Granulosa cell
Embryology - 29 Mar 2024 Expand to Translate |
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Introduction
Surrounding the oocyte as it develops within the ovary follicle are multiple layers of granulosa cells that are bound to the thick specialised extracellular matrix, the zona pellucida. Following release of the oocyte at ovulation, these cells form the granolas layer.
In human development, during the first week of development following fertilization the granolas cell layer and zona pellucida remains surrounding the blastocyst from which it "hatches" to commence implantation.
Some Recent Findings
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More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Granulosa cell development <pubmed limit=5>Granulosa cell development</pubmed> |
Follicle Granulosa Cells
Granulosa cells can also have specific names depending upon location within the follicle.
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Mouse Granulosa Cells
Terms
- acrosome reaction - The chemical change within the spermatozoa following binding to the zona pellucida, that leads to the release of acrosomal enzymatic contents. These enzymes degrade the zona pellucida and allow a spermatozoa to penetrate an oocyte.
- granulosa cell - A specific cell type that proliferates in association with the oocyte within the developing follicles of the ovary. These cells form the follicle stratum granulosa and are also given specific names based upon their position within the follicle. In the antral follicle, membrana granulosa sits on the follicular basal lamina and lines the antrum as a stratified epithelium. The cumulus oophorus is a column of granulosa cells that attaches the oocyte to the follicle wall. The corona radiata are the granulosa cells that directly surround the oocyte, and are released along with it at ovulation. Following ovulation the corona radiata provide physical protection to the oocyte and granulosa cells within the ovulating follicle contribute to corpus luteum.
References
Reviews
<pubmed>18539589</pubmed>
Articles
Bookshelf
Search NCBI Bookshelf zona pellucida | acrosome reaction
Search Pubmed
July 2010 "zona pellucida" All (4801) Review (582) Free Full Text (1408)
Search Pubmed: zona pellucida | acrosome reaction | Zona pellucida protein 1 | Zona pellucida protein 2 | Zona pellucida protein 3 | Zona pellucida protein 4
Search Images: zona pellucida
Additional Images
Mouse oocyte and zona pellucida - light and TEM
Mouse oocyte and zona pellucida TEM
Cat oocyte zona pellucida SEM
Cat oocyte zona pellucida SEM
Cat oocyte zona pellucida spermatozoa bound SEM
Hamster oocyte zona pellucida SEM
Pig ZPC deposition in oocyte-cumulus complexes
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Cite this page: Hill, M.A. (2024, March 29) Embryology Granulosa cell. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Granulosa_cell
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G