File:Thermoreceptor development diagram.JPG

This diagram shows some of the genes required for the development of the thermosensory nerves. Under the influence of Neurog1 and Neurog2, nerve progenitors begin to express TrkA, a nerve growth factor receptor. Approximately 50% of these nerves continue to express TrkA during differentiation, the other half however start expressing RET, a glial-cell-derived neurotrophic factor. This differentiation occurs under the influence of Runx1, a transcription factor. It is from the pool of RET+ neurons that nerves expressing the thermoTRP ion channels develop. These nerves are capable of thermosensation.

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