Integumentary System - Eyelid Development: Difference between revisions
mNo edit summary |
mNo edit summary |
||
Line 15: | Line 15: | ||
|-bgcolor="F5FAFF" | |-bgcolor="F5FAFF" | ||
| | | | ||
* '''Molecular biology and genetics of embryonic eyelid development'''<ref name="PMID26863902"><pubmed>26863902</pubmed></ref> "The embryology of the eyelid is a complex process that includes interactions between the surface ectoderm and mesenchymal tissues. In the mouse and human, the eyelids form and fuse before birth; they open prenatally in the human and postnatally in the mouse. In the mouse, cell migration is stimulated by different growth factors such as FGF10, TGF-α, Activin B, and HB-EGF. These growth factors modulate downstream BMP4 signaling, the ERK cascade, and JNK/c-JUN. Several mechanisms, such as the Wnt/β-catenin signaling pathway, may inhibit and regulate eyelid fusion." | |||
* '''Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development'''<ref><pubmed>21136383</pubmed></ref> "Eyelid formation constitutes a useful model to study epithelial development, as it requires coordinated regulation of keratinocyte proliferation, apoptosis and migration. ...Our data demonstrate that glucocorticoid receptor (GR) deficiency results in delayed and impaired eyelid closure, as illustrated by increased keratinocyte proliferation and apoptosis along with impaired differentiation in GR(-/-) eyelid epithelial cells." | * '''Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development'''<ref><pubmed>21136383</pubmed></ref> "Eyelid formation constitutes a useful model to study epithelial development, as it requires coordinated regulation of keratinocyte proliferation, apoptosis and migration. ...Our data demonstrate that glucocorticoid receptor (GR) deficiency results in delayed and impaired eyelid closure, as illustrated by increased keratinocyte proliferation and apoptosis along with impaired differentiation in GR(-/-) eyelid epithelial cells." | ||
* '''HB-EGF promotes epithelial cell migration in eyelid development'''<ref><pubmed>16141218</pubmed></ref> "Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and ERBB4. ...These results indicate that soluble HB-EGF secreted from the tip of the leading edge activates the EGFR and ERK pathway, and that synergy with TGFalpha is required for leading edge extension in epithelial sheet migration during eyelid closure." | * '''HB-EGF promotes epithelial cell migration in eyelid development'''<ref><pubmed>16141218</pubmed></ref> "Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and ERBB4. ...These results indicate that soluble HB-EGF secreted from the tip of the leading edge activates the EGFR and ERK pathway, and that synergy with TGFalpha is required for leading edge extension in epithelial sheet migration during eyelid closure." |
Revision as of 13:03, 24 July 2016
Introduction
Note that some species, such as rodents, are born with closed eyelids.
The palpebral commissure (canthus) is located at the corner of the eye where the upper and lower eyelids meet.
Vision Links: vision | lens | retina | placode | extraocular muscle | cornea | eyelid | lacrima gland | vision abnormalities | Student project 1 | Student project 2 | Category:Vision | sensory | ||
|
Some Recent Findings
|
More recent papers |
---|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Eyelid Embryology <pubmed limit=5>Eyelid Embryology</pubmed> |
Human Eyelid Timeline
The following data is from a study of human embryonic carnegie stages.[5]
|
The images below link to virtual slides of the human developing eye at Carnegie stage 22. Click on the image to open or select specific regions from the regions of interest links.
|
| ||||||
Virtual Slide - Regions of InterestLinks: Embryo Virtual Slides |
Adult Anatomy
The palpebral commissure (canthus) is located at the corner of the eye where the upper and lower eyelids meet.
Abnormalities
Congenital upper eyelid ectopic cilia
References
Reviews
<pubmed>15558481</pubmed> <pubmed>6387662</pubmed>
Articles
<pubmed>15020428</pubmed> <pubmed>8270467</pubmed> <pubmed>7125235</pubmed>
Search PubMed
Search Pubmed: Eyelid Development
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 19) Embryology Integumentary System - Eyelid Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Integumentary_System_-_Eyelid_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G