J

UNSW Embryology

Glossary J

Jagged1

ligand for the Notch cell surface receptor. Has an important role in blood vessel development. Signal activation leads to cleavage of the intracellular part of the Notch receptor from the membrane which translocates to the nucleus and activate s transcription factors.

(More? [/heart19.htm Cardiovascular System - Blood Vessels] | [/heart11.htm Cardiovascular System - Molecular] | OMIM - Jagged1 | Pubmed - Jagged1 is required for vascular smooth muscle development)

JAK

acronym for "just another kinase" a kinase family involved in signal transduction.

(More? Molecular Development)

jaundice

Yellow colouration of the skin caused by high levels of bilirubin in the body. Present to some extent in most newborns due mainly to the time taken for the newborn liver to develop and functionally process bilirubin. Jaundice can also occur with normally with breast feeding (breastfeeding jaundice) and abnormally as a sign of a range of newborn abnormalities (conditions increasing red blood cell number or interference with bilirubin processing/removal).

(More? Medline Plus - Newborn jaundice)

JAWS

acronym for "Joints Abnormal With Splitting" a protein in mouse musculoskeletal development which coordinates cartilage formation and synovial joint positioning.

(More? [skmus31.htm Musculoskeletal - Joints] | Molecular Development)

jejunum

(Latin, jejunus = empty of food) Second part of the small intestine extending from the duodenum to the ileum.

(More? GIT Notes)

Joints Abnormal With Splitting

(JAWS) a protein in mouse musculoskeletal development which coordinates cartilage formation and synovial joint positioning identified in digit formation.

(More? [skmus31.htm Musculoskeletal - Joints] | Molecular Development)==== Created: 01.06.1997Updated: 27.01.2009 UNSW CRICOS Provider Code No. 00098G ====