Integumentary System - Eyelid Development: Difference between revisions

Revision as of 09:17, 9 March 2011

Notice - Mark Hill

Currently this page is only a template and is being updated (this notice removed when completed).

Introduction

Note that some species, such as rodents, are born with closed eyelids.

Human embryo head showing eyelid development (Stage 22, Week 8)

Embryo head cross-section.

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Historic Embryology - Integumentary
1906 Papillary ridges \| 1910 Manual of Human Embryology \| 1914 Integumentary \| 1923 Head Subcutaneous Plexus \| 1921 Text-Book of Embryology \| 1924 Developmental Anatomy \| 1941 Skin Sensory \| Historic Disclaimer

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Historic Embryology - Vision
Historic Embryology: 1906 Eye Embryology \| 1907 Development Atlas \| 1912 Eye Development \| 1912 Nasolacrimal Duct \| 1917 Extraocular Muscle \| 1918 Grays Anatomy \| 1921 Eye Development \| 1922 Optic Primordia \| 1925 Eyeball and optic nerve \| 1925 Iris \| 1927 Oculomotor \| 1928 Human Retina \| 1928 Retina \| 1928 Hyaloid Canal \| Historic Disclaimer

Some Recent Findings

Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development^[1] "Eyelid formation constitutes a useful model to study epithelial development, as it requires coordinated regulation of keratinocyte proliferation, apoptosis and migration. ...Our data demonstrate that glucocorticoid receptor (GR) deficiency results in delayed and impaired eyelid closure, as illustrated by increased keratinocyte proliferation and apoptosis along with impaired differentiation in GR(-/-) eyelid epithelial cells."
HB-EGF promotes epithelial cell migration in eyelid development^[2] "Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and ERBB4. ...These results indicate that soluble HB-EGF secreted from the tip of the leading edge activates the EGFR and ERK pathway, and that synergy with TGFalpha is required for leading edge extension in epithelial sheet migration during eyelid closure."
Eyelid fusion and epithelial differentiation at the ocular surface during mouse embryonic development^[3] "Eyelid fusion is a critical period for differentiation of the ocular surface ectoderm into the epithelia of the conjunctiva, cornea, and eyelid skin. The conjunctival epithelium differentiates before the corneal epithelium, which in turn differentiates before the eyelid epidermis."

Human Eyelid Timeline

The following data is from a study of human embryonic carnegie stages.^[4]

Stage 13 - By the end of the fourth week the optic vesicle lies close to the surface ectoderm. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode.
Stage 14 - (about 32 days) the lens placode is indented by the lens pit.
Stage 15 - (about 33 days) the lens pit is closed. The lens vesicle and optic cup lie close to the surface ectoderm and appear to press against the surface.
Stage 16 - (37 days) Prior to the development of the eyelids, one small sulcus or groove forms above the eye (eyelid groove) and another below it.
Stages 17 - 19 - these grooves deepen, eyelid folds develop, first below, and then above, the eye.
Stages 19 - 22 - the eyelid folds develop into the eyelids and cover more of the eye as the palpebral fissure takes shape. The upper and the lower eyelids meet at the outer canthus in Stage 19.
Stage 20 - the inner canthus is established.
Stage 23 - closure of the eyelids is complete (shown as still open in the Kyoto embryo).

Abnormalities

Congenital upper eyelid ectopic cilia

References

↑ <pubmed>21136383</pubmed>
↑ <pubmed>16141218</pubmed>
↑ <pubmed>15944823 </pubmed>
↑ <pubmed>7364662</pubmed>

Reviews

Articles

Search PubMed

Search Pubmed: Eyelid Development

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Cite this page: Hill, M.A. (2024, April 16) Embryology Integumentary System - Eyelid Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Integumentary_System_-_Eyelid_Development

What Links Here?

[1] <pubmed>21136383</pubmed>

[2] <pubmed>16141218</pubmed>

[3] <pubmed>15944823 </pubmed>

[4] <pubmed>7364662</pubmed>

[1]

[2]

[3]

[4]

@@ Line 28: / Line 28: @@
 The following data is from a study of human embryonic carnegie stages.<ref><pubmed>7364662</pubmed></ref>
-* '''Stage 13''' - By the end of the fourth week the optic vesicle lies close to the surface ectoderm. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode.
+* Stage 13 - By the end of the fourth week the optic vesicle lies close to the surface ectoderm. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode.
-* '''Stage 14''' - (about 32 days) the lens placode is indented by the lens pit.
+* Stage 14 - (about 32 days) the lens placode is indented by the lens pit.
-* '''Stage 15''' - (about 33 days) the lens pit is closed. The lens vesicle and optic cup lie close to the surface ectoderm and appear to press against the surface.
+* Stage 15 - (about 33 days) the lens pit is closed. The lens vesicle and optic cup lie close to the surface ectoderm and appear to press against the surface.
-* '''Stage 16''' - (37 days) Prior to the development of the eyelids, one small sulcus or groove forms above the eye (eyelid groove) and another below it.
+* Stage 16 - (37 days) Prior to the development of the eyelids, one small sulcus or groove forms above the eye (eyelid groove) and another below it.
-* '''Stages 17 - 19''' - these grooves deepen, eyelid folds develop, first below, and then above, the eye.
+* Stages 17 - 19 - these grooves deepen, eyelid folds develop, first below, and then above, the eye.
-* '''Stages 19 - 22''' - the eyelid folds develop into the eyelids and cover more of the eye as the palpebral fissure takes shape. The upper and the lower eyelids meet at the outer canthus in Stage 19.
+* Stages 19 - 22 - the eyelid folds develop into the eyelids and cover more of the eye as the palpebral fissure takes shape. The upper and the lower eyelids meet at the outer canthus in Stage 19.
-* '''Stage 20''' - the inner canthus is established.
+* Stage 20 - the inner canthus is established.
-* '''Stage 23''' - closure of the eyelids is complete (shown as still open in the Kyoto embryo).
+* Stage 23 - closure of the eyelids is complete (shown as still open in the Kyoto embryo).
 ==Abnormalities==