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==Introduction==
==Introduction==
[[File:Hypothalamus endocrine system.jpg|thumb|300px|Hypothalamus endocrine system]]
[[File:Week10 adrenal.jpg|thumb|300px|Human adrenal gland ([[Second_Trimester|Week 10]])]]
[[File:Week10 adrenal.jpg|thumb|300px|Human adrenal gland ([[Second_Trimester|Week 10]])]]
The endocrine system resides within specific endocrine organs and both organs and tissues with other specific functions. Epithelia (ectoderm and endoderm) form the majority of the “ductless” endocrine glands like gastrointestinal and skin associated “ducted” glands. Differentiation of several also organs involves a epithelial/mesenchye interaction, seen in repeated in many differentiation of many different tissues. The endocrine glands produce hormones, which are distributed by the vascular system to the many body tissues, subsequently these organs are richly vascularized.
The endocrine system resides within specific endocrine organs and both organs and tissues with other specific functions. Epithelia (ectoderm and endoderm) form the majority of the “ductless” endocrine glands like gastrointestinal and skin associated “ducted” glands. Differentiation of several also organs involves a epithelial/mesenchye interaction, seen in repeated in many differentiation of many different tissues. The endocrine glands produce hormones, which are distributed by the vascular system to the many body tissues, subsequently these organs are richly vascularized.


Hormones “orchestrate” responses in other tissues, including other endocrine organs, and these overall effects can be similar or different in different tissues. These signaling pathways are often described as "axes" the two major types are the: '''HPA''' ('''H'''ypothalamus-'''P'''ituitary-'''A'''drenal) and  '''HPG''' ('''H'''ypothalamus-'''P'''ituitary-'''G'''onad). These hormone effects (like music) can be rapid, slow, brief, diurnal, or long-term. Hormone effects can be mimicked, stimulated, and blocked by therapeutic drugs, nutritional and environmental chemicals. Importantly, fetal endocrine development is required for normal fetal growth and differentiation.
Hormones “orchestrate” responses in other tissues, including other endocrine organs, and these overall effects can be similar or different in different tissues. These signaling pathways are often described as "axes" the two major types are the: '''HPA''' ('''H'''ypothalamus-'''P'''ituitary-'''A'''drenal) and  '''HPG''' ('''H'''ypothalamus-'''P'''ituitary-'''G'''onad). These hormone effects (like music) can be rapid, slow, brief, diurnal, or long-term. Hormone effects can be mimicked, stimulated, and blocked by therapeutic drugs, nutritional and environmental chemicals. Importantly, fetal endocrine development is required for normal fetal growth and differentiation.


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[[Media:ANAT2341Lecture 2018 - Endocrine Development.pdf|2018 Lecture - Print PDF]]


==Lecture Objectives==


{|
| [[File:Podcast icon.jpg]]
| --[[User:S8600021|Mark Hill]] 06:17, 26 September 2011 (EST) '''Interested in endocrine and hormone history?''' Listen to ABC Radio Ockham's Razor 2005-07-31 Centenary of the word "hormone" ([[File:Audio_-_centenary_of_hormone.mp3]]), by Sydney medical scientist (from SOMS) and writer Dr John Carmody commemorates the centenary of the entry of the word 'hormone' into the English language.
|}
==Lecture Objectives==
{|
| width="500px"|
* Understanding of hormone types
* Understanding of hormone types
* Understanding of endocrine gland development
* Understanding of endocrine gland development
* Understanding of endocrine developmental functions
* Understanding of endocrine developmental functions


Lecture Date: 2013-10-08  Lecture Time: 12:00 Venue: Wallace Wurth LG02 Speaker: Steve Palmer


The Powerpoint file used to present this lecture is available as a pdf document [[Media:Endocrine Development.pdf‎‎| HERE]]


The audio will be available via the Lectopia system through Blackboard
{| class="wikitable mw-collapsible mw-collapsed"
! Endocrine in the News &nbsp;
|-
| [[File:Human stem cell pancreas implants 01.jpg|300px|left|alt=Human stem cell pancreas implants|link=Stem Cells]]
 
 
{{#pmid:26808346}}
 
Implanted in the intraperitoneal space of mice treated to chemically induce type 1 diabetes. Implants induced glycemic correction without any immunosuppression until their removal at 174 d after implantation. Human C-peptide concentrations and in vivo glucose responsiveness demonstrated therapeutically relevant glycemic control and retrieved implants contained viable insulin-producing cells.
 
:'''Links:''' [[Stem Cells]] | [[Endocrine - Pancreas Development]]
|-
| [[File:Menstrual cycle.png|300px|left|alt=Menstrual cycle|link=Menstrual Cycle]] Oral Contraceptives A recent 2016 Danish study births from Danish registries between 1997 and 2011 identified that:


| [[File:Historic-pituitary.jpg|200px]]


Historic drawing of the Pituitary.
{{#pmid:26738512}}
|}


==Textbooks==
:'''Links:''' [[Menstrual Cycle]] | [[Abnormal_Development_-_Drugs|Abnormal Development]]
The endocrine "System" is not covered by a specific chapter in the embryology textbooks and you will need to look for related chapters on the development of individual components (some selected examples are listed below). Use the listed Endocrinology textbook for detained descriptions of function.
===Embryology===
{| border='0px'
|-
|-
| [[File:Logo.png|80px]]
| [[File:Ernest Henry Starling (1866-1927).jpg|150px|left|alt=Ernest Henry Starling (1866-1927)|]]Ernest Henry Starling (1866-1927)
| Hill, M.A. (2012) <i>UNSW Embryology</i> (12<sup>th</sup> ed.). Sydney:UNSW.


{{Endocrine Links}} | [[2010_Lecture_17|2010 Lecture]]  
 
Interested in hormone history?
 
 
Listen ABC Radio Ockham's Razor 2005-07-31 Centenary of the word "hormone" (6.2 Mb mp3) [[Media:Audio - centenary of hormone.mp3| Centenary of the word 'hormone']], Sydney medical scientist and writer Dr John Carmody commemorates the centenary of the entry of the word 'hormone' into the English language.
 
<html5media>File:Audio - centenary of hormone.mp3</html5media>
|}
|}


===Endocrinology - An Integrated Approach===
==Lecture Resources==
{|
{| class="wikitable mw-collapsible mw-collapsed"
! Movies  &nbsp;
|-
| valign="bottom"|{{Adrenal movie}}
| valign="bottom"|{{Aschheim-Zondek1928 movie}}
| valign="bottom"|{{Adrenal GA32 movie}}
| valign="bottom"|{{Gastrointestinal stage 13 movie}}
| valign="bottom"|{{Urogenital stage 22 movie}}
|-
|}
{| class="wikitable mw-collapsible mw-collapsed"
! colspan=2|References &nbsp;
|-
| {{Embryo logocitation}}
|  
{{Endocrine Links}}
* Lecture Archive: [https://embryology.med.unsw.edu.au/embryology/index.php?title=Lecture_-_Endocrine_Development&oldid=340760 2017] | [[Media:Lecture 2016 - Endocrine Development.pdf|2016 PDF]] | [https://embryology.med.unsw.edu.au/embryology/index.php?title=Lecture_-_Endocrine_Development&oldid=198711 2015] | [[Media:2015ANAT2341_Lecture_13_-_Endocrine Development.pdf|2015 PDF]][https://embryology.med.unsw.edu.au/embryology/index.php?title=Lecture_-_Endocrine_Development&oldid=144833 2014]
|-
| colspan=2|The endocrine "System" is not covered by a specific chapter in the embryology textbooks and you will need to look for related chapters on the development of individual components (some selected examples are listed below). Use the listed Endocrinology textbook for detained descriptions of function.
|-
| [[File:Endocrinology - An Integrated Approach.png|80px]]
| [[File:Endocrinology - An Integrated Approach.png|80px]]
| Nussey, S. and Whitehead, S. (2001). ''Endocrinology - An Integrated Approach''. UK Oxford: BIOS Scientific Publishers. ISBN-10: 1-85996-252-1.
Nussey, S. and Whitehead, S. (2001). ''Endocrinology - An Integrated Approach''. UK Oxford: BIOS Scientific Publishers. ISBN-10: 1-85996-252-1
 
| [[Talk:Lecture_-_Endocrine_Development#Endocrinology_-_An_Integrated_Approach|Detailed Table of Contents]] | [http://www.ncbi.nlm.nih.gov/books/NBK22 Bookshelf Link]
[[Talk:Lecture_-_Endocrine_Development#Endocrinology_-_An_Integrated_Approach|Detailed Table of Contents]] | [http://www.ncbi.nlm.nih.gov/books/NBK22 Bookshelf Link]
 
* [http://www.ncbi.nlm.nih.gov/books/n/endocrin/A3/ Chapter 1. Principles of endocrinology]
* [http://www.ncbi.nlm.nih.gov/books/n/endocrin/A3/ Chapter 1. Principles of endocrinology]
* [http://www.ncbi.nlm.nih.gov/books/n/endocrin/A43/ Chapter 2. The endocrine pancreas]
* [http://www.ncbi.nlm.nih.gov/books/n/endocrin/A43/ Chapter 2. The endocrine pancreas]
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* [http://www.ncbi.nlm.nih.gov/books/n/endocrin/A1257/ Chapter 7. The pituitary gland]
* [http://www.ncbi.nlm.nih.gov/books/n/endocrin/A1257/ Chapter 7. The pituitary gland]
* [http://www.ncbi.nlm.nih.gov/books/n/endocrin/A1527/ Chapter 8. Cardiovascular and renal endocrinology]
* [http://www.ncbi.nlm.nih.gov/books/n/endocrin/A1527/ Chapter 8. Cardiovascular and renal endocrinology]
|-
| [[File:Larsen's human embryology 5th ed.jpg|90px|left]] Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R., Francis-West, P.H. & Philippa H. (2015). Larsen's human embryology (5th ed.). New York; Edinburgh: Churchill Livingstone.
 
UNSW students have full access to this textbook edition through [http://er.library.unsw.edu.au/er/cgi-bin/eraccess.cgi?url=http://www.unsw.eblib.com.wwwproxy0.library.unsw.edu.au/patron/FullRecord.aspx?p=2074524 UNSW Library subscription] (with student Zpass log-in). Note that most embryology textbooks do no have specific chapter for endocrine development and this information is often found in other chapters (neural, renal, head, genital).
|
* Chapter 9 [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=235 Development of the Hypothalamus]
* Chapter 9 [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=236 Development of the Pineal Gland]
* Chapter 9 [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=243 Development of the Pituitary]
* Chapter 14 [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=371 Development of the Pancreas]
* Chapter 15 [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=407  Development of the Suprarenal Gland]
* Chapter 16 [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=417 Development of the Gonad]
* Chapter 17 [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=479 Development of the Thyroid]
{{UNSW textbook - Larsen's Human Embryology}}
{{UNSW textbook - The Developing Human}}
|}
|}
{| class="wikitable mw-collapsible mw-collapsed"
! 2016 Lecture Video Recording &nbsp;
|-
| This 2016 lecture video recording is similar in content to the current 2017 online lecture.


<html5media height="600" width="800">File:2016Lecture-Endocrine.mp4</html5media>


===The Developing Human: Clinically Oriented Embryology===
Click to play new window - [[Media:2016Lecture-Endocrine.mp4|'''2016 Lecture Video''']] (48 MB)
{|
|-
| [[File:The Developing Human, 9th edn.jpg|90px]]
| '''Citation:''' The Developing Human: clinically oriented embryology 9<sup>th</sup> ed. Keith L. Moore, T.V.N. Persaud, Mark G. Torchia. Philadelphia, PA: Saunders, 2011. (links available to UNSW students)
* [http://er.library.unsw.edu.au/er/cgi-bin/eraccess.cgi?url=http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-2002-0..00009-6&isbn=978-1-4377-2002-0&uniqId=330028653-2#4-u1.0-B978-1-4377-2002-0..00009-6 Chapter 9 – Pharyngeal Apparatus, Face, and Neck]
* [http://er.library.unsw.edu.au/er/cgi-bin/eraccess.cgi?url=http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-2002-0..00012-6&isbn=978-1-4377-2002-0&uniqId=330028653-2#4-u1.0-B978-1-4377-2002-0..00012-6 Chapter 12 - Urogenital System]
|}
===Larsen's Human Embryology===
{| border='0px'
|-
| [[File:Larsen's human embryology 4th edn.jpg|90px]]
| '''Citation:''' Larsen's human embryology 4th ed. Schoenwolf, Gary C; Larsen, William J, (William James). Philadelphia, PA : Elsevier/Churchill Livingstone, c2009. (links available to UNSW students)
* [http://er.library.unsw.edu.au/er/cgi-bin/eraccess.cgi?url=http://www.mdconsult.com/books/linkTo?type=bookPage&isbn=978-0-443-06811-9&eid=4-u1.0-B978-0-443-06811-9..10016-8 Chapter 16 - Development of the Pharyngeal Apparatus and Face]
* [http://er.library.unsw.edu.au/er/cgi-bin/eraccess.cgi?url=http://www.mdconsult.com/books/linkTo?type=bookPage&isbn=978-0-443-06811-9&eid=4-u1.0-B978-0-443-06811-9..10015-6 Chapter 15 - Development of the Urogenital System]
|}
|}


:'''Links:''' [[Embryology Textbooks]]
==Endocrine Origins==
 
* '''Epithelia''' - (ectoderm) covering embryo, (endoderm) lining gastrointestinal tract, (mesoderm) lining coelomic cavity
* '''Mesenchyme''' -  (mesoderm) contribution, connective tissue, blood vessels


==Hormones==
==Hormones==
[[File:Steroid hormone receptor signaling.jpg|thumb|Steroid hormone receptor signaling<ref><pubmed>17464358</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853070 PMC1853070] | [http://www.nursa.org/article.cfm?doi=10.1621/nrs.05003 Nucl Recept Signal.]</ref>]]
[[File:Steroid hormone receptor signaling.jpg|thumb|Steroid hormone receptor signaling{{#pmid:17464358|PMID17464358}}]]
===Hormone Types===
===Hormone Types===
[[File:Steroid biosynthesis pathway.png|thumb|Steroid biosynthesis pathway]]
* '''Amino acid derivatives''' - noradrenaline (norepinepherine), adrenalin (epinepherine) , thyroid hormone
* '''Amino acid derivatives''' - noradrenaline (norepinepherine), adrenalin (epinepherine) , thyroid hormone
* '''Proteins, peptides''' - thyroid stimulating hormone, leutenising hormone, follicle stimulating hormone
* '''Proteins, peptides''' - thyroid stimulating hormone, leutenising hormone, follicle stimulating hormone
* '''Steroids''' - androgens, glucocorticoids, mineralocorticoids
* '''Steroids''' - androgens, glucocorticoids, mineralocorticoids
[[File:Steroid biosynthesis pathway.png|600px]]
Steroid biosynthesis pathway


===Hormone Actions===
===Hormone Actions===
All hormones act upon cells in different tissues and can be classified by the "distance" of their action, the classical description is that hormones are delivered by the blood.
* '''Autocrine''' - acts on self (extracellular fluid)
 
* '''Paracrine''' - acts locally (extracellular fluid)
* '''Autocrine''' - acts on self (extracellular fluid).
* '''Endocrine''' - acts by secretion into blood stream (endocrine organs are richly vascularized)
* '''Paracrine''' - acts locally (extracellular fluid or blood).
* '''Endocrine''' - acts by secretion into blood stream (endocrine organs are richly vascularized).


===Hormone Receptors===
===Hormone Receptors===
A cell or tissue can only directly respond to a hormone if it expresses a receptor for that hormone.
* '''Cell surface receptors''' - modified amino acids, peptides, proteins
* '''Cytoplasmic/Nuclear Receptors''' - steroids


Hormone receptors are either:
# '''cell surface''' - modified amino acids, peptides, proteins.
# '''intracellular cytoplasmic/nuclear''' - steroids.


==Endocrine Origins==
:Interested in hormone history? Listen ABC Radio Ockham's Razor 2005-07-31 6.2 Mb mp3 [http://embryology.med.unsw.edu.au/Podcast/OckhamRazor/CentenaryofHormone.mp3 Centenary of the word 'hormone'], Sydney medical scientist and writer Dr John Carmody commemorates the centenary of the entry of the word 'hormone' into the English language.
 
* Derived from epithelia - covering embryo, lining gastrointestinal tract, lining coelomic cavity
* Also mesenchymal contribution


==Pineal Gland==
==Pineal Gland==
[[File:pineal-body.jpg|thumb|Adult pineal body]]
{|
[[File:Pineal gland position.jpg|thumb|Pineal gland position]]
| [[File:Keith1902 fig167.jpg|600px]]
 
| valign=top|'''Pineal Development'''
* part of epithalmus - neurons, glia and pinealocytes
* '''Neuroectoderm''' - prosenecephalon then diencephalon
* pinealocytes secrete melatonin - cyclic nature of activity, melatonin lowest during daylight
** caudal roof, median diverticulum, epiphysis
** inhibit hypothalamic secretion of GnRH until puberty, pineal gland then rapidly regresses.
* Initially a hollow diverticulum, cell proliferation to solid, pinealocytes (neuroglia), cone-shaped gland innervated by epithalamus
|}
{|
| [[File:pineal-body.jpg|300px|Adult pineal body]]
| [[File:Pineal gland position.jpg|300px|Pineal gland position]]
|-
| Adult pineal body
| Pineal gland position
|-
| col width=300px|
* part of '''epithalamus''' - neurons, glia and pinealocytes
* '''pinealocytes''' secrete melatonin - cyclic nature of activity, melatonin lowest during daylight
* maternal melatonin crosses the placental barrier
* inhibit hypothalamic secretion of GnRH until puberty, pineal gland then rapidly regresses.
* other activities - possibly gamete maturation, antioxidant effect, protect neurons?
* other activities - possibly gamete maturation, antioxidant effect, protect neurons?
| [[File:Pineal_histology_001.jpg|300px]]
|}
{|
| [[File:Fetal pineal gland 01.jpg|400px]]
| valign=top|Fetal Pineal Anatomy{{#pmid:24757681|PMID24757681}}


===Pineal Development===
* Human fetus (3.5 month) superior (dorsal) view diencephalic-mesencephalic area.
* Neuroectoderm - prosenecephalon then diencephalon
* Third ventricle (3 ventr) without pial covering is seen to the right.
* caudal roof, median diverticulum, epiphysis
* Pineal gland is a small protuberance (arrow) and merging via the broad stalk with the habenula (Ha). Superior colliculus (Sup col.)
* Initially a hollow diverticulum, cell proliferation to solid, pinealocytes (neuroglia), cone-shaped gland innervated by epithalmus
|}


:'''Links:''' {{Pineal}} | [[Talk:BGD_Lecture_-_Endocrine_Development#Chapter_7._The_pituitary_gland|Endocrinology]]


:'''Links:''' [[Endocrine - Pineal Development]]
==Hypothalamus==
==Hypothalamus==
 
[[File:Hypothalamus_histology_001.jpg|thumb|Adult hypothalamus]]
'''Hormones''' - Thyrotrophin releasing hormone (TRH), Corticotrophin releasing hormone (CRH), Arginine vasopressin (AVP), Gonadotrophin releasing hormone (GnRH), Growth hormone releasing hormone (GHRH), Somatostatin, Prolactin relasing factor (PRF), Dopamine
'''Hormones''' - Corticotrophin releasing hormone (CRH), Thyrotrophin releasing hormone (TRH), Arginine vasopressin (AVP), Gonadotrophin releasing hormone (GnRH), Growth hormone releasing hormone (GHRH), Somatostatin, Prolactin relasing factor (PRF), Dopamine


===Hypothalamus Development===
===Hypothalamus Development===
* Neuroectoderm - prosenecephalon then diencephalon
* Neuroectoderm - prosenecephalon then '''diencephalon'''
* ventro-lateral wall intermediate zone proliferation
* ventro-lateral wall intermediate zone proliferation
* Mamillary bodies - form pea-sized swellings ventral wall of hypothalamus
* Mamillary bodies - form pea-sized swellings ventral wall of hypothalamus


{|
|-
| [[File:Stage_13_image_061.jpg|300px]]
| [[File:Stage_22_image_055.jpg|300px]]
|-
| Week 5 Secondary Brain Vesicles - Stage 13|Diencephalon region, shown by [[O#optic stalk|optic stalk]]<br>([[Carnegie_stage_13|Stage 13]])
| Week 8 Embryo Brain - Stage 22|Late embryonic hypothalamus<br>([[Carnegie_stage_22|Stage 22]])
|}
<gallery>
File:Gray0651.jpg|Human Embryo Brain <br>(week 4.5 exterior view)
File:Gray0652.jpg|Human Embryo Brain <br>(week 5 exterior view)
File:Gray0653.jpg|Human Embryo Brain <br>(week 5 interior view)
File:Gray0654.jpg|Human Fetal Brain <br>(3 months)
File:Gray0655.jpg|Human Fetal Brain <br>(4 months)
</gallery>


:'''Links:''' [[Endocrine - Hypothalamus Development]]
:'''Links:''' [[Endocrine - Hypothalamus Development]]
==Pituitary==
==Pituitary==
[[File:Embryonic_and_fetal_pituitary.jpg]]
{|
[[File:Historic-pituitary.jpg|thumb|Adult pituitary]]
| [[File:Historic-pituitary.jpg|300px|Adult pituitary]]
| [[File:Turkish saddle-17th century.jpg|150px|right|alt=Turkish saddle (17th century)]]The pituitary (hypophysis) sits anatomically within the sella turcica, a space within the sphenoid bone.
 
 


'''Anterior pituitary hormones''' - Thyroid-stimulating hormone (TSH), Adrenocorticotrophic hormone (ACTH), Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Somatotrophin/growth hormone (GH), Prolactin (PRL), Melanocyte-stimulating hormone (MSH)
'''Anterior pituitary hormones''' - Thyroid-stimulating hormone (TSH), Adrenocorticotrophic hormone (ACTH), Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Somatotrophin/growth hormone (GH), Prolactin (PRL), Melanocyte-stimulating hormone (MSH)


'''Posterior pituitary hormones''' - Oxytocin, Arginine vasopressin
'''Posterior pituitary hormones''' - Oxytocin, Arginine vasopressin
|}


===Pituitary Development===
===Pituitary Development===
[[File:Pituitary rabbit development.jpg|thumb|Pituitary rabbit development]]
{|
| [[File:Keith1902 fig015a.jpg|400px]]
| [[File:Pituitary rabbit development.jpg|400px]]
|}
 
{|
{|
| [[File:Pituitary development animation.gif]]
| [[File:Pituitary development animation.gif]]
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* Dual ectoderm origins
* Dual ectoderm origins
** Ectoderm - ectoderm roof of stomodeum, Rathke's pouch, adenohypophysis
** '''Ectoderm''' - ectoderm roof of stomodeum, Rathke's pouch, adenohypophysis
** Neuroectoderm - prosenecephalon then diencephalon, neurohypophysis
** '''Neuroectoderm''' - prosenecephalon then diencephalon, neurohypophysis


'''Adenohypophysis'''
'''Adenohypophysis'''
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* Infundibulum – median eminence, infundibulum, pars nervosa
* Infundibulum – median eminence, infundibulum, pars nervosa


[[File:Embryonic_and_fetal_pituitary.jpg]]<br>
[[File:Stage_22_image_220.jpg|400px]]
===Pituitary Timeline===
===Pituitary Timeline===
[[File:Fetal_head_section_03.jpg|thumb|Early Fetal (week 12)]]
* '''Week 4''' - hypophysial pouch, Rathke’s pouch, diverticulum from roof
* '''Week 4''' - hypophysial pouch, Rathke’s pouch, diverticulum from roof
* '''Week 5''' - elongation, contacts infundibulum, diverticulum of diencephalon
* '''Week 5''' - elongation, contacts infundibulum, diverticulum of diencephalon
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:'''Links:''' [[Endocrine - Pituitary Development]] | [http://www.med.unc.edu/embryo_images/unit-nervous/nerv_htms/nerv016.htm Embryo Images - Pituitary] | [[Talk:Lecture - Endocrine Development#Chapter_7._The_pituitary_gland|Endocrinology]]
:'''Links:''' {{Pituitary}} | [http://www.med.unc.edu/embryo_images/unit-nervous/nerv_htms/nerv016.htm Embryo Images - Pituitary] | [[Talk:BGD_Lecture_-_Endocrine_Development#Chapter_7._The_pituitary_gland|Endocrinology]]


==Thyroid==
==Thyroid==
[[File:Stage13 and 22 thyroid development a.jpg|thumb|Stage 13 and Stage 22 thyroid development]]
[[File:HPT axis.jpg|thumb|Hypothalamus - Pituitary - Thyroid Axis]]
* Functions from week 10, required for neural development, stimulates metabolism (protein, carbohydrate, lipid), reduced/absence = cretinism (see abnormalities)
* '''Maternal thyroid hormone''' - required for early stages of brain development
* '''Fetal thyroid''' - begins function from week10, ({{GA}} week 12) required for neural development, stimulates metabolism (protein, carbohydrate, lipid), reduced/absence = cretinism (see abnormalities)


'''Hormones''' - (amino acid derivatives) Thyroxine (T4), Triiodothyronine (T3)
'''Hormones''' - TH (amino acid derivatives) Thyroxine (T4), Triiodothyronine (T3)


===Thyroid Development===
===Thyroid Development===
{|
{|
|
| [[File:Stage13 and 22 thyroid development a.jpg|250px|Stage 13 and Stage 22 thyroid development]]
* thyroid median endodermal thickening in the floor of pharynx, outpouch – thyroid diverticulum
| [[File:Tongue1.png|250px|foramen caecum]]
* tongue grows, cells descend in neck
| [[File:Thyroid-development-cartoon.jpg|250px|thyroid development]]
* thyroglossal duct - proximal end at the foramen cecum of tongue thyroglossal duct
* thyroid diverticulum - hollow then solid, right and left lobes, central isthmus
| [[File:Tongue1.png|thumb|foramen caecum]]
| [[File:Thyroid-development-cartoon.jpg|thumb|Thyroid development cartoon]]
|}
|}
* thyroid median endodermal thickening in the floor of pharynx, outpouch – '''thyroid diverticulum'''.
* tongue grows, cells descend in neck.
* thyroglossal duct - proximal end at the foramen caecum of tongue.
* thyroid diverticulum - hollow then solid, right and left lobes, central isthmus.
===Thyroid Timeline===
===Thyroid Timeline===
* 24 days - thyroid median endodermal thickening in the floor of pharynx, outpouch – thyroid diverticulum
* '''24 days''' - thyroid median endodermal thickening in the floor of pharynx, outpouch – thyroid diverticulum
* Week 11 - colloid appearance in thyroid follicles, iodine and thyroid hormone (TH) synthesis
* '''Week 11''' - colloid appearance in thyroid follicles, iodine and thyroid hormone (TH) synthesis. Growth factors (insulin-like, epidermal) stimulates follicular growth.
growth factors (insulin-like, epidermal) stimulates follicular growth
* '''Week 16 - 18''' - ({{GA}} 18-20 weeks) fully functional


:'''Links:''' [http://www.ncbi.nlm.nih.gov/books/NBK28/box/A331/?report=objectonly Box 3.21 Embryology of the thyroid and parathyroid glands]
===Fetal Thyroid Hormone===
===Fetal Thyroid Hormone===
* Initial secreted biologically inactivated by modification, late fetal secretion develops brown fat
 
* Iodine deficiency- during this period, leads to neurological defects (cretinism)
* Initial secreted biologically inactivated by modification
** serum thyroid hormone levels are relatively low and tissue concentration of thyroid hormone is modified by iodothyronine deiodinases
* Iodine deficiency - during this period, leads to neurological defects (cretinism)
* Late fetal secretion - develops brown fat
* Birth - TSH levels increase, thyroxine (T3) and T4 levels increase to 24 h, then 5-7 days postnatal decline to normal levels
* Birth - TSH levels increase, thyroxine (T3) and T4 levels increase to 24 h, then 5-7 days postnatal decline to normal levels
* Post-natal - TH required for bone development


'''Maternal TH''' - iodine/thyroid status can affect development.
* recent studies show that both high and low maternal thyroid hormone impact on neural development (PMID 26497402)


:'''Links:''' [[Endocrine - Thyroid Development]] | [[Abnormal_Development_-_Iodine_Deficiency|Iodine Deficiency]] | [[Talk:Lecture - Endocrine Development#Chapter_3._The_thyroid_gland|Endocrinology]]


:'''Links:''' {{Thyroid}} | [[Talk:BGD_Lecture_-_Endocrine_Development#Chapter_3._The_thyroid_gland|Endocrinology]] |
==Parathyroid==
==Parathyroid==
[[File:Parathyroid adult.jpg|thumb|Parathyroid adult]]
{|
 
|
* Parathyroid Hormone - Increase calcium ions [Ca2+], stimulates osteoclasts, increase Ca GIT absorption (opposite effect to calcitonin)
* Parathyroid Hormone - Increase calcium ions [Ca2+], stimulates osteoclasts, increase Ca GIT absorption (opposite effect to calcitonin)
* Adult Calcium and Phosphate - Daily turnover in human with dietary intake of 1000 mg/day
* Adult Calcium and Phosphate - Daily turnover in human with dietary intake of 1000 mg/day
* secreted by chief cells
* secreted by chief cells
Principal cells cords of cells
Principal cells cords of cells
| [[File:Parathyroid adult.jpg|200px|alt=Parathyroid adult]]
Adult Parathyroid
|}
===Parathyroid Development===
===Parathyroid Development===
[[File:Pharyngeal pouches.jpg|thumb|Pharyngeal pouches]]
{|
|
* Endoderm - third and fourth pharyngeal pouches, could also have ectoderm and neural crest
* Endoderm - third and fourth pharyngeal pouches, could also have ectoderm and neural crest
** 3rd Pharyngeal Pouch - inferior parathyroid, initially descends with thymus
** 3rd Pharyngeal Pouch - inferior parathyroid, initially descends with thymus
** 4th Pharyngeal Pouch - superior parathyroid
** 4th Pharyngeal Pouch - superior parathyroid
* Week 6 - diverticulum elongate, hollow then solid, dorsal cell proliferation
* '''Week 6''' - diverticulum elongate, hollow then solid, dorsal cell proliferation
* Fetal parathyroids - respond to calcium levels, fetal calcium levels higher than maternal
* Fetal parathyroids - respond to calcium levels, fetal calcium levels higher than maternal
* parathyroid hormone - (PTH, parathormone or parathyrin)
| [[File:Pharyngeal pouches.jpg|300px|alt=Pharyngeal pouches]]


Pharyngeal pouches
|}


:'''Links:''' [[Endocrine - Parathyroid Development]]
:'''Links:''' {{Parathyroid}} | [[Talk:BGD_Lecture_-_Endocrine_Development#Chapter_5._The_parathyroid_glands_and_vitamin_D|Endocrinology]]
==Thymus==
==Thymus==


* Thymus - bone-marrow lymphocyte precursors become thymocytes, and subsequently mature into T lymphocytes (T cells)
* Thymus - bone-marrow lymphocyte precursors become thymocytes, and subsequently mature into T lymphocytes (T cells)
* Thymus hormones - thymosins stimulate the development and differentiation of T lymphocytes
* Thymus hormones - thymosins stimulate the development and differentiation of T lymphocytes
===Thymus Development===
{|
|
* Endoderm - third pharyngeal pouch
* '''Week 6''' - diverticulum elongates, hollow then solid, ventral cell proliferation
* '''Thymic primordia''' - surrounded by neural crest mesenchyme, epithelia/mesenchyme interaction
* Postnatal - '''involution''', thymus regression after puberty.


===Thymus Development===
| [[File:Gray1178.jpg|300px]]


* Endoderm - third pharyngeal pouch
Fetal Thymus
* Week 6 - diverticulum elongates, hollow then solid, ventral cell proliferation
|}
* Thymic primordia - surrounded by neural crest mesenchyme, epithelia/mesenchyme interaction


:'''Links:''' {{Thymus}}


:'''Links:''' [[Endocrine - Thymus Development]]
==Pancreas==
==Pancreas==
[[File:Pancreas adult.jpg|thumb|Pancreas adult]]
{|
[[File:Pancreas cartoon.jpg|thumb|pancreas structure]]
|
 
* Functions - exocrine (amylase, alpha-fetoprotein), 99% by volume; endocrine (pancreatic islets) 1% by volume
* Functions - exocrine (amylase, alpha-fetoprotein), 99% by volume; endocrine (pancreatic islets) 1% by volume
* Exocrine function - begins after birth
* Exocrine function - begins after birth
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** exact roles of hormones in regulating fetal growth?
** exact roles of hormones in regulating fetal growth?


[[File:Pancreas cartoon.jpg|300px|alt=pancreas structure]]
|  [[File:Pancreas adult.jpg|300px|alt=Pancreas adult]]
|}
===Pancreas Development===
===Pancreas Development===
[[File:Pancreatic_duct_developing.jpg|thumb|Pancreatic buds and duct developing]]
[[File:Stage22_pancreas_a.jpg|thumb|Stage22 pancreas]]
* Pancreatic buds -  duodenal level endoderm, splanchnic mesoderm forms dorsal and ventral mesentery, dorsal bud (larger, first), ventral bud (smaller, later)
* Pancreatic buds -  duodenal level endoderm, splanchnic mesoderm forms dorsal and ventral mesentery, dorsal bud (larger, first), ventral bud (smaller, later)
* Pancreas Endoderm - pancreas may be opposite of liver
* Pancreas Endoderm - pancreas may be opposite of liver
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** Notochord may promote pancreas formation
** Notochord may promote pancreas formation
** Heart may block pancreas formation
** Heart may block pancreas formation
 
{|
* Duodenum growth/rotation - brings ventral and dorsal buds together, fusion of buds
| [[File:Pancreatic_duct_developing.jpg|400px|alt=Pancreatic buds and duct developing]]
| [[File:Stage22_pancreas_a.jpg|400px|alt=Stage 22 pancreas]]
|-
| Pancreatic buds and duct developing
| Pancreas week 8 (Stage 22)
|}
* Duodenum growth/rotation - brings ventral and dorsal buds together, fusion of buds [http://www.ncbi.nlm.nih.gov/books/NBK30/box/A171/?report=objectonly See Figure 2.32]
* Pancreatic duct - ventral bud duct and distal part of dorsal bud, exocrine function
* Pancreatic duct - ventral bud duct and distal part of dorsal bud, exocrine function
* Islet cells - cords of endodermal cells form ducts, from which cells bud off to form islets
* Islet cells - cords of '''endodermal cells''' form ducts, from which cells bud off to form islets
{| class="wikitable mw-collapsible mw-collapsed"
! Islet
|-
| [[File:Pancreas histology 104.jpg|300px|left]] Arterial blood (from splenic, hepatic and superior mesenteric arteries) enters the core of each islet and capillaries then drain outwardly to the periphery where venous blood drains into the splenic and superior mesenteric veins.


Histology image shows blood vessels injected with ink.
|}
===Pancreatic Islets===
===Pancreatic Islets===
* Islets of Langerhans - 4 endocrine cell types
* Islets of Langerhans - 4 endocrine cell types
Line 271: Line 380:


===Pancreas Timeline===
===Pancreas Timeline===
* Week 7 to 20 - pancreatic hormones secretion increases, small amount maternal insulin
* '''Week 7 to 20''' - pancreatic hormones secretion increases, small amount maternal insulin
* Week 10 - glucagon (alpha) differentiate first, somatostatin (delta), insulin (beta) cells differentiate, insulin secretion begins
* '''Week 10''' - glucagon (alpha) differentiate first, somatostatin (delta), insulin (beta) cells differentiate, insulin secretion begins
* Week 15 - glucagon detectable in fetal plasma
* '''Week 15''' - glucagon detectable in fetal plasma
 


:'''Links:''' [[Endocrine - Pancreas Development]] | [[Gastrointestinal Tract - Pancreas Development]] | [[Talk:BGD_Lecture_-_Endocrine_Development#Chapter_2._The_endocrine_pancreas|Endocrinology]]


:'''Links:''' [[Endocrine - Pancreas Development]] | [[Gastrointestinal Tract - Pancreas Development]]
==Adrenal==
==Adrenal==
 
[[File:Week10 adrenal.jpg|thumb|Fetal adrenal gland (Week 10, {{GA}} week 12]]
* Richly vascularized - arterioles passing through cortex, capillaries from cortex to medulla, portal-like circulation
* Richly vascularized - arterioles passing through cortex, capillaries from cortex to medulla, portal-like circulation
* Fetal Cortex - produces a steroid precursor (DEA), converted by placenta into estrogen
* Fetal Cortex - produces a steroid precursor (DEA), converted by placenta into estrogen
Line 292: Line 402:


===Adrenal Development===
===Adrenal Development===
[[File:Week10 adrenal.jpg|thumb|Week 10 adrenal gland]]
[[File:Adrenal_medulla.jpg|300px|right|link=Adrenal Medulla Development Movie]]
{|
* '''Week 6''' - fetal cortex, from mesothelium adjacent to dorsal mesentery; Medulla, neural crest cells from adjacent sympathetic ganglia
|
* Fetal Adrenals - fetal cortex later replaced by adult cortex
* Fetal Adrenals - fetal cortex later replaced by adult cortex
* Week 6 - fetal cortex, from mesothelium adjacent to dorsal mesentery; Medulla, neural crest cells from adjacent sympathetic ganglia
* Adult cortex - mesothelium mesenchyme encloses fetal cortex
* Adult cortex - mesothelium mesenchyme encloses fetal cortex


'''Adrenal Cortex'''
'''Adrenal Cortex'''
* mesothelium origin, epithelium lining the body cavity at the site of adrenal development
* Late Fetal Period - differentiates to form cortical zones
* Late Fetal Period - differentiates to form cortical zones
* Birth - zona glomerulosa, zona fasiculata present
* Birth - zona glomerulosa, zona fasiculata present
* Year 3 - zona reticularis present
* Year 3 - zona reticularis present
 
{|
[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A442&rendertype=box&id=A466 Endocrinology - Adrenal Cortex Development]
|
 
'''Adrenal Medulla'''
'''Adrenal Medulla'''
* neural crest origin, migrate adjacent to coelomic cavity, initially uncapsulated and not surrounded by fetal cortex, cells have neuron-like morphology
* neural crest origin, migrate adjacent to coelomic cavity, initially uncapsulated and not surrounded by fetal cortex, cells have neuron-like morphology
* 2 cell types - secrete epinepherine (adrenaline) 80%; secrete norepinepherine (noradrenaline* 20%
* 2 cell types - secrete epinepherine (adrenaline) 80%; secrete norepinepherine (noradrenaline* 20%


| {{Adrenal movie}}
| valign="bottom"|{{Adrenal movie}}
|}
|}


:'''Links:''' [[Endocrine - Adrenal Development]]
 
:'''Links:''' {{Adrenal}} | [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A442&rendertype=box&id=A466 Endocrinology - Adrenal Cortex Development] | [[Talk:BGD_Lecture_-_Endocrine_Development#Chapter_4._The_adrenal_gland|Endocrinology]]


==Gonad==
==Gonad==
[[File:XXhpgaxis.gif|thumb|Female HPG axis]]
{|
| [[File:HPG female axis.jpg|300px]]
 
Adult Hypothalamus - Pituitary - Gonad (female)
| [[File:HPG male axis.jpg|300px]]
 
Adult Hypothalamus - Pituitary - Gonad (male)
|}


HPG Axis - [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A972&rendertype=box&id=A1057 Endocrinology - Simplified diagram of the actions of gonadotrophins]
HPG Axis - [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A972&rendertype=box&id=A1057 Endocrinology - Simplified diagram of the actions of gonadotrophins]


===Gonad Development===
===Gonad Development===
--[[User:S8600021|Mark Hill]] 07:31, 27 September 2011 (EST) Covered in last weeks [[Lecture_-_Genital_Development|lecture]] and [[2011_Lab_8|lab]].
* '''mesoderm''' - mesothelium and underlying mesenchyme
 
* '''Gonadal ridge''' - mesothelium thickening, medial mesonephros
* mesoderm - mesothelium and underlying mesenchyme, primordial germ cells
* '''Primordial Germ cells''' - yolk sac, to mesentery of hindgut, to genital ridge of developing kidney
* Gonadal ridge - mesothelium thickening, medial mesonephros
* Primordial Germ cells - yolk sac, to mesentery of hindgut, to genital ridge of developing kidney


'''Differentiation'''
Differentiation
* testis-determining factor (TDF) from Y chromosome: presence (testes), absence (ovaries)
* testis-determining factor (TDF) from Y chromosome: presence (testes), absence (ovaries)


'''Testis'''
====Testis====
* 8 Weeks, mesenchyme, interstitial cells (of Leydig) secrete testosterone, androstenedione
* '''8 Weeks''' mesenchyme, interstitial cells (of Leydig) secrete testosterone, androstenedione.
* 8 to 12 Weeks - hCG stimulates testosterone production
* '''8 to 12 Weeks''' - hCG stimulates testosterone production (required for male genital development)
* Sustentacular cells - produce anti-mullerian hormone to puberty
* Sustentacular (Sertoli) cells - produce anti-mullerian hormone (AMH) to puberty.
** '''AMH''' - anti-Müllerian hormone (Müllerian inhibiting factor (MIF), Müllerian-inhibiting hormone (MIH), and Müllerian-inhibiting substance (MIS)).
[[File:Male_testosterone_and_AMH_level_graph.jpg|500px]]


'''Ovary'''
====Ovary====
[[File:Infant_ovary.jpg|thumb|Infant Ovary]]
* X chromosome genes regulate ovary development
* X chromosome genes regulate ovary development
* Hormone levels increase at puberty with follicle development.
I covered this topic in detail  in sexual differentiation lecture/practical.




:'''Links:''' [[Endocrine - Gonad Development]]
:'''Links:''' [[Endocrine - Gonad Development]] | [[Talk:BGD_Lecture_-_Endocrine_Development#Chapter_6._The_gonad|Endocrinology]]


==Placenta==
==Placenta==
Line 361: Line 480:


:'''Links:''' [[Endocrine - Placenta Development]]
:'''Links:''' [[Endocrine - Placenta Development]]
==Other Endocrine==
==Other Endocrine==
===Endocrine Heart===
===Endocrine Heart===
Line 385: Line 505:
* Adiponectin - regulation of energy homeostasis and glucose and lipid metabolism, as well as acting as an anti-inflammatory on the cellular vascular wall
* Adiponectin - regulation of energy homeostasis and glucose and lipid metabolism, as well as acting as an anti-inflammatory on the cellular vascular wall
* Resistin - (for resistance to insulin, RETN) a 108 amino acid polypeptide and the related resistin-like protein-beta (Resistin-like molecule-beta, RELMbeta) stimulate endogenous glucose production
* Resistin - (for resistance to insulin, RETN) a 108 amino acid polypeptide and the related resistin-like protein-beta (Resistin-like molecule-beta, RELMbeta) stimulate endogenous glucose production


:'''Links:''' [[Endocrine - Other Tissues]]
:'''Links:''' [[Endocrine - Other Tissues]]
==Endocrine Functional Changes==
==Endocrine Functional Changes==
* Puberty- Increased activity
* '''Puberty''' - Increased activity.
* Menopause- Decreased activity
* '''Menopause''' - Decreased activity.
* Disease (diabetes, thyroid, kidney) suggested trends that genetics, health, nutrition, lifestyle may influence time that these events occur
* '''Disease''' - (diabetes, thyroid, kidney) suggested trends that genetics, health, nutrition, lifestyle may influence time that these events occur.
* Pharmaceutical impact - birth control, steroids, Hormone Replacement Therapy (HRT)
* '''Pharmaceutical impact''' - birth control, steroids, Hormone Replacement Therapy (HRT).


==Abnormalities==
==Abnormalities==
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* pituitary tumours (adenomas) - several abnormalities associated with abnormal levels of the hormonal output of the pituitary.
* pituitary tumours (adenomas) - several abnormalities associated with abnormal levels of the hormonal output of the pituitary.
** Growth hormone (GH) adenomas - benign pituitary tumors lead to chronic high GH output levels, that may lead to acromegaly.
** Growth hormone (GH) adenomas - benign pituitary tumors lead to chronic high GH output levels, that may lead to acromegaly.
* Cushing's disease - caused either by a pituitary adenoma produces excess adrenocorticotropic hormone (ACTH, corticotropin) or due to ectopic tumors secreting ACTH or corticotropin-releasing hormone (CRH).
* '''Cushing's disease''' - caused either by a pituitary adenoma produces excess adrenocorticotropic hormone (ACTH, corticotropin) or due to ectopic tumors secreting ACTH or corticotropin-releasing hormone (CRH).


=== Thyroid ===
=== Thyroid ===
Line 423: Line 546:
===Parathyroid===
===Parathyroid===
* Usually four glands are present (2 on each side), but three to six glands have been found in human.
* Usually four glands are present (2 on each side), but three to six glands have been found in human.
* Can have displaced parathyroid development with thymus.
* Lower parathyroid glands arise from the third pharyngeal pouch and descend with the thymus. Variable descent can lead to a range of adult locations, from just beneath the mandible to the anterior mediastinum.
* Lower parathyroid glands arise from the third pharyngeal pouch and descend with the thymus. Variable descent can lead to a range of adult locations, from just beneath the mandible to the anterior mediastinum.


Line 438: Line 562:


===Endocrine Disruptors===
===Endocrine Disruptors===
[[File:Diethylstilbestrol.jpg|thumb|Diethylstilbestrol]]
Exogenous chemicals that interfere with the function of hormones. There are 3 main mechanisms: mimic, block or interfere.
Exogenous chemicals that interfere with the function of hormones. There are 3 main mechanisms: mimic, block or interfere.


Line 450: Line 575:


*  Polychlorinated biphenyl pollutants - (PCBs) Rats exposed to PCBs have low levels of thyroid hormone. Compete for binding sites of thyroid hormone transport protein. Without being bound to this protein, thyroid hormones are excreted from the body (McKinney et al. 1985; Morse et al. 1996)
*  Polychlorinated biphenyl pollutants - (PCBs) Rats exposed to PCBs have low levels of thyroid hormone. Compete for binding sites of thyroid hormone transport protein. Without being bound to this protein, thyroid hormones are excreted from the body (McKinney et al. 1985; Morse et al. 1996)
:Links:


==References==
==References==
<references/>
<references/>


* Endocrinology: An Integrated Approach Nussey, S.S. and Whitehead, S.A. London:Taylor & Francis; c2001 [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A3&rendertype=box&id=A11 Major hormone types]
* '''Endocrinology: An Integrated Approach''' Nussey, S.S. and Whitehead, S.A. London:Taylor & Francis; c2001 [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A3&rendertype=box&id=A11 Major hormone types]
* Genes and Disease, Bethesda (MD): National Library of Medicine (US), NCBI [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=gnd.chapter.41 Chapter 41 - Glands and Hormones]
* '''Genes and Disease''', Bethesda (MD): National Library of Medicine (US), NCBI [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=gnd.chapter.41 Chapter 41 - Glands and Hormones]
===Search ===
===Search ===


Line 488: Line 615:
==Terms==
==Terms==


'''adrenocorticotropin''' - (ACTH  or corticotropin) anterior pituitary, peptide hormone
{{Endocrine terms}}
 
'''antidiuretic hormone''' - (ADH) hypothalamus, peptide hormone
 
'''atrial natriuretic factor''' - (ANP) heart, , peptide hormone
 
'''calcitonin''' - (CT) C cells of thyroid, peptide hormone
 
'''follicle stimulating hormone''' - (FSH)  pituitary, protein hormone
 
'''growth hormone''' - (GH) pituitary, peptide hormone
 
'''human chorionic gonadotropin''' -  (hCG) pancreas glycoprotein hormone with 2 subunits (alpha and beta joined non covalently). Similar in structure to luteinizing hormone (LH), hCG exists in multiple hormonal and non-endocrine agents (regular hCG, hyperglycosylated hCG and the free beta-subunit of hyperglycosylated hCG). [http://www.ncbi.nlm.nih.gov/pubmed/19171054 PMID: 19171054]
 
'''lutenizing hormone''' - (LH) pituitary, protein hormone
 
'''melaocyte stimulating hormone''' - (MSH) pituitary, peptide hormone
 
'''prolactin''' - (PRL) pituitary, peptide hormone
 
'''parathyroid hormone''' - (PTH) parathyroid, peptide hormone
 
'''thyroid hormone''' - (TH) thyroid,amino acid derivative


'''thyroid stimulating hormone''' - (TSH) pituitary, protein hormone


{{2018ANAT2341}}
[[Category:Endocrine]] [[Category:Adrenal]] [[Category:Thyroid]] [[Category:Parathyroid]] [[Category:Pituitary]] [[Category:Pancreas]] [[Category:Genital]]
[[Category:Endocrine]] [[Category:Adrenal]] [[Category:Thyroid]] [[Category:Parathyroid]] [[Category:Pituitary]] [[Category:Pancreas]] [[Category:Genital]]
{{2012ANAT2341}}

Latest revision as of 10:48, 4 September 2018

Introduction

Hypothalamus endocrine system
Human adrenal gland (Week 10)

The endocrine system resides within specific endocrine organs and both organs and tissues with other specific functions. Epithelia (ectoderm and endoderm) form the majority of the “ductless” endocrine glands like gastrointestinal and skin associated “ducted” glands. Differentiation of several also organs involves a epithelial/mesenchye interaction, seen in repeated in many differentiation of many different tissues. The endocrine glands produce hormones, which are distributed by the vascular system to the many body tissues, subsequently these organs are richly vascularized.


Hormones “orchestrate” responses in other tissues, including other endocrine organs, and these overall effects can be similar or different in different tissues. These signaling pathways are often described as "axes" the two major types are the: HPA (Hypothalamus-Pituitary-Adrenal) and HPG (Hypothalamus-Pituitary-Gonad). These hormone effects (like music) can be rapid, slow, brief, diurnal, or long-term. Hormone effects can be mimicked, stimulated, and blocked by therapeutic drugs, nutritional and environmental chemicals. Importantly, fetal endocrine development is required for normal fetal growth and differentiation.



2018 Lecture - Print PDF

Lecture Objectives

  • Understanding of hormone types
  • Understanding of endocrine gland development
  • Understanding of endocrine developmental functions


Endocrine in the News  
Human stem cell pancreas implants


Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R & Anderson DG. (2016). Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat. Med. , 22, 306-11. PMID: 26808346 DOI.

Implanted in the intraperitoneal space of mice treated to chemically induce type 1 diabetes. Implants induced glycemic correction without any immunosuppression until their removal at 174 d after implantation. Human C-peptide concentrations and in vivo glucose responsiveness demonstrated therapeutically relevant glycemic control and retrieved implants contained viable insulin-producing cells.

Links: Stem Cells | Endocrine - Pancreas Development
Menstrual cycle
Oral Contraceptives A recent 2016 Danish study births from Danish registries between 1997 and 2011 identified that:


Charlton BM, Mølgaard-Nielsen D, Svanström H, Wohlfahrt J, Pasternak B & Melbye M. (2016). Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study. BMJ , 352, h6712. PMID: 26738512

Links: Menstrual Cycle | Abnormal Development
Ernest Henry Starling (1866-1927)
Ernest Henry Starling (1866-1927)


Interested in hormone history?


Listen ABC Radio Ockham's Razor 2005-07-31 Centenary of the word "hormone" (6.2 Mb mp3) Centenary of the word 'hormone', Sydney medical scientist and writer Dr John Carmody commemorates the centenary of the entry of the word 'hormone' into the English language.

<html5media>File:Audio - centenary of hormone.mp3</html5media>

Lecture Resources

Movies  
Adrenal medulla.jpg
 ‎‎Adrenal Medulla
Page | Play
Aschheim-Zondek Test 1928.jpg
 ‎‎Pregnancy Test
Page | Play
Human fetal adrenal GA32.jpg
 ‎‎Adrenal GA32
Page | Play
Stage13-GIT-icon.jpg
 ‎‎GIT Stage 13
Page | Play
Stage22-CNS-icon.jpg
 ‎‎Urogenital
Page | Play
References  
UNSW Embryology logo
Hill, M.A. (2020). UNSW Embryology (20th ed.) Retrieved March 28, 2024, from https://embryology.med.unsw.edu.au
Endocrine Links: Introduction | BGD Lecture | Science Lecture | Lecture Movie | pineal | hypothalamus‎ | pituitary | thyroid | parathyroid | thymus | pancreas | adrenal | endocrine gonad‎ | endocrine placenta | other tissues | Stage 22 | endocrine abnormalities | Hormones | Category:Endocrine
Historic Embryology - Endocrine  
1903 Islets of Langerhans | 1903 Pig Adrenal | 1904 interstitial Cells | 1908 Pancreas Different Species | 1908 Pituitary | 1908 Pituitary histology | 1911 Rathke's pouch | 1912 Suprarenal Bodies | 1914 Suprarenal Organs | 1915 Pharynx | 1916 Thyroid | 1918 Rabbit Hypophysis | 1920 Adrenal | 1935 Mammalian Hypophysis | 1926 Human Hypophysis | 1927 Adrenal | 1927 Hypophyseal fossa | 1930 Adrenal | 1932 Pineal Gland and Cysts | 1935 Hypophysis | 1935 Pineal | 1937 Pineal | 1935 Parathyroid | 1940 Adrenal | 1941 Thyroid | 1950 Thyroid Parathyroid Thymus | 1957 Adrenal
The endocrine "System" is not covered by a specific chapter in the embryology textbooks and you will need to look for related chapters on the development of individual components (some selected examples are listed below). Use the listed Endocrinology textbook for detained descriptions of function.
Endocrinology - An Integrated Approach.png

Nussey, S. and Whitehead, S. (2001). Endocrinology - An Integrated Approach. UK Oxford: BIOS Scientific Publishers. ISBN-10: 1-85996-252-1

Detailed Table of Contents | Bookshelf Link
Larsen's human embryology 5th ed.jpg
Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R., Francis-West, P.H. & Philippa H. (2015). Larsen's human embryology (5th ed.). New York; Edinburgh: Churchill Livingstone.

  UNSW students have full access to this textbook edition through UNSW Library subscription (with student Zpass log-in). Note that most embryology textbooks do no have specific chapter for endocrine development and this information is often found in other chapters (neural, renal, head, genital).

Larsen's Human Embryology (5th edn) 
Larsen's human embryology 5th ed.jpg
UNSW students have full access to this textbook edition through UNSW Library subscription (with student Zpass log-in).


APA Citation: Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R., Francis-West, P.H. & Philippa H. (2015). Larsen's human embryology (5th ed.). New York; Edinburgh: Churchill Livingstone.

Links: PermaLink | UNSW Embryology Textbooks | Embryology Textbooks | UNSW Library
  1. Gametogenesis, Fertilization, and First Week
  2. Second Week: Becoming Bilaminar and Fully Implanting
  3. Third Week: Becoming Trilaminar and Establishing Body Axes
  4. Fourth Week: Forming the Embryo
  5. Principles and Mechanisms of Morphogenesis and Dysmorphogenesis
  6. Fetal Development and the Fetus as Patient
  7. Development of the Skin and Its Derivatives
  8. Development of the Musculoskeletal System
  9. Development of the Central Nervous System
  10. Development of the Peripheral Nervous System
  11. Development of the Respiratory System and Body Cavities
  12. Development of the Heart
  13. Development of the Vasculature
  14. Development of the Gastrointestinal Tract
  15. Development of the Urinary System
  16. Development of the Reproductive System
  17. Development of the Pharyngeal Apparatus and Face
  18. Development of the Ears
  19. Development of the Eyes
  20. Development of the Limbs
The Developing Human: Clinically Oriented Embryology (10th edn) 
The Developing Human, 10th edn.jpg

UNSW Students have online access to the current 10th edn. through the UNSW Library subscription (with student Zpass log-in).


APA Citation: Moore, K.L., Persaud, T.V.N. & Torchia, M.G. (2015). The developing human: clinically oriented embryology (10th ed.). Philadelphia: Saunders.

Links: PermaLink | UNSW Embryology Textbooks | Embryology Textbooks | UNSW Library
  1. Introduction to the Developing Human
  2. First Week of Human Development
  3. Second Week of Human Development
  4. Third Week of Human Development
  5. Fourth to Eighth Weeks of Human Development
  6. Fetal Period
  7. Placenta and Fetal Membranes
  8. Body Cavities and Diaphragm
  9. Pharyngeal Apparatus, Face, and Neck
  10. Respiratory System
  11. Alimentary System
  12. Urogenital System
  13. Cardiovascular System
  14. Skeletal System
  15. Muscular System
  16. Development of Limbs
  17. Nervous System
  18. Development of Eyes and Ears
  19. Integumentary System
  20. Human Birth Defects
  21. Common Signaling Pathways Used During Development
  22. Appendix : Discussion of Clinically Oriented Problems
2016 Lecture Video Recording  
This 2016 lecture video recording is similar in content to the current 2017 online lecture.

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Click to play new window - 2016 Lecture Video (48 MB)

Endocrine Origins

  • Epithelia - (ectoderm) covering embryo, (endoderm) lining gastrointestinal tract, (mesoderm) lining coelomic cavity
  • Mesenchyme - (mesoderm) contribution, connective tissue, blood vessels

Hormones

Steroid hormone receptor signaling[1]

Hormone Types

  • Amino acid derivatives - noradrenaline (norepinepherine), adrenalin (epinepherine) , thyroid hormone
  • Proteins, peptides - thyroid stimulating hormone, leutenising hormone, follicle stimulating hormone
  • Steroids - androgens, glucocorticoids, mineralocorticoids

Steroid biosynthesis pathway.png

Steroid biosynthesis pathway

Hormone Actions

  • Autocrine - acts on self (extracellular fluid)
  • Paracrine - acts locally (extracellular fluid)
  • Endocrine - acts by secretion into blood stream (endocrine organs are richly vascularized)

Hormone Receptors

  • Cell surface receptors - modified amino acids, peptides, proteins
  • Cytoplasmic/Nuclear Receptors - steroids


Interested in hormone history? Listen ABC Radio Ockham's Razor 2005-07-31 6.2 Mb mp3 Centenary of the word 'hormone', Sydney medical scientist and writer Dr John Carmody commemorates the centenary of the entry of the word 'hormone' into the English language.

Pineal Gland

Keith1902 fig167.jpg Pineal Development
  • Neuroectoderm - prosenecephalon then diencephalon
    • caudal roof, median diverticulum, epiphysis
  • Initially a hollow diverticulum, cell proliferation to solid, pinealocytes (neuroglia), cone-shaped gland innervated by epithalamus
Adult pineal body Pineal gland position
Adult pineal body Pineal gland position
  • part of epithalamus - neurons, glia and pinealocytes
  • pinealocytes secrete melatonin - cyclic nature of activity, melatonin lowest during daylight
  • maternal melatonin crosses the placental barrier
  • inhibit hypothalamic secretion of GnRH until puberty, pineal gland then rapidly regresses.
  • other activities - possibly gamete maturation, antioxidant effect, protect neurons?
Pineal histology 001.jpg
Fetal pineal gland 01.jpg Fetal Pineal Anatomy[2]
  • Human fetus (3.5 month) superior (dorsal) view diencephalic-mesencephalic area.
  • Third ventricle (3 ventr) without pial covering is seen to the right.
  • Pineal gland is a small protuberance (arrow) and merging via the broad stalk with the habenula (Ha). Superior colliculus (Sup col.)
Links: pineal | Endocrinology

Hypothalamus

Adult hypothalamus

Hormones - Corticotrophin releasing hormone (CRH), Thyrotrophin releasing hormone (TRH), Arginine vasopressin (AVP), Gonadotrophin releasing hormone (GnRH), Growth hormone releasing hormone (GHRH), Somatostatin, Prolactin relasing factor (PRF), Dopamine

Hypothalamus Development

  • Neuroectoderm - prosenecephalon then diencephalon
  • ventro-lateral wall intermediate zone proliferation
  • Mamillary bodies - form pea-sized swellings ventral wall of hypothalamus
Stage 13 image 061.jpg Stage 22 image 055.jpg
Diencephalon region, shown by optic stalk
(Stage 13)
Late embryonic hypothalamus
(Stage 22)
Links: Endocrine - Hypothalamus Development

Pituitary

Adult pituitary
Turkish saddle (17th century)
The pituitary (hypophysis) sits anatomically within the sella turcica, a space within the sphenoid bone.


Anterior pituitary hormones - Thyroid-stimulating hormone (TSH), Adrenocorticotrophic hormone (ACTH), Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Somatotrophin/growth hormone (GH), Prolactin (PRL), Melanocyte-stimulating hormone (MSH)

Posterior pituitary hormones - Oxytocin, Arginine vasopressin

Pituitary Development

Keith1902 fig015a.jpg Pituitary rabbit development.jpg
Pituitary development animation.gif Blue - neural tube ectoderm


Red - surface ectoderm

  • Dual ectoderm origins
    • Ectoderm - ectoderm roof of stomodeum, Rathke's pouch, adenohypophysis
    • Neuroectoderm - prosenecephalon then diencephalon, neurohypophysis

Adenohypophysis

  • Anterior wall proliferates - pars distalis
  • Posterior wall little growth – pars intermedia
  • Rostral growth around infundibular stem – pars tuberalis

Neurohypophysis

  • Infundibulum – median eminence, infundibulum, pars nervosa

Embryonic and fetal pituitary.jpg
Stage 22 image 220.jpg

Pituitary Timeline

Early Fetal (week 12)
  • Week 4 - hypophysial pouch, Rathke’s pouch, diverticulum from roof
  • Week 5 - elongation, contacts infundibulum, diverticulum of diencephalon
  • Week 6 - connecting stalk between pouch and oral cavity degenerates
  • Week 8 - basophilic staining cells appear
  • Week 9 - acidophilic staining cells appear
  • Week 10 - growth hormone and ACTH detectable
  • Week 16 - adenohypophysis fully differentiated and TSH increases to peak at 22 weeks
  • Week 20 to 24 - growth hormone levels peak, then decline
  • Birth - second TSH surge and decreases postnatally


Links: pituitary | Embryo Images - Pituitary | Endocrinology

Thyroid

Hypothalamus - Pituitary - Thyroid Axis
  • Maternal thyroid hormone - required for early stages of brain development
  • Fetal thyroid - begins function from week10, (GA week 12) required for neural development, stimulates metabolism (protein, carbohydrate, lipid), reduced/absence = cretinism (see abnormalities)

Hormones - TH (amino acid derivatives) Thyroxine (T4), Triiodothyronine (T3)

Thyroid Development

Stage 13 and Stage 22 thyroid development foramen caecum thyroid development
  • thyroid median endodermal thickening in the floor of pharynx, outpouch – thyroid diverticulum.
  • tongue grows, cells descend in neck.
  • thyroglossal duct - proximal end at the foramen caecum of tongue.
  • thyroid diverticulum - hollow then solid, right and left lobes, central isthmus.

Thyroid Timeline

  • 24 days - thyroid median endodermal thickening in the floor of pharynx, outpouch – thyroid diverticulum
  • Week 11 - colloid appearance in thyroid follicles, iodine and thyroid hormone (TH) synthesis. Growth factors (insulin-like, epidermal) stimulates follicular growth.
  • Week 16 - 18 - (GA 18-20 weeks) fully functional
Links: Box 3.21 Embryology of the thyroid and parathyroid glands

Fetal Thyroid Hormone

  • Initial secreted biologically inactivated by modification
    • serum thyroid hormone levels are relatively low and tissue concentration of thyroid hormone is modified by iodothyronine deiodinases
  • Iodine deficiency - during this period, leads to neurological defects (cretinism)
  • Late fetal secretion - develops brown fat
  • Birth - TSH levels increase, thyroxine (T3) and T4 levels increase to 24 h, then 5-7 days postnatal decline to normal levels
  • Post-natal - TH required for bone development

Maternal TH - iodine/thyroid status can affect development.

  • recent studies show that both high and low maternal thyroid hormone impact on neural development (PMID 26497402)


Links: thyroid | Endocrinology |

Parathyroid

  • Parathyroid Hormone - Increase calcium ions [Ca2+], stimulates osteoclasts, increase Ca GIT absorption (opposite effect to calcitonin)
  • Adult Calcium and Phosphate - Daily turnover in human with dietary intake of 1000 mg/day
  • secreted by chief cells

Principal cells cords of cells

Parathyroid adult

Adult Parathyroid

Parathyroid Development

  • Endoderm - third and fourth pharyngeal pouches, could also have ectoderm and neural crest
    • 3rd Pharyngeal Pouch - inferior parathyroid, initially descends with thymus
    • 4th Pharyngeal Pouch - superior parathyroid
  • Week 6 - diverticulum elongate, hollow then solid, dorsal cell proliferation
  • Fetal parathyroids - respond to calcium levels, fetal calcium levels higher than maternal
  • parathyroid hormone - (PTH, parathormone or parathyrin)
Pharyngeal pouches

Pharyngeal pouches

Links: parathyroid | Endocrinology

Thymus

  • Thymus - bone-marrow lymphocyte precursors become thymocytes, and subsequently mature into T lymphocytes (T cells)
  • Thymus hormones - thymosins stimulate the development and differentiation of T lymphocytes

Thymus Development

  • Endoderm - third pharyngeal pouch
  • Week 6 - diverticulum elongates, hollow then solid, ventral cell proliferation
  • Thymic primordia - surrounded by neural crest mesenchyme, epithelia/mesenchyme interaction
  • Postnatal - involution, thymus regression after puberty.
Gray1178.jpg

Fetal Thymus

Links: thymus

Pancreas

  • Functions - exocrine (amylase, alpha-fetoprotein), 99% by volume; endocrine (pancreatic islets) 1% by volume
  • Exocrine function - begins after birth
  • Endocrine function - from 10 to 15 weeks onward hormone release
    • exact roles of hormones in regulating fetal growth?

pancreas structure

Pancreas adult

Pancreas Development

  • Pancreatic buds - duodenal level endoderm, splanchnic mesoderm forms dorsal and ventral mesentery, dorsal bud (larger, first), ventral bud (smaller, later)
  • Pancreas Endoderm - pancreas may be opposite of liver
    • Heart cells promote/notochord prevents liver formation
    • Notochord may promote pancreas formation
    • Heart may block pancreas formation
Pancreatic buds and duct developing Stage 22 pancreas
Pancreatic buds and duct developing Pancreas week 8 (Stage 22)
  • Duodenum growth/rotation - brings ventral and dorsal buds together, fusion of buds See Figure 2.32
  • Pancreatic duct - ventral bud duct and distal part of dorsal bud, exocrine function
  • Islet cells - cords of endodermal cells form ducts, from which cells bud off to form islets
Islet
Pancreas histology 104.jpg
Arterial blood (from splenic, hepatic and superior mesenteric arteries) enters the core of each islet and capillaries then drain outwardly to the periphery where venous blood drains into the splenic and superior mesenteric veins.

Histology image shows blood vessels injected with ink.

Pancreatic Islets

  • Islets of Langerhans - 4 endocrine cell types
  • Alpha - glucagon, mobilizes lipid
  • Beta - insulin, increase glucose uptake
    • Beta cells, stimulate fetal growth, continue to proliferate to postnatal, in infancy most abundant
  • Delta - somatostatin, inhibits glucagon, insulin secretion
  • F-cells - pancreatic polypeptide

Pancreas Timeline

  • Week 7 to 20 - pancreatic hormones secretion increases, small amount maternal insulin
  • Week 10 - glucagon (alpha) differentiate first, somatostatin (delta), insulin (beta) cells differentiate, insulin secretion begins
  • Week 15 - glucagon detectable in fetal plasma


Links: Endocrine - Pancreas Development | Gastrointestinal Tract - Pancreas Development | Endocrinology

Adrenal

Fetal adrenal gland (Week 10, GA week 12
  • Richly vascularized - arterioles passing through cortex, capillaries from cortex to medulla, portal-like circulation
  • Fetal Cortex - produces a steroid precursor (DEA), converted by placenta into estrogen
  • Adult Medulla - produces adrenalin (epinephrine), noradrenaline (norepinephrine)
  • Fetal adrenal hormones - influence lung maturation

Adrenal cortical hormones - (steroids) Cortisol, Aldosterone, Dehydroepiandrosterone

  • zona glomerulosa - regulated by renin-angiotensin-aldosterone system controlled by the juxtaglomerular apparatus of the kidney.
  • zona fasciculata - regulated by hypothalamo-pituitary axis with the release of CRH and ACTH respectively.


Adrenal medullary hormones - (amino acid derivatives) Epinephrine, Norepinephrine

Adrenal Development

Adrenal medulla.jpg
  • Week 6 - fetal cortex, from mesothelium adjacent to dorsal mesentery; Medulla, neural crest cells from adjacent sympathetic ganglia
  • Fetal Adrenals - fetal cortex later replaced by adult cortex
  • Adult cortex - mesothelium mesenchyme encloses fetal cortex

Adrenal Cortex

  • Late Fetal Period - differentiates to form cortical zones
  • Birth - zona glomerulosa, zona fasiculata present
  • Year 3 - zona reticularis present

Adrenal Medulla

  • neural crest origin, migrate adjacent to coelomic cavity, initially uncapsulated and not surrounded by fetal cortex, cells have neuron-like morphology
  • 2 cell types - secrete epinepherine (adrenaline) 80%; secrete norepinepherine (noradrenaline* 20%
Adrenal medulla.jpg
 ‎‎Adrenal Medulla
Page | Play


Links: adrenal | Endocrinology - Adrenal Cortex Development | Endocrinology

Gonad

HPG female axis.jpg

Adult Hypothalamus - Pituitary - Gonad (female)

HPG male axis.jpg

Adult Hypothalamus - Pituitary - Gonad (male)

HPG Axis - Endocrinology - Simplified diagram of the actions of gonadotrophins

Gonad Development

  • mesoderm - mesothelium and underlying mesenchyme
  • Gonadal ridge - mesothelium thickening, medial mesonephros
  • Primordial Germ cells - yolk sac, to mesentery of hindgut, to genital ridge of developing kidney

Differentiation

  • testis-determining factor (TDF) from Y chromosome: presence (testes), absence (ovaries)

Testis

  • 8 Weeks - mesenchyme, interstitial cells (of Leydig) secrete testosterone, androstenedione.
  • 8 to 12 Weeks - hCG stimulates testosterone production (required for male genital development)
  • Sustentacular (Sertoli) cells - produce anti-mullerian hormone (AMH) to puberty.
    • AMH - anti-Müllerian hormone (Müllerian inhibiting factor (MIF), Müllerian-inhibiting hormone (MIH), and Müllerian-inhibiting substance (MIS)).

Male testosterone and AMH level graph.jpg

Ovary

Infant Ovary
  • X chromosome genes regulate ovary development
  • Hormone levels increase at puberty with follicle development.


I covered this topic in detail in sexual differentiation lecture/practical.


Links: Endocrine - Gonad Development | Endocrinology

Placenta

Trophoblast hCG function
  • Human chorionic gonadotrophin (hCG) - like leutenizing hormone, supports corpus luteum in ovary, pregnant state rather than menstrual, maternal urine in some pregnancy testing
  • Human chorionic somatommotropin (hCS) - or placental lactogen stimulate (maternal) mammary development
  • Human chorionic thyrotropin (hCT)
  • Human chorionic corticotropin (hCACTH)
  • progesterone and estrogens - support maternal endometrium
  • Relaxin
  • Placenta - Maternal (decidua) and Fetal (trophoblastic cells, extraembryonic mesoderm) components
  • Endocrine function - maternal and fetal precursors, synthesis and secretion
    • Protein Hormones - chorionic gonadotropin (hCG), chorionic somatomammotropin (hCS) or placental lactogen (hPL), chorionic thyrotropin (hCT), chorionic corticotropin (hCACTH)
      • hCG - up to 20 weeks, fetal adrenal cortex growth and maintenance
      • hCS – rise through pregnancy, stimulates maternal metabolic processes, breast growth
    • Steroid Hormones - progesterone (maintains pregnancy), estrogens (fetal adrenal/placenta)


Links: Endocrine - Placenta Development

Other Endocrine

Endocrine Heart

  • Atrial natriuretic peptide (ANP) - Increase Filtration rate / decrease Na+ reabsorption
  • Endothelins - ET-1, ET-2, ET-3, Vasoconstriction / Increase NO
  • Nitric oxide (NO) - Vasodilatation

Endocrine Kidney

  • Renin - Increase Angiotensin-aldosterone system
  • Prostaglandins - decrease Na+ reabsorption
  • Erythropoietin - Increase Erythrocyte (rbc) production
  • 1,25 (OH)2 vitamin D - calcium homeostasis
  • Prekallikreins - Increase Kinin production

GIT Endocrine

Enteric control of digestive function

  • Gastrin - Secreted from stomach (G cells), role in control of gastric acid secretion
  • Cholecystokinin - small intestine hormone, stimulates secretion of pancreatic enzymes and bile
  • Secretin - small intestine hormone (epithelial cells), stimulates secretion of bicarbonate-rich fluids from pancreas and liver

Adipose Tissue

  • Leptin - polypeptide hormone produced in adipose and many other tissues with also many different roles
  • Adiponectin - regulation of energy homeostasis and glucose and lipid metabolism, as well as acting as an anti-inflammatory on the cellular vascular wall
  • Resistin - (for resistance to insulin, RETN) a 108 amino acid polypeptide and the related resistin-like protein-beta (Resistin-like molecule-beta, RELMbeta) stimulate endogenous glucose production


Links: Endocrine - Other Tissues


Endocrine Functional Changes

  • Puberty - Increased activity.
  • Menopause - Decreased activity.
  • Disease - (diabetes, thyroid, kidney) suggested trends that genetics, health, nutrition, lifestyle may influence time that these events occur.
  • Pharmaceutical impact - birth control, steroids, Hormone Replacement Therapy (HRT).

Abnormalities

NIH Genes & Disease Chapter 41 - Glands and Hormones

Pineal

  • hypoplasia - associated with retinal disease.
  • tumours - in children are associated with abnormal puberty development.

Pituitary

  • craniopharyngeal canal - Rathke's pouch abnormality, from the anterior part of the fossa hypophyseos of the sphenoid bone to the under surface of the skull.
  • pituitary tumours (adenomas) - several abnormalities associated with abnormal levels of the hormonal output of the pituitary.
    • Growth hormone (GH) adenomas - benign pituitary tumors lead to chronic high GH output levels, that may lead to acromegaly.
  • Cushing's disease - caused either by a pituitary adenoma produces excess adrenocorticotropic hormone (ACTH, corticotropin) or due to ectopic tumors secreting ACTH or corticotropin-releasing hormone (CRH).

Thyroid

Thyroid pyramidal lobe
Thyroid uptake scans
  • Pyramidal lobe - from isthmus (50% of people) attached to hyoid bone distal end of thryoglossal duct.
  • Congenital hypothyroidism - approximately 1 in 3000 births, associated with neurological abnormalities.
  • Lingual thyroid gland - failure of thyroid descent.
  • Thyroglossal cyst - persistance of thyroglossal duct. Image - thyroglossal duct
  • Thyroglossal fistula - partial degeneration of the thyroglossal duct.
  • Abnormal development of the thyroid - incomplete or excessive descent.
  • Childhood hypothyroidism delays ossification and bone mineralization.

Iodine Deficiency

  • A teaspoon of iodine, total lifetime requirement, cannot be stored for long periods by our body, tiny amounts are needed regularly
  • Areas of endemic iodine deficiency, where soil and therefore crops and grazing animals do not provide sufficient dietary iodine to the populace
  • food fortification and supplementation - Iodized salt programs and iodized oil supplements are the most common tools in fight against IDD

Parathyroid

  • Usually four glands are present (2 on each side), but three to six glands have been found in human.
  • Can have displaced parathyroid development with thymus.
  • Lower parathyroid glands arise from the third pharyngeal pouch and descend with the thymus. Variable descent can lead to a range of adult locations, from just beneath the mandible to the anterior mediastinum.

Pancreas

  • Type 1 Diabetes - juvenile onset diabetes, more severe form of illness, increases risk of blindness, heart disease, kidney failure, neurological disease, T-lymphocyte-dependent autoimmune disease, infiltration and destruction of the islets of Langerhans, Approx 16 million Americans
  • Type 2 Diabetes - loosely defined as "adult onset" diabetes, becoming more common cases of type 2 diabetes seen in younger people
  • Risk of developing diabetes - environmental factors (food intake and exercise play an important role, either overweight or obese), Inherited factors (genes involved remain poorly defined)

Adrenal

  • Congenital Adrenal Hyperplasia (CAH) - family of inherited disorders of adrenal steroidogenesis enzymes which impairs cortisol production by the adrenal cortex. Androgen excess leads newborn females with external genital ambiguity and postnatal progressive virilization in both sexes.
    • Enzymes most commonly affected: 21-hydroxylase (21-OH), 11beta-hydroxylase, 3beta-hydroxysteroid dehydrogenase.
    • Enzymes less commonly affected: 17alpha-hydroxylase/17,20-lyase and cholesterol desmolase.
  • Pheochromocytomas (PCC) - Catecholamine-producing (neuro)endocrine tumor located in the adrenal medulla. Similar catecholamine-producing tumors outside the adrenal gland are called paragangliomas (PGL).

Endocrine Disruptors

Diethylstilbestrol

Exogenous chemicals that interfere with the function of hormones. There are 3 main mechanisms: mimic, block or interfere.

Mimic - effects of natural hormones by binding receptors

  • Diethylstilbestrol - (DES or diethylstilbetrol) a drug prescribed to women from 1938-1971 to prevent miscarriage in high-risk pregnancies. Acts as a potent estrogen (mimics natural hormone) and therefore a potential endocrine disruptor. Female fetus, increased risk abnormal reproductive tract and cancer. Male fetus, abnormal genitalia. Banned by USA FDA in 1979 as a teratogen, previously used as livestock growth promoter.

Block - binding of a hormone to receptor or hormone synthesis

  • Finasteride - chemical used to prevent male pattern baldness and enlargement of prostate glands. An anti-androgen (blocks synthesis of dihydrotestosterone) and therefore a potential endocrine disruptor, exposed pregnant women can impact on male fetus genetial development.
  • Vinclozolin - a dicarboximide fungicide, perinatal exposure in rats inhibits morphological sex differentiation. In adult rats, shown to cause gonad tumours (Leydig cell) and atrophy. Chemical has androgen-antagonist (antiandrogenic) activity, metabolies compete with natural androgen

Interfere - with hormone transport or elimination

  • Polychlorinated biphenyl pollutants - (PCBs) Rats exposed to PCBs have low levels of thyroid hormone. Compete for binding sites of thyroid hormone transport protein. Without being bound to this protein, thyroid hormones are excreted from the body (McKinney et al. 1985; Morse et al. 1996)
Links:

References

  1. Griekspoor A, Zwart W, Neefjes J & Michalides R. (2007). Visualizing the action of steroid hormone receptors in living cells. Nucl Recept Signal , 5, e003. PMID: 17464358 DOI.
  2. Møller M, Phansuwan-Pujito P & Badiu C. (2014). Neuropeptide Y in the adult and fetal human pineal gland. Biomed Res Int , 2014, 868567. PMID: 24757681 DOI.

Search

Histology

Adult

Embryonic

Terms

Endocrine Terms (expand to view) 
  • adenohypophysis - (anterior pituitary, pars distalis) anterior part of pituitary embryonic development from surface ectoderm adenohypophyseal placode. Placode folds inward on the roof of the pharynx forming a transient structure Rathke's pouch.
  • adrenocorticotropin - (ACTH or corticotropin) anterior pituitary, peptide hormone stimulates the adrenal cortex to produce corticosteroid hormones — primarily cortisol — as well as small amounts of female and male sex hormones.
  • androstenedione - hormone precursor of testosterone and other steroidal androgens.
  • atrial natriuretic peptide - (ANP) heart, peptide hormone regulates blood pressure. A study suggests that its activating enzyme corin, and ANP together, have a role in placentation, by promoting trophoblast invasion and spiral artery remodelling. (PMID 22437503)
  • basophil cell - pituitary named by histological staining (deep blue, purple) different types produce different hormones: corticotrophs (ACTH, CRH), gonadotrophs (FSH, LH, GnRH), and thyrotrophs (TSH, TRH). See acidophil and chromophore cells.
  • C cells - parafollicular cells of the thyroid.
  • calcitonin - (CT) C cells of thyroid, peptide hormone thyroid
  • corpus luteum - ovarian endocrine organ from ovulating follicle, stimulated by hCG and supports early pregnancy by secreting progesterone, 17β-progesterone, estradiol and androstenedione.
  • corticosteroid binding globulin - (CBG) binds and transports glucocorticoids in the plasma. Globin is synthesised in the liver. adrenal
  • dihydrotestosterone - (DHT) steroidal hormone made locally by 5-alpha reductase conversion of testosterone into a more active form in genital effects.
  • dehydroepiandrosterone - (DHEA, androstenolone) adrenal cortex, gonads and brain make this steroid intermediate that may also have adult hormonal functions.
  • dehydroepiandrosterone sulphate - (DHEAS, DHEA-S) fetal adrenal cortex makes this inactive precursor of a steroid hormone.
  • dydrogesterone - clinical oral retrosteroid structurally related to progesterone, with a greater bioavailability and selectivity for the progesterone receptor.
  • estrogen (oestrogen) family of female steroidal hormones - estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4) synthesised from testosterone and androstenedione, by aromatase. Also produced in male testis, and required for genital development (PMID 29438493)
  • estrone (E1) - steroid hormone with weak estrogenic activity.
  • estradiol (E2) - (oestradiol) estrogen steroid hormone with main estrogenic female activity.
  • estriol (E3) - (oestriol) steroid hormone with weak estrogenic activity.
  • estetrol (E4) (oestetrol) steroid hormone with weak estrogenic activity produced only during pregnancy.
  • follicle stimulating hormone - (FSH) pituitary glycoprotein hormone secreted by gonadotrophs (basophilic cell subgroup) acts on gametogenesis and other systems in both males and females. Females, acts on the ovary to stimulate follicle development. Negative feedback by inhibin from the developing follicle decreases FSH secretion. Males, acts on the testis Sertoli cells to increase androgen-binding protein (ABP) that binds androgens and has a role in spermatogenesis.
  • growth hormone - (GH) pituitary, peptide hormone that stimulates tissue and skeletal growth. In the ovary, growth hormone also increases granulosa cell FSH-dependent E2 production.
  • growth hormone releasing hormone - (GHRH) hypothalamus‎, protein that activates growth hormone synthesis and release from the anterior pituitary.
  • human chorionic gonadotropin - (hCG) glycoprotein hormone with 2 subunits (alpha and beta joined non covalently). Similar in structure to luteinizing hormone (LH), hCG exists in multiple hormonal and non-endocrine agents (regular hCG, hyperglycosylated hCG and the free beta-subunit of hyperglycosylated hCG). PMID 19171054
  • human chorionic somatommotropin - (hCS, CSH, placental lactogen) Placental hormone is structurally similar to both growth hormone (GH) and prolactin (PRL} and binds strongly to PRL receptors but weakly to GH receptors. Role in stimulating maternal mammary gland development. endocrine placenta
  • interstitial cell - (Leydig cell) Male testis cell secrete the androgen testosterone, required for fetal male genital tract differentiation and masculinisation after puberty.
  • Leydig cell - (interstitial cell) Male testis cell secrete the androgen testosterone, beginning in the fetus. These cells are named after Franz von Leydig (1821 - 1908) a German scientist who histologically described these cells.
  • lutenizing hormone - (LH, gonadotropin, lutropin, Interstitial Cell Stimulating Hormone, ICSH) pituitary, glycoprotein hormone acts on the gonad and has a role in male and female reproduction. Female, increase in concentration during the menstrual cycle triggers ovulation. Male, stimulates testis interstital cell production of testosterone. Gonadotrophins have been used clinically in humans for the treatment of female infertility.
  • melaocyte stimulating hormone - (MSH) pituitary, peptide hormone pituitary
  • melatonin - (N-acetyl-5-methoxytryptamine) pineal amino acid amino (precursor tryptophan) hormone involved with the diurnal cycle, melatoinin levels are high in dark, low in daylight. Also acts as an antioxidant, free radical scavenger, and anti-inflammatory molecule.
  • prolactin - (PRL) pituitary, peptide hormone pituitary
  • parathyroid - endocrine gland through parathyroid hormone (PTH) regulates calcium and phosphate levels in conjunction with parafollicular cells of the thyroid gland (calcitonin) and Vitamin D, dietary or synthesized in the skin. Develops from pharyngeal endoderm, in this case the 3rd and 4th pharyngeal pouches.
  • parathyroid hormone - (PTH) parathyroid, peptide hormone parathyroid
  • synthetic ACTH test = (synacthen test) A diagnostic test to both measure the amount of cortisol in the body and to determine the ability to produce cortisol.
  • testosterone - testis ovary steroidal hormone. In males is the androgen which regulates genital (gonadal and tract), secondary sex characteristics and neural development. The steroid is converted to the active metabolite dihydrotestosterone (DHT) by the enzyme 5-alpha reductase for the genital effects and estradiol by the enzyme aromatase for the neural effects.
  • thyroid - endocrine gland located in the neck with a developmental role in neurological development and metabolism.
  • thyroid diverticulum - the primordium of the thyroid gland, beginning as an median endodermal thickening in the floor of pharynx between the pharyngeal pouch 1 and 2.
  • thyroid hormone - (TH) thyroid amino acid derivative with two main forms (T3, T4) regulates tissue metabolic activity.
  • thyroid stimulating hormone - (TSH) pituitary protein hormone
  • ultimobranchial body - historic term for the embryonic structure that forms the parafollicular cells (C cells) of the thyroid.
Other Terms Lists  
Terms Lists: ART | Birth | Bone | Cardiovascular | Cell Division | Endocrine | Gastrointestinal | Genital | Genetic | Head | Hearing | Heart | Immune | Integumentary | Neonatal | Neural | Oocyte | Palate | Placenta | Radiation | Renal | Respiratory | Spermatozoa | Statistics | Tooth | Ultrasound | Vision | Historic | Drugs | Glossary


 2018 ANAT2341 - Timetable | Course Outline | Moodle | Tutorial 1 | Tutorial 2 | Tutorial 3

Labs: 1 Preimplantation and Implantation | 2 Reproductive Technology Revolution | 3 Group Projects | 4 GM manipulation mouse embryos | 5 Early chicken eggs | 6 Female reproductive tract | 7 Skin regeneration | 8 Vertebral development | 9 Organogenesis Lab | 10 Cardiac development | 11 Group projects | 12 Stem Cell Journal Club

Lectures: 1 Introduction | 2 Fertilization | 3 Week 1/2 | 4 Week 3 | 5 Ectoderm | 6 Placenta | 7 Mesoderm | 8 Endoderm | 9 Research Technology | 10 Cardiovascular | 11 Respiratory | 12 Neural crest | 13 Head | 14 Musculoskeletal | 15 Limb | 16 Renal | 17 Genital | 18 Endocrine | 19 Sensory | 20 Fetal | 21 Integumentary | 22 Birth | 23 Stem cells | 24 Revision

 Student Projects: Group Projects Information Project 1 | Project 3 | Project 4 | Project 5 | 2018 Test Student | Copyright