Genetics, Inc.]  
* [http://www.cdc.gov/ncidod/EID/vol1no4/barton.htm#top Lymphocytic Choriomeningitis Virus: An Unrecognized Teratogenic Pathogen (CDC)]  
* [http://www.cdc.gov/ncidod/EID/vol1no4/barton.htm#top Lymphocytic Choriomeningitis Virus: An Unrecognized Teratogenic Pathogen (CDC)]  
* [http://www.m-b.dk/ M & B Breeding and Research Centre Ltd.]  
* [http://www.m-b.dk/ M & B Breeding and Research Centre Ltd.]  
* [http://condor.mbcr.bcm.tmc.edu/BEP/ERMB/home.html Mammary Transgene Database (Baylor College of Medicine)]
* [http://www.cshl.org/books/manipulating_mouse_embryo.html Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory)]
* [http://mcbio.med.buffalo.edu/mapmgr.html Map Manager Software]  
* [http://mcbio.med.buffalo.edu/mapmgr.html Map Manager Software]  
* [http://www.ornl.gov/ORNLReview/rev27-12/text/mnmmain.html Mice and Men: Making the Most of Our Similarities (ORNL)]  
* [http://www.ornl.gov/ORNLReview/rev27-12/text/mnmmain.html Mice and Men: Making the Most of Our Similarities (ORNL)]  
Line 305: Line 345:
* [http://genex.hgu.mrc.ac.uk/ Mouse Atlas and Gene Expression Database Project]  
* [http://genex.hgu.mrc.ac.uk/ Mouse Atlas and Gene Expression Database Project]  
* [http://ws4.niai.affrc.go.jp/dbsearch2/mmap/mmap.html Mouse Cytogenetic Map Image]  
* [http://ws4.niai.affrc.go.jp/dbsearch2/mmap/mmap.html Mouse Cytogenetic Map Image]  
* [http://www.informatics.jax.org/ Mouse Genome Informatics (Jackson Laboratory)]
* [gopher://larry.pathology.washington.edu:70/11/idiograms/Mouse Mouse Idiograms]  
* [gopher://larry.pathology.washington.edu:70/11/idiograms/Mouse Mouse Idiograms]  
* [http://www.informatics.jax.org/bin/strains/search Mouse Inbred Strains (Jackson Labs)]  
* [http://www.informatics.jax.org/bin/strains/search Mouse Inbred Strains (Jackson Labs)]  
Line 313: Line 352:
* [http://hyperarchive.lcs.mit.edu/HyperArchive/Archive/sci/mouse-up-15-hc.hqx MouseUp HyperCard Transgenic Mouse Database (Macintosh)]  
* [http://hyperarchive.lcs.mit.edu/HyperArchive/Archive/sci/mouse-up-15-hc.hqx MouseUp HyperCard Transgenic Mouse Database (Macintosh)]  
* [http://www.mgc.har.mrc.ac.uk/ MRC Mouse Genome Centre]  
* [http://www.mgc.har.mrc.ac.uk/ MRC Mouse Genome Centre]  
* [http://www.ncifcrf.gov/VETPATH/emerg.html Murine Helicobacters (NCI)]
* [http://www.grs.nig.ac.jp/NIG_mouse/mouse.default.html National Institute of Genetics Mouse Genetic Resources (Japan)]  
* [http://www.grs.nig.ac.jp/NIG_mouse/mouse.default.html National Institute of Genetics Mouse Genetic Resources (Japan)]  
* [http://www.nih.gov/od/ors/dirs/vrp/nihagr.htm NIH Animal Genetic Resource]  
* [http://www.nih.gov/od/ors/dirs/vrp/nihagr.htm NIH Animal Genetic Resource]  
Line 324: Line 362:
* [http://www.criver.com/techdocs/past-1.html Review of Pasteurella pneumotropica (Charles River)]  
* [http://www.criver.com/techdocs/past-1.html Review of Pasteurella pneumotropica (Charles River)]  
* [http://www.taconic.com/ Taconic]  
* [http://www.taconic.com/ Taconic]  
* [http://www.cshl.org/books/targeted_mutagenesis.html Targeted Mutagenesis in Mice: A Video Guide]
* [http://www.bis.med.jhmi.edu/Dan/tbase/tbase.html TBASE - Transgenic/Targeted Mutation Database]
* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/cancer.htm The Mouse in Science: Cancer Research]  
* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/cancer.htm The Mouse in Science: Cancer Research]  
* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/mabs.htm The Mouse in Science: Monoclonal Antibodies]  
* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/mabs.htm The Mouse in Science: Monoclonal Antibodies]  
* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/vaccines.htm The Mouse in Science: Vaccines]  
* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/vaccines.htm The Mouse in Science: Vaccines]  
* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/whymice.htm The Mouse in Science: Why Mice?]  
* [http://www.vetmed.ucdavis.edu/Animal_Alternatives/whymice.htm The Mouse in Science: Why Mice?]  
* [http://www.ucc.uconn.edu/%7Ewwwbiotc/Transg.html Transgenic Animal Facility (University of Connecticut Biotechnology Center)]
* [http://www.life.uiuc.edu/biotech/transgenic.html Transgenic Animal Facility (University of Illinois Biotechnology Center)]
* [http://www.uiowa.edu/~vpr/research/units/transgen.htm Transgenic Animal Facility (University of Iowa)]
* [http://www.ki.se/core/meg.html Transgenic Animal Facility (Karolinska Institute)]
* [http://ccmb.microbiol.uwa.edu.au/ccmbtrans.html Transgenic Animal Facility (University of Western Australia)]
* [http://www.biotech.wisc.edu/Service/transan.html Transgenic Animal Facility (University of Wisconsin Biotechnology Center)]
* [http://www.med.umich.edu/tamc/ Transgenic Animal Model Core (University of Michigan)]
* [http://www.bcm.tmc.edu/urol/spore/transgen_core.html Transgenic Core (Baylor College of Medicine SPORE)]
* [http://www.uchsc.edu/sm/animal/tmcl/txhmpg.html Transgenic Facility (University of Colorado Health Science Center)]
* [http://www.uky.edu/Transgenic/ Transgenic Facility (University of Kentucky)]
* [http://som1.ab.umd.edu/Microbiology/Transgene.html Transgenic & Knockout Mouse Facility (University of Maryland at Baltimore)]
* [http://www.lists.ic.ac.uk/hypermail/transgenic-list/ Transgenic-List Archives]
* [http://www-rics.bwh.harvard.edu/derm/tg_core.html Transgenic Models of Skin Disease Core (Harvard Skin Disease Research Center)]
* [http://www.mssm.edu/molbio/bcmb/BCMB_Core_Facilities.html Transgenic Mouse Core Facilities (Mount Sinai School of Medicine)]
* [http://www.med.virginia.edu/~sp3i/tghome.html Transgenic Mouse Core Facility (University of Virginia)]
* [http://cpmcnet.columbia.edu/research/equip/eq-cctrn.htm Transgenic Mouse Facility (Columbia-Presbyterian Cancer Center)]
* [http://genetics.mc.duke.edu/transgenX.html Transgenic Mouse Facility (Duke Comprehensive Cancer Center)]
* [http://www.pharm.sunysb.edu/transgenic/Transgenic.html Transgenic Mouse Facility (SUNY-Stony Brook)]
* [http://darwin.bio.uci.edu/~tjf/index.html Transgenic Mouse Facility (University of California-Irvine)]
* [http://www.cosm.sc.edu/ibrt/mouse.html Transgenic Mouse Facility (University of South Carolina)]
* [http://info.med.yale.edu/ycc/transgenic.html Transgenic Mouse Facility (Yale University Cancer Center)]
* [http://www-mp.ucdavis.edu/tgmice/firststop.html Transgenic Mouse Program (University of California-Davis)]
* [http://kccc-www.med.nyu.edu/mouse.htm Transgenic Mouse Research Facility (New York University Kaplan Comprehensive Cancer Center)]
* [http://www.cshl.org/books/transgenic_techniques.html Transgenic Techniques in Mice: A Video Guide (Cold Spring Harbor Laboratory)]
* [http://www.transgenics-berlin.com/ Transgenics (Berlin-Buch GmbH)]




Revision as of 15:31, 26 May 2011

Mouse.jpg

Introduction

Mouse E0-E5.jpg

The mouse (taxon-mus) has always been a good embryological model, generating easily (litters 8-20) and quickly (21d). Mouse embryology really expanded when molecular biologists used mice for gene knockouts. Suddenly it was necessary to understand development in order to understand the effect of knocking out the gene. There are over 450 different strains of inbred research mice, and these strains have recently been organized into a chart. While being an ideal model organism, only a relatively small amount (1.5%) of the total mouse genome has been sequenced. Those interested in the mouse reproductive cycle should also look at the mouse estrous cycle.

There are several systems for staging mouse development. The original and most widely used is the Theiler Stages system, which divides mouse development into 26 prenatal and 2 postnatal stages. [1]

mouse | original page

Mouse Stages: E1 | E2.5 | E3.0 | E3.5 | E4.5 | E5.0 | E5.5 | E6.0 | E7.0 | E7.5 | E8.0 | E8.5 | E9.0 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E20 | Timeline | About timed pregnancy


Species Embryonic Comparison Timeline
Carnegie Stage
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human Days 1 2-3 4-5 5-6 7-12 13-15 15-17 17-19 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse Days 1 2 3 E4.5 E5.0 E6.0 E7.0 E8.0 E9.0 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16
Rat Days 1 3.5 4-5 5 6 7.5 8.5 9 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5
Note these Carnegie stages are only approximate day timings for average of embryos. Links: Carnegie Stage Comparison
Table References  
Human

O'Rahilly R. (1979). Early human development and the chief sources of information on staged human embryos. Eur. J. Obstet. Gynecol. Reprod. Biol. , 9, 273-80. PMID: 400868
Otis EM and Brent R. Equivalent ages in mouse and human embryos. (1954) Anat Rec. 120(1):33-63. PMID 13207763

Mouse
Theiler K. The House Mouse: Atlas of Mouse Development (1972, 1989) Springer-Verlag, NY. Online
OTIS EM & BRENT R. (1954). Equivalent ages in mouse and human embryos. Anat. Rec. , 120, 33-63. PMID: 13207763

Rat
Witschi E. Rat Development. In: Growth Including Reproduction and Morphological Development. (1962) Altman PL. and Dittmer DS. ed. Fed. Am. Soc. Exp. Biol., Washington DC, pp. 304-314.
Pérez-Cano FJ, Franch À, Castellote C & Castell M. (2012). The suckling rat as a model for immunonutrition studies in early life. Clin. Dev. Immunol. , 2012, 537310. PMID: 22899949 DOI.

Timeline Links: human timeline | mouse timeline | mouse detailed timeline | chicken timeline | rat timeline | Medaka | Category:Timeline

Some Recent Findings

Mouse E14.5 from transcriptome atlas[2]
  • A high-resolution anatomical atlas of the transcriptome in the mouse embryo[2] "We generated anatomy-based expression profiles for over 18,000 coding genes and over 400 microRNAs. We identified 1,002 tissue-specific genes that are a source of novel tissue-specific markers for 37 different anatomical structures."

Early Mouse Development

Mouse E0-E5.jpg



  • Mouse follicle in vitro

    Mouse follicle in vitro

  • Mouse germinal vesicle oocyte protein expression

    Mouse germinal vesicle oocyte protein expression

  • Mouse germinal vesicle oocyte protein expression

    Mouse germinal vesicle oocyte protein expression

  • Mouse zygote protein expression

    Mouse zygote protein expression

  • Mouse 1 cell

    Mouse 1 cell

  • Mouse 2 cell

    Mouse 2 cell

  • Mouse morula

    Mouse morula

  • Mouse early blastocyst

    Mouse early blastocyst

  • Mouse hatched blastocyst

    Mouse hatched blastocyst


Links: Mouse Stages

Later Mouse Development

Links: Mouse Stages | Mouse Timeline Detailed

Carnegie Stages Comparison

The table below gives an approximate comparison of human, mouse and rat embryos based upon Carnegie staging.

Species Stage
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human [6] Days 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse [1] Days 9 9.5 10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16
Rat [7] Days 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5

Spermatozoa Development

Mouse spermatogonial self-renewal[8]

The process of spermatogenesis takes approximately 35 days:

  • mitotic phase (11 days)
  • meiotic phase (10 days)
  • post-meiotic phase (14 days)

Spermatogonial stem cells (SSCs)

The diploid germ cells, spermatogonial stem cells (SSCs), are located on the basement membrane of the seminiferous tubules

  • adult mouse testis about 30,000 SSCs
  • either divides into two new single cells
  • or into a pair of spermatogonia (Apr)
    • that do not complete cytokinesis and stay connected by an intercellular bridge

Primitive spermatogonia subset

  • Asingle (As, single isolated spermatogonia)
  • Apaired (Apr, interconnected spermatogonial pairs)
  • Aaligned (Aal, interconnected 4, 8, or 16 spermatogonia)
    • specifically termed Aal-4, Aal-8, and Aal-16

Primitive spermatogonia cells transform without cell division into more differentiating A1 spermatogonia that undergo 6 mitotic and 2 meiotic divisions to eventually form haploid spermatids.


Links: Spermatozoa Development | Testis Development

Neural Development

The data below is summarised from a study of early neural development in the mouse.[9]

  • initial fusion of apposing neural folds occurred at the level of the intermediate point between the third and fourth somites (caudal myelencephalon) both rostrally and caudally
  • second fusion - at the original rostral end of the neural plate (rostrodorsally).
  • third fusion - in the caudal diencephalon (rostrally and caudally)
    • followed by complete closure of the telencephalic neuropore at the midpoint of the telencephalic roof
    • then complete closure of the metencephalic neuropore at the rostral part of the metencephalic roof
  • fourth fusion - at the original caudal end of the neural plate (rostrally)
  • caudal neuropore completely closed at the level of the future 33rd somite

See also these 1980's papers.[10] [11]

Mouse Knockouts

Knowledge about mouse development has rapidly expanded as it has become the model animal system for genetic "knock out " studies. This technology actually requires development of defined breeding programs, pseudo-pregnancy, in vitro fertilization, molecular biology, and good old fashioned histology. Without understanding normal development the molecular biologists don't stand a hope of understanding what their gene knock out has done. There is a database of all existing mouse knockouts and their consequences.

Murine Development Control Genes

Kessel, M. and Gruss, P. Science 249 374-379 (1990)

An early review of the genes, and method of identifying them, involved in early mouse development. In particular discusses Homeobox genes. (homeobox is 183bp encoding a 61 amino acid DNA-binding domain)

  • Gene families
    • Hox
    • Pax
    • POU

The Genealogy Chart of Inbred Strains

This chart shows the origins and relationships of inbred mouse strains. The chart is available as a PDF document [../pdf/mouse_genealogy.pdf Locally] or from JAX Labs and was originally published by Beck etal., 2000.

Mouse Genome

Mouse Genome completed December 2002, a draft sequence and analysis of the genome of the C57BL/6J mouse strain.

  • less than 30,000 genes
  • estimated size is 2.5 Gb, smaller than the human genome
  • about 40% of the human and mouse genomes can be directly aligned
  • about 80% of human genes have one corresponding gene in the mouse genome
Links: Mouse Genome Sequencing: Mus musculus | Mouse Genome Informatics | Mouse Genome Project | Nature - Mouse Genome

References

  1. ↑ 1.0 1.1 The House Mouse: Atlas of Mouse Development by Theiler Springer-Verlag, NY (1972, 1989). | online book
  2. ↑ 2.0 2.1 <pubmed>21267068</pubmed>| PLoS Biol. | Eurexpress transcriptome atlas
  3. ↑ <pubmed>20704721</pubmed>| BMC Dev Biol.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 <pubmed>16683035</pubmed>| PLoS Genetics
  5. ↑ <pubmed>18713865</pubmed>| PNAS
  6. ↑ <pubmed>400868</pubmed>
  7. ↑ Witschi, E. (1962) Development: Rat. In: Growth Including Reproduction and Morphological Development. Altman, P. L. , and D. S. Dittmer, ed. Fed. Am. Soc. Exp. Biol., Washington DC, pp. 304-314.
  8. ↑ Zhou Q, Griswold MD. Regulation of spermatogonia. StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute. PMID20614596 | http://www.ncbi.nlm.nih.gov/books/NBK27035/ Bookshelf]
  9. ↑ Neurulation in the mouse: manner and timing of neural tube closure. Sakai Y. Anat Rec. 1989 Feb;223(2):194-203. PMID: 2712345
  10. ↑ The histogenetic potential of neural plate cells of early-somite-stage mouse embryos. Chan WY, Tam PP. J Embryol Exp Morphol. 1986 Jul;96:183-93. PMID: 3805982
  11. ↑ Neurulation in the mouse. I. The ontogenesis of neural segments and the determination of topographical regions in a central nervous system. Sakai Y. Anat Rec. 1987 Aug;218(4):450-7. PMID: 3662046

Search Pubmed

Search Pubmed: Mouse Development | Mouse Embryology

Additional Images

  • Mouse 1 cell

    Mouse 1 cell

  • Mouse 2 cell

    Mouse 2 cell

  • Mouse morula

    Mouse morula

  • Mouse early blastocyst

    Mouse early blastocyst

  • Mouse blastocyst

    Mouse blastocyst

  • early conceptus

    early conceptus

  • axial rotation

    axial rotation

  • Mouse ruga pattern

    Mouse ruga pattern

Movies

Fertilization 001 icon.jpg Parental genome mix 01 icon.jpg Nodal-cilia-001-icon.jpg Somitogenesis 01 icon.jpg
Fertilization
mouse 		Parental genome
mouse 		Nodal cilia rotation
mouse 		Somitogenesis
mouse
Primordial germ cell 001 icon.jpg Primordial germ cell 002 icon.jpg Primordial germ cell 003 icon.jpg Mouse CT E11.5 movie-icon.jpg
Migration 1 Migration 2 Migration 3 microCT E11.5

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

Mouse Embryology

Mouse Gene Expression

  • EMAGE is a database of in situ gene expression data in the mouse embryo and an accompanying suite of tools to search and analyse the data. (All site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.)
  • Eurexpress transcriptome atlas a High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo.
  • GenePaint.org is a digital atlas of gene expression patterns in the mouse.

Mouse Genome

Mouse Jackson Laboratory


Mouse Diseases

Mouse Transgenics

Mouse Unsorted Links


Animal Development: axolotl | bat | cat | chicken | cow | dog | dolphin | echidna | fly | frog | goat | grasshopper | guinea pig | hamster | horse | kangaroo | koala | lizard | medaka | mouse | opossum | pig | platypus | rabbit | rat | salamander | sea squirt | sea urchin | sheep | worm | zebrafish | life cycles | development timetable | development models | K12
Historic Embryology  
1897 Pig | 1900 Chicken | 1901 Lungfish | 1904 Sand Lizard | 1905 Rabbit | 1906 Deer | 1907 Tarsiers | 1908 Human | 1909 Northern Lapwing | 1909 South American and African Lungfish | 1910 Salamander | 1951 Frog | Embryology History | Historic Disclaimer

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, April 20) Embryology Mouse Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Mouse_Development

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
Retrieved from ‘https://embryology.med.unsw.edu.au/embryology/index.php?title=Mouse_Development&oldid=56480’
Powered by MediaWiki