Mouse Development: Difference between revisions

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'''Search Pubmed:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Mouse+development Mouse Development]
'''Search Pubmed:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Mouse+development Mouse Development]


==Additional Images==


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<gallery>
File:Mouse- early conceptus.jpg|early conceptus
File:Mouse_ruga_pattern.jpg|Mouse ruga pattern
File:Mouse_ruga_pattern.jpg|Mouse ruga pattern
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</gallery>

Revision as of 09:44, 5 April 2010

Mouse.jpg

Introduction

Mouse E0-E5.jpg

The mouse (taxon-mus) has always been a good embryological model, easy to generate (litters 8-20) and quick (21d). Mouse embryology really expanded when molecular biologists used mice for gene knockouts, suddenly you had to understand about development in order to understand the effect of knocking out the gene. There are over 450 different strains of inbred research mice, and this has recently been organized into a chart. While being an ideal model organism, only a relatively small amount (1.5%) of the total mouse genome sequenced. Those interested in the mouse reproductive cycle, should also look at the mouse estrous cycle.

mouse

Early Mouse Development

Mouse E0-E5.jpg

Carnegie Stages Comparison

Data For Carnegie Stages Comparison Graph (Species/Days) (All Species Data)
Species Stage
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human Days 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse Days 9 9.5 10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16
Rat Days 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5

References

Human - O'Rahilly, Early human development and the chief source of information on staged human embryos. Eur. J. Obstet. Gynec. Reprod. Biol. 9 p273 (1979)

Mouse - Theiler, The house mouse. Springer-Verlag, NY (1972)

Rat - Witschi, Growth. Altman and Dittmer (ed), Fed. Soc. Exp. Biol., Washington (1962)

 

Reference for Staging the Mouse Embryo

Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Downs KM, Davies T Development 1993 Aug;118(4):1255-66 PubMed Entry | Development Article

"We describe and illustrate a set of morphological landmarks for classifying mouse embryos by gross morphology from before gastrulation to the beginning of organogenesis. These landmarks are visible at the resolution of the dissecting microscope in embryos that are intact except for reflexion of Reichert's membrane. Adoption of these criteria should facilitate interpretation of both the expression patterns of genes and the consequences of experimental manipulation of embryos during early postimplantation development."

The Mouse its Reproduction and Development Rugh, R. Oxford University Press, Oxford (1990)


Demonstration of the E12.5 mouse embryo cardiovascular system. (lateral and dorsal views) placental vessels in the first image (on right of embryo).

Mouse Knockouts

Knowledge about mouse development has rapidly expanded as it has become the model animal system for genetic "knock out " studies. This technology actually requires development of defined breeding programs, pseudo-pregnancy, in vitro fertilization, molecular biology, and good old fashioned histology. Without understanding normal development the molecular biologists don't stand a hope of understanding what their gene knock out has done. There is a database of all existing mouse knockouts and their consequences.

Murine Development Control Genes

Kessel, M. and Gruss, P. Science 249 374-379 (1990)

An early review of the genes, and method of identifying them, involved in early mouse development. In particular discusses Homeobox genes. (homeobox is 183bp encoding a 61 amino acid DNA-binding domain)

  • Gene families
    • Hox
    • Pax
    • POU

The Genealogy Chart of Inbred Strains

This chart shows the origins and relationships of inbred mouse strains. The chart is available as a PDF document [../pdf/mouse_genealogy.pdf Locally] or from JAX Labs and was originally published by Beck etal., 2000.

Mouse Genome Sequencing

Mouse Genome (17 August 2001)

  • Finished Sequence- 47.6 Mb,1.5 % of genome
  • Draft Sequence- 375 Mb, 11.7 % of genome
  • See also Breakdown by chromosome

C57BL/6J strain of Mus musculus

More? see external Link- Mouse Genome Sequencing: Mus musculus | Mouse Genome Informatics | Mouse Genome Project | Nature - Mouse Genome

References


Search Pubmed: Mouse Development

Additional Images

Mouse Internet Links


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Cite this page: Hill, M.A. (2024, March 28) Embryology Mouse Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Mouse_Development

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G