File:Wnt signalling pathways.png

Description

Figure 10

Wnt signalling pathways

Wire diagram of the canonical Wnt/β-Catenin signaling and non-canonical Wnt signaling pathways with known function in heart development. In canonical Wnt/β-Catenin (β-Cat), activation of the pathway by binding of Wnt ligand to the Frz/LRP5/6 co-receptor activates signaling through disheveled (dsh) that disrupts the activity of the β-Cat destruction complex (consisting of adenomatous polyposis coli (APC), Axin and glycogen, synthase kinase 3 (gsk3β), and CK1). Disruption of this complex allows for the nuclear localization of β-Cat and establishes transcriptional activation of downstream targets by the TCF/β-Cat complex. Non-canonical Wnt signaling is established by binding of Wnt11 (or other non-canonical Wnt) to the Frz receptor (most likely with a different co-receptor) and this activates downstream phosphorylation of G-proteins and Jnk. This pathway also regulates intracellular calcium (Ca2+) levels within the cell. The Wnt antagonist Dkk1 acts by disrupting the interaction between Frz and LRP5/6 such that the pathway can no longer be activated even in the presence of Wnt ligand.

Reference

Picture was drawn from the Signaling pathways in early cardiac development in <pubmed>20830688 </pubmed>

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