Kyoto Collection

Embryology - 20 Apr 2024 Expand to Translate
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Introduction

Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Japan.

Begun by Dr. Hideo Nishimura in 1961 and has over 44,000 human specimens.
Developed and curated by Prof. Kohei Shiota.
Currently curated by Prof. Shigehito Yamada.

Prof. Kohei Shiota, Dr Mark Hill, Prof. Shigehito Yamada and Prof. Mineo Yasuda

Shiota, Hill and Yamada
40th Symposium
40th Symposium

| Kyoto Homepage

Kyoto Embryos

Hideo Nishimura (1912–1995)

40th Anniversary Commemoration Symposium (2015) (Kyoto University, Japan)

Sample Publications

Sequential atlas of human congenital malformations (1976)

Atlas of Human Prenatal Histology (1984)

A detailed comparison of mouse and human cardiac development^[1] "Episcopic fluorescence image capture (EFIC) was performed on 66 wild-type mouse embryos from embryonic day (E) 9.5 to birth; 2-dimensional and 3-dimensional datasets were compared with EFIC and magnetic resonance images from a study of 52 human fetuses (Carnegie stage 13-23). Time course of atrial, ventricular, and outflow septation were outlined and followed a similar sequence in both species. Bilateral venae cavae and prominent atrial appendages were seen in the mouse fetus; in human fetuses, atrial appendages were small, and a single right superior vena cava was present. In contrast to humans with separate pulmonary vein orifices, a pulmonary venous confluence with one orifice enters the left atrium in mice. The cardiac developmental sequences observed in mouse and human fetuses are comparable, with minor differences in atrial and venous morphology. These comparisons of mouse and human cardiac development strongly support that mouse morphogenesis is a good model for human development."
Morphogenesis of the spleen during the human embryonic period^[2] "Between Carnegie stages (CSs) 14 and 17, the spleen was usually recognized as a bulge in the dorsal mesogastrium (DM), and after CS 20, the spleen became apparent. Intrasplenic folds were observed later. A high-density area was first recognized in 6 of the 58 cases at CS 16 and in all cases examined after CS 18. The spleen was recognized neither as a bulge nor as a high-density area at CS 13. The mesothelium was pseudostratified until CS 16 and was replaced with high columnar cells and then with low columnar cells. The basement membrane was obvious after CS 17. The mesenchymal cells differentiated from cells in the DM, and sinus formation started at CS 20. Hematopoietic cells were detected after CS 18. The vessels were observed at CS 14 in the DM. Hilus formation was observed after CS 20. The parallel entries of the arteries and veins were observed at CS 23. The rate of increase in spleen length in relation to that of stomach length along the cranial-caudal direction was 0.51 ± 0.11, which remained constant during CSs 19 and 23, indicating that their growths were similar."
Human embryo imaging with a super-parallel magnetic resonance (MR) microscope^[3]
Polydactyly in human embryos^[4] "129 embryos with polydactyly in 36,380 human conceptuses obtained through induced abortion during the period from 1962 to 1974."

Sample Embryos

Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.

Kyoto Specimens (Last Updated - April 7, 2014) Specimens 23,813

Stage	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	Embryonic	Fetal
Normal	14	16	5	25	44	298	745	2133	1569	2653	2621	2697	2417	2393	1620	1101	909	21260	920
Abnormal	0	0	1	2	4	9	42	69	40	167	236	186	131	265	260	114	50	1576	54
Total	14	16	6	27	48	307	787	2202	1609	2820	2857	2883	2548	2658	1880	1215	959	22836	974