Human Spermatozoa Motility Movie

Embryology - 18 Apr 2024        Expand to Translate
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<html5media height="520" width="512">File:Spermatozoa_motility_01.mp4</html5media> Click Here to play on mobile device

Human Spermatozoa Motility This movie shows normal human spermatozoa motility and the response to the photo-release of progesterone. Spermatozoa showing different types of responses to photorelease of progesterone, monitored at 30 frames/s. The flash for progesterone photorelease was at 5 s. Both spermatozoa hyperactivation and the acrosome reaction are regulated by progesterone signalling, through activation of kinases present in the spermatozoa. These two processes appear to use different signalling pathways. Links: MP4 version | spermatozoa | testis

Molecular CatSper - cation channel of spermatozoa flagellum, calcium influx in response to progesterone through tyrosine phosphorylation mechanism. PMID 24813608 Slo3 - a potassium ion channel sets the membrane potential, in mouse allows potassium ions to leave spermatozoa and shifts the membrane voltage to more negative. Mouse Slo3 channel opened in response to a decrease in the concentration of protons within the sperm (increase in pH). Human Slo3 channel controlled by changes in the levels of calcium ions. PMID 24670955

Reference

Armon L & Eisenbach M. (2011). Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation. PLoS ONE , 6, e28359. PMID: 22163296 DOI.

Copyright

© 2011 Armon, Eisenbach. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.