Mouse Bronchial Branching Movie
|Embryology - 23 May 2019 Expand to Translate|
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This animation is designed to show the changing bronchial branching pattern in the developing mouse lung between E10 to E14 of development. The referenced article identified a thickening of the respiratory epithelium in a specific region before bending of that epithelium to commence a branch point. Mesoderm did not appear to have morphological changes associated with this process.
Mouse whole-mount immunohistochemistry using vimentin to mark mesenchyme (red) and E-cadherin to mark epithelium (blue) was used to characterize bronchial branching morphogenesis.
Note the animation is based upon images from reference figure 1 and are not from the same mouse, but a sequence of fluorescent images.
|Mouse E10 to E14|
|36 somites||44 somites||48 somites||54 somites||Mouse 60 somites|
|Detail of the left lung
Proceedings National Academy of Sciences (PNAS) Liberalization of PNAS copyright policy: Noncommercial use freely allowed Note original Author should be contacted for permission to reuse for Educational purposes. See also PNAS Author Rights and Permission FAQs
- Cozzarelli NR, Fulton KR, Sullenberger DM. Liberalization of PNAS copyright policy: noncommercial use freely allowed. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12399. PMID15314225 "Our guiding principle is that, while PNAS retains copyright, anyone can make noncommercial use of work in PNAS without asking our permission, provided that the original source is cited."
Cropped and relabelled from figure 1. http://www.pnas.org/content/111/34/12444/F1.large.jpg W394 × H426
Cite this page: Hill, M.A. (2019, May 23) Embryology Mouse Bronchial Branching Movie. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Mouse_Bronchial_Branching_Movie
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G