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Tooth Eruption Signaling

Three phases of tooth eruption, preeruptive, intraosseous, and supraosseous, require signaling in the PTHrP/PTH1R pathway.

(A) In the preeruptive phase, teeth are fully surrounded by a bony crypt. The enamel organ produces PTHrP and CSF1 (arrows) which feed back to the dental follicle.

(B) The intraosseous phase is characterized by the spatially restricted removal of bone on the coronal side of the tooth due to signals from the dental follicle (arrows). Osteoclasts invade and resorb the bone to create an eruption pathway (ep). Cementum starts to form on the root surfaces (c).

(C) First molars in the present study (1) create an eruption pathway but do not move into the occlusal plane (red X). Excess cementum forms (c), perhaps forming transient fusions with bone, preventing eruption.

(D) Normally, teeth move through the eruption pathway and form an attachment to the surrounding bone via the periodontal ligament. A full deletion of Pthrp followed by restoration of expression in the enamel organ using K14-Pthrp rescues eruption (5).

See research article Takahashi A, Nagata M, Gupta A, Matsushita Y, Yamaguchi T, Mizuhashi K, Maki K, Ruellas AC, Cevidanes LS, Kronenberg HM, Ono N & Ono W. (2019). Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption. Proc. Natl. Acad. Sci. U.S.A. , 116, 575-580. PMID: 30509999 DOI.

Links: tooth

Reference

Richman JM. (2019). Shedding new light on the mysteries of tooth eruption. Proc. Natl. Acad. Sci. U.S.A. , 116, 353-355. PMID: 30602459 DOI.

Pnas.1819412116fig01.jpg

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Cozzarelli NR, Fulton KR, Sullenberger DM. Liberalization of PNAS copyright policy: noncommercial use freely allowed. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12399. PMID15314225 "Our guiding principle is that, while PNAS retains copyright, anyone can make noncommercial use of work in PNAS without asking our permission, provided that the original source is cited."

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current12:14, 16 July 2019Thumbnail for version as of 12:14, 16 July 2019667 × 917 (166 KB)Z8600021 (talk | contribs)==Tooth Eruption Signaling== Three phases of tooth eruption, preeruptive, intraosseous, and supraosseous, require signaling in the PTHrP/PTH1R pathway. (A) In the preeruptive phase, teeth are fully surrounded by a bony crypt. The enamel organ produces...

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