- 1 Introduction
- 2 Lecture Objectives
- 3 Lecture Resources
- 4 Gestation Period
- 5 Childbirth
- 6 Newborn Homoeostasis
- 7 Neonatal Testing
- 8 Premature Birth
- 9 Fetal Origins Hypothesis
- 10 Abnormalities
- 11 Birth Terms
This lecture will finish prenatal human development with birth (parturition) and also review the course lecture theory in preparation for the final theory exam.
Birth or parturition is a critical stage in development, representing in mammals a transition from direct maternal support of fetal development, physical expulsion, shift from aqueous to air environment. This is accompanied by establishment of the new borns own respiratory, circulatory and digestive systems. This topic is not covered in a detailed chapter in your embryology textbooks.
|2017 Students - Please note this draft online lecture content is currently being updated for the current course. This notice removed when update completed.|
|2016 Lecture Video Recording|
|This 2016 lecture video recording is similar in content to the current 2017 online lecture. Please note that the lecture also includes revision information specific to the 2016 course structure that will be covered separately in 2017.
Click to play new window - 2016 Lecture Video (51 MB)
- Understanding of gestation period
- Understanding of maternal changes at birth
- Understanding of fetal to neonatal transition
- Understanding of system changes
- Understanding of abnormalities and diagnostic testing
|Movies and Virtual Slides|
|The following chapter links only work with a UNSW connection.|
|The following chapter links only work with a UNSW connection.|
The median duration of gestation for first births from assumed ovulation to delivery was 274 days (just over 39 weeks). For multiple births, the median duration of pregnancy was 269 days (38.4 weeks).
- "...one should count back 3 months from the first day of the last menses, then add 15 days for primiparas or 10 days for multiparas, instead of using the common algorithm for Naegele's rule." Reference: Mittendorf R, Williams MA, Berkey CS, Cotter PF. The length of uncomplicated human gestation. Obstet Gynecol. 1990 Jun;75(6):929-32
Historically, Franz Carl Naegele (1777-1851) developed the first scientific rule for estimating length of a pregnany.
- Parturition (Latin, parturitio = "childbirth") describes expelling the fetus, placenta and fetal membranes and is probably initiated by fetus not mother.
- Preterm birth - Risks of preterm birth in abnormal low birth weight (intrauterine growth restriction) and high (large for gestational age) categories are 2- to 3-fold greater than the risk among appropriate-for-gestational-age infants.
- Maternal labor - uterine contractions and dilation of cervix, process under endocrine regulation
- Placenta and fetal membranes - (Latin, secundina = "following") expelled after neonate birth
Uterine Myometrial Changes
- Smooth muscle fibers - hypertrophy not proliferation
- Stretching of myometrium - stimulates spontaneous muscular contraction, during pregnancy progesterone inhibits contraction
- Stimulating contraction - increased estrogen levels (placental secretion sensitizes smooth muscle), increased oxytocin levels (fetal oxytocin release- force and frequency of contraction), fetal pituitary prostaglandin production (estrogen and oxytocin stimulate endometrial production of prostaglandin)
- maintains pregnancy - initially synthesized by corpus luteum, then levels maintained by placenta
- hyperpolarizes myometrial cells (-65 mV), reduces excitability and conductivity
- Level in plasma may fall just before parturition, definitely decreases following delivery of placenta
- Group of steroidal hormones, peak when parturition begins
- induce increased synthesis of actomyosin and ATP in myometrial cells
- alter membrane potential (-50 Mv) enhances excitation/conduction
- act to directly increase myometrial contraction
- indirectly by increasing oxytocin from pituitary gland
- Estriol - synthesized by fetus and placenta
- Peptide hormone (8aa) from maternal posterior pituitary, initiation and maintenance of labour (synthetic form labour induction)
- myometrium sensitivity to oxytocin (increased by estrogen, decreased by progesterone)
- stimulus for release - mechanical stimulation of uterus, cervix and vagina (ethanol inhibits release)
- hydroxy fatty acids - sythesized by placenta, amniotic fliud contains mainly PGF2 alpha, causes myometrial contraction (also in maternal plasma)
- PGF2 alpha and PGE2 - used to induce labour (intravenous, oral, intravaginal, intraamniotic)
- Aspirin inhibitor of PG synthesis - leads to increased duration of pregnancy
- mainly shown in other species parturition occurs in peaceful undisturbed surroundings, stress may have an inhibitory effect on oxytocin release
- Most human births occur at night (peak at 3am) diurnal rhythm influence
- dilatation - 7 -12 hours - uterine contractions 10 minutes apart, function to dilate cervix fetal membranes rupture releasing amnion, (longer for first child)
- expulsion - 20 - 50 minutes - uterine contractions push fetus through cervix and vagina, contractions 2-3 minutes apart
- placental - 15 minutes - following child delivery contractions continue to expel placenta. haematoma separates placenta from uterine wall, separation occurs at spongy layer of decidua basalis
- recovery - 2+ hours - continued myometrial contraction closes spiral arteries
Newborn has to establish new functioning systems in a balanced and regulated manner (homoeostasis).
- lung function
- circulatory changes
- endocrine function
- gastrointestinal tract function
- kidney function
Glucocorticoids - have an important role in the preparation for birth, including involvement in lung and cardiac development, and the maturation of enzymes in a variety of pathways.
- Lungs at birth collapsed and fluid-filled - replaced with air by powerful inspiratory movement and absorption through the alveoli
- Lung epithelia has to rapidly change from its prenatal secretory function to that of fluid absorbtion.
- initiated by a late fetal change in alveolar epithelial cell (AEC) chloride and fluid secretion to sodium and fluid absorption.
- absorption requires sodium-potassium ATPase (Na-K-ATPase) together with apical sodium entry mechanisms (Epithelial Sodium Channels, ENaC)
- Fetal thyroid hormone is thought to have a hormonal role in this developmental switch
- These changes and pressure also lead to the pulmonary sytem becoming activated and changes in the circulatory shunting that existed before birth.
- During the late fetal period regular fetal breathing movements (FBM) also occur preparing both the skeletomuscular sysyem and lungs mechanically for respiration.
- Respiratory Rate is higher than adult (30 breaths/minute).
- Rib Orientation - Infant rib is virtually horizontal, allowing diaphragmatic breathing only. Adult rib orientation is oblique (both anterior and lateral views), allows for pump-handle and bucket handle types of inspiration.
- Umbilical Vasculature - The umbilical blood vessel cavity is lost postnatally over the course of weeks to months after birth. The adult anatomical remnant of the umbilical vein between the umbilicus and liver is the ligamentum teres.
- Foramen Ovale - two separate forms of foramen ovale closure; functional and structural. Functional closure begins at the first breath and is rapid. Structural (anatomical) closure is much slower and generally occurs before the end of the first year.
- Ductus Arteriosus - a direct connection between the pulmonary trunk and the dorsal aorta. Postnatal closure occurs initially by by smooth muscle contraction and begins at the first breath and is rapid, completed within the first day (about 15 hr after birth). Anatomical closure is much slower occuring by 2–3 weeks after birth (33% of infants), by 2 months (90% of infants) and by 1 year (99% of infants). The adult anatomical remnant of the ductus arteriosus is the ligamentum arteriosum.
- Ductus Venosus - connects portal and umbilical blood to the inferior vena cava. Functional closure occurs postnatally within hours. Structural closure commences days after birth and completes by 18 to 20 days. The adult anatomical remnant of the ductus venosus is the ligamentum venosum (a dorsal fissure on the liver).
|A historic neonatal test designed by Dr Virginia Apgar, Measured at one and five minutes after birth.
|A blood screening test developed by Dr Robert Guthrie (1916-95) at University of Buffalo. The test is carried out on neonatal (newborn) blood detecting markers for a variety of known disorders (phenylketonuria (PKU), hypothyroidism and cystic fibrosis). In the Australian states of NSW and Victoria, the Guthrie Cards are currently stored indefinitely.
An electrocardiogram (ECG / EKG) is an electrical recording of the heart which may identify electrical disorders including long QT syndrome.
- Non-specific hip instability is a common finding in newborns, particularly in females.
- More than 80% of clinically unstable hips at birth resolve spontaneously. Screening newborns for Developmental dysplasia of the hip (DDH) shows an incidence in infants between 1.5 and 20 per 1000 births. This incidence is influenced by several factors (diagnostic criteria, gender, genetic and racial factors, and age of the population).
Links: PMID 16770931
- The incidence of significant permanent hearing loss is approximately 1-3/1000 newborns.
- Neonatal hearing screening is carried out in the USA, UK and in Australia (2002 NSW Statewide Infant Screening Hearing Program, SWISH) There is a general guide giving a timetable for a number of simple responses that a neonate should make if hearing has developed normally.
- State Wide Infant Screening Hearing Program (SWISH) a newborn hearing testing program using an automated auditory response technology (AABR). Program was introduced in NSW Australia in 2002 across 17 area health service coordinators. It is thought that in NSW 86,000 births/year = 86-172 babies potentially born with significant permanent hearing loss.
- Automated Auditory Brainstem Response (AABR) uses a stimulus which is delivered through earphones and detected by scalp electrodes. The test takes between 8 to 20 minutes and has a sensitivity 96-99%.
|Year||< 34 weeks %||34-36 weeks %||total preterm %|
Data from: Prevention of preterm birth: a renewed national priority Damus K. Curr Opin Obstet Gynecol. 2008 Dec;20(6):590-6 PMID: 18989136
Perinatal care at the borderlines of viability: a consensus statement based on a NSW and ACT consensus workshop (February 2005) published in The Medical Journal of Australia 2006; 185 (9): 495-500.
- < 23 weeks survival is minimal and the risk of major morbidity is so high that initiation of resuscitation is not appropriate.
- 23 weeks active treatment may be discussed, but would be discouraged in NSW/ACT neonatal intensive care units.
- 23 to 25 weeks otherwise normal infant, there is an increasing obligation to treat. However, it is acceptable medical practice not to initiate intensive care if parents so wish, following appropriate counselling.
- 24 weeks antenatal transfer to a tertiary centre for fetal reasons is indicated. The option of non-initiation of intensive care/resuscitation should be offered.
- 25 weeks active treatment is usually offered, but the option of non-initiation of intensive care/resuscitation (presence of adverse fetal factors such as twin-to-twin transfusion, intrauterine growth restriction or chorioamnionitis) should also be discussed.
- 26 weeks + otherwise normal infant the obligation to treat is very high, and treatment should generally be initiated unless there are exceptional circumstances.
Fetal Origins Hypothesis
Maternal derived abnormalities relate to lifestyle, environment and nutrition and while some of these directly effect development. There is also growing evidence that some effects are more subtle and relate to later life health events. This theory is based on the early statistical analysis carried out by Barker of low birth weight data collected in the early 1900's in the south east of England which he then compared with these same babies later health outcomes. The theory was therefore originally called the "Barker Hypothesis" and has recently been renamed as "fetal origins" or "programming".
- Links: Fetal Origins Hypothesis
How different environmental effects during the pregnancy may influence outcomes. A teratogen (Greek, teraton = monster) is defined as any agent that causes a structural abnormality (congenital abnormalities) following fetal exposure during pregnancy. The overall effect depends on dosage and time of exposure (see critical periods below).
- Absolute risk - the rate of occurrence of an abnormal phenotype among individuals exposed to the agent. (e.g. fetal alcohol syndrome)
- Relative risk - the ratio of the rate of the condition among the exposed and the nonexposed. (e.g. smokers risk of having a low birth weight baby compared to non-smokers) A high relative risk may indicate a low absolute risk if the condition is rare.
- Mutagen - a chemical or agent that can cause permanent damage to the deoxyribonucleic acid (DNA) in a cell. DNA damage in the human egg or sperm may lead to reduced fertility, spontaneous abortion (miscarriage), birth defects and heritable diseases.
- Fetotoxicant - is a chemical that adversely affects the developing fetus, resulting in low birth weight, symptoms of poisoning at birth or stillbirth (fetus dies before it is born).
- Synergism - when the combined effect of exposure to more than one chemical at one time, or to a chemical in combination with other hazards (heat, radiation, infection) results in effects of such exposure to be greater than the sum of the individual effects of each hazard by itself.
- Toxicogenomics - the interaction between the genome, chemicals in the environment, and disease. Cells exposed to a stress, drug or toxicant respond by altering the pattern of expression of genes within their chromosomes. Based on new genetic and microarray technologies.
There are many birth associated abnormalities, only a few examples are listed below.
- Premature Labor - occurs 7 -10% in humans, contributes 75% perinatal mortalities
- Underdeveloped Systems - particularly respiratory, surfactant, hyaline membrane disease (see respiratory development lecture)
- placenta accreta - abnormal adherence, with absence of decidua basalis
- placenta percreta - villi penetrate myometrium
- placenta previa - placenta overlies internal os of uterus, abnormal bleeding, cesarian delivery
- Historically, breech-born children were called agrippi, meaning "delivered with difficulty" (aegre parti).
- Breech position - occurs in about 3% of fetuses when buttocks or lower limb are presented to the birth canal rather than normal cephalic (head-first) position (presentation).
- Associated increased - perinatal mortality, perinatal morbidity, recurrence in successive siblings
Current research suggests that genetically that both men and women delivered in breech presentation at term could also contribute to an increased risk of breech delivery in their offspring. ([#18369204 Nordtveit TI, etal., 2008])
Meconium aspiration syndrome
- meconium is formed from gut and associated organ secretions as well as cells and debris from the swallowed amniotic fluid.
- Meconium accumulates during the fetal period in the large intestine (bowel). It can be described as being a generally dark colour (green black) , sticky and odourless.
- Normally this meconium is defaecated (passed) postnatally over the first 48 hours and then transitional stools from day 4.
- Abnormally this meconium is defaecated in utero, due to oxygen deprivation and other stresses. Premature discharge into the amniotic sac can lead to mixing with amniotic fluid and be reswallowed by the fetus. This is meconium aspiration syndrome and can damage both the developing lungs and placental vessels.
Occurs postnatally in mainly in premature and low birth weight infants (1 in 2,000 - 4,000 births). The underdeveloped gastointestinal tract appears to be susceptible to bacteria, normally found within the tract,to spread widely to other regions where they damage the tract wall and may enter the bloodstream.
|Stillbirth and Perinatal Death|
|Note - This material is not examinable.
The distorted world map above shows the relative distribution of early neonatal death by country. Note the over-representation of Africa and Asia compared with Europe, USA and Australia. 
- <pubmed>17411312</pubmed>| PLoS
|2017 ANAT2341 - Timetable | Course Outline | Group Projects | Moodle | Tutorial 1 | Tutorial 2 | Tutorial 3|
Labs: 1 Fertility and IVF | 2 ES Cells to Genome Editing | 3 Preimplantation and Early Implantation | 4 Reproductive Technology Revolution | 5 Cardiac and Vascular Development | 6 CRISPR-Cas9 | 7 Somitogenesis and Vertebral Malformation | 8 Organogenesis | 9 Genetic Disorders | 10 Melanocytes | 11 Stem Cells | 12 Group
Lectures: 1 Introduction | 2 Fertilization | 3 Week 1/2 | 4 Week 3 | 5 Ectoderm | 6 Placenta | 7 Mesoderm | 8 Endoderm | 9 Research Technology | 10 Cardiovascular | 11 Respiratory | 12 Neural crest | 13 Head | 14 Musculoskeletal | 15 Limb | 16 Renal | 17 Genital | 18 Endocrine | 19 Sensory | 20 Fetal | 21 Integumentary | 22 Birth | 23 Stem cells | 24 Revision
|Student Projects: 1 Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum|