Lecture - Stem Cells

Introduction

Week 1 human development

Blastocyst development

Embryology is all about stem cells, a single cell (zygote) divides and differentiates to form all the tissues throughout the body. Furthermore within some tissues, stem cells remain to continuously replace cells that are lost through the life of that tissue. In recent years scientific and general interest in this topic has increased due to the many issues that surround this specialised cell type. This lecture will introduce the various types/sources of stem cells as well as their practical and therapeutic potentials. A brief discussion of the pros and cons of different types of stem cells currently investigated in the field of medical research will be discussed.

Here are the slides for today's lecture ANAT2341 Beverdam 2016 - Stem cell biology and technology.

Objectives

• Tissue development and regeneration Stem cell biology
• Stem cell niches
• Stem cell regulation
• Stem cells and cancer Regenerative medicine
• Stem cell sources
• Future of regenerative medicine

Additional Lecture Resources

References
Hill, M.A. (2020). UNSW Embryology (20th ed.) Retrieved April 18, 2024, from https://embryology.med.unsw.edu.au	Stem Cell Links: Introduction | Timeline | Placental Cord Blood | Adult | Induced pluripotent stem cell | Yamanaka Factors | Somatic Cell Nuclear Transfer | Ethics | Organoids | Adult Human Cell Types | Category:Stem Cell Archive: 2015 PDF	2014 PDF
The Nobel Prize in Physiology or Medicine 2012	Awarded jointly to Sir John B. Gurdon and Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent" Yamanaka Factors Are a set of 4 transcription factors when introduced into cells induces stem cell formation. PMID 16904174 | PMID 18035408 | PMID 20535199 John Gurdon used nuclear transplantation and cloning to show that the nucleus of a differentiated somatic cell retains the totipotency necessary to form a whole organism. 2003 Current Biology Interview PMID 14521852 2009 Interview - "The birth of cloning" PMID 19132124 Stem Cells - Induced
Stem Cell Therapies	Opportunities for Ensuring the Quality and Safety of Clinical Offerings: Summary of a Joint Workshop. Board on Health Sciences Policy; Board on Life Sciences; Division on Earth and Life Studies; Institute of Medicine; National Academy of Sciences. Washington (DC): National Academies Press (US); 2014 Jun 18. http://www.ncbi.nlm.nih.gov/books/NBK223197
NIH Report	NIH - Regenerative Medicine 2006

ANAT2341 Course Timetable
Week (Mon)	Lecture 1 (Mon 1-2pm)	Lecture 2 (Tue 3-4pm)	Practical (Fri 1-3pm)
Week 2 (1 Aug)	Introduction	Fertilization	Lab 1
Week 3 (8 Aug)	Week 1 and 2	Week 3	Lab 2
Week 4 (15 Aug)	Mesoderm	Ectoderm	Lab 3
Week 5 (22 Aug)	Early Vascular	Placenta	Lab 4
Week 6 (29 Aug)	Gastrointestinal	Respiratory	Lab 5
Week 7 (5 Sep)	Head	Neural Crest	Lab 6
Week 8 (12 Sep)	Musculoskeletal	Limb Development	Lab 7
Week 9 (19 Sep)	Renal	Genital	Lab 8
Mid-semester break
Week 10 (3 Oct)	Public Holiday	Stem Cells	Lab 9
Week 11 (10 Oct)	Integumentary	Endocrine	Lab 10
Week 12 (17 Oct)	Heart	Sensory	Lab 11
Week 13 (24 Oct)	Fetal	Birth and Revision	Lab 12
ANAT2341 2016: Moodle page | ECHO360 | Textbooks | Students 2016 | Projects 2016