Mouse Bronchial Branching Movie

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This animation is designed to show the changing bronchial branching pattern in the developing mouse lung between E10 to E14 of development. The referenced article identified a thickening of the respiratory epithelium in a specific region before bending of that epithelium to commence a branch point. Mesoderm did not appear to have morphological changes associated with this process.

Mouse whole-mount immunohistochemistry using vimentin to mark mesenchyme (red) and E-cadherin to mark epithelium (blue) was used to characterize bronchial branching morphogenesis.

Note the animation is based upon images from reference figure 1 and are not from the same mouse, but a sequence of fluorescent images.


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Mouse Respiratory Links: image - 36-60 somites | image - 44-60 somites | image - 36 somites | image - 44 somites | image - 48 somites | image - 54 somites | image - 60 somites | Mouse Bronchial Branching Movie | Respiratory System Development | Mouse Development
Mouse Stages: E1 | E2.5 | E3 | E3.5 | E4.5 | E7.0 | E7.5 | E8.5 | E9.0 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E18 | E18.5 | E19 | E20 | Timeline | About timed pregnancy
Mouse E10 to E14
Mouse respiratory 36 somites.jpg Mouse respiratory 44 somites.jpg Mouse respiratory 48 somites.jpg Mouse respiratory 54 somites.jpg Mouse respiratory 60 somites.jpg
36 somites 44 somites 48 somites 54 somites Mouse 60 somites
Detail of the left lung
branching pattern.
Mouse respiratory 44 to 60 somites.jpg

Reference

<pubmed> 25114215</pubmed>PMC4151720 | Proc Natl Acad Sci U S A.


Copyright

Proceedings National Academy of Sciences (PNAS) Liberalization of PNAS copyright policy: Noncommercial use freely allowed Note original Author should be contacted for permission to reuse for Educational purposes. See also PNAS Author Rights and Permission FAQs

Cozzarelli NR, Fulton KR, Sullenberger DM. Liberalization of PNAS copyright policy: noncommercial use freely allowed. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12399. PMID15314225 "Our guiding principle is that, while PNAS retains copyright, anyone can make noncommercial use of work in PNAS without asking our permission, provided that the original source is cited."

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Cropped and relabelled from figure 1. http://www.pnas.org/content/111/34/12444/F1.large.jpg W394 × H426

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Cite this page: Hill, M.A. (2019, June 18) Embryology Mouse Bronchial Branching Movie. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Mouse_Bronchial_Branching_Movie

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G