K12 Thalidomide: Difference between revisions

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Revision as of 18:33, 6 April 2016

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K12 Professional Development 2016

Teacher Note 
50px|left]] This is currently only a draft designed to help K12 students understand the drug thalidomide.

Below are links to more detailed pages that are designed for university level students, that would also be valuable for teacher reference. These collapsible tables are additional information and the pages can also be printed out with these sections collapsed, so students do not see the contents.

Links: Thalidomide | Australian Drug Categories

K12 Professional Development 2016 | K12 Professional Development 2014

What is the history of thalidomide?

Thalidomide is a drug that was introduced on to the market on October 1, 1957 in West Germany as "contergan". When taken, mainly in first world countries, early in a pregnancy children were born with limb and other defects. In the late 1950's and early 1960's these children became known as "thalidomide babies".

Contergan tablets.jpg

Originally intended to be prescribed as a general "sleeping pill", once its effects on suppressing sickness (nausea) were identified, it soon became a drug also prescribed to pregnant women to combat the symptoms associated with morning sickness.

Teacher Note 
Mark Hill.jpg
Thalidomide is the "chemical name" of the drug, and like many other drugs released today was known by doctors and patients by its "commercial| or "trade". This commercial name can also differ between countries, even though the active chemical remains the same.

Thalidomide Commercial (trade) names

  • Germany - Contergan
  • UK/Australia - Distaval


Here is an example of another chemical drug, ibuprofen (isobutylphenylpropanoic acid) a nonsteroidal anti-inflammatory drug (NSAID) used for treating pain, fever, and inflammation. Its trade names in different countries include - Advil, Motrin, and Nurofen. Note this is not as dangerous as thalidomide, but has its own cautions as to its use.

Morning sickness

Around half to two-thirds of all pregnant women will experience nausea and vomiting of pregnancy, typically called "morning sickness". This occurs mainly in the first trimester of pregnancy (the first 3 months) due to pregnancy changes in hormone levels, blood pressure fluctuations, and changes in carbohydrate metabolism.


This feeling unwell can be ongoing (day after day) and may also be severely weakening for the woman. Some women also experience this for a longer period of time.

Therefore drugs which could "suppress" this feeling of nausea were, and still are, in high demand.

<html5media width="352" height="240">https://www.youtube.com/embed/https://youtu.be/xg3zhW-4_B0</html5media>

What does thalidomide look like?

Thalidomide.jpg

The molecular structure of thalidomide.

Thalidomide was first synthesised in 1954 by Wilhelm Kunz, a German drug discovery pharmacist for Chemie Grünenthal, searching for new organic compounds.


C13H10N2O4

It has a small mass (Molecular Mass 258.23 Da) and appears as a white crystalline powder with no smell or taste.

The drug was manufactured as a mix of two forms that have the same chemical structure, only one of them was dangerous!

<html5media width="240" height="300">File:Thalidomide 3 model.mp4</html5media>
Teacher Note 
Mark Hill.jpg
Thalidomide two chemical format with the same molecular structure are called an "enantiomer isomer mix" (laevo+ and dextro-).

Both have the physical properties, but are non-superimposable mirror images of each other and rotate plane-polarized light (+/−) by equal amounts but in the opposite directions (laevo+ and dextro-).

The teratogenic form was laevo+ thalidomide.


Who discovered the danger of this drug?

It was identified initially as dangerous by two doctors who saw serious abnormalities appearing more frequently in newborn children.

Dr Widukind Lenz Dr William McBride
Dr Widukind Lenz Dr William McBride
In Germany, a 1961 report by Dr Widukind Lenz described abnormalities with "Contergan". In Australia, a brief letter by Dr William McBride, linked "Distaval" to newborn abnormalities.


Teacher Note 
Mark Hill.jpg
This is an example for students of inadequate drug testing and a lack of understanding of environmental effects on human development. This is often cited today as a reason to have significant testing of drugs before release and classification of drugs based upon their affects on development.

How do we test drugs today?

How do we classify drugs?


Cite this page: Hill, M.A. (2024, March 29) Embryology K12 Thalidomide. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/K12_Thalidomide

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G